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UniProtKB - P9WI15 (PPE24_MYCTU)

Entry version 25 (10 Feb 2021)
Sequence version 1 (16 Apr 2014)
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Protein

Uncharacterized PPE family protein PPE24

Gene

PPE24

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Was identified as a high-confidence drug target.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized PPE family protein PPE24
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPE24
Ordered Locus Names:Rv1753c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...TubercuListi		Rv1753c

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003784801 – 1053Uncharacterized PPE family protein PPE24Add BLAST1053

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P9WI15

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		83332.Rv1753c

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P9WI15

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 201Ala-richAdd BLAST189
Compositional biasi202 – 451Gly-richAdd BLAST250
Compositional biasi208 – 441Asn-richAdd BLAST234
Compositional biasi802 – 942Thr-richAdd BLAST141
Compositional biasi854 – 939Pro-richAdd BLAST86
Compositional biasi922 – 1024Gly-richAdd BLAST103

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mycobacterial PPE family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG5263, Bacteria
COG5651, Bacteria

Identification of Orthologs from Complete Genome Data

More...OMAi		HPWHRRL

Database for complete collections of gene phylogenies

More...PhylomeDBi		P9WI15

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1260.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002989, Mycobac_pentapep
IPR000030, PPE_family
IPR038332, PPE_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01469, Pentapeptide_2, 4 hits
PF00823, PPE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P9WI15-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFSVLPPEI NSALIFAGAG PEPMAAAATA WDGLAMELAS AAASFGSVTS 
        60         70         80         90        100
GLVGGAWQGA SSSAMAAAAA PYAAWLAAAA VQAEQTAAQA AAMIAEFEAV 
       110        120        130        140        150
KTAVVQPMLV AANRADLVSL VMSNLFGQNA PAIAAIEATY EQMWAADVSA 
       160        170        180        190        200
MSAYHAGASA IASALSPFSK PLQNLAGLPA WLASGAPAAA MTAAAGIPAL 
       210        220        230        240        250
AGGPTAINLG IANVGGGNVG NANNGLANIG NANLGNYNFG SGNFGNSNIG 
       260        270        280        290        300
SASLGNNNIG FGNLGSNNVG VGNLGNLNTG FANTGLGNFG FGNTGNNNIG 
       310        320        330        340        350
IGLTGNNQIG IGGLNSGTGN FGLFNSGSGN VGFFNSGNGN FGIGNSGNFN 
       360        370        380        390        400
TGGWNSGHGN TGFFNAGSFN TGMLDVGNAN TGSLNTGSYN MGDFNPGSSN 
       410        420        430        440        450
TGTFNTGNAN TGFLNAGNIN TGVFNIGHMN NGLFNTGDMN NGVFYRGVGQ 
       460        470        480        490        500
GSLQFSITTP DLTLPPLQIP GISVPAFSLP AITLPSLNIP AATTPANITV 
       510        520        530        540        550
GAFSLPGLTL PSLNIPAATT PANITVGAFS LPGLTLPSLN IPAATTPANI 
       560        570        580        590        600
TVGAFSLPGL TLPSLNIPAA TTPANITVGA FSLPGLTLPS LNIPAATTPA 
       610        620        630        640        650
NITVGAFSLP GLTLPSLNIP AATTPANITV SGFQLPPLSI PSVAIPPVTV 
       660        670        680        690        700
PPITVGAFNL PPLQIPEVTI PQLTIPAGIT IGGFSLPAIH TQPITVGQIG 
       710        720        730        740        750
VGQFGLPSIG WDVFLSTPRI TVPAFGIPFT LQFQTNVPAL QPPGGGLSTF 
       760        770        780        790        800
TNGALIFGEF DLPQLVVHPY TLTGPIVIGS FFLPAFNIPG IDVPAINVDG 
       810        820        830        840        850
FTLPQITTPA ITTPEFAIPP IGVGGFTLPQ ITTQEIITPE LTINSIGVGG 
       860        870        880        890        900
FTLPQITTPP ITTPPLTIDP INLTGFTLPQ ITTPPITTPP LTIDPINLTG 
       910        920        930        940        950
FTLPQITTPP ITTPPLTIEP IGVGGFTTPP LTVPGIHLPS TTIGAFAIPG 
       960        970        980        990       1000
GPGYFNSSTA PSSGFFNSGA GGNSGFGNNG SGLSGWFNTN PAGLLGGSGY 
      1010       1020       1030       1040       1050
QNFGGLSSGF SNLGSGVSGF ANRGILPFSV ASVVSGFANI GTNLAGFFQG 

TTS
Length:1,053
Mass (Da):104,650
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2657C1A1651AF9B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44519.1

Protein sequence database of the Protein Information Resource

More...PIRi		B70987

NCBI Reference Sequences

More...RefSeqi		WP_010886126.1, NC_018143.2
YP_177830.1, NC_000962.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		CCP44519; CCP44519; Rv1753c

Database of genes from NCBI RefSeq genomes

More...GeneIDi		885544

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mtu:Rv1753c

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|83332.111.peg.1949

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44519.1
PIRiB70987
RefSeqiWP_010886126.1, NC_018143.2
YP_177830.1, NC_000962.3

3D structure databases

SMRiP9WI15
ModBaseiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1753c

Proteomic databases

PaxDbiP9WI15

Genome annotation databases

EnsemblBacteriaiCCP44519; CCP44519; Rv1753c
GeneIDi885544
KEGGimtu:Rv1753c
PATRICifig|83332.111.peg.1949

Organism-specific databases

TubercuListiRv1753c

Phylogenomic databases

eggNOGiCOG5263, Bacteria
COG5651, Bacteria
OMAiHPWHRRL
PhylomeDBiP9WI15

Family and domain databases

Gene3Di1.20.1260.20, 1 hit
InterProiView protein in InterPro
IPR002989, Mycobac_pentapep
IPR000030, PPE_family
IPR038332, PPE_sf
PfamiView protein in Pfam
PF01469, Pentapeptide_2, 4 hits
PF00823, PPE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPE24_MYCTU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P9WI15
Secondary accession number(s): L0TAA3, Q79FL2, Q8VJX6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: February 10, 2021
This is version 25 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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