UniProtKB - P9WFX4 (TRPD_MYCTO)
Protein
Anthranilate phosphoribosyltransferase
Gene
trpD
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Functioni
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation
Catalytic activityi
- diphosphate + N-(5-phospho-β-D-ribosyl)anthranilate = 5-phospho-α-D-ribose 1-diphosphate + anthranilateUniRule annotationEC:2.4.2.18UniRule annotation
Cofactori
Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation
: L-tryptophan biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotationProteins known to be involved in the 5 steps of the subpathway in this organism are:
- Anthranilate synthase component 1 (trpE), Anthranilate synthase component 2 (trpG)
- Anthranilate phosphoribosyltransferase (trpD)
- Phosphoribosyl isomerase A (priA)
- Indole-3-glycerol phosphate synthase (trpC)
- Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 107 | Anthranilate 1; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 107 | Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 115 | PhosphoribosylpyrophosphateUniRule annotation | 1 | |
Metal bindingi | 119 | Magnesium 1UniRule annotation | 1 | |
Binding sitei | 138 | Anthranilate 1UniRule annotation | 1 | |
Binding sitei | 147 | Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 193 | Anthranilate 2UniRule annotation | 1 | |
Metal bindingi | 251 | Magnesium 2UniRule annotation | 1 | |
Metal bindingi | 252 | Magnesium 1UniRule annotation | 1 | |
Metal bindingi | 252 | Magnesium 2UniRule annotation | 1 |
GO - Molecular functioni
- anthranilate phosphoribosyltransferase activity Source: UniProtKB-UniRule
- magnesium ion binding Source: UniProtKB-UniRule
GO - Biological processi
- tryptophan biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00035;UER00041 |
Names & Taxonomyi
Protein namesi | Recommended name: Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation) |
Gene namesi | Name:trpDUniRule annotation Ordered Locus Names:MT2248 |
Organismi | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
Taxonomic identifieri | 83331 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000428461 | 1 – 370 | Anthranilate phosphoribosyltransferaseAdd BLAST | 370 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 110 – 111 | Phosphoribosylpyrophosphate bindingUniRule annotation | 2 | |
Regioni | 117 – 120 | Phosphoribosylpyrophosphate bindingUniRule annotation | 4 | |
Regioni | 135 – 143 | Phosphoribosylpyrophosphate bindingUniRule annotation | 9 |
Sequence similaritiesi
Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_034315_4_1_11 |
Family and domain databases
Gene3Di | 1.20.970.10, 1 hit 3.40.1030.10, 1 hit |
HAMAPi | MF_00211, TrpD, 1 hit |
InterProi | View protein in InterPro IPR005940, Anthranilate_Pribosyl_Tfrase IPR000312, Glycosyl_Trfase_fam3 IPR017459, Glycosyl_Trfase_fam3_N_dom IPR036320, Glycosyl_Trfase_fam3_N_dom)sf IPR035902, Nuc_phospho_transferase |
Pfami | View protein in Pfam PF02885, Glycos_trans_3N, 1 hit PF00591, Glycos_transf_3, 1 hit |
SUPFAMi | SSF47648, SSF47648, 1 hit SSF52418, SSF52418, 1 hit |
TIGRFAMsi | TIGR01245, trpD, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WFX4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALSAEGSSG GSRGGSPKAE AASVPSWPQI LGRLTDNRDL ARGQAAWAMD
60 70 80 90 100
QIMTGNARPA QIAAFAVAMT MKAPTADEVG ELAGVMLSHA HPLPADTVPD
110 120 130 140 150
DAVDVVGTGG DGVNTVNLST MAAIVVAAAG VPVVKHGNRA ASSLSGGADT
160 170 180 190 200
LEALGVRIDL GPDLVARSLA EVGIGFCFAP RFHPSYRHAA AVRREIGVPT
210 220 230 240 250
VFNLLGPLTN PARPRAGLIG CAFADLAEVM AGVFAARRSS VLVVHGDDGL
260 270 280 290 300
DELTTTTTST IWRVAAGSVD KLTFDPAGFG FARAQLDQLA GGDAQANAAA
310 320 330 340 350
VRAVLGGARG PVRDAVVLNA AGAIVAHAGL SSRAEWLPAW EEGLRRASAA
360 370
IDTGAAEQLL ARWVRFGRQI
Sequence cautioni
The sequence AAK46534 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK46534.1 Different initiation. |
PIRi | A70784 |
RefSeqi | WP_003411387.1, NZ_KK341227.1 |
Genome annotation databases
EnsemblBacteriai | AAK46534; AAK46534; MT2248 |
KEGGi | mtc:MT2248 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK46534.1 Different initiation. |
PIRi | A70784 |
RefSeqi | WP_003411387.1, NZ_KK341227.1 |
3D structure databases
SMRi | P9WFX4 |
ModBasei | Search... |
Chemistry databases
BindingDBi | P9WFX4 |
Genome annotation databases
EnsemblBacteriai | AAK46534; AAK46534; MT2248 |
KEGGi | mtc:MT2248 |
Phylogenomic databases
HOGENOMi | CLU_034315_4_1_11 |
Enzyme and pathway databases
UniPathwayi | UPA00035;UER00041 |
Family and domain databases
Gene3Di | 1.20.970.10, 1 hit 3.40.1030.10, 1 hit |
HAMAPi | MF_00211, TrpD, 1 hit |
InterProi | View protein in InterPro IPR005940, Anthranilate_Pribosyl_Tfrase IPR000312, Glycosyl_Trfase_fam3 IPR017459, Glycosyl_Trfase_fam3_N_dom IPR036320, Glycosyl_Trfase_fam3_N_dom)sf IPR035902, Nuc_phospho_transferase |
Pfami | View protein in Pfam PF02885, Glycos_trans_3N, 1 hit PF00591, Glycos_transf_3, 1 hit |
SUPFAMi | SSF47648, SSF47648, 1 hit SSF52418, SSF52418, 1 hit |
TIGRFAMsi | TIGR01245, trpD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRPD_MYCTO | |
Accessioni | P9WFX4Primary (citable) accession number: P9WFX4 Secondary accession number(s): L0T8W2, P66992, Q10382 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | December 2, 2020 | |
This is version 34 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families