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Protein

Group 2 truncated hemoglobin GlbO

Gene

glbO

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

When expressed in E.coli and M.smegmatis, HbO increases oxygen uptake. Membrane vesicles of E.coli carrying HbO show a respiration activity about twice that of membranes without HbO. HbO seems to interact with a terminal oxidase. Therefore, HbO could participate in oxygen/electron-transfer process, suggesting a function related to the facilitation of oxygen transfer during aerobic metabolism of M.tuberculosis (By similarity).By similarity

Cofactori

hemeBy similarityNote: Binds 1 heme group per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi75Iron (heme proximal ligand)By similarity1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Group 2 truncated hemoglobin GlbO
Alternative name(s):
Hemoglobin-like protein HbO
Truncated hemoglobin
Short name:
trHbO
Gene namesi
Name:glbO
Ordered Locus Names:MT2546
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001020 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004272021 – 128Group 2 truncated hemoglobin GlbOAdd BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki23 ↔ 36Isodityrosine (Tyr-Tyr)By similarity
Modified residuei363',4'-dihydroxyphenylalanineBy similarity1

Post-translational modificationi

Contains L-DOPA (3',4'-dihydroxyphenylalanine).By similarity

Keywords - PTMi

Hydroxylation

Interactioni

Subunit structurei

Homododecamer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP9WN22
SMRiP9WN22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK06886
OrthoDBiPOG091H04TN

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR019795 Globin_bac-like_CS
IPR001486 Hemoglobin_trunc
PfamiView protein in Pfam
PF01152 Bac_globin, 1 hit
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01213 GLOBIN_FAM_2, 1 hit

Sequencei

Sequence statusi: Complete.

P9WN22-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKSFYDAVG GAKTFDAIVS RFYAQVAEDE VLRRVYPEDD LAGAEERLRM
60 70 80 90 100
FLEQYWGGPR TYSEQRGHPR LRMRHAPFRI SLIERDAWLR CMHTAVASID
110 120
SETLDDEHRR ELLDYLEMAA HSLVNSPF
Length:128
Mass (Da):14,950
Last modified:April 16, 2014 - v1
Checksum:iCEF4CD23907B0CCA
GO

Sequence cautioni

The sequence AAK46846 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA Translation: AAK46846.1 Different initiation.
PIRiE70866
RefSeqiWP_003412688.1, NC_002755.2

Genome annotation databases

EnsemblBacteriaiAAK46846; AAK46846; MT2546
KEGGimtc:MT2546
PATRICifig|83331.31.peg.2747

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA Translation: AAK46846.1 Different initiation.
PIRiE70866
RefSeqiWP_003412688.1, NC_002755.2

3D structure databases

ProteinModelPortaliP9WN22
SMRiP9WN22
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK46846; AAK46846; MT2546
KEGGimtc:MT2546
PATRICifig|83331.31.peg.2747

Phylogenomic databases

KOiK06886
OrthoDBiPOG091H04TN

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR019795 Globin_bac-like_CS
IPR001486 Hemoglobin_trunc
PfamiView protein in Pfam
PF01152 Bac_globin, 1 hit
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01213 GLOBIN_FAM_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRHBO_MYCTO
AccessioniPrimary (citable) accession number: P9WN22
Secondary accession number(s): L0TBB1, O53197, P0A595
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: May 23, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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