UniProtKB - P9WHH2 (MTR_MYCTO)
Protein
Mycothione reductase
Gene
mtr
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Functioni
Catalyzes the NAD(P)H-dependent reduction of mycothione (the oxidized disulfide form of mycothiol) to mycothiol.By similarity
Catalytic activityi
Cofactori
FADBy similarityNote: Binds 1 FAD per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 444 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 31 – 39 | FADBy similarity | 9 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: InterPro
- mycothione reductase activity Source: UniProtKB-EC
GO - Biological processi
- cell redox homeostasis Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein, NAD, NADP |
Names & Taxonomyi
Protein namesi | Recommended name: Mycothione reductase (EC:1.8.1.15)Alternative name(s): Mycothiol-disulfide reductase NADPH-dependent mycothione reductase |
Gene namesi | Name:mtr Synonyms:gorA Ordered Locus Names:MT2922 |
Organismi | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
Taxonomic identifieri | 83331 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000428187 | 1 – 459 | Mycothione reductaseAdd BLAST | 459 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 39 ↔ 44 | Redox-activeBy similarity |
Keywords - PTMi
Disulfide bondInteractioni
Subunit structurei
Homodimer.
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.Curated
Keywords - Domaini
Redox-active centerPhylogenomic databases
HOGENOMi | CLU_016755_1_2_11 |
Family and domain databases
Gene3Di | 3.30.390.30, 1 hit 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR023753, FAD/NAD-binding_dom IPR016156, FAD/NAD-linked_Rdtase_dimer_sf IPR017817, Mycothione_reductase IPR001100, Pyr_nuc-diS_OxRdtase IPR004099, Pyr_nucl-diS_OxRdtase_dimer IPR012999, Pyr_OxRdtase_I_AS |
Pfami | View protein in Pfam PF07992, Pyr_redox_2, 1 hit PF02852, Pyr_redox_dim, 1 hit |
PIRSFi | PIRSF000350, Mercury_reductase_MerA, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit SSF55424, SSF55424, 1 hit |
TIGRFAMsi | TIGR03452, mycothione_red, 1 hit |
PROSITEi | View protein in PROSITE PS00076, PYRIDINE_REDOX_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WHH2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METYDIAIIG TGSGNSILDE RYASKRAAIC EQGTFGGTCL NVGCIPTKMF
60 70 80 90 100
VYAAEVAKTI RGASRYGIDA HIDRVRWDDV VSRVFGRIDP IALSGEDYRR
110 120 130 140 150
CAPNIDVYRT HTRFGPVQAD GRYLLRTDAG EEFTAEQVVI AAGSRPVIPP
160 170 180 190 200
AILASGVDYH TSDTVMRIAE LPEHIVIVGS GFIAAEFAHV FSALGVRVTL
210 220 230 240 250
VIRGSCLLRH CDDTICERFT RIASTKWELR THRNVVDGQQ RGSGVALRLD
260 270 280 290 300
DGCTINADLL LVATGRVSNA DLLDAEQAGV DVEDGRVIVD EYQRTSARGV
310 320 330 340 350
FALGDVSSPY LLKHVANHEA RVVQHNLLCD WEDTQSMIVT DHRYVPAAVF
360 370 380 390 400
TDPQIAAVGL TENQAVAKGL DISVKIQDYG DVAYGWAMED TSGIVKLITE
410 420 430 440 450
RGSGRLLGAH IMGYQASSLI QPLIQAMSFG LTAAEMARGQ YWIHPALPEV
VENALLGLR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK47247.1 |
PIRi | B70590 |
RefSeqi | WP_003414557.1, NZ_KK341227.1 |
Genome annotation databases
EnsemblBacteriai | AAK47247; AAK47247; MT2922 |
GeneIDi | 23490908 |
KEGGi | mtc:MT2922 |
PATRICi | fig|83331.31.peg.3155 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK47247.1 |
PIRi | B70590 |
RefSeqi | WP_003414557.1, NZ_KK341227.1 |
3D structure databases
SMRi | P9WHH2 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | AAK47247; AAK47247; MT2922 |
GeneIDi | 23490908 |
KEGGi | mtc:MT2922 |
PATRICi | fig|83331.31.peg.3155 |
Phylogenomic databases
HOGENOMi | CLU_016755_1_2_11 |
Family and domain databases
Gene3Di | 3.30.390.30, 1 hit 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR023753, FAD/NAD-binding_dom IPR016156, FAD/NAD-linked_Rdtase_dimer_sf IPR017817, Mycothione_reductase IPR001100, Pyr_nuc-diS_OxRdtase IPR004099, Pyr_nucl-diS_OxRdtase_dimer IPR012999, Pyr_OxRdtase_I_AS |
Pfami | View protein in Pfam PF07992, Pyr_redox_2, 1 hit PF02852, Pyr_redox_dim, 1 hit |
PIRSFi | PIRSF000350, Mercury_reductase_MerA, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit SSF55424, SSF55424, 1 hit |
TIGRFAMsi | TIGR03452, mycothione_red, 1 hit |
PROSITEi | View protein in PROSITE PS00076, PYRIDINE_REDOX_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MTR_MYCTO | |
Accessioni | P9WHH2Primary (citable) accession number: P9WHH2 Secondary accession number(s): L0TB27 Q7D6G4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | December 2, 2020 | |
This is version 44 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |