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Entry version 31 (16 Oct 2019)
Sequence version 1 (16 Apr 2014)
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Protein

Uncharacterized glycosyl hydrolase Rv2006

Gene

Rv2006

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Despite its similarity with the trehalose-phosphate phosphatase enzymes, it does not display trehalose-phosphate phosphatase activity.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1023Proton donorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:G185E-6208-MONOMER
MTBH37RV:G185E-6208-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized glycosyl hydrolase Rv2006 (EC:3.2.1.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Rv2006
ORF Names:MTCY39.11c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv2006

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

This protein serves as an immunogenic antigen, inducing gamma-interferon responses in whole-blood cultures from M.tuberculosis-exposed adults in Uganda, The Gambia and South Africa, indicating this might be a good vaccine candidate.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001080191 – 1327Uncharacterized glycosyl hydrolase Rv2006Add BLAST1327

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P9WN15

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

A member of the dormancy regulon. Induced in response to reduced oxygen tension (hypoxia), low levels of nitric oxide (NO) and carbon monoxide (CO). It is hoped that this regulon will give insight into the latent, or dormant phase of infection.3 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
83332.Rv2006

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P9WN15

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni884 – 885Substrate bindingBy similarity2
Regioni1143 – 1144Substrate bindingBy similarity2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the trehalose phosphatase family.Curated
In the C-terminal section; belongs to the glycosyl hydrolase 65 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108K4C Bacteria
COG0637 LUCA
COG1554 LUCA
COG1877 LUCA

KEGG Orthology (KO)

More...
KOi
K01194

Identification of Orthologs from Complete Genome Data

More...
OMAi
WIPDNSR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P9WN15

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.240, 1 hit
1.50.10.10, 1 hit
2.70.98.40, 1 hit
3.40.50.1000, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR011013 Gal_mutarotase_sf_dom
IPR005194 Glyco_hydro_65_C
IPR005195 Glyco_hydro_65_M
IPR005196 Glyco_hydro_65_N
IPR037018 Glyco_hydro_65_N_sf
IPR036412 HAD-like_sf
IPR006379 HAD-SF_hydro_IIB
IPR023214 HAD_sf
IPR023198 PGP-like_dom2
IPR003337 Trehalose_PPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03633 Glyco_hydro_65C, 1 hit
PF03632 Glyco_hydro_65m, 1 hit
PF03636 Glyco_hydro_65N, 1 hit
PF02358 Trehalose_PPase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48208 SSF48208, 1 hit
SSF56784 SSF56784, 2 hits
SSF74650 SSF74650, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01484 HAD-SF-IIB, 1 hit
TIGR00685 T6PP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P9WN15-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRCGIVVNVT GPPPTIDRRY HDAVIVGLDN VVDKATRVHA AAWTKFLDDY
60 70 80 90 100
LTRRPQRTGE DHCPLTHDDY RRFLAGKPDG VADFLAARGI RLPPGSPTDL
110 120 130 140 150
TDDTVYGLQN LERQTFLQLL NTGVPEGKSI ASFARRLQVA GVRVAAHTSH
160 170 180 190 200
RNYGHTLDAT GLAEVFAVFV DGAVTAELGL PAEPNPAGLI ETAKRLGANP
210 220 230 240 250
GRCVVIDSCQ TGLRAGRNGG FALVIAVDAH GDAENLLSSG ADAVVADLAA
260 270 280 290 300
VTVGSGDAAI STIPDALQVY SQLKRLLTGR RPAVFLDFDG TLSDIVERPE
310 320 330 340 350
AATLVDGAAE ALRALAAQCP VAVISGRDLA DVRNRVKVDG LWLAGSHGFE
360 370 380 390 400
LVAPDGSHHQ NAAATAAIDG LAEAAAQLAD ALREIAGAVV EHKRFAVAVH
410 420 430 440 450
YRNVADDSVD NLIAAVRRLG HAAGLRVTTG RKVVELRPDI AWDKGKALDW
460 470 480 490 500
IGERLGPAEV GPDLRLPIYI GDDLTDEDAF DAVRFTGVGI VVRHNEHGDR
510 520 530 540 550
RSAATFRLEC PYTVCQFLSQ LACDLQEAVQ HDDPWTLVFH GYDPGQERLR
560 570 580 590 600
EALCAVGNGY LGSRGCAPES AESEAHYPGT YVAGVYNQLT DHIEGCTVDN
610 620 630 640 650
ESLVNLPNWL SLTFRIDGGA WFNVDTVELL SYRQTFDLRR ATLTRSLRFR
660 670 680 690 700
DAGGRVTTMT QERFASMNRP NLVALQTRIE SENWSGTVDF RSLVDGGVHN
710 720 730 740 750
TLVDRYRQLS SQHLTTAEIE VLADSVLLRT QTSQSGIAIA VAARSTLWRD
760 770 780 790 800
GQRVDAQYRV ARDTNRGGHD IQVTLSAGQS VTLEKVATIF TSRDAATLTA
810 820 830 840 850
AISAQRCLGE AGRYAELCQQ HVRAWARLWE RCAIDLTGNT EELRLVRLHL
860 870 880 890 900
LHLLQTISPH TAELDAGVPA RGLNGEAYRG HVFWDALFVA PVLSLRMPKV
910 920 930 940 950
ARSLLDYRYR RLPAARRAAH RAGHLGAMYP WQSGSDGSEV SQQLHLNPRS
960 970 980 990 1000
GRWTPDPSDR AHHVGLAVAY NAWHYYQVTG DRQYLVDCGA ELLVEIARFW
1010 1020 1030 1040 1050
VGLAKLDDSR GRYLIRGVIG PDEFHSGYPG NEYDGIDNNA YTNVMAVWVI
1060 1070 1080 1090 1100
LRAMEALDLL PLTDRRHLIE KLGLTTQERD QWDDVSRRMF VPFHDGVISQ
1110 1120 1130 1140 1150
FEGYSELAEL DWDHYRHRYG NIQRLDRILE AEGDSVNNYQ ASKQADALML
1160 1170 1180 1190 1200
LYLLSSDELI GLLARLGYRF APTQIPGTVD YYLARTSDGS TLSAVVHAWV
1210 1220 1230 1240 1250
LARANRSNAM EYFRQVLRSD IADVQGGTTQ EGIHLAAMAG SIDLLQRCYS
1260 1270 1280 1290 1300
GLELRDDRLV LSPQWPEALG PLEFPFVYRR HQLSLRISGR SATLTAESGD
1310 1320
AEPIEVECRG HVQRLRCGHT IEVGCSR
Length:1,327
Mass (Da):145,784
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i21F3BBC2F4CF9D91
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44778.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D70759

NCBI Reference Sequences

More...
RefSeqi
WP_003410063.1, NZ_NVQJ01000043.1
YP_177855.1, NC_000962.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP44778; CCP44778; Rv2006

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
888943

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv2006
mtv:RVBD_2006

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44778.1
PIRiD70759
RefSeqiWP_003410063.1, NZ_NVQJ01000043.1
YP_177855.1, NC_000962.3

3D structure databases

SMRiP9WN15
ModBaseiSearch...

Protein-protein interaction databases

STRINGi83332.Rv2006

Proteomic databases

PaxDbiP9WN15

Genome annotation databases

EnsemblBacteriaiCCP44778; CCP44778; Rv2006
GeneIDi888943
KEGGimtu:Rv2006
mtv:RVBD_2006

Organism-specific databases

TubercuListiRv2006

Phylogenomic databases

eggNOGiENOG4108K4C Bacteria
COG0637 LUCA
COG1554 LUCA
COG1877 LUCA
KOiK01194
OMAiWIPDNSR
PhylomeDBiP9WN15

Enzyme and pathway databases

BioCyciMetaCyc:G185E-6208-MONOMER
MTBH37RV:G185E-6208-MONOMER

Family and domain databases

Gene3Di1.10.150.240, 1 hit
1.50.10.10, 1 hit
2.70.98.40, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR011013 Gal_mutarotase_sf_dom
IPR005194 Glyco_hydro_65_C
IPR005195 Glyco_hydro_65_M
IPR005196 Glyco_hydro_65_N
IPR037018 Glyco_hydro_65_N_sf
IPR036412 HAD-like_sf
IPR006379 HAD-SF_hydro_IIB
IPR023214 HAD_sf
IPR023198 PGP-like_dom2
IPR003337 Trehalose_PPase
PfamiView protein in Pfam
PF03633 Glyco_hydro_65C, 1 hit
PF03632 Glyco_hydro_65m, 1 hit
PF03636 Glyco_hydro_65N, 1 hit
PF02358 Trehalose_PPase, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit
SSF56784 SSF56784, 2 hits
SSF74650 SSF74650, 1 hit
TIGRFAMsiTIGR01484 HAD-SF-IIB, 1 hit
TIGR00685 T6PP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiY2006_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P9WN15
Secondary accession number(s): L0T8I0, Q10850
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: October 16, 2019
This is version 31 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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