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Protein

GTP cyclohydrolase 1 feedback regulatory protein

Gene

Gchfr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 feedback regulatory protein
Short name:
GFRP
Alternative name(s):
GTP cyclohydrolase I feedback regulatory protein
p35
Gene namesi
Name:Gchfr
Synonyms:Gfrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2443977 Gchfr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001896762 – 84GTP cyclohydrolase 1 feedback regulatory proteinAdd BLAST83

Proteomic databases

PaxDbiP99025
PeptideAtlasiP99025
PRIDEiP99025

2D gel databases

SWISS-2DPAGEiP99025

PTM databases

iPTMnetiP99025
PhosphoSitePlusiP99025
SwissPalmiP99025

Expressioni

Gene expression databases

BgeeiENSMUSG00000046814 Expressed in 132 organ(s), highest expression level in liver
CleanExiMM_GCHFR
ExpressionAtlasiP99025 baseline and differential
GenevisibleiP99025 MM

Interactioni

Subunit structurei

Homopentamer. Forms a complex with GCH1 where a GCH1 homodecamer is sandwiched by two GFRP homopentamers. Interacts with GCH1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060835

Structurei

3D structure databases

ProteinModelPortaliP99025
SMRiP99025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GFRP family.Curated

Phylogenomic databases

eggNOGiENOG410J0GT Eukaryota
ENOG4111X10 LUCA
GeneTreeiENSGT00440000033849
HOGENOMiHOG000008074
HOVERGENiHBG000233
InParanoidiP99025
OMAiTMVGDEY
OrthoDBiEOG091G15IO
PhylomeDBiP99025
TreeFamiTF329303

Family and domain databases

Gene3Di3.30.1410.10, 1 hit
InterProiView protein in InterPro
IPR036717 GFRP_sf
IPR009112 GTP_CycHdrlase_I_reg
PANTHERiPTHR16852 PTHR16852, 1 hit
PfamiView protein in Pfam
PF06399 GFRP, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD028559 GTP_CycHdrlase_I_reg, 1 hit
SUPFAMiSSF69761 SSF69761, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P99025-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPYLLISTQI RMEVGPTMVG DEHSDPELMQ HLGASKRSVL GNNFYEYYVN
60 70 80
DPPRIVLDKL ECKGFRVLSM TGVGQTLVWC LHKE
Length:84
Mass (Da):9,584
Last modified:January 23, 2007 - v3
Checksum:i553BB3B28EC6F6EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028116 mRNA Translation: BAC25756.1
AK028122 mRNA Translation: BAC25761.1
CCDSiCCDS38204.1
RefSeqiNP_796131.1, NM_177157.4
UniGeneiMm.86373

Genome annotation databases

EnsembliENSMUST00000057454; ENSMUSP00000060835; ENSMUSG00000046814
GeneIDi320415
KEGGimmu:320415
UCSCiuc008ltf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028116 mRNA Translation: BAC25756.1
AK028122 mRNA Translation: BAC25761.1
CCDSiCCDS38204.1
RefSeqiNP_796131.1, NM_177157.4
UniGeneiMm.86373

3D structure databases

ProteinModelPortaliP99025
SMRiP99025
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060835

PTM databases

iPTMnetiP99025
PhosphoSitePlusiP99025
SwissPalmiP99025

2D gel databases

SWISS-2DPAGEiP99025

Proteomic databases

PaxDbiP99025
PeptideAtlasiP99025
PRIDEiP99025

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057454; ENSMUSP00000060835; ENSMUSG00000046814
GeneIDi320415
KEGGimmu:320415
UCSCiuc008ltf.1 mouse

Organism-specific databases

CTDi2644
MGIiMGI:2443977 Gchfr

Phylogenomic databases

eggNOGiENOG410J0GT Eukaryota
ENOG4111X10 LUCA
GeneTreeiENSGT00440000033849
HOGENOMiHOG000008074
HOVERGENiHBG000233
InParanoidiP99025
OMAiTMVGDEY
OrthoDBiEOG091G15IO
PhylomeDBiP99025
TreeFamiTF329303

Enzyme and pathway databases

ReactomeiR-MMU-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

Miscellaneous databases

PROiPR:P99025
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046814 Expressed in 132 organ(s), highest expression level in liver
CleanExiMM_GCHFR
ExpressionAtlasiP99025 baseline and differential
GenevisibleiP99025 MM

Family and domain databases

Gene3Di3.30.1410.10, 1 hit
InterProiView protein in InterPro
IPR036717 GFRP_sf
IPR009112 GTP_CycHdrlase_I_reg
PANTHERiPTHR16852 PTHR16852, 1 hit
PfamiView protein in Pfam
PF06399 GFRP, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD028559 GTP_CycHdrlase_I_reg, 1 hit
SUPFAMiSSF69761 SSF69761, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGFRP_MOUSE
AccessioniPrimary (citable) accession number: P99025
Secondary accession number(s): Q8BH29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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