UniProtKB - P9WHQ1 (Y1711_MYCTU)
Protein
Uncharacterized RNA pseudouridine synthase Rv1711
Gene
Rv1711
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Miscellaneous
Was identified as a high-confidence drug target.
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 119 | NucleophileBy similarity | 1 |
GO - Molecular functioni
- pseudouridine synthase activity Source: InterPro
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- pseudouridine synthesis Source: InterPro
Keywordsi
Molecular function | Isomerase, RNA-binding |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-5903-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Uncharacterized RNA pseudouridine synthase Rv1711 (EC:5.4.99.-)Alternative name(s): RNA pseudouridylate synthase RNA-uridine isomerase |
Gene namesi | Ordered Locus Names:Rv1711 ORF Names:MTCI125.33 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv1711 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000100029 | 1 – 254 | Uncharacterized RNA pseudouridine synthase Rv1711Add BLAST | 254 |
Proteomic databases
PaxDbi | P9WHQ1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 81 | S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST | 68 |
Sequence similaritiesi
Belongs to the pseudouridine synthase RsuA family.Curated
Phylogenomic databases
eggNOGi | ENOG4105FE9 Bacteria COG1187 LUCA |
KOi | K06178 |
OMAi | HVPKTYE |
PhylomeDBi | P9WHQ1 |
Family and domain databases
CDDi | cd00165 S4, 1 hit |
Gene3Di | 3.10.290.10, 1 hit 3.30.70.1560, 1 hit |
InterProi | View protein in InterPro IPR042092 PsdUridine_s_RsuA/RluB/E/F_cat IPR020103 PsdUridine_synth_cat_dom_sf IPR006145 PsdUridine_synth_RsuA/RluA IPR000748 PsdUridine_synth_RsuA/RluB/E/F IPR018496 PsdUridine_synth_RsuA/RluB_CS IPR002942 S4_RNA-bd IPR036986 S4_RNA-bd_sf |
Pfami | View protein in Pfam PF00849 PseudoU_synth_2, 1 hit PF01479 S4, 1 hit |
SMARTi | View protein in SMART SM00363 S4, 1 hit |
SUPFAMi | SSF55120 SSF55120, 1 hit |
TIGRFAMsi | TIGR00093 TIGR00093, 1 hit |
PROSITEi | View protein in PROSITE PS01149 PSI_RSU, 1 hit PS50889 S4, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WHQ1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMAEPEESRE PRGIRLQKVL SQAGIASRRA AEKMIVDGRV EVDGHVVTEL
60 70 80 90 100
GTRVDPQVAV VRVDGARVVL DDSLVYLALN KPRGMHSTMS DDRGRPCIGD
110 120 130 140 150
LIERKVRGTK KLFHVGRLDA DTEGLMLLTN DGELAHRLMH PSHEVPKTYL
160 170 180 190 200
ATVTGSVPRG LGRTLRAGIE LDDGPAFVDD FAVVDAIPGK TLVRVTLHEG
210 220 230 240 250
RNRIVRRLLA AAGFPVEALV RTDIGAVSLG KQRPGSVRAL RSNEIGQLYQ
AVGL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44477.1 |
PIRi | F70504 |
RefSeqi | NP_216227.1, NC_000962.3 WP_003408439.1, NZ_NVQJ01000010.1 |
Genome annotation databases
EnsemblBacteriai | CCP44477; CCP44477; Rv1711 |
GeneIDi | 885122 |
KEGGi | mtu:Rv1711 mtv:RVBD_1711 |
PATRICi | fig|83332.111.peg.1901 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44477.1 |
PIRi | F70504 |
RefSeqi | NP_216227.1, NC_000962.3 WP_003408439.1, NZ_NVQJ01000010.1 |
3D structure databases
SMRi | P9WHQ1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv1711 |
Proteomic databases
PaxDbi | P9WHQ1 |
Genome annotation databases
EnsemblBacteriai | CCP44477; CCP44477; Rv1711 |
GeneIDi | 885122 |
KEGGi | mtu:Rv1711 mtv:RVBD_1711 |
PATRICi | fig|83332.111.peg.1901 |
Organism-specific databases
TubercuListi | Rv1711 |
Phylogenomic databases
eggNOGi | ENOG4105FE9 Bacteria COG1187 LUCA |
KOi | K06178 |
OMAi | HVPKTYE |
PhylomeDBi | P9WHQ1 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-5903-MONOMER |
Family and domain databases
CDDi | cd00165 S4, 1 hit |
Gene3Di | 3.10.290.10, 1 hit 3.30.70.1560, 1 hit |
InterProi | View protein in InterPro IPR042092 PsdUridine_s_RsuA/RluB/E/F_cat IPR020103 PsdUridine_synth_cat_dom_sf IPR006145 PsdUridine_synth_RsuA/RluA IPR000748 PsdUridine_synth_RsuA/RluB/E/F IPR018496 PsdUridine_synth_RsuA/RluB_CS IPR002942 S4_RNA-bd IPR036986 S4_RNA-bd_sf |
Pfami | View protein in Pfam PF00849 PseudoU_synth_2, 1 hit PF01479 S4, 1 hit |
SMARTi | View protein in SMART SM00363 S4, 1 hit |
SUPFAMi | SSF55120 SSF55120, 1 hit |
TIGRFAMsi | TIGR00093 TIGR00093, 1 hit |
PROSITEi | View protein in PROSITE PS01149 PSI_RSU, 1 hit PS50889 S4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Y1711_MYCTU | |
Accessioni | P9WHQ1Primary (citable) accession number: P9WHQ1 Secondary accession number(s): L0T7P5, O33210, P65842 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 16, 2019 | |
This is version 30 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names