Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog

Gene

Arvcf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in protein-protein interactions at adherens junctions.By similarity

GO - Molecular functioni

  • cadherin binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog
Gene namesi
Name:Arvcf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:109620 Arvcf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642951 – 962Armadillo repeat protein deleted in velo-cardio-facial syndrome homologAdd BLAST962

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103PhosphothreonineBy similarity1
Modified residuei105PhosphothreonineBy similarity1
Modified residuei171Omega-N-methylarginineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei345PhosphoserineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei607PhosphoserineBy similarity1
Modified residuei643PhosphothreonineCombined sources1
Modified residuei864PhosphoserineBy similarity1
Modified residuei871PhosphoserineBy similarity1
Modified residuei872PhosphothreonineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiP98203
PaxDbiP98203
PeptideAtlasiP98203
PRIDEiP98203

PTM databases

iPTMnetiP98203
PhosphoSitePlusiP98203
SwissPalmiP98203

Expressioni

Gene expression databases

BgeeiENSMUSG00000000325 Expressed in 257 organ(s), highest expression level in epithelium of lens
ExpressionAtlasiP98203 baseline and differential
GenevisibleiP98203 MM

Interactioni

Subunit structurei

Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198214, 5 interactors
IntActiP98203, 2 interactors
MINTiP98203
STRINGi10090.ENSMUSP00000087562

Structurei

3D structure databases

ProteinModelPortaliP98203
SMRiP98203
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati350 – 389ARM 1Add BLAST40
Repeati392 – 431ARM 2Add BLAST40
Repeati435 – 469ARM 3Add BLAST35
Repeati470 – 510ARM 4Add BLAST41
Repeati528 – 567ARM 5Add BLAST40
Repeati577 – 623ARM 6Add BLAST47
Repeati647 – 687ARM 7Add BLAST41
Repeati700 – 739ARM 8Add BLAST40
Repeati740 – 782ARM 9Add BLAST43
Repeati783 – 827ARM 10Add BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili11 – 46Sequence analysisAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi608 – 624Nuclear localization signalSequence analysisAdd BLAST17

Sequence similaritiesi

Belongs to the beta-catenin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1048 Eukaryota
ENOG410Y21Q LUCA
GeneTreeiENSGT00760000119167
HOVERGENiHBG004284
InParanoidiP98203
OMAiWSTYIRA
OrthoDBiEOG091G018V
PhylomeDBiP98203
TreeFamiTF321877

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR028444 ARVCF
IPR028435 Plakophilin/d_Catenin
PANTHERiPTHR10372 PTHR10372, 1 hit
PTHR10372:SF5 PTHR10372:SF5, 1 hit
PfamiView protein in Pfam
PF00514 Arm, 4 hits
SMARTiView protein in SMART
SM00185 ARM, 6 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 3 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P98203-1) [UniParc]FASTAAdd to basket
Also known as: A1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDCNVHSAA SILASVKEQE ARFERLTRAL EQERRHVALQ LERAQQPGMS
60 70 80 90 100
SGGMVGSGQP LPMAWQQLVL QEQSPGSQAS LATMPEAPEV LEETVTVEED
110 120 130 140 150
PGTPTSHVSI VTSEDGTTRR TETKVTKTVK TVTTRTVRQV PLGPDGLPLL
160 170 180 190 200
DGGPPLGSFA DGPLDRHYLL RGGGGPAATL SRTYHSSGGG FPDGPESRDI
210 220 230 240 250
PSYGSLSRGL GVRPPRTGLL GPGPGDGCFT LPGRREAFPM GSESGPPSGR
260 270 280 290 300
SLPEHFQAEP YGLEDDTRSL AADDEGGPDL EPDYSTATRR RPEYGRGLRA
310 320 330 340 350
RAFEDTADDA GELIEERPPF PAATAPLAQP ERGSLGSLDR VVRRSPSVDS
360 370 380 390 400
TRKEPRWRDP ELPEVLAMLR HPVDPVKANA AAYLQHLCFE NEGIKRRVRQ
410 420 430 440 450
LRGLPLLVAL LDHPRAEVRR RACGALRNLS YGRDTDNKAA IRDCGGVPAL
460 470 480 490 500
VRLLRAARDN EVRELVTGTL WNLSSYEPLK MVIIDHGLQT LTHEVIVPHS
510 520 530 540 550
GWEREPNEDS KPRDAEWTTV FKNTSGCLRN VSSDGAEARR RLRECEGLVD
560 570 580 590 600
ALLHALQSAV GRKDTDNKSV ENCVCIMRNL SYHVHKEVPG ADRYQEAEPG
610 620 630 640 650
IPGSTTSQRR RKDDASCFGG KKAKEEWFHQ GKKDAEMDRN FDTLDLPKRT
660 670 680 690 700
EAAKGFELLY QPEVVRLYLS LLTESRNFNT LEAAAGALQN LSAGNWTWAT
710 720 730 740 750
YIRATVRKER GLPVLVELLQ SETDKVVRAV AIALRNLSLD QRNKDLIGSY
760 770 780 790 800
AMTELVRNVR NAQAPAHPSA HLEEDTVVAV LNTIHEIVSD SLDNARSLLQ
810 820 830 840 850
ARGVPALVAL VASSQSVREA KAASHVLQTV WSYKELRGAL QRDGWTKSRF
860 870 880 890 900
QSASTAKGPK GTPSSGGFDD STLPLVDKSL DGEKSNTRDV IPMDTLGPDG
910 920 930 940 950
YATVDRRERR TLGSDSTGDT SEKELLRPDP GRKAPPPGPS RPSVRLVDAV
960
GDTKPQPVDS WV
Length:962
Mass (Da):105,066
Last modified:August 2, 2005 - v2
Checksum:i8F43E9DC34709406
GO
Isoform 2 (identifier: P98203-2) [UniParc]FASTAAdd to basket
Also known as: A2

