UniProtKB - P9WIY1 (MUTT2_MYCTU)
Protein
Putative 8-oxo-dGTP diphosphatase 2
Gene
mutT2
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate (By similarity). In vitro has 8-oxo-dGTPase activity.By similarity1 Publication
Miscellaneous
There are 4 mutT paralogs in M.tuberculosis; the exact function of each is unknown.
Catalytic activityi
- EC:3.6.1.55
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 37 | Magnesium or manganese; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 52 | Magnesium or manganeseBy similarity | 1 | |
Metal bindingi | 55 | Magnesium or manganeseBy similarity | 1 | |
Metal bindingi | 56 | Magnesium or manganeseBy similarity | 1 |
GO - Molecular functioni
- 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity Source: GO_Central
- 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity Source: GO_Central
- 8-oxo-dGDP phosphatase activity Source: GO_Central
- 8-oxo-GDP phosphatase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- DNA repair Source: GO_Central
- DNA replication Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Mutator protein |
Biological process | DNA damage, DNA repair, DNA replication |
Ligand | Magnesium, Manganese, Metal-binding |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-5329-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Putative 8-oxo-dGTP diphosphatase 2 (EC:3.6.1.55)Short name: 8-oxo-dGTPase 2 Alternative name(s): 7,8-dihydro-8-oxoguanine-triphosphatase 2 Mutator protein MutT2 dGTP pyrophosphohydrolase 2 |
Gene namesi | Name:mutT2 Ordered Locus Names:Rv1160 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv1160 |
Pathology & Biotechi
Disruption phenotypei
No visible phenotype.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000391776 | 1 – 141 | Putative 8-oxo-dGTP diphosphatase 2Add BLAST | 141 |
Proteomic databases
PaxDbi | P9WIY1 |
PRIDEi | P9WIY1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 131 | Nudix hydrolasePROSITE-ProRule annotationAdd BLAST | 130 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 37 – 58 | Nudix boxAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the Nudix hydrolase family.Curated
Phylogenomic databases
eggNOGi | ENOG41080JQ Bacteria COG0494 LUCA |
KOi | K03574 |
OMAi | RPPHADQ |
PhylomeDBi | P9WIY1 |
Family and domain databases
InterProi | View protein in InterPro IPR020476 Nudix_hydrolase IPR015797 NUDIX_hydrolase-like_dom_sf IPR020084 NUDIX_hydrolase_CS IPR000086 NUDIX_hydrolase_dom |
Pfami | View protein in Pfam PF00293 NUDIX, 1 hit |
PRINTSi | PR00502 NUDIXFAMILY |
SUPFAMi | SSF55811 SSF55811, 1 hit |
PROSITEi | View protein in PROSITE PS51462 NUDIX, 1 hit PS00893 NUDIX_BOX, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WIY1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLNQIVVAGA IVRGCTVLVA QRVRPPELAG RWELPGGKVA AGETERAALA
60 70 80 90 100
RELAEELGLE VADLAVGDRV GDDIALNGTT TLRAYRVHLL GGEPRARDHR
110 120 130 140
ALCWVTAAEL HDVDWVPADR GWIADLARTL NGSAADVHRR C
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43916.1 |
PIRi | A70556 |
RefSeqi | NP_215676.1, NC_000962.3 WP_003406084.1, NZ_NVQJ01000025.1 |
Genome annotation databases
EnsemblBacteriai | CCP43916; CCP43916; Rv1160 |
GeneIDi | 888485 |
KEGGi | mtu:Rv1160 mtv:RVBD_1160 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43916.1 |
PIRi | A70556 |
RefSeqi | NP_215676.1, NC_000962.3 WP_003406084.1, NZ_NVQJ01000025.1 |
3D structure databases
SMRi | P9WIY1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv1160 |
Proteomic databases
PaxDbi | P9WIY1 |
PRIDEi | P9WIY1 |
Genome annotation databases
EnsemblBacteriai | CCP43916; CCP43916; Rv1160 |
GeneIDi | 888485 |
KEGGi | mtu:Rv1160 mtv:RVBD_1160 |
Organism-specific databases
TubercuListi | Rv1160 |
Phylogenomic databases
eggNOGi | ENOG41080JQ Bacteria COG0494 LUCA |
KOi | K03574 |
OMAi | RPPHADQ |
PhylomeDBi | P9WIY1 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-5329-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR020476 Nudix_hydrolase IPR015797 NUDIX_hydrolase-like_dom_sf IPR020084 NUDIX_hydrolase_CS IPR000086 NUDIX_hydrolase_dom |
Pfami | View protein in Pfam PF00293 NUDIX, 1 hit |
PRINTSi | PR00502 NUDIXFAMILY |
SUPFAMi | SSF55811 SSF55811, 1 hit |
PROSITEi | View protein in PROSITE PS51462 NUDIX, 1 hit PS00893 NUDIX_BOX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MUTT2_MYCTU | |
Accessioni | P9WIY1Primary (citable) accession number: P9WIY1 Secondary accession number(s): L0T5W0, O06558, Q7D8R0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 16, 2019 | |
This is version 28 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names