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Entry version 48 (16 Oct 2019)
Sequence version 1 (16 Apr 2014)
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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processAntibiotic resistance, Transcription

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTBH37RV:G185E-4810-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:Rv0667
ORF Names:MTCI376.08c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv0667

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

DNA-directed RNA polymerase

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi138E → R: Weakens interaction with TRCF and CarD. 1 Publication1
Mutagenesisi147I → A: Weakens interaction with TRCF and CarD. 1 Publication1
Mutagenesisi148K → A: Does not affect association with TRCF, but weakens interaction with CarD. 1 Publication1
Mutagenesisi149S → A: Does not affect association with TRCF, but weakens interaction with CarD. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2006

DrugCentral

More...
DrugCentrali
P9WGY9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000479271 – 1178DNA-directed RNA polymerase subunit betaAdd BLAST1178

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P9WGY9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

Interacts with CarD, TRCF (Mfd) and RbpA.

UniRule annotation2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P9WJG35EBI-6419676,EBI-6421028

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P9WGY9, 3 interactors

STRING: functional protein association networks

More...
STRINGi
83332.Rv0667

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P9WGY9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P9WGY9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108IIJ Bacteria
COG0085 LUCA

KEGG Orthology (KO)

More...
KOi
K03043

Identification of Orthologs from Complete Genome Data

More...
OMAi
FMTWEGY

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00653 RNA_pol_B_RPB2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.150.10, 1 hit
2.40.270.10, 1 hit
2.40.50.150, 1 hit
3.90.1110.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01321 RNApol_bact_RpoB, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042107 DNA-dir_RNA_pol_bsu_ext_1_sf
IPR019462 DNA-dir_RNA_pol_bsu_external_1
IPR015712 DNA-dir_RNA_pol_su2
IPR007120 DNA-dir_RNAP_su2_dom
IPR037033 DNA-dir_RNAP_su2_hyb_sf
IPR010243 RNA_pol_bsu_bac
IPR007121 RNA_pol_bsu_CS
IPR007644 RNA_pol_bsu_protrusion
IPR007642 RNA_pol_Rpb2_2
IPR037034 RNA_pol_Rpb2_2_sf
IPR007645 RNA_pol_Rpb2_3
IPR007641 RNA_pol_Rpb2_7
IPR014724 RNA_pol_RPB2_OB-fold

The PANTHER Classification System

More...
PANTHERi
PTHR20856 PTHR20856, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04563 RNA_pol_Rpb2_1, 1 hit
PF04561 RNA_pol_Rpb2_2, 1 hit
PF04565 RNA_pol_Rpb2_3, 1 hit
PF10385 RNA_pol_Rpb2_45, 1 hit
PF00562 RNA_pol_Rpb2_6, 1 hit
PF04560 RNA_pol_Rpb2_7, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02013 rpoB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01166 RNA_POL_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P9WGY9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEGCILADS RQSKTAASPS PSRPQSSSNN SVPGAPNRVS FAKLREPLEV
60 70 80 90 100
PGLLDVQTDS FEWLIGSPRW RESAAERGDV NPVGGLEEVL YELSPIEDFS
110 120 130 140 150
GSMSLSFSDP RFDDVKAPVD ECKDKDMTYA APLFVTAEFI NNNTGEIKSQ
160 170 180 190 200
TVFMGDFPMM TEKGTFIING TERVVVSQLV RSPGVYFDET IDKSTDKTLH
210 220 230 240 250
SVKVIPSRGA WLEFDVDKRD TVGVRIDRKR RQPVTVLLKA LGWTSEQIVE
260 270 280 290 300
RFGFSEIMRS TLEKDNTVGT DEALLDIYRK LRPGEPPTKE SAQTLLENLF
310 320 330 340 350
FKEKRYDLAR VGRYKVNKKL GLHVGEPITS STLTEEDVVA TIEYLVRLHE
360 370 380 390 400
GQTTMTVPGG VEVPVETDDI DHFGNRRLRT VGELIQNQIR VGMSRMERVV
410 420 430 440 450
RERMTTQDVE AITPQTLINI RPVVAAIKEF FGTSQLSQFM DQNNPLSGLT
460 470 480 490 500
HKRRLSALGP GGLSRERAGL EVRDVHPSHY GRMCPIETPE GPNIGLIGSL
510 520 530 540 550
SVYARVNPFG FIETPYRKVV DGVVSDEIVY LTADEEDRHV VAQANSPIDA
560 570 580 590 600
DGRFVEPRVL VRRKAGEVEY VPSSEVDYMD VSPRQMVSVA TAMIPFLEHD
610 620 630 640 650
DANRALMGAN MQRQAVPLVR SEAPLVGTGM ELRAAIDAGD VVVAEESGVI
660 670 680 690 700
EEVSADYITV MHDNGTRRTY RMRKFARSNH GTCANQCPIV DAGDRVEAGQ
710 720 730 740 750
VIADGPCTDD GEMALGKNLL VAIMPWEGHN YEDAIILSNR LVEEDVLTSI
760 770 780 790 800
HIEEHEIDAR DTKLGAEEIT RDIPNISDEV LADLDERGIV RIGAEVRDGD
810 820 830 840 850
ILVGKVTPKG ETELTPEERL LRAIFGEKAR EVRDTSLKVP HGESGKVIGI
860 870 880 890 900
RVFSREDEDE LPAGVNELVR VYVAQKRKIS DGDKLAGRHG NKGVIGKILP
910 920 930 940 950
VEDMPFLADG TPVDIILNTH GVPRRMNIGQ ILETHLGWCA HSGWKVDAAK
960 970 980 990 1000
GVPDWAARLP DELLEAQPNA IVSTPVFDGA QEAELQGLLS CTLPNRDGDV
1010 1020 1030 1040 1050
LVDADGKAML FDGRSGEPFP YPVTVGYMYI MKLHHLVDDK IHARSTGPYS
1060 1070 1080 1090 1100
MITQQPLGGK AQFGGQRFGE MECWAMQAYG AAYTLQELLT IKSDDTVGRV
1110 1120 1130 1140 1150
KVYEAIVKGE NIPEPGIPES FKVLLKELQS LCLNVEVLSS DGAAIELREG
1160 1170
EDEDLERAAA NLGINLSRNE SASVEDLA
Length:1,178
Mass (Da):129,865
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3DA88DEC6A7DF661
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CCP43410 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti441D → E in AAB31207 (PubMed:8027320).Curated1
Sequence conflicti527E → G in AAA20242 (Ref. 3) Curated1
Sequence conflicti639 – 645GDVVVAE → ATSSSQ in AAA21416 (PubMed:8031050).Curated7
Sequence conflicti639 – 645GDVVVAE → ATSSSQ in AAA20242 (Ref. 3) Curated7
Sequence conflicti967 – 968QP → HA in AAA21416 (PubMed:8031050).Curated2
Sequence conflicti1174V → F in AAA21416 (PubMed:8031050).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti423V → A in strain: vr1; rifampicin-resistant. 1
Natural varianti436L → P in strain: vr2; rifampicin-resistant. 1
Natural varianti437S → T in strain: vr3; rifampicin-resistant. 1
Natural varianti438 – 441QFMD → H in strain: RJ49; rifampicin-resistant. 4
Natural varianti438Q → L in strain: vr4; rifampicin-resistant. 1
Natural varianti439F → V in strain: RJ37; rifampicin-resistant. 1
Natural varianti440 – 443Missing in strain: RJ55; rifampicin-resistant. 4
Natural varianti441D → V in strain: vr3; rifampicin-resistant. 1
Natural varianti449 – 452LTHK → WPQ in strain: RJ48; rifampicin-resistant. 4
Natural varianti451H → D in strain: vr5; rifampicin-resistant. 1
Natural varianti451H → L in strain: SP28; rifampicin-resistant. 1
Natural varianti451H → N in strain: vr6; rifampicin-resistant. 1
Natural varianti451H → P in strain: vr8; rifampicin-resistant. 1
Natural varianti451H → Q in strain: vr1; rifampicin-resistant. 1
Natural varianti451H → R in strain: vr7; rifampicin-resistant. 1
Natural varianti456S → L in strain: vr11 and RJ37; rifampicin-resistant. 1
Natural varianti456S → Q in strain: vr9; rifampicin-resistant. 1
Natural varianti456S → W in strain: vr10; rifampicin-resistant. 1
Natural varianti458L → P in strain: vr12 and SP22; rifampicin-resistant. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L27989 Genomic DNA Translation: AAA21416.1
AL123456 Genomic DNA Translation: CCP43410.1 Different initiation.
U12205 Genomic DNA Translation: AAA20242.2
L05910 Genomic DNA Translation: AAB59068.1
AF143771 Genomic DNA Translation: AAD29720.1
AF146567 Genomic DNA Translation: AAD37379.1
AF147030 Genomic DNA Translation: AAD45505.1
AF147031 Genomic DNA Translation: AAD45506.1
AF147033 Genomic DNA Translation: AAD45507.1
AF147034 Genomic DNA Translation: AAD45508.1
S71246 Genomic DNA Translation: AAB31207.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F70535

NCBI Reference Sequences

More...
RefSeqi
NP_215181.1, NC_000962.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP43410; CCP43410; Rv0667

