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UniProtKB - P9WG90 (STP_MYCTO)
Protein
Multidrug resistance protein Stp
Gene
stp
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- response to antibiotic Source: UniProtKB-KW
Keywordsi
Biological process | Antibiotic resistance, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Multidrug resistance protein StpAlternative name(s): Spectinomycin tetracycline efflux pump |
Gene namesi | Name:stp Ordered Locus Names:MT2395 |
Organismi | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
Taxonomic identifieri | 83331 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 26 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 46 – 66 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 104 – 124 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 136 – 156 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 163 – 183 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 200 – 220 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 223 – 243 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 262 – 282 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 300 – 320 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 327 – 347 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 352 – 372 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 397 – 417 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 478 – 498 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000428403 | 1 – 537 | Multidrug resistance protein StpAdd BLAST | 537 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_000960_28_2_11 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR004638, EmrB-like IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00711, efflux_EmrB, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WG90-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNRTQLLTLI ATGLGLFMIF LDALIVNVAL PDIQRSFAVG EDGLQWVVAS
60 70 80 90 100
YSLGMAVFIM SAATLADLYG RRRWYLIGVS LFTLGSIACG LAPSIAVLTT
110 120 130 140 150
ARGAQGLGAA AVSVTSLALV SAAFPEAKEK ARAIGIWTAI ASIGTTTGPT
160 170 180 190 200
LGGLLVDQWG WRSIFYVNLP MGALVLFLTL CYVEESCNER ARRFDLSGQL
210 220 230 240 250
LFIVAVGALV YAVIEGPQIG WTSVQTIVML WTAAVGCALF VWLERRSSNP
260 270 280 290 300
MMDLTLFRDT SYALAIATIC TVFFAVYGML LLTTQFLQNV RGYTPSVTGL
310 320 330 340 350
MILPFSAAVA IVSPLVGHLV GRIGARVPIL AGLCMLMLGL LMLIFSEHRS
360 370 380 390 400
SALVLVGLGL CGSGVALCLT PITTVAMTAV PAERAGMASG IMSAQRAIGS
410 420 430 440 450
TIGFAVLGSV LAAWLSATLE PHLERAVPDP VQRHVLAEII IDSANPRAHV
460 470 480 490 500
GGIVPRRHIE HRDPVAIAEE DFIEGIRVAL LVATATLAVV FLAGWRWFPR
510 520 530
DVHTAGSDLS ERLPTAMTVE CAVSHMPGAT WCRLWPA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK46687.1 |
PIRi | F70705 |
RefSeqi | WP_003899274.1, NZ_KK341227.1 |
Genome annotation databases
EnsemblBacteriai | AAK46687; AAK46687; MT2395 |
KEGGi | mtc:MT2395 |
PATRICi | fig|83331.31.peg.2583 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK46687.1 |
PIRi | F70705 |
RefSeqi | WP_003899274.1, NZ_KK341227.1 |
3D structure databases
AlphaFoldDBi | P9WG90 |
SMRi | P9WG90 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | AAK46687; AAK46687; MT2395 |
KEGGi | mtc:MT2395 |
PATRICi | fig|83331.31.peg.2583 |
Phylogenomic databases
HOGENOMi | CLU_000960_28_2_11 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR004638, EmrB-like IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00711, efflux_EmrB, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STP_MYCTO | |
Accessioni | P9WG90Primary (citable) accession number: P9WG90 Secondary accession number(s): L0TC78 Q7D7B2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | May 25, 2022 | |
This is version 32 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |