UniProtKB - P9WIG7 (PE35_MYCTU)
Protein
PE family immunomodulator PE35
Gene
PE35
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Plays a major role in RD1-associated pathogenesis, and may contribute to the establishment and maintenance of M.tuberculosis infection. Together with PPE68, stimulates the secretion of IL-10 and MCP-1 from human macrophages, via the interaction with human Toll-like receptor 2 (TLR2).1 Publication
Miscellaneous
Could be used for serodiagnosis of both pulmonary and extra-pulmonary tuberculosis.1 Publication
GO - Biological processi
- pathogenesis Source: UniProtKB-KW
Keywordsi
Biological process | Virulence |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-8170-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: PE family immunomodulator PE35Curated |
Gene namesi | Name:PE35 Ordered Locus Names:Rv3872 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv3872 |
Subcellular locationi
- Secreted 1 Publication
- Cell surface 1 Publication
GO - Cellular componenti
- cell surface Source: UniProtKB-SubCell
- extracellular region Source: MTBBASE
Keywords - Cellular componenti
SecretedPathology & Biotechi
Disruption phenotypei
Inactivation impairs expression of EsxA (ESAT-6) and EsxB (CFP-10).1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000394202 | 1 – 99 | PE family immunomodulator PE35Add BLAST | 99 |
Proteomic databases
PaxDbi | P9WIG7 |
Interactioni
Subunit structurei
Interacts with PPE68. PE35/PPE68 complex interacts with human TLR2.
1 PublicationBinary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
P9WHW9 | 3 | EBI-9086211,EBI-9086224 |
Protein-protein interaction databases
IntActi | P9WIG7, 2 interactors |
MINTi | P9WIG7 |
STRINGi | 83332.Rv3872 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 90 | PESequence analysisAdd BLAST | 90 |
Sequence similaritiesi
Belongs to the mycobacterial PE family.Curated
Phylogenomic databases
OMAi | MEIAGIY |
Family and domain databases
InterProi | View protein in InterPro IPR000084 PE-PGRS_N |
Pfami | View protein in Pfam PF00934 PE, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WIG7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKMSHDPIA ADIGTQVSDN ALHGVTAGST ALTSVTGLVP AGADEVSAQA
60 70 80 90
ATAFTSEGIQ LLASNASAQD QLHRAGEAVQ DVARTYSQID DGAAGVFAE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46701.1 |
PIRi | F70802 |
RefSeqi | WP_003912361.1, NZ_NVQJ01000074.1 YP_178021.1, NC_000962.3 |
Genome annotation databases
EnsemblBacteriai | CCP46701; CCP46701; Rv3872 |
GeneIDi | 886191 |
KEGGi | mtu:Rv3872 mtv:RVBD_3872 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46701.1 |
PIRi | F70802 |
RefSeqi | WP_003912361.1, NZ_NVQJ01000074.1 YP_178021.1, NC_000962.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | P9WIG7, 2 interactors |
MINTi | P9WIG7 |
STRINGi | 83332.Rv3872 |
Proteomic databases
PaxDbi | P9WIG7 |
Genome annotation databases
EnsemblBacteriai | CCP46701; CCP46701; Rv3872 |
GeneIDi | 886191 |
KEGGi | mtu:Rv3872 mtv:RVBD_3872 |
Organism-specific databases
TubercuListi | Rv3872 |
Phylogenomic databases
OMAi | MEIAGIY |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-8170-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR000084 PE-PGRS_N |
Pfami | View protein in Pfam PF00934 PE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PE35_MYCTU | |
Accessioni | P9WIG7Primary (citable) accession number: P9WIG7 Secondary accession number(s): L0TGV1, Q79F93, Q8VIR8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | September 18, 2019 | |
This is version 23 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names