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
888164

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv0667

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|83332.12.peg.742

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27989 Genomic DNA Translation: AAA21416.1
AL123456 Genomic DNA Translation: CCP43410.1 Different initiation.
U12205 Genomic DNA Translation: AAA20242.2
L05910 Genomic DNA Translation: AAB59068.1
AF143771 Genomic DNA Translation: AAD29720.1
AF146567 Genomic DNA Translation: AAD37379.1
AF147030 Genomic DNA Translation: AAD45505.1
AF147031 Genomic DNA Translation: AAD45506.1
AF147033 Genomic DNA Translation: AAD45507.1
AF147034 Genomic DNA Translation: AAD45508.1
S71246 Genomic DNA Translation: AAB31207.1
PIRiF70535
RefSeqiNP_215181.1, NC_000962.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KBJX-ray2.45A/B53-439[»]
4KBMX-ray2.11A53-439[»]
5UH5X-ray3.75C1-1178[»]
5UH6X-ray3.84C1-1178[»]
5UH8X-ray4.18C1-1178[»]
5UH9X-ray4.40C1-1178[»]
5UHAX-ray3.91C1-1178[»]
5UHBX-ray4.29C1-1178[»]
5UHCX-ray3.80C1-1178[»]
5UHDX-ray4.01C1-1178[»]
5UHEX-ray4.04C1-1178[»]
5UHFX-ray4.34C1-1178[»]
5UHGX-ray3.97C1-1178[»]
5ZX2X-ray2.80C7-1178[»]
5ZX3X-ray2.75C7-1178[»]
6BZOelectron microscopy3.38C7-1178[»]
6C04electron microscopy3.27C7-1178[»]
6C05electron microscopy5.15C7-1178[»]
6C06electron microscopy5.15C7-1178[»]
6DV9X-ray3.80C1-1178[»]
6DVBX-ray3.80C1-1178[»]
6DVCX-ray3.30C1-1178[»]
6DVDX-ray3.90C1-1178[»]
6DVEX-ray3.81C1-1178[»]
6EDTelectron microscopy-C7-1140[»]
6EE8electron microscopy3.92C7-1140[»]
6EECelectron microscopy3.55C7-1178[»]
6FBVelectron microscopy3.50C1-1178[»]
6JCXX-ray2.90C7-1178[»]
6JCYX-ray3.11C7-1178[»]
6M7Jelectron microscopy4.40C7-1178[»]
SMRiP9WGY9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiP9WGY9, 3 interactors
STRINGi83332.Rv0667

Chemistry databases

BindingDBiP9WGY9
ChEMBLiCHEMBL2006
DrugCentraliP9WGY9

Proteomic databases

PaxDbiP9WGY9

Genome annotation databases

EnsemblBacteriaiCCP43410; CCP43410; Rv0667
GeneIDi888164
KEGGimtu:Rv0667
PATRICifig|83332.12.peg.742

Organism-specific databases

TubercuListiRv0667

Phylogenomic databases

eggNOGiENOG4108IIJ Bacteria
COG0085 LUCA
KOiK03043
OMAiFMTWEGY

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4810-MONOMER

Family and domain databases

CDDicd00653 RNA_pol_B_RPB2, 1 hit
Gene3Di2.30.150.10, 1 hit
2.40.270.10, 1 hit
2.40.50.150, 1 hit
3.90.1110.10, 1 hit
HAMAPiMF_01321 RNApol_bact_RpoB, 1 hit
InterProiView protein in InterPro
IPR042107 DNA-dir_RNA_pol_bsu_ext_1_sf
IPR019462 DNA-dir_RNA_pol_bsu_external_1
IPR015712 DNA-dir_RNA_pol_su2
IPR007120 DNA-dir_RNAP_su2_dom
IPR037033 DNA-dir_RNAP_su2_hyb_sf
IPR010243 RNA_pol_bsu_bac
IPR007121 RNA_pol_bsu_CS
IPR007644 RNA_pol_bsu_protrusion
IPR007642 RNA_pol_Rpb2_2
IPR037034 RNA_pol_Rpb2_2_sf
IPR007645 RNA_pol_Rpb2_3
IPR007641 RNA_pol_Rpb2_7
IPR014724 RNA_pol_RPB2_OB-fold
PANTHERiPTHR20856 PTHR20856, 1 hit
PfamiView protein in Pfam
PF04563 RNA_pol_Rpb2_1, 1 hit
PF04561 RNA_pol_Rpb2_2, 1 hit
PF04565 RNA_pol_Rpb2_3, 1 hit
PF10385 RNA_pol_Rpb2_45, 1 hit
PF00562 RNA_pol_Rpb2_6, 1 hit
PF04560 RNA_pol_Rpb2_7, 1 hit
TIGRFAMsiTIGR02013 rpoB, 1 hit
PROSITEiView protein in PROSITE
PS01166 RNA_POL_BETA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPOB_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P9WGY9
Secondary accession number(s): L0T4D5
, O08406, P0A680, P47766, Q53424, Q59564, Q9X6Q3, Q9X6U9, Q9XC82, Q9XC83, Q9XC84, Q9XC85
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: October 16, 2019
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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