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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes (By similarity).By similarity

Miscellaneous

Does not bind zinc ions. Has normal enzyme activity in the absence of zinc ions.

Caution

Lacks two conserved histidine residues that bind copper and zinc.Curated

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Cu cationNote: Binds 1 copper ion per subunit.

Activity regulationi

Inhibited by the copper chelator diethyl dithiocarbamate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi116Copper; catalytic1
Metal bindingi118Copper; catalytic1
Metal bindingi144Copper; catalytic1
Metal bindingi195Copper; catalytic1

GO - Molecular functioni

  • superoxide dismutase activity Source: MTBBASE

GO - Biological processi

Keywordsi

Molecular functionAntioxidant, Oxidoreductase
LigandCopper, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1222387 Tolerance of reactive oxygen produced by macrophages

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Gene namesi
Name:sodC
Ordered Locus Names:Rv0432
ORF Names:MTCY22G10.29
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0432

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32CuratedAdd BLAST32
ChainiPRO_000003284033 – 240Superoxide dismutase [Cu-Zn]Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi33N-palmitoyl cysteineCurated1
Lipidationi33S-diacylglycerol cysteineCurated1
Disulfide bondi123 ↔ 234

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP9WGE9

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi83332.Rv0432

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP9WGE9
SMRiP9WGE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105H08 Bacteria
COG2032 LUCA
KOiK04565
OMAiHADADNF
PhylomeDBiP9WGE9

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P9WGE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKPADHRNH AAVSTSVLSA LFLGAGAALL SACSSPQHAS TVPGTTPSIW
60 70 80 90 100
TGSPAPSGLS GHDEESPGAQ SLTSTLTAPD GTKVATAKFE FANGYATVTI
110 120 130 140 150
ATTGVGKLTP GFHGLHIHQV GKCEPNSVAP TGGAPGNFLS AGGHYHVPGH
160 170 180 190 200
TGTPASGDLA SLQVRGDGSA MLVTTTDAFT MDDLLSGAKT AIIIHAGADN
210 220 230 240
FANIPPERYV QVNGTPGPDE TTLTTGDAGK RVACGVIGSG
Length:240
Mass (Da):23,844
Last modified:April 16, 2014 - v1
Checksum:iAFC08C0B302B84FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP43163.1
PIRiF70631
RefSeqiNP_214946.1, NC_000962.3
WP_003402198.1, NZ_KK339370.1

Genome annotation databases

EnsemblBacteriaiCCP43163; CCP43163; Rv0432
GeneIDi886358
KEGGimtu:Rv0432

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP43163.1
PIRiF70631
RefSeqiNP_214946.1, NC_000962.3
WP_003402198.1, NZ_KK339370.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PZSX-ray1.63A33-240[»]
ProteinModelPortaliP9WGE9
SMRiP9WGE9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0432

Proteomic databases

PaxDbiP9WGE9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP43163; CCP43163; Rv0432
GeneIDi886358
KEGGimtu:Rv0432

Organism-specific databases

TubercuListiRv0432

Phylogenomic databases

eggNOGiENOG4105H08 Bacteria
COG2032 LUCA
KOiK04565
OMAiHADADNF
PhylomeDBiP9WGE9

Enzyme and pathway databases

ReactomeiR-HSA-1222387 Tolerance of reactive oxygen produced by macrophages

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSODC_MYCTU
AccessioniPrimary (citable) accession number: P9WGE9
Secondary accession number(s): L0T6G1, P0A608, P96278
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: September 12, 2018
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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