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Protein

HTH-type transcriptional regulator CmtR

Gene

cmtR

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57Cadmium1
Metal bindingi61Cadmium1
Metal bindingi102Cadmium; shared with dimeric partner1

GO - Molecular functioni

  • cadmium ion binding Source: MTBBASE
  • cadmium ion sensor activity Source: MTBBASE
  • DNA binding Source: MTBBASE
  • DNA-binding transcription factor activity Source: MTBBASE
  • lead ion binding Source: MTBBASE

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandCadmium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator CmtR
Gene namesi
Name:cmtR
Ordered Locus Names:Rv1994c
ORF Names:MTCY39.25
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1994c

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi4C → S: No effect. 1 Publication1
Mutagenesisi24C → S: Loss of repressor activity. 1 Publication1
Mutagenesisi57C → S: Abolishes metal-induced derepression. 1 Publication1
Mutagenesisi61C → S: Abolishes metal-induced derepression. 1 Publication1
Mutagenesisi102C → S: Abolishes metal-induced derepression. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606291 – 118HTH-type transcriptional regulator CmtRAdd BLAST118

Proteomic databases

PaxDbiP9WMI9

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

STRINGi83332.Rv1994c

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP9WMI9
SMRiP9WMI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 97HTH arsR-typePROSITE-ProRule annotationAdd BLAST95

Phylogenomic databases

eggNOGiENOG4108Y4S Bacteria
COG0640 LUCA
KOiK21885
OMAiADEKGCC
PhylomeDBiP9WMI9

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR001845 HTH_ArsR_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01022 HTH_5, 1 hit
PRINTSiPR00778 HTHARSR
SMARTiView protein in SMART
SM00418 HTH_ARSR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50987 HTH_ARSR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P9WMI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTCEMRESA LARLGRALAD PTRCRILVAL LDGVCYPGQL AAHLGLTRSN
60 70 80 90 100
VSNHLSCLRG CGLVVATYEG RQVRYALADS HLARALGELV QVVLAVDTDQ
110
PCVAERAASG EAVEMTGS
Length:118
Mass (Da):12,495
Last modified:April 16, 2014 - v1
Checksum:i1997F68DC2574989
GO

Mass spectrometryi

Molecular mass is 25211 Da from positions 1 - 118. Determined by ESI. The measured mass is that of a dimer, plus 2 cadmium ions.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44766.1
PIRiH70757
RefSeqiNP_216510.1, NC_000962.3
WP_003410018.1, NZ_KK339370.1

Genome annotation databases

EnsemblBacteriaiCCP44766; CCP44766; Rv1994c
GeneIDi888889
KEGGimtu:Rv1994c

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44766.1
PIRiH70757
RefSeqiNP_216510.1, NC_000962.3
WP_003410018.1, NZ_KK339370.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JSCNMR-A/B1-118[»]
ProteinModelPortaliP9WMI9
SMRiP9WMI9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1994c

Proteomic databases

PaxDbiP9WMI9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP44766; CCP44766; Rv1994c
GeneIDi888889
KEGGimtu:Rv1994c

Organism-specific databases

TubercuListiRv1994c

Phylogenomic databases

eggNOGiENOG4108Y4S Bacteria
COG0640 LUCA
KOiK21885
OMAiADEKGCC
PhylomeDBiP9WMI9

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR001845 HTH_ArsR_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01022 HTH_5, 1 hit
PRINTSiPR00778 HTHARSR
SMARTiView protein in SMART
SM00418 HTH_ARSR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50987 HTH_ARSR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCMTR_MYCTU
AccessioniPrimary (citable) accession number: P9WMI9
Secondary accession number(s): L0T9V9, P67731, Q10864
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: September 12, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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