UniProtKB - P9WGE7 (SODF_MYCTU)
Protein
Superoxide dismutase [Fe]
Gene
sodB
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Caution
Although found extracellularly, no signal sequence is present. An alternative secretory pathway may be used.Curated
Catalytic activityi
- EC:1.15.1.1
Cofactori
Fe cationNote: Binds 1 Fe cation per subunit.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 28 | Iron | 1 | |
Metal bindingi | 76 | Iron | 1 | |
Metal bindingi | 160 | Iron | 1 | |
Metal bindingi | 164 | Iron | 1 |
GO - Molecular functioni
- iron ion binding Source: MTBBASE
- manganese ion binding Source: GO_Central
- metal ion binding Source: GO_Central
- superoxide dismutase activity Source: MTBBASE
GO - Biological processi
- pathogenesis Source: MTBBASE
- response to oxidative stress Source: MTBBASE
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
Reactomei | R-HSA-1222387, Tolerance of reactive oxygen produced by macrophages |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:sodB Synonyms:sod, sodA Ordered Locus Names:Rv3846 ORF Names:MTCY01A6.22c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv3846 |
Subcellular locationi
GO - Cellular componenti
- cytosol Source: MTBBASE
- extracellular region Source: MTBBASE
- periplasmic space Source: Reactome
- plasma membrane Source: MTBBASE
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000159990 | 1 – 207 | Superoxide dismutase [Fe]Add BLAST | 207 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 202 | Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)1 Publication |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
PaxDbi | P9WGE7 |
Interactioni
Subunit structurei
Homotetramer.
Protein-protein interaction databases
STRINGi | 83332.Rv3846 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P9WGE7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the iron/manganese superoxide dismutase family.Curated
Phylogenomic databases
eggNOGi | COG0605, Bacteria |
OMAi | KWGSFDK |
PhylomeDBi | P9WGE7 |
Family and domain databases
Gene3Di | 1.10.287.990, 1 hit 2.40.500.20, 1 hit |
InterProi | View protein in InterPro IPR001189, Mn/Fe_SOD IPR019833, Mn/Fe_SOD_BS IPR019832, Mn/Fe_SOD_C IPR019831, Mn/Fe_SOD_N IPR036324, Mn/Fe_SOD_N_sf IPR036314, SOD_C_sf |
Pfami | View protein in Pfam PF02777, Sod_Fe_C, 1 hit PF00081, Sod_Fe_N, 1 hit |
PIRSFi | PIRSF000349, SODismutase, 1 hit |
PRINTSi | PR01703, MNSODISMTASE |
SUPFAMi | SSF46609, SSF46609, 1 hit SSF54719, SSF54719, 1 hit |
PROSITEi | View protein in PROSITE PS00088, SOD_MN, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WGE7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEYTLPDLD WDYGALEPHI SGQINELHHS KHHATYVKGA NDAVAKLEEA
60 70 80 90 100
RAKEDHSAIL LNEKNLAFNL AGHVNHTIWW KNLSPNGGDK PTGELAAAIA
110 120 130 140 150
DAFGSFDKFR AQFHAAATTV QGSGWAALGW DTLGNKLLIF QVYDHQTNFP
160 170 180 190 200
LGIVPLLLLD MWEHAFYLQY KNVKVDFAKA FWNVVNWADV QSRYAAATSQ
TKGLIFG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52861 Genomic DNA Translation: CAA37042.1 AF061030 Genomic DNA Translation: AAD15824.1 AL123456 Genomic DNA Translation: CCP46675.1 |
PIRi | S15205 |
RefSeqi | NP_218363.1, NC_000962.3 WP_003399735.1, NZ_NVQJ01000057.1 |
Genome annotation databases
EnsemblBacteriai | CCP46675; CCP46675; Rv3846 |
GeneIDi | 45427849 886174 |
KEGGi | mtu:Rv3846 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52861 Genomic DNA Translation: CAA37042.1 AF061030 Genomic DNA Translation: AAD15824.1 AL123456 Genomic DNA Translation: CCP46675.1 |
PIRi | S15205 |
RefSeqi | NP_218363.1, NC_000962.3 WP_003399735.1, NZ_NVQJ01000057.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GN2 | X-ray | 3.40 | A/B/C/D/E/F/G/H | 1-207 | [»] | |
1GN3 | X-ray | 4.00 | A/B | 1-207 | [»] | |
1GN4 | X-ray | 2.50 | A/B/C/D | 1-207 | [»] | |
1GN6 | X-ray | 2.90 | A/B/C/D | 1-207 | [»] | |
1IDS | X-ray | 2.00 | A/B/C/D | 1-207 | [»] | |
SMRi | P9WGE7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv3846 |
Proteomic databases
PaxDbi | P9WGE7 |
Genome annotation databases
EnsemblBacteriai | CCP46675; CCP46675; Rv3846 |
GeneIDi | 45427849 886174 |
KEGGi | mtu:Rv3846 |
Organism-specific databases
TubercuListi | Rv3846 |
Phylogenomic databases
eggNOGi | COG0605, Bacteria |
OMAi | KWGSFDK |
PhylomeDBi | P9WGE7 |
Enzyme and pathway databases
Reactomei | R-HSA-1222387, Tolerance of reactive oxygen produced by macrophages |
Family and domain databases
Gene3Di | 1.10.287.990, 1 hit 2.40.500.20, 1 hit |
InterProi | View protein in InterPro IPR001189, Mn/Fe_SOD IPR019833, Mn/Fe_SOD_BS IPR019832, Mn/Fe_SOD_C IPR019831, Mn/Fe_SOD_N IPR036324, Mn/Fe_SOD_N_sf IPR036314, SOD_C_sf |
Pfami | View protein in Pfam PF02777, Sod_Fe_C, 1 hit PF00081, Sod_Fe_N, 1 hit |
PIRSFi | PIRSF000349, SODismutase, 1 hit |
PRINTSi | PR01703, MNSODISMTASE |
SUPFAMi | SSF46609, SSF46609, 1 hit SSF54719, SSF54719, 1 hit |
PROSITEi | View protein in PROSITE PS00088, SOD_MN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SODF_MYCTU | |
Accessioni | P9WGE7Primary (citable) accession number: P9WGE7 Secondary accession number(s): L0TGX2, P17670, P96231 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | February 10, 2021 | |
This is version 36 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families