The sequence of this isoform differs from the canonical sequence as follows:
     625-630: Missing.

Show »
Length:956
Mass (Da):104,209
Checksum:i11BA42849409059E
GO
Isoform 4 (identifier: P98203-4) [UniParc]FASTAAdd to basket
Also known as: B2

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: MEDCNVHSAA...LPMAWQQLVL → MPAELR
     625-630: Missing.

Show »
Length:892
Mass (Da):97,165
Checksum:i937AA47D6064ED90
GO
Isoform 5 (identifier: P98203-5) [UniParc]FASTAAdd to basket
Also known as: B1

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: MEDCNVHSAA...LPMAWQQLVL → MPAELR

Show »
Length:898
Mass (Da):98,022
Checksum:i0876464C4BF836C6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A338P7H0A0A338P7H0_MOUSE
Armadillo repeat protein deleted in...
Arvcf
131Annotation score:
D6RI19D6RI19_MOUSE
Armadillo repeat protein deleted in...
Arvcf
142Annotation score:

Sequence cautioni

The sequence AJ243418 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72E → G in AAH56980 (PubMed:15489334).Curated1
Sequence conflicti372P → T in BAC39302 (PubMed:16141072).Curated1
Sequence conflicti504R → L in AAK64214 (Ref. 1) Curated1
Sequence conflicti504R → L in AAK64215 (Ref. 1) Curated1
Sequence conflicti504R → L in AAK64216 (Ref. 1) Curated1
Sequence conflicti504R → L in AAK64217 (Ref. 1) Curated1
Sequence conflicti560V → E in BAC39302 (PubMed:16141072).Curated1
Sequence conflicti761N → K in BAC39302 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0149221 – 70MEDCN…QQLVL → MPAELR in isoform 4 and isoform 5. 2 PublicationsAdd BLAST70
Alternative sequenceiVSP_014923625 – 630Missing in isoform 2 and isoform 4. 3 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286212 mRNA Translation: AAK64214.1
AF286213 mRNA Translation: AAK64215.1
AF286214 mRNA Translation: AAK64216.1
AF286215 mRNA Translation: AAK64217.1
AK044982 mRNA Translation: BAC32169.1
AK051627 mRNA Translation: BAC34696.1
AK084886 mRNA Translation: BAC39302.1
BC056980 mRNA Translation: AAH56980.1
AJ243418 mRNA No translation available.
CCDSiCCDS28020.1 [P98203-1]
CCDS70693.1 [P98203-2]
CCDS70694.1 [P98203-4]
RefSeqiNP_001258957.1, NM_001272028.1 [P98203-1]
NP_001258958.1, NM_001272029.1 [P98203-2]
NP_001258959.1, NM_001272030.1 [P98203-2]
NP_001258960.1, NM_001272031.1 [P98203-5]
NP_001258961.1, NM_001272032.1 [P98203-4]
NP_258435.2, NM_033474.3 [P98203-1]
UniGeneiMm.293599

Genome annotation databases

EnsembliENSMUST00000090103; ENSMUSP00000087562; ENSMUSG00000000325 [P98203-1]
ENSMUST00000115610; ENSMUSP00000111273; ENSMUSG00000000325 [P98203-4]
ENSMUST00000115612; ENSMUSP00000111275; ENSMUSG00000000325 [P98203-2]
ENSMUST00000115613; ENSMUSP00000111276; ENSMUSG00000000325 [P98203-1]
ENSMUST00000115614; ENSMUSP00000111278; ENSMUSG00000000325 [P98203-2]
ENSMUST00000150253; ENSMUSP00000118505; ENSMUSG00000000325 [P98203-4]
ENSMUST00000184717; ENSMUSP00000139078; ENSMUSG00000098615 [P98203-1]
ENSMUST00000230969; ENSMUSP00000155564; ENSMUSG00000098615 [P98203-1]
ENSMUST00000232025; ENSMUSP00000155883; ENSMUSG00000000325 [P98203-5]
GeneIDi11877
KEGGimmu:11877
UCSCiuc007ynl.2 mouse [P98203-1]
uc007ynm.2 mouse [P98203-2]
uc007ynq.2 mouse [P98203-5]
uc007yns.2 mouse [P98203-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286212 mRNA Translation: AAK64214.1
AF286213 mRNA Translation: AAK64215.1
AF286214 mRNA Translation: AAK64216.1
AF286215 mRNA Translation: AAK64217.1
AK044982 mRNA Translation: BAC32169.1
AK051627 mRNA Translation: BAC34696.1
AK084886 mRNA Translation: BAC39302.1
BC056980 mRNA Translation: AAH56980.1
AJ243418 mRNA No translation available.
CCDSiCCDS28020.1 [P98203-1]
CCDS70693.1 [P98203-2]
CCDS70694.1 [P98203-4]
RefSeqiNP_001258957.1, NM_001272028.1 [P98203-1]
NP_001258958.1, NM_001272029.1 [P98203-2]
NP_001258959.1, NM_001272030.1 [P98203-2]
NP_001258960.1, NM_001272031.1 [P98203-5]
NP_001258961.1, NM_001272032.1 [P98203-4]
NP_258435.2, NM_033474.3 [P98203-1]
UniGeneiMm.293599

3D structure databases

ProteinModelPortaliP98203
SMRiP98203
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198214, 5 interactors
IntActiP98203, 2 interactors
MINTiP98203
STRINGi10090.ENSMUSP00000087562

PTM databases

iPTMnetiP98203
PhosphoSitePlusiP98203
SwissPalmiP98203

Proteomic databases

MaxQBiP98203
PaxDbiP98203
PeptideAtlasiP98203
PRIDEiP98203

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090103; ENSMUSP00000087562; ENSMUSG00000000325 [P98203-1]
ENSMUST00000115610; ENSMUSP00000111273; ENSMUSG00000000325 [P98203-4]
ENSMUST00000115612; ENSMUSP00000111275; ENSMUSG00000000325 [P98203-2]
ENSMUST00000115613; ENSMUSP00000111276; ENSMUSG00000000325 [P98203-1]
ENSMUST00000115614; ENSMUSP00000111278; ENSMUSG00000000325 [P98203-2]
ENSMUST00000150253; ENSMUSP00000118505; ENSMUSG00000000325 [P98203-4]
ENSMUST00000184717; ENSMUSP00000139078; ENSMUSG00000098615 [P98203-1]
ENSMUST00000230969; ENSMUSP00000155564; ENSMUSG00000098615 [P98203-1]
ENSMUST00000232025; ENSMUSP00000155883; ENSMUSG00000000325 [P98203-5]
GeneIDi11877
KEGGimmu:11877
UCSCiuc007ynl.2 mouse [P98203-1]
uc007ynm.2 mouse [P98203-2]
uc007ynq.2 mouse [P98203-5]
uc007yns.2 mouse [P98203-4]

Organism-specific databases

CTDi421
MGIiMGI:109620 Arvcf

Phylogenomic databases

eggNOGiKOG1048 Eukaryota
ENOG410Y21Q LUCA
GeneTreeiENSGT00760000119167
HOVERGENiHBG004284
InParanoidiP98203
OMAiWSTYIRA
OrthoDBiEOG091G018V
PhylomeDBiP98203
TreeFamiTF321877

Miscellaneous databases

PROiPR:P98203
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000325 Expressed in 257 organ(s), highest expression level in epithelium of lens
ExpressionAtlasiP98203 baseline and differential
GenevisibleiP98203 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR028444 ARVCF
IPR028435 Plakophilin/d_Catenin
PANTHERiPTHR10372 PTHR10372, 1 hit
PTHR10372:SF5 PTHR10372:SF5, 1 hit
PfamiView protein in Pfam
PF00514 Arm, 4 hits
SMARTiView protein in SMART
SM00185 ARM, 6 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiARVC_MOUSE
AccessioniPrimary (citable) accession number: P98203
Secondary accession number(s): Q6PGJ6
, Q8BQ36, Q8BRF2, Q8C3U7, Q924L2, Q924L3, Q924L4, Q924L5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 2, 2005
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again