UniProtKB - P9WGP1 (SECD_MYCTU)
Protein
Protein translocase subunit SecD
Gene
secD
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.UniRule annotation
GO - Molecular functioni
GO - Biological processi
- evasion or tolerance by symbiont of host-produced reactive oxygen species Source: Reactome
- intracellular protein transmembrane transport Source: UniProtKB-UniRule
- protein targeting Source: UniProtKB-UniRule
- protein transport Source: GO_Central
- protein transport by the Sec complex Source: UniProtKB-UniRule
Keywordsi
Biological process | Protein transport, Translocation, Transport |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-6829-MONOMER |
Reactomei | R-HSA-1222387 Tolerance of reactive oxygen produced by macrophages |
Names & Taxonomyi
Protein namesi | Recommended name: Protein translocase subunit SecDUniRule annotation |
Gene namesi | Name:secDUniRule annotation Ordered Locus Names:Rv2587c ORF Names:MTCY227.14 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv2587c |
Subcellular locationi
- Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 13 – 33 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 385 – 405 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 410 – 430 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 441 – 461 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 489 – 509 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 514 – 534 | HelicalUniRule annotationAdd BLAST | 21 |
GO - Cellular componenti
- cell wall Source: MTBBASE
- cytosol Source: MTBBASE
- extracellular region Source: MTBBASE
- integral component of plasma membrane Source: MTBBASE
- plasma membrane Source: Reactome
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000095966 | 1 – 573 | Protein translocase subunit SecDAdd BLAST | 573 |
Proteomic databases
PaxDbi | P9WGP1 |
Interactioni
Subunit structurei
Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
UniRule annotationProtein-protein interaction databases
STRINGi | 83332.Rv2587c |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4107RSV Bacteria COG0342 LUCA |
KOi | K03072 |
OMAi | WPRARRT |
PhylomeDBi | P9WGP1 |
Family and domain databases
HAMAPi | MF_01463_B SecD_B, 1 hit |
InterProi | View protein in InterPro IPR005791 SecD IPR022813 SecD/SecF_arch_bac IPR022645 SecD/SecF_bac IPR022646 SecD/SecF_CS |
PANTHERi | PTHR30081 PTHR30081, 1 hit |
Pfami | View protein in Pfam PF07549 Sec_GG, 1 hit PF02355 SecD_SecF, 1 hit |
TIGRFAMsi | TIGR00916 2A0604s01, 1 hit TIGR01129 secD, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WGP1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSSAPVHP ARYLSVFLVM LIGIYLLVFF TGDKHTAPKL GIDLQGGTRV
60 70 80 90 100
TLTARTPDGS APSREALAQA QQIISARVNG LGVSGSEVVV DGDNLVITVP
110 120 130 140 150
GNDGSEARNL GQTARLYIRP VLNSMPAQPA AEEPQPAPSA EPQPPGQPAA
160 170 180 190 200
PPPAQSGAPA SPQPGAQPRP YPQDPAPSPN PTSPASPPPA PPAEAPATDP
210 220 230 240 250
RKDLAERIAQ EKKLRQSTNQ YMQMVALQFQ ATRCESDDIL AGNDDPKLPL
260 270 280 290 300
VTCSTDHKTA YLLAPSIISG DQIQNATSGM DQRGIGYVVD LQFKGPAANI
310 320 330 340 350
WADYTAAHIG TQTAFTLDSQ VVSAPQIQEA IPGGRTQISG GDPPFTAATA
360 370 380 390 400
RQLANVLKYG SLPLSFEPSE AQTVSATLGL SSLRAGMIAG AIGLLLVLVY
410 420 430 440 450
SLLYYRVLGL LTALSLVASG SMVFAILVLL GRYINYTLDL AGIAGLIIGI
460 470 480 490 500
GTTADSFVVF FERIKDEIRE GRSFRSAVPR GWARARKTIV SGNAVTFLAA
510 520 530 540 550
AVLYFLAIGQ VKGFAFTLGL TTILDLVVVF LVTWPLVYLA SKSSLLAKPA
560 570
YNGLGAVQQV ARERRAMART GRG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45383.1 |
PIRi | B70726 |
RefSeqi | NP_217103.1, NC_000962.3 WP_003413385.1, NZ_NVQJ01000023.1 |
Genome annotation databases
EnsemblBacteriai | CCP45383; CCP45383; Rv2587c |
GeneIDi | 888192 |
KEGGi | mtu:Rv2587c mtv:RVBD_2587c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45383.1 |
PIRi | B70726 |
RefSeqi | NP_217103.1, NC_000962.3 WP_003413385.1, NZ_NVQJ01000023.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 83332.Rv2587c |
Proteomic databases
PaxDbi | P9WGP1 |
Genome annotation databases
EnsemblBacteriai | CCP45383; CCP45383; Rv2587c |
GeneIDi | 888192 |
KEGGi | mtu:Rv2587c mtv:RVBD_2587c |
Organism-specific databases
TubercuListi | Rv2587c |
Phylogenomic databases
eggNOGi | ENOG4107RSV Bacteria COG0342 LUCA |
KOi | K03072 |
OMAi | WPRARRT |
PhylomeDBi | P9WGP1 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-6829-MONOMER |
Reactomei | R-HSA-1222387 Tolerance of reactive oxygen produced by macrophages |
Family and domain databases
HAMAPi | MF_01463_B SecD_B, 1 hit |
InterProi | View protein in InterPro IPR005791 SecD IPR022813 SecD/SecF_arch_bac IPR022645 SecD/SecF_bac IPR022646 SecD/SecF_CS |
PANTHERi | PTHR30081 PTHR30081, 1 hit |
Pfami | View protein in Pfam PF07549 Sec_GG, 1 hit PF02355 SecD_SecF, 1 hit |
TIGRFAMsi | TIGR00916 2A0604s01, 1 hit TIGR01129 secD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SECD_MYCTU | |
Accessioni | P9WGP1Primary (citable) accession number: P9WGP1 Secondary accession number(s): L0TCU8, Q50634 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 16, 2019 | |
This is version 30 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names