UniProtKB - P9WGE6 (SODF_MYCTO)
Protein
Superoxide dismutase [Fe]
Gene
sodB
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Functioni
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.By similarity
Caution
Although found extracellularly, no signal sequence is present. An alternative secretory pathway may be used.Curated
Catalytic activityi
- EC:1.15.1.1
Cofactori
Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 28 | IronBy similarity | 1 | |
Metal bindingi | 76 | IronBy similarity | 1 | |
Metal bindingi | 160 | IronBy similarity | 1 | |
Metal bindingi | 164 | IronBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- superoxide dismutase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:sodB Synonyms:sod, sodA Ordered Locus Names:MT3960 |
Organismi | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
Taxonomic identifieri | 83331 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Subcellular locationi
- Secreted By similarity
GO - Cellular componenti
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000428375 | 1 – 207 | Superoxide dismutase [Fe]Add BLAST | 207 |
Interactioni
Subunit structurei
Homotetramer.
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the iron/manganese superoxide dismutase family.Curated
Phylogenomic databases
HOGENOMi | CLU_031625_2_2_11 |
Family and domain databases
Gene3Di | 1.10.287.990, 1 hit 2.40.500.20, 1 hit |
InterProi | View protein in InterPro IPR001189, Mn/Fe_SOD IPR019833, Mn/Fe_SOD_BS IPR019832, Mn/Fe_SOD_C IPR019831, Mn/Fe_SOD_N IPR036324, Mn/Fe_SOD_N_sf IPR036314, SOD_C_sf |
Pfami | View protein in Pfam PF02777, Sod_Fe_C, 1 hit PF00081, Sod_Fe_N, 1 hit |
PIRSFi | PIRSF000349, SODismutase, 1 hit |
PRINTSi | PR01703, MNSODISMTASE |
SUPFAMi | SSF46609, SSF46609, 1 hit SSF54719, SSF54719, 1 hit |
PROSITEi | View protein in PROSITE PS00088, SOD_MN, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WGE6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEYTLPDLD WDYGALEPHI SGQINELHHS KHHATYVKGA NDAVAKLEEA
60 70 80 90 100
RAKEDHSAIL LNEKNLAFNL AGHVNHTIWW KNLSPNGGDK PTGELAAAIA
110 120 130 140 150
DAFGSFDKFR AQFHAAATTV QGSGWAALGW DTLGNKLLIF QVYDHQTNFP
160 170 180 190 200
LGIVPLLLLD MWEHAFYLQY KNVKVDFAKA FWNVVNWADV QSRYAAATSQ
TKGLIFG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK48327.1 |
PIRi | S15205 |
RefSeqi | WP_003399735.1, NZ_KK341227.1 |
Genome annotation databases
EnsemblBacteriai | AAK48327; AAK48327; MT3960 |
KEGGi | mtc:MT3960 |
PATRICi | fig|83331.31.peg.4258 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK48327.1 |
PIRi | S15205 |
RefSeqi | WP_003399735.1, NZ_KK341227.1 |
3D structure databases
SMRi | P9WGE6 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | AAK48327; AAK48327; MT3960 |
KEGGi | mtc:MT3960 |
PATRICi | fig|83331.31.peg.4258 |
Phylogenomic databases
HOGENOMi | CLU_031625_2_2_11 |
Family and domain databases
Gene3Di | 1.10.287.990, 1 hit 2.40.500.20, 1 hit |
InterProi | View protein in InterPro IPR001189, Mn/Fe_SOD IPR019833, Mn/Fe_SOD_BS IPR019832, Mn/Fe_SOD_C IPR019831, Mn/Fe_SOD_N IPR036324, Mn/Fe_SOD_N_sf IPR036314, SOD_C_sf |
Pfami | View protein in Pfam PF02777, Sod_Fe_C, 1 hit PF00081, Sod_Fe_N, 1 hit |
PIRSFi | PIRSF000349, SODismutase, 1 hit |
PRINTSi | PR01703, MNSODISMTASE |
SUPFAMi | SSF46609, SSF46609, 1 hit SSF54719, SSF54719, 1 hit |
PROSITEi | View protein in PROSITE PS00088, SOD_MN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SODF_MYCTO | |
Accessioni | P9WGE6Primary (citable) accession number: P9WGE6 Secondary accession number(s): L0TGX2, P17670, P96231 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | February 10, 2021 | |
This is version 32 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |