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Protein

60S acidic ribosomal protein P2

Gene

Rplp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the elongation step of protein synthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S acidic ribosomal protein P2
Gene namesi
Name:Rplp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914436 Rplp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001576411 – 11560S acidic ribosomal protein P2Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei17PhosphoserineCombined sources1
Modified residuei19PhosphoserineBy similarity1
Modified residuei21N6-acetyllysine; alternateCombined sources1
Modified residuei21N6-succinyllysine; alternateCombined sources1
Modified residuei79PhosphoserineBy similarity1
Modified residuei86PhosphoserineCombined sources1
Modified residuei102PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP99027
MaxQBiP99027
PaxDbiP99027
PeptideAtlasiP99027
PRIDEiP99027
TopDownProteomicsiP99027

2D gel databases

REPRODUCTION-2DPAGEiIPI00139795
SWISS-2DPAGEiP99027

PTM databases

iPTMnetiP99027
PhosphoSitePlusiP99027

Expressioni

Gene expression databases

BgeeiENSMUSG00000025508
CleanExiMM_RPLP2
GenevisibleiP99027 MM

Interactioni

Subunit structurei

Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.By similarity

Protein-protein interaction databases

BioGridi212002, 4 interactors
IntActiP99027, 8 interactors
MINTiP99027
STRINGi10090.ENSMUSP00000081474

Structurei

3D structure databases

ProteinModelPortaliP99027
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3449 Eukaryota
COG2058 LUCA
GeneTreeiENSGT00550000074828
HOGENOMiHOG000229897
HOVERGENiHBG014761
InParanoidiP99027
KOiK02943
OMAiAFFNFTM
OrthoDBiEOG091G14BD
PhylomeDBiP99027
TreeFamiTF320650

Family and domain databases

Gene3Di1.10.10.1410, 1 hit
HAMAPiMF_01478 Ribosomal_L12_arch, 1 hit
InterProiView protein in InterPro
IPR038716 P1/P2_N_sf
IPR027534 Ribosomal_L12

Sequencei

Sequence statusi: Complete.

P99027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYVASYLLA ALGGNSSPSA KDIKKILDSV GIEADDDRLN KVISELNGKN
60 70 80 90 100
IEDVIAQGVG KLASVPAGGA VAVSAAPGSA APAAGSAPAA AEEKKDEKKE
110
ESEESDDDMG FGLFD
Length:115
Mass (Da):11,651
Last modified:April 13, 2004 - v3
Checksum:iAAF3FE3A0FA756BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19S → N in BAB28297 (PubMed:16141072).Curated1
Sequence conflicti61K → R in BAB28297 (PubMed:16141072).Curated1
Sequence conflicti81A → T in BAB28297 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002419 mRNA Translation: BAB22086.1
AK008344 mRNA Translation: BAB25616.1
AK010618 mRNA Translation: BAB27066.1
AK012402 mRNA Translation: BAB28217.1
AK012526 mRNA Translation: BAB28297.1
AK028140 mRNA Translation: BAC25768.1
AK028149 mRNA Translation: BAC25777.1
AK088737 mRNA Translation: BAC40539.1
AK134206 mRNA Translation: BAE22051.1
AK166774 mRNA Translation: BAE39010.1
BC012413 mRNA Translation: AAH12413.1
CCDSiCCDS40187.1
RefSeqiNP_080296.3, NM_026020.6
XP_006536292.1, XM_006536229.1
UniGeneiMm.380435

Genome annotation databases

EnsembliENSMUST00000084434; ENSMUSP00000081474; ENSMUSG00000025508
ENSMUST00000106003; ENSMUSP00000101625; ENSMUSG00000025508
ENSMUST00000106004; ENSMUSP00000101626; ENSMUSG00000025508
GeneIDi67186
KEGGimmu:67186
UCSCiuc009klf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRLA2_MOUSE
AccessioniPrimary (citable) accession number: P99027
Secondary accession number(s): Q3TKY3, Q9CQ99, Q9CZJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 13, 2004
Last modified: May 23, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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