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Protein

Hypoxic response protein 1

Gene

hrp1

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Unlike some other CBS-domain containing proteins does not seem to bind AMP.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi97Zinc 1By similarity1
Metal bindingi122Zinc 2By similarity1

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxic response protein 1
Short name:
HRP1
Gene namesi
Name:hrp1
Ordered Locus Names:MT2701
OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Taxonomic identifieri83331 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001020 Componenti: Chromosome

Subcellular locationi

  • Secreted By similarity
  • Note: Not seen to be associated with the cell wall.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004278651 – 143Hypoxic response protein 1Add BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi14 ↔ 39By similarity
Disulfide bondi136InterchainBy similarity

Keywords - PTMi

Disulfide bond

Expressioni

Inductioni

A member of the dormancy regulon. Induced in response to reduced oxygen tension (hypoxia) and low levels of nitric oxide (NO).1 Publication

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP9WJA2
SMRiP9WJA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 65CBS 1PROSITE-ProRule annotationAdd BLAST58
Domaini73 – 131CBS 2PROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

OrthoDBiPOG091H04HU

Family and domain databases

InterProiView protein in InterPro
IPR000644 CBS_dom
PfamiView protein in Pfam
PF00571 CBS, 2 hits
SMARTiView protein in SMART
SM00116 CBS, 2 hits
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits

Sequencei

Sequence statusi: Complete.

P9WJA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTARDIMNA GVTCVGEHET LTAAAQYMRE HDIGALPICG DDDRLHGMLT
60 70 80 90 100
DRDIVIKGLA AGLDPNTATA GELARDSIYY VDANASIQEM LNVMEEHQVR
110 120 130 140
RVPVISEHRL VGIVTEADIA RHLPEHAIVQ FVKAICSPMA LAS
Length:143
Mass (Da):15,518
Last modified:April 16, 2014 - v1
Checksum:iCF65AA9144341038
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA Translation: AAK47017.1
PIRiA70573
RefSeqiWP_003413598.1, NZ_KK341227.1

Genome annotation databases

EnsemblBacteriaiAAK47017; AAK47017; MT2701
KEGGimtc:MT2701
PATRICifig|83331.31.peg.2912

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000516 Genomic DNA Translation: AAK47017.1
PIRiA70573
RefSeqiWP_003413598.1, NZ_KK341227.1

3D structure databases

ProteinModelPortaliP9WJA2
SMRiP9WJA2
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK47017; AAK47017; MT2701
KEGGimtc:MT2701
PATRICifig|83331.31.peg.2912

Phylogenomic databases

OrthoDBiPOG091H04HU

Family and domain databases

InterProiView protein in InterPro
IPR000644 CBS_dom
PfamiView protein in Pfam
PF00571 CBS, 2 hits
SMARTiView protein in SMART
SM00116 CBS, 2 hits
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHRP1_MYCTO
AccessioniPrimary (citable) accession number: P9WJA2
Secondary accession number(s): L0TBT6, O06186, Q7D6V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: June 7, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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