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Protein

Bacterial proteasome activator

Gene

bpa

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterial proteasome activatorBy similarity
Gene namesi
Name:bpa
Ordered Locus Names:MT3889
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001020 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004275791 – 174Bacterial proteasome activatorAdd BLAST174

Interactioni

Subunit structurei

Forms a homooligomeric, either hexameric or heptameric, ring-like structure which stacks co-axially with the proteasomal alpha-rings.By similarity

Structurei

3D structure databases

ProteinModelPortaliP9WKX2
SMRiP9WKX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi172 – 174HbYX motifBy similarity3

Sequence similaritiesi

Belongs to the Bpa family.Curated

Phylogenomic databases

OrthoDBiPOG091H09V4

Family and domain databases

InterProiView protein in InterPro
IPR019695 Proteasome_act
PfamiView protein in Pfam
PF10759 DUF2587, 1 hit

Sequencei

Sequence statusi: Complete.

P9WKX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVIGLSTGSD DDDVEVIGGV DPRLIAVQEN DSDESSLTDL VEQPAKVMRI
60 70 80 90 100
GTMIKQLLEE VRAAPLDEAS RNRLRDIHAT SIRELEDGLA PELREELDRL
110 120 130 140 150
TLPFNEDAVP SDAELRIAQA QLVGWLEGLF HGIQTALFAQ QMAARAQLQQ
160 170
MRQGALPPGV GKSGQHGHGT GQYL
Length:174
Mass (Da):18,944
Last modified:April 16, 2014 - v1
Checksum:i1A7D60E1A4F3713E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA Translation: AAK48254.1
PIRiH70695

Genome annotation databases

EnsemblBacteriaiAAK48254; AAK48254; MT3889
KEGGimtc:MT3889

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA Translation: AAK48254.1
PIRiH70695

3D structure databases

ProteinModelPortaliP9WKX2
SMRiP9WKX2
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK48254; AAK48254; MT3889
KEGGimtc:MT3889

Phylogenomic databases

OrthoDBiPOG091H09V4

Family and domain databases

InterProiView protein in InterPro
IPR019695 Proteasome_act
PfamiView protein in Pfam
PF10759 DUF2587, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBPA_MYCTO
AccessioniPrimary (citable) accession number: P9WKX2
Secondary accession number(s): L0TDS4, P65091, P72046
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: March 15, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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