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Protein

Probable molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei28GTPUniRule annotation1
Binding sitei75GTPUniRule annotation1
Metal bindingi107MagnesiumUniRule annotation1
Binding sitei107GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 18GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:MT2528
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001020 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004277871 – 201Probable molybdenum cofactor guanylyltransferaseAdd BLAST201

Structurei

3D structure databases

ProteinModelPortaliP9WJQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

KOiK03752.
OrthoDBiPOG091H05CW.

Family and domain databases

CDDicd02503. MobA. 1 hit.
Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA. 1 hit.
InterProiView protein in InterPro
IPR025877. MobA-like_NTP_Trfase.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
PfamiView protein in Pfam
PF12804. NTP_transf_3. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

P9WJQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELAPDTVP LAGVVLAGGE SRRMGRDKAT LPLPGGTTTL VEHMVGILGQ
60 70 80 90 100
RCAPVFVMAA PGQPLPTLPV PVLRDELPGL GPLPATGRGL RAAAEAGVRL
110 120 130 140 150
AFVCAVDMPY LTVELIEDLA RRAVQTDAEV VLPWDGRNHY LAAVYRTDLA
160 170 180 190 200
DRVDTLVGAG ERKMSALVDA SDALRIVMAD SRPLTNVNSA AGLHAPMQPG

R
Length:201
Mass (Da):21,084
Last modified:April 16, 2014 - v1
Checksum:iD11A81501BBFEC72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA. Translation: AAK46828.1.
PIRiD70864.
RefSeqiWP_003412618.1. NZ_KK341227.1.

Genome annotation databases

EnsemblBacteriaiAAK46828; AAK46828; MT2528.
KEGGimtc:MT2528.
PATRICifig|83331.31.peg.2728.

Similar proteinsi

Entry informationi

Entry nameiMOBA_MYCTO
AccessioniPrimary (citable) accession number: P9WJQ8
Secondary accession number(s): L0T9V2, O53180, P65402
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: March 28, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome