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UniProtKB - P98198 (AT8B2_HUMAN)

Entry version 185 (29 Sep 2021)
Sequence version 2 (30 Apr 2003)
Previous versions | rss
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Protein

Phospholipid-transporting ATPase ID

Gene

ATP8B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. May contribute to the maintenance of membrane lipid asymmetry.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4114-aspartylphosphate intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi833MagnesiumBy similarity1
Metal bindingi837MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processLipid transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		7.6.2.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P98198

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-936837, Ion transport by P-type ATPases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipid-transporting ATPase ID (EC:7.6.2.11 Publication)
Alternative name(s):
ATPase class I type 8B member 2
P4-ATPase flippase complex alpha subunit ATP8B2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP8B21 Publication
Synonyms:ATPID, KIAA1137
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13534, ATP8B2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605867, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P98198

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000143515

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 64CytoplasmicSequence analysisAdd BLAST64
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei65 – 86HelicalSequence analysisAdd BLAST22
Topological domaini87 – 92Exoplasmic loopSequence analysis6
Transmembranei93 – 112HelicalSequence analysisAdd BLAST20
Topological domaini113 – 295CytoplasmicSequence analysisAdd BLAST183
Transmembranei296 – 317HelicalSequence analysisAdd BLAST22
Topological domaini318 – 346Exoplasmic loopSequence analysisAdd BLAST29
Transmembranei347 – 368HelicalSequence analysisAdd BLAST22
Topological domaini369 – 889CytoplasmicSequence analysisAdd BLAST521
Transmembranei890 – 910HelicalSequence analysisAdd BLAST21
Topological domaini911 – 922Exoplasmic loopSequence analysisAdd BLAST12
Transmembranei923 – 942HelicalSequence analysisAdd BLAST20
Topological domaini943 – 972CytoplasmicSequence analysisAdd BLAST30
Transmembranei973 – 994HelicalSequence analysisAdd BLAST22
Topological domaini995 – 1008Exoplasmic loopSequence analysisAdd BLAST14
Transmembranei1009 – 1031HelicalSequence analysisAdd BLAST23
Topological domaini1032 – 1037CytoplasmicSequence analysis6
Transmembranei1038 – 1058HelicalSequence analysisAdd BLAST21
Topological domaini1059 – 1078Exoplasmic loopSequence analysisAdd BLAST20
Transmembranei1079 – 1103HelicalSequence analysisAdd BLAST25
Topological domaini1104 – 1209CytoplasmicSequence analysisAdd BLAST106

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi204E → Q: Impairs ATPase flippase activity. 1 Publication1
Mutagenesisi411D → N: Impairs ATPase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		57198

Open Targets

More...OpenTargetsi		ENSG00000143515

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25167

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P98198, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATP8B2

Domain mapping of disease mutations (DMDM)

More...DMDMi		30316371

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000463651 – 1209Phospholipid-transporting ATPase IDAdd BLAST1209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1175PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P98198

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P98198

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P98198

MaxQB - The MaxQuant DataBase

More...MaxQBi		P98198

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P98198

PeptideAtlas

More...PeptideAtlasi		P98198

PRoteomics IDEntifications database

More...PRIDEi		P98198

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57827 [P98198-1]
57828 [P98198-2]
57829 [P98198-3]
57830 [P98198-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P98198

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P98198

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 3 is ubiquitous, with highest expression in aorta, cerebellum and uterus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143515, Expressed in thoracic aorta and 220 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P98198, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143515, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP8B2 and an accessory beta subunit TMEM30A or TMEM30B.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121445, 22 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6302, ATP8B2-CDC50A P4-ATPase complex
CPX-6303, ATP8B2-CDC50B P4-ATPase complex

Protein interaction database and analysis system

More...IntActi		P98198, 15 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357475

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P98198, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P98198

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 36DisorderedSequence analysisAdd BLAST36
Regioni1181 – 1209DisorderedSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0206, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160804

