UniProtKB - P9WIC2 (PHEA_MYCTO)
Protein
Prephenate dehydratase
Gene
pheA
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Functioni
Catalytic activityi
- EC:4.2.1.51
: L-phenylalanine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes phenylpyruvate from prephenate.Proteins known to be involved in this subpathway in this organism are:
- Prephenate dehydratase (pheA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phenylpyruvate from prephenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 182 | Essential for activityBy similarity | 1 |
GO - Molecular functioni
- chorismate mutase activity Source: InterPro
- prephenate dehydratase activity Source: UniProtKB-EC
GO - Biological processi
- L-phenylalanine biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Allosteric enzyme, Lyase |
Biological process | Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00121;UER00345 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pheA Ordered Locus Names:MT3946 |
Organismi | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
Taxonomic identifieri | 83331 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000428032 | 1 – 321 | Prephenate dehydrataseAdd BLAST | 321 |
Interactioni
Subunit structurei
Homodimer.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 189 | Prephenate dehydratasePROSITE-ProRule annotationAdd BLAST | 187 | |
Domaini | 203 – 280 | ACTPROSITE-ProRule annotationAdd BLAST | 78 |
Phylogenomic databases
HOGENOMi | CLU_035008_0_0_11 |
Family and domain databases
InterProi | View protein in InterPro IPR002912, ACT_dom IPR008242, Chor_mutase/pphenate_deHydtase IPR001086, Preph_deHydtase IPR018528, Preph_deHydtase_CS |
Pfami | View protein in Pfam PF01842, ACT, 1 hit PF00800, PDT, 1 hit |
PIRSFi | PIRSF001500, Chor_mut_pdt_Ppr, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit PS00858, PREPHENATE_DEHYDR_2, 1 hit PS51171, PREPHENATE_DEHYDR_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WIC2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVRIAYLGPE GTFTEAALVR MVAAGLVPET GPDALQRMPV ESAPAALAAV
60 70 80 90 100
RDGGADYACV PIENSIDGSV LPTLDSLAIG VRLQVFAETT LDVTFSIVVK
110 120 130 140 150
PGRNAADVRT LAAFPVAAAQ VRQWLAAHLP AADLRPAYSN ADAARQVADG
160 170 180 190 200
LVDAAVTSPL AAARWGLAAL ADGVVDESNA RTRFVLVGRP GPPPARTGAD
210 220 230 240 250
RTSAVLRIDN QPGALVAALA EFGIRGIDLT RIESRPTRTE LGTYLFFVDC
260 270 280 290 300
VGHIDDEAVA EALKAVHRRC ADVRYLGSWP TGPAAGAQPP LVDEASRWLA
310 320
RLRAGKPEQT LVRPDDQGAQ A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK48313.1 |
PIRi | C70653 |
RefSeqi | WP_003420906.1, NZ_KK341227.1 |
Genome annotation databases
EnsemblBacteriai | AAK48313; AAK48313; MT3946 |
GeneIDi | 23489871 |
KEGGi | mtc:MT3946 |
PATRICi | fig|83331.31.peg.4244 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK48313.1 |
PIRi | C70653 |
RefSeqi | WP_003420906.1, NZ_KK341227.1 |
3D structure databases
SMRi | P9WIC2 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | AAK48313; AAK48313; MT3946 |
GeneIDi | 23489871 |
KEGGi | mtc:MT3946 |
PATRICi | fig|83331.31.peg.4244 |
Phylogenomic databases
HOGENOMi | CLU_035008_0_0_11 |
Enzyme and pathway databases
UniPathwayi | UPA00121;UER00345 |
Family and domain databases
InterProi | View protein in InterPro IPR002912, ACT_dom IPR008242, Chor_mutase/pphenate_deHydtase IPR001086, Preph_deHydtase IPR018528, Preph_deHydtase_CS |
Pfami | View protein in Pfam PF01842, ACT, 1 hit PF00800, PDT, 1 hit |
PIRSFi | PIRSF001500, Chor_mut_pdt_Ppr, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit PS00858, PREPHENATE_DEHYDR_2, 1 hit PS51171, PREPHENATE_DEHYDR_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PHEA_MYCTO | |
Accessioni | P9WIC2Primary (citable) accession number: P9WIC2 Secondary accession number(s): L0TFE5, P96240, Q7D4S0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | December 2, 2020 | |
This is version 31 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |