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Protein

Uncharacterized HTH-type transcriptional regulator Rv0081

Gene

Rv0081

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi37 – 60H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized HTH-type transcriptional regulator Rv0081
Gene namesi
Ordered Locus Names:Rv0081
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0081

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: MTBBASE

Pathology & Biotechi

Biotechnological usei

This protein serves as an immunogenic antigen, inducing gamma-interferon responses in whole-blood cultures from M.tuberculosis-exposed adults in Uganda, The Gambia and South Africa, indicating this might be a good vaccine candidate.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003926811 – 114Uncharacterized HTH-type transcriptional regulator Rv0081Add BLAST114

Proteomic databases

PaxDbiP9WMI7

Expressioni

Inductioni

A member of the dormancy regulon. Induced in response to reduced oxygen tension (hypoxia), low levels of nitric oxide (NO) and carbon monoxide (CO). It is hoped that this regulon will give insight into the latent, or dormant phase of infection.4 Publications

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0081

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP9WMI7
SMRiP9WMI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 97HTH arsR-typePROSITE-ProRule annotationAdd BLAST96

Phylogenomic databases

eggNOGiENOG4105M9X Bacteria
COG0640 LUCA
OMAiPLYQLKA
PhylomeDBiP9WMI7

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR001845 HTH_ArsR_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PRINTSiPR00778 HTHARSR
SMARTiView protein in SMART
SM00418 HTH_ARSR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50987 HTH_ARSR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P9WMI7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESEPLYKLK AEFFKTLAHP ARIRILELLV ERDRSVGELL SSDVGLESSN
60 70 80 90 100
LSQQLGVLRR AGVVAARRDG NAMIYSIAAP DIAELLAVAR KVLARVLSDR
110
VAVLEDLRAG GSAT
Length:114
Mass (Da):12,356
Last modified:April 16, 2014 - v1
Checksum:iAF3C88714DCC1B4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP42806.1
PIRiB70850
RefSeqiNP_214595.1, NC_000962.3
WP_003400657.1, NZ_KK339370.1

Genome annotation databases

EnsemblBacteriaiCCP42806; CCP42806; Rv0081
GeneIDi887012
KEGGimtu:Rv0081

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP42806.1
PIRiB70850
RefSeqiNP_214595.1, NC_000962.3
WP_003400657.1, NZ_KK339370.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XPQX-ray3.30A/B/C/D2-114[»]
ProteinModelPortaliP9WMI7
SMRiP9WMI7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0081

Proteomic databases

PaxDbiP9WMI7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP42806; CCP42806; Rv0081
GeneIDi887012
KEGGimtu:Rv0081

Organism-specific databases

TubercuListiRv0081

Phylogenomic databases

eggNOGiENOG4105M9X Bacteria
COG0640 LUCA
OMAiPLYQLKA
PhylomeDBiP9WMI7

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR001845 HTH_ArsR_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PRINTSiPR00778 HTHARSR
SMARTiView protein in SMART
SM00418 HTH_ARSR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50987 HTH_ARSR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiY0081_MYCTU
AccessioniPrimary (citable) accession number: P9WMI7
Secondary accession number(s): L0T5M3, O53626, Q7DAH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: September 12, 2018
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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Main funding by: National Institutes of Health

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