UniProtKB - P9WJL9 (MURB_MYCTU)
Protein
UDP-N-acetylenolpyruvoylglucosamine reductase
Gene
murB
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Cell wall formation.By similarity
Catalytic activityi
- EC:1.3.1.98
Cofactori
FADBy similarity
: peptidoglycan biosynthesis Pathwayi
This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 176 | By similarity | 1 | |
Active sitei | 257 | Proton donorBy similarity | 1 | |
Active sitei | 361 | By similarity | 1 |
GO - Molecular functioni
- FAD binding Source: InterPro
- UDP-N-acetylmuramate dehydrogenase activity Source: UniProtKB-UniRule
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cell wall organization Source: UniProtKB-KW
- peptidoglycan biosynthetic process Source: UniProtKB-UniRule
- regulation of cell shape Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis |
Ligand | FAD, Flavoprotein, NADP |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-4610-MONOMER |
UniPathwayi | UPA00219 |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-N-acetylenolpyruvoylglucosamine reductase (EC:1.3.1.98)Alternative name(s): UDP-N-acetylmuramate dehydrogenase |
Gene namesi | Name:murB Ordered Locus Names:Rv0482 ORF Names:MTCY20G9.08 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv0482 |
Subcellular locationi
- Cytoplasm By similarity
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000179230 | 1 – 369 | UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST | 369 |
Proteomic databases
PaxDbi | P9WJL9 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P9WJL9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 202 | FAD-binding PCMH-typeAdd BLAST | 174 |
Sequence similaritiesi
Belongs to the MurB family.Curated
Phylogenomic databases
eggNOGi | ENOG4107R4N Bacteria COG0812 LUCA |
KOi | K00075 |
OMAi | IGNAGSF |
PhylomeDBi | P9WJL9 |
Family and domain databases
Gene3Di | 3.30.43.10, 1 hit 3.30.465.10, 1 hit 3.90.78.10, 1 hit |
HAMAPi | MF_00037 MurB, 1 hit |
InterProi | View protein in InterPro IPR016166 FAD-bd_PCMH IPR036318 FAD-bd_PCMH-like_sf IPR016167 FAD-bd_PCMH_sub1 IPR016169 FAD-bd_PCMH_sub2 IPR003170 MurB IPR011601 MurB_C IPR036635 MurB_C_sf IPR006094 Oxid_FAD_bind_N |
PANTHERi | PTHR21071 PTHR21071, 1 hit |
Pfami | View protein in Pfam PF01565 FAD_binding_4, 1 hit PF02873 MurB_C, 1 hit |
SUPFAMi | SSF56176 SSF56176, 1 hit SSF56194 SSF56194, 1 hit |
TIGRFAMsi | TIGR00179 murB, 1 hit |
PROSITEi | View protein in PROSITE PS51387 FAD_PCMH, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WJL9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRSGVGSLF AGAHIAEAVP LAPLTTLRVG PIARRVITCT SAEQVVAALR
60 70 80 90 100
HLDSAAKTGA DRPLVFAGGS NLVIAENLTD LTVVRLANSG ITIDGNLVRA
110 120 130 140 150
EAGAVFDDVV VRAIEQGLGG LECLSGIPGS AGATPVQNVG AYGAEVSDTI
160 170 180 190 200
TRVRLLDRCT GEVRWVSARD LRFGYRTSVL KHADGLAVPT VVLEVEFALD
210 220 230 240 250
PSGRSAPLRY GELIAALNAT SGERADPQAV REAVLALRAR KGMVLDPTDH
260 270 280 290 300
DTWSVGSFFT NPVVTQDVYE RLAGDAATRK DGPVPHYPAP DGVKLAAGWL
310 320 330 340 350
VERAGFGKGY PDAGAAPCRL STKHALALTN RGGATAEDVV TLARAVRDGV
360
HDVFGITLKP EPVLIGCML
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43216.1 |
PIRi | E70743 |
RefSeqi | NP_214996.1, NC_000962.3 WP_003402354.1, NZ_NVQJ01000002.1 |
Genome annotation databases
EnsemblBacteriai | CCP43216; CCP43216; Rv0482 |
GeneIDi | 887169 |
KEGGi | mtu:Rv0482 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43216.1 |
PIRi | E70743 |
RefSeqi | NP_214996.1, NC_000962.3 WP_003402354.1, NZ_NVQJ01000002.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5JZX | X-ray | 2.20 | A/B/C/D/E/F | 1-369 | [»] | |
SMRi | P9WJL9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv0482 |
Proteomic databases
PaxDbi | P9WJL9 |
Genome annotation databases
EnsemblBacteriai | CCP43216; CCP43216; Rv0482 |
GeneIDi | 887169 |
KEGGi | mtu:Rv0482 |
Organism-specific databases
TubercuListi | Rv0482 |
Phylogenomic databases
eggNOGi | ENOG4107R4N Bacteria COG0812 LUCA |
KOi | K00075 |
OMAi | IGNAGSF |
PhylomeDBi | P9WJL9 |
Enzyme and pathway databases
UniPathwayi | UPA00219 |
BioCyci | MTBH37RV:G185E-4610-MONOMER |
Family and domain databases
Gene3Di | 3.30.43.10, 1 hit 3.30.465.10, 1 hit 3.90.78.10, 1 hit |
HAMAPi | MF_00037 MurB, 1 hit |
InterProi | View protein in InterPro IPR016166 FAD-bd_PCMH IPR036318 FAD-bd_PCMH-like_sf IPR016167 FAD-bd_PCMH_sub1 IPR016169 FAD-bd_PCMH_sub2 IPR003170 MurB IPR011601 MurB_C IPR036635 MurB_C_sf IPR006094 Oxid_FAD_bind_N |
PANTHERi | PTHR21071 PTHR21071, 1 hit |
Pfami | View protein in Pfam PF01565 FAD_binding_4, 1 hit PF02873 MurB_C, 1 hit |
SUPFAMi | SSF56176 SSF56176, 1 hit SSF56194 SSF56194, 1 hit |
TIGRFAMsi | TIGR00179 murB, 1 hit |
PROSITEi | View protein in PROSITE PS51387 FAD_PCMH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MURB_MYCTU | |
Accessioni | P9WJL9Primary (citable) accession number: P9WJL9 Secondary accession number(s): L0T3W0, P65460, Q11148 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 16, 2019 | |
This is version 32 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references