UniProtKB - P9WF75 (VPC31_MYCTU)
Protein
Ribonuclease VapC31
Gene
vapC31
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB31 (By similarity).UniRule annotation1 Publication
Cofactori
Mg2+UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 5 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 108 | MagnesiumUniRule annotation | 1 |
GO - Molecular functioni
- magnesium ion binding Source: UniProtKB-UniRule
- ribonuclease activity Source: InterPro
GO - Biological processi
- negative regulation of growth Source: MTBBASE
Keywordsi
Molecular function | Hydrolase, Nuclease |
Biological process | Toxin-antitoxin system |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-4894-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Ribonuclease VapC31UniRule annotation (EC:3.1.-.-UniRule annotation)Short name: RNase VapC31UniRule annotation Alternative name(s): Toxin VapC31UniRule annotation |
Gene namesi | Name:vapC31UniRule annotation Ordered Locus Names:Rv0749 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv0749 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000407888 | 1 – 142 | Ribonuclease VapC31Add BLAST | 142 |
Proteomic databases
PaxDbi | P9WF75 |
PRIDEi | P9WF75 |
Expressioni
Inductioni
Induced in persister cells in response to D-cycloserine.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 139 | PINcUniRule annotationAdd BLAST | 137 |
Sequence similaritiesi
Belongs to the PINc/VapC protein family.UniRule annotation
Phylogenomic databases
eggNOGi | COG1848 LUCA |
KOi | K07064 |
OMAi | FARFTSV |
PhylomeDBi | P9WF75 |
Family and domain databases
HAMAPi | MF_00265 VapC_Nob1, 1 hit |
InterProi | View protein in InterPro IPR006226 Mtu_PIN IPR029060 PIN-like_dom_sf IPR002716 PIN_dom IPR022907 VapC_family |
Pfami | View protein in Pfam PF01850 PIN, 1 hit |
SUPFAMi | SSF88723 SSF88723, 1 hit |
TIGRFAMsi | TIGR00028 Mtu_PIN_fam, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WF75-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFLLDANVLL AAHRGDHPNH RTVRPWFDRL LAADDPFTVP NLVWASFLRL
60 70 80 90 100
ATNRRIFEIP SPRAEAFAFV EAVTAQPHHL PTNPGPRHLM LLRKLCDEAD
110 120 130 140
ASGDLIPDAV LAAIAVGHHC AVVSLDRDFA RFASVRHIRP PL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43494.1 |
PIRi | H70824 |
RefSeqi | NP_215263.1, NC_000962.3 WP_003403837.1, NZ_NVQJ01000035.1 |
Genome annotation databases
EnsemblBacteriai | CCP43494; CCP43494; Rv0749 |
GeneIDi | 888681 |
KEGGi | mtu:Rv0749 mtv:RVBD_0749 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43494.1 |
PIRi | H70824 |
RefSeqi | NP_215263.1, NC_000962.3 WP_003403837.1, NZ_NVQJ01000035.1 |
3D structure databases
SMRi | P9WF75 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv0749 |
Proteomic databases
PaxDbi | P9WF75 |
PRIDEi | P9WF75 |
Genome annotation databases
EnsemblBacteriai | CCP43494; CCP43494; Rv0749 |
GeneIDi | 888681 |
KEGGi | mtu:Rv0749 mtv:RVBD_0749 |
Organism-specific databases
TubercuListi | Rv0749 |
Phylogenomic databases
eggNOGi | COG1848 LUCA |
KOi | K07064 |
OMAi | FARFTSV |
PhylomeDBi | P9WF75 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-4894-MONOMER |
Family and domain databases
HAMAPi | MF_00265 VapC_Nob1, 1 hit |
InterProi | View protein in InterPro IPR006226 Mtu_PIN IPR029060 PIN-like_dom_sf IPR002716 PIN_dom IPR022907 VapC_family |
Pfami | View protein in Pfam PF01850 PIN, 1 hit |
SUPFAMi | SSF88723 SSF88723, 1 hit |
TIGRFAMsi | TIGR00028 Mtu_PIN_fam, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VPC31_MYCTU | |
Accessioni | P9WF75Primary (citable) accession number: P9WF75 Secondary accession number(s): L0T6C8, O53812, Q7D9C4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | September 18, 2019 | |
This is version 30 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names