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UniProtKB - P9WG89 (EMRB_MYCTU)
Protein
Multidrug resistance protein B homolog
Gene
emrB
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- transmembrane transport Source: GO_Central
Keywordsi
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Multidrug resistance protein B homolog |
Gene namesi | Name:emrB Ordered Locus Names:Rv0783c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv0783c |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Extracellular region or secreted
- extracellular region Source: MTBBASE
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 45 – 65 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 78 – 98 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 171 – 191 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 198 – 218 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 229 – 249 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 262 – 282 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 304 – 324 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 337 – 357 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 365 – 385 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 390 – 410 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 431 – 451 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 505 – 525 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000390687 | 1 – 540 | Multidrug resistance protein B homologAdd BLAST | 540 |
Proteomic databases
PaxDbi | P9WG89 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0477, Bacteria |
OMAi | FKIHTFS |
PhylomeDBi | P9WG89 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR004638, EmrB-like IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00711, efflux_EmrB, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WG89-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGNAMVEAC PAEGDAPVPI TPAGRPRSGQ RSYPDRLDVG LLRTAGVCVL
60 70 80 90 100
ASVMAHVDVT VVSVAQRTFV ADFGSTQAVV AWTMTGYMLA LATVIPTAGW
110 120 130 140 150
AADRFGTRRL FMGSVLAFTL GSLLCAVAPN ILLLIIFRVV QGFGGGMLTP
160 170 180 190 200
VSFAILAREA GPKRLGRVMA VVGIPMLLGP VGGPILGGWL IGAYGWRWIF
210 220 230 240 250
LVNLPVGLSA LVLAAIVFPR DRPAASENFD YMGLLLLSPG LATFLFGVSS
260 270 280 290 300
SPARGTMADR HVLIPAITGL ALIAAFVAHS WYRTEHPLID MRLFQNRAVA
310 320 330 340 350
QANMTMTVLS LGLFGSFLLL PSYLQQVLHQ SPMQSGVHII PQGLGAMLAM
360 370 380 390 400
PIAGAMMDRR GPAKIVLVGI MLIAAGLGTF AFGVARQADY LPILPTGLAI
410 420 430 440 450
MGMGMGCSMM PLSGAAVQTL APHQIARGST LISVNQQVGG SIGTALMSVL
460 470 480 490 500
LTYQFNHSEI IATAKKVALT PESGAGRGAA VDPSSLPRQT NFAAQLLHDL
510 520 530 540
SHAYAVVFVI ATALVVSTLI PAAFLPKQQA SHRRAPLLSA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43530.1 |
PIRi | B70709 |
RefSeqi | NP_215297.1, NC_000962.3 WP_003403977.1, NZ_NVQJ01000035.1 |
Genome annotation databases
GeneIDi | 885836 |
KEGGi | mtu:Rv0783c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43530.1 |
PIRi | B70709 |
RefSeqi | NP_215297.1, NC_000962.3 WP_003403977.1, NZ_NVQJ01000035.1 |
3D structure databases
AlphaFoldDBi | P9WG89 |
SMRi | P9WG89 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv0783c |
Proteomic databases
PaxDbi | P9WG89 |
Protocols and materials databases
DNASUi | 885836 |
Genome annotation databases
GeneIDi | 885836 |
KEGGi | mtu:Rv0783c |
Organism-specific databases
TubercuListi | Rv0783c |
Phylogenomic databases
eggNOGi | COG0477, Bacteria |
OMAi | FKIHTFS |
PhylomeDBi | P9WG89 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR004638, EmrB-like IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00711, efflux_EmrB, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EMRB_MYCTU | |
Accessioni | P9WG89Primary (citable) accession number: P9WG89 Secondary accession number(s): L0T4Q5, P71836, Q8VKE2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | May 25, 2022 | |
This is version 42 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families