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UniProtKB - P9WMU2 (GLPQ1_MYCTO)
Protein
Probable glycerophosphodiester phosphodiesterase 1
Gene
glpQ1
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Functioni
Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols.
By similarityCatalytic activityi
- EC:3.1.4.46
Cofactori
Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 44 | CalciumBy similarity | 1 | |
Metal bindingi | 46 | CalciumBy similarity | 1 | |
Metal bindingi | 126 | CalciumBy similarity | 1 |
GO - Molecular functioni
- glycerophosphodiester phosphodiesterase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- glycerol metabolic process Source: UniProtKB-KW
- lipid metabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Biological process | Glycerol metabolism |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Probable glycerophosphodiester phosphodiesterase 1 (EC:3.1.4.46)Short name: Glycerophosphoryl diester phosphodiesterase 1 |
Gene namesi | Name:glpQ1 Ordered Locus Names:MT3950 |
Organismi | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
Taxonomic identifieri | 83331 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000427242 | 1 – 274 | Probable glycerophosphodiester phosphodiesterase 1Add BLAST | 274 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 264 | GP-PDEAdd BLAST | 253 |
Sequence similaritiesi
Belongs to the glycerophosphoryl diester phosphodiesterase family.Curated
Phylogenomic databases
HOGENOMi | CLU_030006_3_0_11 |
Family and domain databases
Gene3Di | 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR030395, GP_PDE_dom IPR017946, PLC-like_Pdiesterase_TIM-brl |
Pfami | View protein in Pfam PF03009, GDPD, 1 hit |
SUPFAMi | SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS51704, GP_PDE, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WMU2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTWADEVLAG HPFVVAHRGA SAARPEHTLA AYDLALKEGA DGVECDVRLT
60 70 80 90 100
RDGHLVCVHD RRLDRTSTGA GLVSTMTLAQ LRELEYGAWH DSWRPDGSHG
110 120 130 140 150
DTSLLTLDAL VSLVLDWHRP VKIFVETKHP VRYGSLVENK LLALLHRFGI
160 170 180 190 200
AAPASADRSR AVVMSFSAAA VWRIRRAAPL LPTVLLGKTP RYLTSSAATA
210 220 230 240 250
VGATAVGPSL PALKEYPQLV DRSAAQGRAV YCWNVDEYED IDFCREVGVA
260 270
WIGTHHPGRT KAWLEDGRAN GTTR
Sequence cautioni
The sequence AAK48317 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK48317.1 Different initiation. |
PIRi | G70653 |
RefSeqi | WP_003420924.1, NZ_KK341227.1 |
Genome annotation databases
EnsemblBacteriai | AAK48317; AAK48317; MT3950 |
GeneIDi | 45427843 |
KEGGi | mtc:MT3950 |
PATRICi | fig|83331.31.peg.4248 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK48317.1 Different initiation. |
PIRi | G70653 |
RefSeqi | WP_003420924.1, NZ_KK341227.1 |
3D structure databases
AlphaFoldDBi | P9WMU2 |
SMRi | P9WMU2 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | AAK48317; AAK48317; MT3950 |
GeneIDi | 45427843 |
KEGGi | mtc:MT3950 |
PATRICi | fig|83331.31.peg.4248 |
Phylogenomic databases
HOGENOMi | CLU_030006_3_0_11 |
Family and domain databases
Gene3Di | 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR030395, GP_PDE_dom IPR017946, PLC-like_Pdiesterase_TIM-brl |
Pfami | View protein in Pfam PF03009, GDPD, 1 hit |
SUPFAMi | SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS51704, GP_PDE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GLPQ1_MYCTO | |
Accessioni | P9WMU2Primary (citable) accession number: P9WMU2 Secondary accession number(s): L0TGR7, P96236, Q7D4R6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | May 25, 2022 | |
This is version 35 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |