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UniProtKB - P9WGE9 (SODC_MYCTU)
Protein
Superoxide dismutase [Cu-Zn]
Gene
sodC
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes (By similarity).
By similarityMiscellaneous
Does not bind zinc ions. Has normal enzyme activity in the absence of zinc ions.
Caution
Lacks two conserved histidine residues that bind copper and zinc.Curated
Catalytic activityi
- EC:1.15.1.1
Cofactori
Cu cationNote: Binds 1 copper ion per subunit.
Activity regulationi
Inhibited by the copper chelator diethyl dithiocarbamate.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 116 | Copper; catalytic | 1 | |
Metal bindingi | 118 | Copper; catalytic | 1 | |
Metal bindingi | 144 | Copper; catalytic | 1 | |
Metal bindingi | 195 | Copper; catalytic | 1 |
GO - Molecular functioni
- copper ion binding Source: GO_Central
- superoxide dismutase activity Source: MTBBASE
GO - Biological processi
- cell redox homeostasis Source: MTBBASE
- removal of superoxide radicals Source: GO_Central
- response to host Source: MTBBASE
- response to hydroperoxide Source: MTBBASE
- response to oxidative stress Source: MTBBASE
- symbiont defense to host-produced nitric oxide Source: MTBBASE
- symbiont defense to host-produced reactive oxygen species Source: MTBBASE
Keywordsi
Molecular function | Antioxidant, Oxidoreductase |
Ligand | Copper, Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-HSA-1222387, Tolerance of reactive oxygen produced by macrophages |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:sodC Ordered Locus Names:Rv0432 ORF Names:MTCY22G10.29 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv0432 |
Subcellular locationi
Plasma membrane
- Cell membrane PROSITE-ProRule annotation; Lipid-anchor PROSITE-ProRule annotation
Cell Wall
- cell wall Source: MTBBASE
Extracellular region or secreted
- extracellular region Source: MTBBASE
Plasma Membrane
- plasma membrane Source: MTBBASE
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 32 | CuratedAdd BLAST | 32 | |
ChainiPRO_0000032840 | 33 – 240 | Superoxide dismutase [Cu-Zn]Add BLAST | 208 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 33 | N-palmitoyl cysteineCurated | 1 | |
Lipidationi | 33 | S-diacylglycerol cysteineCurated | 1 | |
Disulfide bondi | 123 ↔ 234 |
Keywords - PTMi
Disulfide bond, Lipoprotein, PalmitateProteomic databases
PaxDbi | P9WGE9 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
STRINGi | 83332.Rv0432 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P9WGE9 |
SMRi | P9WGE9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 36 – 77 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 36 – 55 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the Cu-Zn superoxide dismutase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG2032, Bacteria |
OMAi | HADADNF |
PhylomeDBi | P9WGE9 |
Family and domain databases
CDDi | cd00305, Cu-Zn_Superoxide_Dismutase, 1 hit |
Gene3Di | 2.60.40.200, 1 hit |
InterProi | View protein in InterPro IPR036423, SOD-like_Cu/Zn_dom_sf IPR024134, SOD_Cu/Zn_/chaperone IPR018152, SOD_Cu/Zn_BS IPR001424, SOD_Cu_Zn_dom |
PANTHERi | PTHR10003, PTHR10003, 1 hit |
Pfami | View protein in Pfam PF00080, Sod_Cu, 1 hit |
SUPFAMi | SSF49329, SSF49329, 1 hit |
PROSITEi | View protein in PROSITE PS51257, PROKAR_LIPOPROTEIN, 1 hit PS00332, SOD_CU_ZN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P9WGE9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKPADHRNH AAVSTSVLSA LFLGAGAALL SACSSPQHAS TVPGTTPSIW
60 70 80 90 100
TGSPAPSGLS GHDEESPGAQ SLTSTLTAPD GTKVATAKFE FANGYATVTI
110 120 130 140 150
ATTGVGKLTP GFHGLHIHQV GKCEPNSVAP TGGAPGNFLS AGGHYHVPGH
160 170 180 190 200
TGTPASGDLA SLQVRGDGSA MLVTTTDAFT MDDLLSGAKT AIIIHAGADN
210 220 230 240
FANIPPERYV QVNGTPGPDE TTLTTGDAGK RVACGVIGSG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43163.1 |
PIRi | F70631 |
RefSeqi | NP_214946.1, NC_000962.3 WP_003402198.1, NZ_NVQJ01000002.1 |
Genome annotation databases
GeneIDi | 886358 |
KEGGi | mtu:Rv0432 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43163.1 |
PIRi | F70631 |
RefSeqi | NP_214946.1, NC_000962.3 WP_003402198.1, NZ_NVQJ01000002.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1PZS | X-ray | 1.63 | A | 33-240 | [»] | |
AlphaFoldDBi | P9WGE9 | |||||
SMRi | P9WGE9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv0432 |
Proteomic databases
PaxDbi | P9WGE9 |
Protocols and materials databases
DNASUi | 886358 |
Genome annotation databases
GeneIDi | 886358 |
KEGGi | mtu:Rv0432 |
Organism-specific databases
TubercuListi | Rv0432 |
Phylogenomic databases
eggNOGi | COG2032, Bacteria |
OMAi | HADADNF |
PhylomeDBi | P9WGE9 |
Enzyme and pathway databases
Reactomei | R-HSA-1222387, Tolerance of reactive oxygen produced by macrophages |
Family and domain databases
CDDi | cd00305, Cu-Zn_Superoxide_Dismutase, 1 hit |
Gene3Di | 2.60.40.200, 1 hit |
InterProi | View protein in InterPro IPR036423, SOD-like_Cu/Zn_dom_sf IPR024134, SOD_Cu/Zn_/chaperone IPR018152, SOD_Cu/Zn_BS IPR001424, SOD_Cu_Zn_dom |
PANTHERi | PTHR10003, PTHR10003, 1 hit |
Pfami | View protein in Pfam PF00080, Sod_Cu, 1 hit |
SUPFAMi | SSF49329, SSF49329, 1 hit |
PROSITEi | View protein in PROSITE PS51257, PROKAR_LIPOPROTEIN, 1 hit PS00332, SOD_CU_ZN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SODC_MYCTU | |
Accessioni | P9WGE9Primary (citable) accession number: P9WGE9 Secondary accession number(s): L0T6G1, P0A608, P96278 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | May 25, 2022 | |
This is version 46 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families