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000846_8_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P98198

Database for complete collections of gene phylogenies

More...PhylomeDBi		P98198

TreeFam database of animal gene trees

More...TreeFami		TF300654

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030347, ATP8B2
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006539, P-type_ATPase_IV
IPR032631, P-type_ATPase_N
IPR001757, P_typ_ATPase
IPR032630, P_typ_ATPase_c
IPR044492, P_typ_ATPase_HD_dom

The PANTHER Classification System

More...PANTHERi		PTHR24092, PTHR24092, 1 hit
PTHR24092:SF46, PTHR24092:SF46, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16212, PhoLip_ATPase_C, 1 hit
PF16209, PhoLip_ATPase_N, 1 hit

Structure-Function Linkage Database

More...SFLDi		SFLDF00027, p-type_atpase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01652, ATPase-Plipid, 1 hit
TIGR01494, ATPase_P-type, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P98198-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTVPKEMPEK WARAQAPPSW SRKKPSWGTE EERRARANDR EYNEKFQYAS 
        60         70         80         90        100
NCIKTSKYNI LTFLPVNLFE QFQEVANTYF LFLLILQLIP QISSLSWFTT 
       110        120        130        140        150
IVPLVLVLTI TAVKDATDDY FRHKSDNQVN NRQSQVLING ILQQEQWMNV 
       160        170        180        190        200
CVGDIIKLEN NQFVAADLLL LSSSEPHGLC YIETAELDGE TNMKVRQAIP 
       210        220        230        240        250
VTSELGDISK LAKFDGEVIC EPPNNKLDKF SGTLYWKENK FPLSNQNMLL 
       260        270        280        290        300
RGCVLRNTEW CFGLVIFAGP DTKLMQNSGR TKFKRTSIDR LMNTLVLWIF 
       310        320        330        340        350
GFLVCMGVIL AIGNAIWEHE VGMRFQVYLP WDEAVDSAFF SGFLSFWSYI 
       360        370        380        390        400
IILNTVVPIS LYVSVEVIRL GHSYFINWDK KMFCMKKRTP AEARTTTLNE 
       410        420        430        440        450
ELGQVEYIFS DKTGTLTQNI MVFNKCSING HSYGDVFDVL GHKAELGERP 
       460        470        480        490        500
EPVDFSFNPL ADKKFLFWDP SLLEAVKIGD PHTHEFFRLL SLCHTVMSEE 
       510        520        530        540        550
KNEGELYYKA QSPDEGALVT AARNFGFVFR SRTPKTITVH EMGTAITYQL 
       560        570        580        590        600
LAILDFNNIR KRMSVIVRNP EGKIRLYCKG ADTILLDRLH HSTQELLNTT 
       610        620        630        640        650
MDHLNEYAGE GLRTLVLAYK DLDEEYYEEW AERRLQASLA QDSREDRLAS 
       660        670        680        690        700
IYEEVENNMM LLGATAIEDK LQQGVPETIA LLTLANIKIW VLTGDKQETA 
       710        720        730        740        750
VNIGYSCKML TDDMTEVFIV TGHTVLEVRE ELRKAREKMM DSSRSVGNGF 
       760        770        780        790        800
TYQDKLSSSK LTSVLEAVAG EYALVINGHS LAHALEADME LEFLETACAC 
       810        820        830        840        850
KAVICCRVTP LQKAQVVELV KKYKKAVTLA IGDGANDVSM IKTAHIGVGI 
       860        870        880        890        900
SGQEGIQAVL ASDYSFSQFK FLQRLLLVHG RWSYLRMCKF LCYFFYKNFA 
       910        920        930        940        950
FTMVHFWFGF FCGFSAQTVY DQYFITLYNI VYTSLPVLAM GVFDQDVPEQ 
       960        970        980        990       1000
RSMEYPKLYE PGQLNLLFNK REFFICIAQG IYTSVLMFFI PYGVFADATR 
      1010       1020       1030       1040       1050
DDGTQLADYQ SFAVTVATSL VIVVSVQIGL DTGYWTAINH FFIWGSLAVY 
      1060       1070       1080       1090       1100
FAILFAMHSN GLFDMFPNQF RFVGNAQNTL AQPTVWLTIV LTTVVCIMPV 
      1110       1120       1130       1140       1150
VAFRFLRLNL KPDLSDTVRY TQLVRKKQKA QHRCMRRVGR TGSRRSGYAF 
      1160       1170       1180       1190       1200
SHQEGFGELI MSGKNMRLSS LALSSFTTRS SSSWIESLRR KKSDSASSPS 

