UniProtKB - P9WGA3 (TAM_MYCTU)
Protein
Probable trans-aconitate 2-methyltransferase
Gene
tam
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.UniRule annotation
Catalytic activityi
- S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.144UniRule annotation
GO - Molecular functioni
- trans-aconitate 2-methyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- growth of symbiont in host cell Source: MTBBASE
Keywordsi
Molecular function | Methyltransferase, Transferase |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-4417-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:tamUniRule annotation Ordered Locus Names:Rv0294 ORF Names:MTV035.22 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv0294 |
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218082 | 1 – 261 | Probable trans-aconitate 2-methyltransferaseAdd BLAST | 261 |
Proteomic databases
PaxDbi | P9WGA3 |
PRIDEi | P9WGA3 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4107R6G Bacteria COG4106 LUCA |
KOi | K00598 |
OMAi | TVFPFRR |
PhylomeDBi | P9WGA3 |
Family and domain databases
Gene3Di | 1.10.150.290, 1 hit |
HAMAPi | MF_00560 Tran_acon_Me_trans, 1 hit |
InterProi | View protein in InterPro IPR029063 SAM-dependent_MTases IPR023506 Trans-aconitate_MeTrfase IPR023149 Trans_acon_MeTrfase_C |
SUPFAMi | SSF53335 SSF53335, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WGA3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWDPDVYLAF SGHRNRPFYE LVSRVGLERA RRVVDLGCGP GHLTRYLARR
60 70 80 90 100
WPGAVIEALD SSPEMVAAAA ERGIDATTGD LRDWKPKPDT DVVVSNAALH
110 120 130 140 150
WVPEHSDLLV RWVDELAPGS WIAVQIPGNF ETPSHAAVRA LARREPYAKL
160 170 180 190 200
MRDIPFRVGA VVQSPAYYAE LLMDTGCKVD VWETTYLHQL TGEHPVLDWI
210 220 230 240 250
TGSALVPVRE RLSDESWQQF RQELIPLLND AYPPRADGST IFPFRRLFMV
260
AEVGGARRSG G
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43024.1 |
PIRi | D70837 |
RefSeqi | NP_214808.1, NC_000962.3 WP_003401538.1, NZ_NVQJ01000026.1 |
Genome annotation databases
EnsemblBacteriai | CCP43024; CCP43024; Rv0294 |
GeneIDi | 886593 |
KEGGi | mtu:Rv0294 mtv:RVBD_0294 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43024.1 |
PIRi | D70837 |
RefSeqi | NP_214808.1, NC_000962.3 WP_003401538.1, NZ_NVQJ01000026.1 |
3D structure databases
SMRi | P9WGA3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv0294 |
Proteomic databases
PaxDbi | P9WGA3 |
PRIDEi | P9WGA3 |
Genome annotation databases
EnsemblBacteriai | CCP43024; CCP43024; Rv0294 |
GeneIDi | 886593 |
KEGGi | mtu:Rv0294 mtv:RVBD_0294 |
Organism-specific databases
TubercuListi | Rv0294 |
Phylogenomic databases
eggNOGi | ENOG4107R6G Bacteria COG4106 LUCA |
KOi | K00598 |
OMAi | TVFPFRR |
PhylomeDBi | P9WGA3 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-4417-MONOMER |
Family and domain databases
Gene3Di | 1.10.150.290, 1 hit |
HAMAPi | MF_00560 Tran_acon_Me_trans, 1 hit |
InterProi | View protein in InterPro IPR029063 SAM-dependent_MTases IPR023506 Trans-aconitate_MeTrfase IPR023149 Trans_acon_MeTrfase_C |
SUPFAMi | SSF53335 SSF53335, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TAM_MYCTU | |
Accessioni | P9WGA3Primary (citable) accession number: P9WGA3 Secondary accession number(s): L0T4Y3, O53698, P66885 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | September 18, 2019 | |
This is version 31 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names