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Protein

Guanylate kinase

Gene

gmk

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 35ATPBy similarity8

GO - Molecular functioni

  • adenylate kinase activity Source: MTBBASE
  • ATP binding Source: MTBBASE
  • GDP binding Source: MTBBASE
  • GMP binding Source: MTBBASE
  • guanylate kinase activity Source: MTBBASE
  • magnesium ion binding Source: MTBBASE

GO - Biological processi

  • growth Source: MTBBASE

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:Rv1389
ORF Names:MTCY21B4.06
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1389.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001705702 – 208Guanylate kinaseAdd BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP9WKE9.

PTM databases

iPTMnetiP9WKE9.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1389.

Structurei

Secondary structure

1208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 27Combined sources5
Helixi34 – 44Combined sources11
Beta strandi54 – 57Combined sources4
Turni65 – 67Combined sources3
Helixi74 – 82Combined sources9
Beta strandi86 – 92Combined sources7
Turni93 – 96Combined sources4
Beta strandi97 – 102Combined sources6
Helixi103 – 111Combined sources9
Beta strandi116 – 119Combined sources4
Helixi122 – 131Combined sources10
Beta strandi135 – 141Combined sources7
Helixi145 – 153Combined sources9
Helixi160 – 175Combined sources16
Helixi176 – 179Combined sources4
Beta strandi180 – 185Combined sources6
Helixi189 – 200Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S4QX-ray2.16A2-208[»]
1Z8FX-ray2.50A2-208[»]
1ZNWX-ray2.10A2-208[»]
1ZNXX-ray2.35A2-208[»]
1ZNYX-ray2.30A2-208[»]
1ZNZX-ray2.50A2-208[»]
ProteinModelPortaliP9WKE9.
SMRiP9WKE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 201Guanylate kinase-likeAdd BLAST181

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108UHA. Bacteria.
COG0194. LUCA.
KOiK00942.
OMAiAGNYYGT.
PhylomeDBiP9WKE9.

Family and domain databases

HAMAPiMF_00328. Guanylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P9WKE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVGEGPDTK PTARGQPAAV GRVVVLSGPS AVGKSTVVRC LRERIPNLHF
60 70 80 90 100
SVSATTRAPR PGEVDGVDYH FIDPTRFQQL IDQGELLEWA EIHGGLHRSG
110 120 130 140 150
TLAQPVRAAA ATGVPVLIEV DLAGARAIKK TMPEAVTVFL APPSWQDLQA
160 170 180 190 200
RLIGRGTETA DVIQRRLDTA RIELAAQGDF DKVVVNRRLE SACAELVSLL

VGTAPGSP
Length:208
Mass (Da):22,095
Last modified:April 16, 2014 - v1
Checksum:i3D2948315974549F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44148.1.
PIRiC70899.
RefSeqiNP_215905.1. NC_000962.3.
WP_003900331.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP44148; CCP44148; Rv1389.
GeneIDi886787.
KEGGimtu:Rv1389.

Similar proteinsi

Entry informationi

Entry nameiKGUA_MYCTU
AccessioniPrimary (citable) accession number: P9WKE9
Secondary accession number(s): L0T9H5, P0A5I4, P71659
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: March 28, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome