UniProtKB - P9WJK7 (MUTA_MYCTU)
Protein
Probable methylmalonyl-CoA mutase small subunit
Gene
mutA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.By similarity
Miscellaneous
Was identified as a high-confidence drug target.
Catalytic activityi
- EC:5.4.99.2
Cofactori
adenosylcob(III)alaminBy similarity
: propanoyl-CoA degradation Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- Probable propionyl-CoA carboxylase beta chain 5 (accD5), Probable propionyl-CoA carboxylase beta chain 6 (accD6)
- no protein annotated in this organism
- Probable methylmalonyl-CoA mutase large subunit (mutB), Probable methylmalonyl-CoA mutase small subunit (mutA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.
GO - Molecular functioni
- cobalamin binding Source: UniProtKB-KW
- metal ion binding Source: InterPro
- methylmalonyl-CoA mutase activity Source: GO_Central
GO - Biological processi
- lactate fermentation to propionate and acetate Source: InterPro
- propionate metabolic process, methylmalonyl pathway Source: MTBBASE
Keywordsi
Molecular function | Isomerase |
Ligand | Cobalamin, Cobalt |
Enzyme and pathway databases
UniPathwayi | UPA00945;UER00910 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:mutA Ordered Locus Names:Rv1492 ORF Names:MTCY277.14 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv1492 |
Subcellular locationi
GO - Cellular componenti
- cell wall Source: MTBBASE
- cytosol Source: MTBBASE
- plasma membrane Source: MTBBASE
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000194265 | 1 – 615 | Probable methylmalonyl-CoA mutase small subunitAdd BLAST | 615 |
Proteomic databases
PaxDbi | P9WJK7 |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta chain.
By similarityProtein-protein interaction databases
STRINGi | 83332.Rv1492 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P9WJK7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the methylmalonyl-CoA mutase family.Curated
Phylogenomic databases
eggNOGi | COG1884, Bacteria |
OMAi | WYVERLT |
PhylomeDBi | P9WJK7 |
Family and domain databases
InterProi | View protein in InterPro IPR016176, Cbl-dep_enz_cat IPR036724, Cobalamin-bd_sf IPR006099, MeMalonylCoA_mutase_a/b_cat IPR004608, MMCoA_mutase_b |
Pfami | View protein in Pfam PF01642, MM_CoA_mutase, 1 hit |
SUPFAMi | SSF51703, SSF51703, 1 hit SSF52242, SSF52242, 1 hit |
TIGRFAMsi | TIGR00642, mmCoA_mut_beta, 1 hit |
PROSITEi | View protein in PROSITE PS00544, METMALONYL_COA_MUTASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WJK7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSIDVPERAD LEQVRGRWRN AVAGVLSKSN RTDSAQLGDH PERLLDTQTA
60 70 80 90 100
DGFAIRALYT AFDELPEPPL PGQWPFVRGG DPLRDVHSGW KVAEAFPANG
110 120 130 140 150
ATADTNAAVL AALGEGVSAL LIRVGESGVA PDRLTALLSG VYLNLAPVIL
160 170 180 190 200
DAGADYRPAC DVMLALVAQL DPGQRDTLSI DLGADPLTAS LRDRPAPPIE
210 220 230 240 250
EVVAVASRAA GERGLRAITV DGPAFHNLGA TAATELAATV AAAVAYLRVL
260 270 280 290 300
TESGLVVSDA LRQISFRLAA DDDQFMTLAK MRALRQLWAR VAEVVGDPGG
310 320 330 340 350
GAAVVHAETS LPMMTQRDPW VNMLRCTLAA FGAGVGGADT VLVHPFDVAI
360 370 380 390 400
PGGFPGTAAG FARRIARNTQ LLLLEESHVG RVLDPAGGSW FVEELTDRLA
410 420 430 440 450
RRAWQRFQAI EARGGFVEAH DFLAGQIAEC AARRADDIAH RRLAITGVNE
460 470 480 490 500
YPNLGEPALP PGDPTSPVRR YAAGFEALRD RSDHHLARTG ARPRVLLLPL
510 520 530 540 550
GPLAEHNIRT TFATNLLASG GIEAIDPGTV DAGTVGNAVA DAGSPSVAVI
560 570 580 590 600
CGTDARYRDE VADIVQAARA AGVSRVYLAG PEKALGDAAH RPDEFLTAKI
610
NVVQALSNLL TRLGA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44253.1 |
PIRi | G70711 |
RefSeqi | NP_216008.1, NC_000962.3 WP_003407585.1, NZ_NVQJ01000004.1 |
Genome annotation databases
EnsemblBacteriai | CCP44253; CCP44253; Rv1492 |
GeneIDi | 45425472 886507 |
KEGGi | mtu:Rv1492 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44253.1 |
PIRi | G70711 |
RefSeqi | NP_216008.1, NC_000962.3 WP_003407585.1, NZ_NVQJ01000004.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6OXC | X-ray | 1.90 | B | 1-615 | [»] | |
6OXD | X-ray | 2.00 | B | 1-615 | [»] | |
SMRi | P9WJK7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv1492 |
Proteomic databases
PaxDbi | P9WJK7 |
Genome annotation databases
EnsemblBacteriai | CCP44253; CCP44253; Rv1492 |
GeneIDi | 45425472 886507 |
KEGGi | mtu:Rv1492 |
Organism-specific databases
TubercuListi | Rv1492 |
Phylogenomic databases
eggNOGi | COG1884, Bacteria |
OMAi | WYVERLT |
PhylomeDBi | P9WJK7 |
Enzyme and pathway databases
UniPathwayi | UPA00945;UER00910 |
Family and domain databases
InterProi | View protein in InterPro IPR016176, Cbl-dep_enz_cat IPR036724, Cobalamin-bd_sf IPR006099, MeMalonylCoA_mutase_a/b_cat IPR004608, MMCoA_mutase_b |
Pfami | View protein in Pfam PF01642, MM_CoA_mutase, 1 hit |
SUPFAMi | SSF51703, SSF51703, 1 hit SSF52242, SSF52242, 1 hit |
TIGRFAMsi | TIGR00642, mmCoA_mut_beta, 1 hit |
PROSITEi | View protein in PROSITE PS00544, METMALONYL_COA_MUTASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MUTA_MYCTU | |
Accessioni | P9WJK7Primary (citable) accession number: P9WJK7 Secondary accession number(s): L0T9S6, P65485, P71773 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | February 10, 2021 | |
This is version 39 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families