UniProtKB - P9WHQ3 (Y1540_MYCTU)
Protein
Uncharacterized RNA pseudouridine synthase Rv1540
Gene
Rv1540
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 139 | By similarity | 1 |
GO - Molecular functioni
- pseudouridine synthase activity Source: GO_Central
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- enzyme-directed rRNA pseudouridine synthesis Source: GO_Central
Keywordsi
Molecular function | Isomerase, RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Uncharacterized RNA pseudouridine synthase Rv1540 (EC:5.4.99.-)Alternative name(s): RNA pseudouridylate synthase RNA-uridine isomerase |
Gene namesi | Ordered Locus Names:Rv1540 ORF Names:MTCY48.25c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv1540 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000162743 | 1 – 308 | Uncharacterized RNA pseudouridine synthase Rv1540Add BLAST | 308 |
Proteomic databases
PaxDbi | P9WHQ3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 81 | S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST | 67 |
Sequence similaritiesi
Belongs to the pseudouridine synthase RluA family.Curated
Phylogenomic databases
eggNOGi | COG0564, Bacteria |
OMAi | AHPSPGW |
PhylomeDBi | P9WHQ3 |
Family and domain databases
CDDi | cd02869, PseudoU_synth_RluCD_like, 1 hit |
Gene3Di | 3.10.290.10, 1 hit |
InterProi | View protein in InterPro IPR020103, PsdUridine_synth_cat_dom_sf IPR006225, PsdUridine_synth_RluC/D IPR006224, PsdUridine_synth_RluC/D_CS IPR006145, PsdUridine_synth_RsuA/RluA IPR002942, S4_RNA-bd IPR036986, S4_RNA-bd_sf |
Pfami | View protein in Pfam PF00849, PseudoU_synth_2, 1 hit |
SMARTi | View protein in SMART SM00363, S4, 1 hit |
SUPFAMi | SSF55120, SSF55120, 1 hit |
TIGRFAMsi | TIGR00005, rluA_subfam, 1 hit |
PROSITEi | View protein in PROSITE PS01129, PSI_RLU, 1 hit PS50889, S4, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WHQ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADRSMPVPD GLAGMRVDTG LARLLGLSRT AAAALAEEGA VELNGVPAGK
60 70 80 90 100
SDRLVSGALL QVRLPEAPAP LQNTPIDIEG MTILYSDDDI VAVDKPAAVA
110 120 130 140 150
AHASVGWTGP TVLGGLAAAG YRITTSGVHE RQGIVHRLDV GTSGVMVVAI
160 170 180 190 200
SERAYTVLKR AFKYRTVDKR YHALVQGHPD PSSGTIDAPI GRHRGHEWKF
210 220 230 240 250
AITKNGRHSL THYDTLEAFV AASLLDVHLE TGRTHQIRVH FAALHHPCCG
260 270 280 290 300
DLVYGADPKL AKRLGLDRQW LHARSLAFAH PADGRRVEIV SPYPADLQHA
LKILRGEG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44304.1 |
PIRi | A70761 |
RefSeqi | NP_216056.1, NC_000962.3 WP_003407723.1, NZ_NVQJ01000004.1 |
Genome annotation databases
EnsemblBacteriai | CCP44304; CCP44304; Rv1540 |
GeneIDi | 23492294 886404 |
KEGGi | mtu:Rv1540 mtv:RVBD_1540 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44304.1 |
PIRi | A70761 |
RefSeqi | NP_216056.1, NC_000962.3 WP_003407723.1, NZ_NVQJ01000004.1 |
3D structure databases
SMRi | P9WHQ3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv1540 |
Proteomic databases
PaxDbi | P9WHQ3 |
Genome annotation databases
EnsemblBacteriai | CCP44304; CCP44304; Rv1540 |
GeneIDi | 23492294 886404 |
KEGGi | mtu:Rv1540 mtv:RVBD_1540 |
Organism-specific databases
TubercuListi | Rv1540 |
Phylogenomic databases
eggNOGi | COG0564, Bacteria |
OMAi | AHPSPGW |
PhylomeDBi | P9WHQ3 |
Family and domain databases
CDDi | cd02869, PseudoU_synth_RluCD_like, 1 hit |
Gene3Di | 3.10.290.10, 1 hit |
InterProi | View protein in InterPro IPR020103, PsdUridine_synth_cat_dom_sf IPR006225, PsdUridine_synth_RluC/D IPR006224, PsdUridine_synth_RluC/D_CS IPR006145, PsdUridine_synth_RsuA/RluA IPR002942, S4_RNA-bd IPR036986, S4_RNA-bd_sf |
Pfami | View protein in Pfam PF00849, PseudoU_synth_2, 1 hit |
SMARTi | View protein in SMART SM00363, S4, 1 hit |
SUPFAMi | SSF55120, SSF55120, 1 hit |
TIGRFAMsi | TIGR00005, rluA_subfam, 1 hit |
PROSITEi | View protein in PROSITE PS01129, PSI_RLU, 1 hit PS50889, S4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Y1540_MYCTU | |
Accessioni | P9WHQ3Primary (citable) accession number: P9WHQ3 Secondary accession number(s): L0T9Q9, P0A5T2, Q10786 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | December 2, 2020 | |
This is version 38 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families