Superoxide dismutase [Fe]

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• 2 H⁺

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  + 2 superoxide

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  = H₂O₂

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  + O₂

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  EC:1.15.1.1
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  Source: Rhea

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  2

  H⁺

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  +

  2

  superoxide

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  zoom

  =

  H₂O₂

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  +

  O₂

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<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• iron ion binding Source: MTBBASE <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.6

    "X-ray structure analysis of the iron-dependent superoxide dismutase from Mycobacterium tuberculosis at 2.0-A resolution reveals novel dimer-dimer interactions."
    Cooper J.B., McIntyre K., Badasso M.O., Wood S.P., Zhang Y., Garbe T.R., Young D.
    J. Mol. Biol. 246:531-544(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
• manganese ion binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• superoxide dismutase activity Source: MTBBASEInferred from direct assayⁱ
  • Ref.1

    "Genetic analysis of superoxide dismutase, the 23 kilodalton antigen of Mycobacterium tuberculosis."
    Zhang Y.
    Mol. Microbiol. 5:381-391(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

GO - Biological processⁱ

• pathogenesis Source: MTBBASE <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Iron-cofactored superoxide dismutase inhibits host responses to Mycobacterium tuberculosis."
    Edwards K.M., Cynamon M.H., Voladri R.K., Hager C.C., DeStefano M.S., Tham K.T., Lakey D.L., Bochan M.R., Kernodle D.S.
    Am. J. Respir. Crit. Care Med. 164:2213-2219(2001) [PubMed] [Europe PMC] [Abstract]
• response to oxidative stress Source: MTBBASEInferred from mutant phenotypeⁱ
  • "Iron-cofactored superoxide dismutase inhibits host responses to Mycobacterium tuberculosis."
    Edwards K.M., Cynamon M.H., Voladri R.K., Hager C.C., DeStefano M.S., Tham K.T., Lakey D.L., Bochan M.R., Kernodle D.S.
    Am. J. Respir. Crit. Care Med. 164:2213-2219(2001) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

GO - Cellular componentⁱ

• cytosol Source: MTBBASEInferred from high throughput direct assayⁱ
  • "Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling."
    Mawuenyega K.G., Forst C.V., Dobos K.M., Belisle J.T., Chen J., Bradbury E.M., Bradbury A.R., Chen X.
    Mol. Biol. Cell 16:396-404(2005) [PubMed] [Europe PMC] [Abstract]
• extracellular region Source: MTBBASEInferred from direct assayⁱ
  • "Superoxide dismutase from Mycobacterium tuberculosis."
    Kusunose E., Ichihara K., Noda Y., Kusunose M.
    J. Biochem. 80:1343-1352(1976) [PubMed] [Europe PMC] [Abstract]
• periplasmic space Source: Reactome
• plasma membrane Source: MTBBASEInferred from high throughput direct assayⁱ
  • "Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain."
    Gu S., Chen J., Dobos K.M., Bradbury E.M., Belisle J.T., Chen X.
    Mol. Cell Proteomics 2:1284-1296(2003) [PubMed] [Europe PMC] [Abstract]
  • "Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling."
    Mawuenyega K.G., Forst C.V., Dobos K.M., Belisle J.T., Chen J., Bradbury E.M., Bradbury A.R., Chen X.
    Mol. Biol. Cell 16:396-404(2005) [PubMed] [Europe PMC] [Abstract]

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAEYTLPDLD WDYGALEPHI SGQINELHHS KHHATYVKGA NDAVAKLEEA 
        60         70         80         90        100
RAKEDHSAIL LNEKNLAFNL AGHVNHTIWW KNLSPNGGDK PTGELAAAIA 
       110        120        130        140        150
DAFGSFDKFR AQFHAAATTV QGSGWAALGW DTLGNKLLIF QVYDHQTNFP 
       160        170        180        190        200
LGIVPLLLLD MWEHAFYLQY KNVKVDFAKA FWNVVNWADV QSRYAAATSQ 

TKGLIFG                                                

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families