UniProtKB - P9WIV1 (NUSB_MYCTU)
Protein
Transcription antitermination protein NusB
Gene
nusB
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.UniRule annotation
Miscellaneous
Was identified as a high-confidence drug target.1 Publication
GO - Molecular functioni
- RNA binding Source: UniProtKB-UniRule
GO - Biological processi
- DNA-templated transcription, termination Source: UniProtKB-UniRule
- transcription antitermination Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding |
Biological process | Transcription, Transcription antitermination, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription antitermination protein NusBUniRule annotationAlternative name(s): Antitermination factor NusBUniRule annotation |
Gene namesi | Name:nusB1 PublicationUniRule annotation Ordered Locus Names:Rv2533c ORF Names:MTCY159.23 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv2533c |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000176557 | 1 – 156 | Transcription antitermination protein NusBAdd BLAST | 156 |
Proteomic databases
PaxDbi | P9WIV1 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
STRINGi | 83332.Rv2533c |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P9WIV1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0781, Bacteria |
OMAi | DRMPVVD |
PhylomeDBi | P9WIV1 |
Family and domain databases
Gene3Di | 1.10.940.10, 1 hit |
HAMAPi | MF_00073, NusB, 1 hit |
InterProi | View protein in InterPro IPR035926, NusB-like_sf IPR011605, NusB_fam IPR006027, NusB_RsmB_TIM44 |
PANTHERi | PTHR11078, PTHR11078, 1 hit |
Pfami | View protein in Pfam PF01029, NusB, 1 hit |
SUPFAMi | SSF48013, SSF48013, 1 hit |
TIGRFAMsi | TIGR01951, nusB, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WIV1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDRKPVRGR HQARKRAVAL LFEAEVRGIS AAEVVDTRAA LAEAKPDIAR
60 70 80 90 100
LHPYTAAVAR GVSEHAAHID DLITAHLRGW TLDRLPAVDR AILRVSVWEL
110 120 130 140 150
LHAADVPEPV VVDEAVQLAK ELSTDDSPGF VNGVLGQVML VTPQLRAAAQ
AVRGGA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45328.1 |
PIRi | A70658 |
RefSeqi | NP_217049.1, NC_000962.3 WP_003899364.1, NZ_NVQJ01000032.1 |
Genome annotation databases
EnsemblBacteriai | CCP45328; CCP45328; Rv2533c |
GeneIDi | 23491240 887359 |
KEGGi | mtu:Rv2533c mtv:RVBD_2533c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45328.1 |
PIRi | A70658 |
RefSeqi | NP_217049.1, NC_000962.3 WP_003899364.1, NZ_NVQJ01000032.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1EYV | X-ray | 1.60 | A/B | 1-156 | [»] | |
SMRi | P9WIV1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv2533c |
Proteomic databases
PaxDbi | P9WIV1 |
Genome annotation databases
EnsemblBacteriai | CCP45328; CCP45328; Rv2533c |
GeneIDi | 23491240 887359 |
KEGGi | mtu:Rv2533c mtv:RVBD_2533c |
Organism-specific databases
TubercuListi | Rv2533c |
Phylogenomic databases
eggNOGi | COG0781, Bacteria |
OMAi | DRMPVVD |
PhylomeDBi | P9WIV1 |
Family and domain databases
Gene3Di | 1.10.940.10, 1 hit |
HAMAPi | MF_00073, NusB, 1 hit |
InterProi | View protein in InterPro IPR035926, NusB-like_sf IPR011605, NusB_fam IPR006027, NusB_RsmB_TIM44 |
PANTHERi | PTHR11078, PTHR11078, 1 hit |
Pfami | View protein in Pfam PF01029, NusB, 1 hit |
SUPFAMi | SSF48013, SSF48013, 1 hit |
TIGRFAMsi | TIGR01951, nusB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NUSB_MYCTU | |
Accessioni | P9WIV1Primary (citable) accession number: P9WIV1 Secondary accession number(s): L0TCN2, P95020 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | December 2, 2020 | |
This is version 34 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families