We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P9WJY5 (EFPA_MYCTU)
Protein
Uncharacterized MFS-type transporter EfpA
Gene
efpA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 2.A.1.3.78, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Uncharacterized MFS-type transporter EfpAAlternative name(s): Efflux protein A |
Gene namesi | Name:efpA Ordered Locus Names:Rv2846c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv2846c |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 50 | CytoplasmicSequence analysisAdd BLAST | 50 | |
Transmembranei | 51 – 71 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 72 – 91 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 92 – 112 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 113 – 119 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 120 – 140 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 141 – 150 | ExtracellularSequence analysis | 10 | |
Transmembranei | 151 – 171 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 172 – 180 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 181 – 201 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 202 – 203 | ExtracellularSequence analysis | 2 | |
Transmembranei | 204 – 224 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 225 – 239 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 240 – 260 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 261 – 266 | ExtracellularSequence analysis | 6 | |
Transmembranei | 267 – 287 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 288 – 306 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 307 – 327 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 328 – 343 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 344 – 364 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 365 – 370 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 371 – 391 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 392 – 400 | ExtracellularSequence analysis | 9 | |
Transmembranei | 401 – 421 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 422 – 437 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 438 – 458 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 459 – 488 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 489 – 509 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 510 – 530 | CytoplasmicSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000390888 | 1 – 530 | Uncharacterized MFS-type transporter EfpAAdd BLAST | 530 |
Proteomic databases
PaxDbi | P9WJY5 |
Expressioni
Inductioni
Expressed during infection of macrophages. Down-regulated by the nucleoid-associated protein Lsr2.2 Publications
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 38 | DisorderedSequence analysisAdd BLAST | 38 |
Sequence similaritiesi
Belongs to the major facilitator superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0477, Bacteria |
OMAi | GNKKGWL |
PhylomeDBi | P9WJY5 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WJY5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTALNDTERA VRNWTAGRPH RPAPMRPPRS EETASERPSR YYPTWLPSRS
60 70 80 90 100
FIAAVIAIGG MQLLATMDST VAIVALPKIQ NELSLSDAGR SWVITAYVLT
110 120 130 140 150
FGGLMLLGGR LGDTIGRKRT FIVGVALFTI SSVLCAVAWD EATLVIARLS
160 170 180 190 200
QGVGSAIASP TGLALVATTF PKGPARNAAT AVFAAMTAIG SVMGLVVGGA
210 220 230 240 250
LTEVSWRWAF LVNVPIGLVM IYLARTALRE TNKERMKLDA TGAILATLAC
260 270 280 290 300
TAAVFAFSIG PEKGWMSGIT IGSGLVALAA AVAFVIVERT AENPVVPFHL
310 320 330 340 350
FRDRNRLVTF SAILLAGGVM FSLTVCIGLY VQDILGYSAL RAGVGFIPFV
360 370 380 390 400
IAMGIGLGVS SQLVSRFSPR VLTIGGGYLL FGAMLYGSFF MHRGVPYFPN
410 420 430 440 450
LVMPIVVGGI GIGMAVVPLT LSAIAGVGFD QIGPVSAIAL MLQSLGGPLV
460 470 480 490 500
LAVIQAVITS RTLYLGGTTG PVKFMNDVQL AALDHAYTYG LLWVAGAAII
510 520 530
VGGMALFIGY TPQQVAHAQE VKEAIDAGEL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 50 | S → T in AAA85344 (PubMed:9008277).Curated | 1 | |
Sequence conflicti | 200 | A → R in AAA85344 (PubMed:9008277).Curated | 1 | |
Sequence conflicti | 342 – 343 | AG → R in AAA85344 (PubMed:9008277).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L39922 Genomic DNA Translation: AAA85344.1 AL123456 Genomic DNA Translation: CCP45647.1 |
PIRi | A70589 |
RefSeqi | NP_217362.1, NC_000962.3 WP_003414532.1, NZ_NVQJ01000006.1 |
Genome annotation databases
GeneIDi | 888575 |
KEGGi | mtu:Rv2846c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L39922 Genomic DNA Translation: AAA85344.1 AL123456 Genomic DNA Translation: CCP45647.1 |
PIRi | A70589 |
RefSeqi | NP_217362.1, NC_000962.3 WP_003414532.1, NZ_NVQJ01000006.1 |
3D structure databases
SMRi | P9WJY5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv2846c |
Chemistry databases
DrugBanki | DB05154, Pretomanid |
Protein family/group databases
TCDBi | 2.A.1.3.78, the major facilitator superfamily (mfs) |
Proteomic databases
PaxDbi | P9WJY5 |
Protocols and materials databases
DNASUi | 888575 |
Genome annotation databases
GeneIDi | 888575 |
KEGGi | mtu:Rv2846c |
Organism-specific databases
TubercuListi | Rv2846c |
Phylogenomic databases
eggNOGi | COG0477, Bacteria |
OMAi | GNKKGWL |
PhylomeDBi | P9WJY5 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EFPA_MYCTU | |
Accessioni | P9WJY5Primary (citable) accession number: P9WJY5 Secondary accession number(s): L0TDQ9 Q7D6G8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | February 23, 2022 | |
This is version 43 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families