GGADKPLKG
Length:1,209
Mass (Da):137,440
Last modified:April 30, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD905A97E9D9724BD
GO
Isoform 2 (identifier: P98198-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     434-461: GDVFDVLGHKAELGERPEPVDFSFNPLA → VGSEGPRRKGPSWPGTVAHAYSHSTLGG
     462-1209: Missing.

Show »
Length:461
Mass (Da):52,624
Checksum:i15CAABEAAE6862DC
GO
Isoform 3 (identifier: P98198-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MTVPKEMPEKWARAQAPPSWSRKKPSWGT → MDTLRAVPLFSISGLFSFPYRVSHGIAGILLGEMAVCAKKRPP

Show »
Length:1,223
Mass (Da):138,719
Checksum:i61AF805A0511A143
GO
Isoform 4 (identifier: P98198-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MTVPKEMPEKWARAQAPPSWSRKKPSWGT → MAVCAKKRPP
     364-406: SVEVIRLGHS...TLNEELGQVE → RYVPSLTWGL...KSSSSCTVNI
     407-1209: Missing.

Show »
Length:387
Mass (Da):44,213
Checksum:iB4C17CA615F4F952
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5K1VW70A0A5K1VW70_HUMAN
Phospholipid-transporting ATPase
ATP8B2
1,190Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH30288 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB70822 differs from that shown. Reason: Frameshift.Curated
The sequence BAG65556 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti834G → E in BAA86451 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0371471 – 29MTVPK…PSWGT → MDTLRAVPLFSISGLFSFPY RVSHGIAGILLGEMAVCAKK RPP in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_0371481 – 29MTVPK…PSWGT → MAVCAKKRPP in isoform 4. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_037149364 – 406SVEVI…LGQVE → RYVPSLTWGLSRESGGPIEL FFSMKMKSLRSNEKSSSSCT VNI in isoform 4. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_037150407 – 1209Missing in isoform 4. 1 PublicationAdd BLAST803
Alternative sequenceiVSP_007302434 – 461GDVFD…FNPLA → VGSEGPRRKGPSWPGTVAHA YSHSTLGG in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_007303462 – 1209Missing in isoform 2. 1 PublicationAdd BLAST748

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY302537 mRNA Translation: AAQ19027.1
AK054886 mRNA Translation: BAB70822.1 Frameshift.
AK304806 mRNA Translation: BAG65556.1 Different initiation.
AL162591 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53205.1
BC007837 mRNA Translation: AAH07837.2
BC030288 mRNA Translation: AAH30288.1 Different initiation.
BC069264 mRNA Translation: AAH69264.1
AB032963 mRNA Translation: BAA86451.1
AL137537 mRNA Translation: CAB70799.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41405.1 [P98198-4]

Protein sequence database of the Protein Information Resource

More...PIRi		T46381

NCBI Reference Sequences

More...RefSeqi		NP_001005855.1, NM_001005855.1 [P98198-4]
NP_065185.1, NM_020452.3
XP_005245412.1, XM_005245355.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000368487; ENSP00000357472; ENSG00000143515 [P98198-4]
ENST00000672630; ENSP00000500034; ENSG00000143515 [P98198-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57198

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57198

UCSC genome browser

More...UCSCi		uc001few.4, human [P98198-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY302537 mRNA Translation: AAQ19027.1
AK054886 mRNA Translation: BAB70822.1 Frameshift.
AK304806 mRNA Translation: BAG65556.1 Different initiation.
AL162591 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53205.1
BC007837 mRNA Translation: AAH07837.2
BC030288 mRNA Translation: AAH30288.1 Different initiation.
BC069264 mRNA Translation: AAH69264.1
AB032963 mRNA Translation: BAA86451.1
AL137537 mRNA Translation: CAB70799.1
CCDSiCCDS41405.1 [P98198-4]
PIRiT46381
RefSeqiNP_001005855.1, NM_001005855.1 [P98198-4]
NP_065185.1, NM_020452.3
XP_005245412.1, XM_005245355.2

3D structure databases

SMRiP98198
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121445, 22 interactors
ComplexPortaliCPX-6302, ATP8B2-CDC50A P4-ATPase complex
CPX-6303, ATP8B2-CDC50B P4-ATPase complex
IntActiP98198, 15 interactors
STRINGi9606.ENSP00000357475

PTM databases

iPTMnetiP98198
PhosphoSitePlusiP98198

Genetic variation databases

BioMutaiATP8B2
DMDMi30316371

Proteomic databases

EPDiP98198
jPOSTiP98198
MassIVEiP98198
MaxQBiP98198
PaxDbiP98198
PeptideAtlasiP98198
PRIDEiP98198
ProteomicsDBi57827 [P98198-1]
57828 [P98198-2]
57829 [P98198-3]
57830 [P98198-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34152, 91 antibodies

The DNASU plasmid repository

More...DNASUi		57198

Genome annotation databases

EnsembliENST00000368487; ENSP00000357472; ENSG00000143515 [P98198-4]
ENST00000672630; ENSP00000500034; ENSG00000143515 [P98198-3]
GeneIDi57198
KEGGihsa:57198
UCSCiuc001few.4, human [P98198-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57198
DisGeNETi57198

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATP8B2
HGNCiHGNC:13534, ATP8B2
HPAiENSG00000143515, Low tissue specificity
MIMi605867, gene
neXtProtiNX_P98198
OpenTargetsiENSG00000143515
PharmGKBiPA25167
VEuPathDBiHostDB:ENSG00000143515

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0206, Eukaryota
GeneTreeiENSGT00940000160804
HOGENOMiCLU_000846_8_4_1
InParanoidiP98198
PhylomeDBiP98198
TreeFamiTF300654

Enzyme and pathway databases

BRENDAi7.6.2.1, 2681
PathwayCommonsiP98198
ReactomeiR-HSA-936837, Ion transport by P-type ATPases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57198, 9 hits in 1015 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ATP8B2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57198
PharosiP98198, Tbio

Protein Ontology

More...PROi		PR:P98198
RNActiP98198, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143515, Expressed in thoracic aorta and 220 other tissues
GenevisibleiP98198, HS

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030347, ATP8B2
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006539, P-type_ATPase_IV
IPR032631, P-type_ATPase_N
IPR001757, P_typ_ATPase
IPR032630, P_typ_ATPase_c
IPR044492, P_typ_ATPase_HD_dom
PANTHERiPTHR24092, PTHR24092, 1 hit
PTHR24092:SF46, PTHR24092:SF46, 1 hit
PfamiView protein in Pfam
PF16212, PhoLip_ATPase_C, 1 hit
PF16209, PhoLip_ATPase_N, 1 hit
SFLDiSFLDF00027, p-type_atpase, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit
TIGRFAMsiTIGR01652, ATPase-Plipid, 1 hit
TIGR01494, ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT8B2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P98198
Secondary accession number(s): B4E3P4
, Q6NT69, Q7Z486, Q96I43, Q96NQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 30, 2003
Last modified: September 29, 2021
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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