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Entry version 165 (29 Sep 2021)
Sequence version 1 (30 May 2000)
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Protein

Phospholipid-transporting ATPase IH

Gene

Atp11a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (By similarity).

Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007).

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4144-aspartylphosphate intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi828MagnesiumBy similarity1
Metal bindingi832MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processLipid transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
7.6.2.1, 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6798695, Neutrophil degranulation
R-MMU-936837, Ion transport by P-type ATPases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipid-transporting ATPase IH (EC:7.6.2.1By similarity)
Alternative name(s):
ATPase IS
ATPase class VI type 11A
P4-ATPase flippase complex alpha subunit ATP11A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Atp11a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1354735, Atp11a

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000031441

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 88ExtracellularSequence analysis6
Transmembranei89 – 110HelicalSequence analysisAdd BLAST22
Topological domaini111 – 296CytoplasmicSequence analysisAdd BLAST186
Transmembranei297 – 318HelicalSequence analysisAdd BLAST22
Topological domaini319 – 349ExtracellularSequence analysisAdd BLAST31
Transmembranei350 – 372HelicalSequence analysisAdd BLAST23
Topological domaini373 – 884CytoplasmicSequence analysisAdd BLAST512
Transmembranei885 – 905HelicalSequence analysisAdd BLAST21
Topological domaini906 – 917ExtracellularSequence analysisAdd BLAST12
Transmembranei918 – 937HelicalSequence analysisAdd BLAST20
Topological domaini938 – 967CytoplasmicSequence analysisAdd BLAST30
Transmembranei968 – 989HelicalSequence analysisAdd BLAST22
Topological domaini990 – 1003ExtracellularSequence analysisAdd BLAST14
Transmembranei1004 – 1026HelicalSequence analysisAdd BLAST23
Topological domaini1027 – 1032CytoplasmicSequence analysis6
Transmembranei1033 – 1053HelicalSequence analysisAdd BLAST21
Topological domaini1054 – 1071ExtracellularSequence analysisAdd BLAST18
Transmembranei1072 – 1096HelicalSequence analysisAdd BLAST25
Topological domaini1097 – 1138CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000463701 – 1187Phospholipid-transporting ATPase IHAdd BLAST1187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei740PhosphoserineBy similarity1
Modified residuei1148PhosphoserineBy similarity1
Modified residuei1158PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved by CASP3.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei457 – 458Cleavage; by CASP3By similarity2
Sitei493 – 494Cleavage; by CASP3By similarity2

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P98197

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P98197

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P98197

PRoteomics IDEntifications database

More...
PRIDEi
P98197

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
281928

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P98197

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P98197

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P98197

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in myoblasts (PubMed:29799007). Expressed in retina, brain, liver, testes and kidney (at protein level) (PubMed:30018401).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031441, Expressed in kidney and 331 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P98197, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P98197, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP11A and an accessory beta subunit TMEM30A.

2 Publications

Protein-protein interaction databases

Molecular INTeraction database

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MINTi
P98197

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000088779

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P98197, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P98197

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0206, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157849

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000846_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P98197

Identification of Orthologs from Complete Genome Data

More...
OMAi
TMWWESH

Database of Orthologous Groups

More...
OrthoDBi
587717at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P98197

TreeFam database of animal gene trees

More...
TreeFami
TF326897

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030361, ATP11A
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006539, P-type_ATPase_IV
IPR032631, P-type_ATPase_N
IPR001757, P_typ_ATPase
IPR032630, P_typ_ATPase_c
IPR044492, P_typ_ATPase_HD_dom

The PANTHER Classification System

More...
PANTHERi
PTHR24092, PTHR24092, 1 hit
PTHR24092:SF33, PTHR24092:SF33, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16212, PhoLip_ATPase_C, 1 hit
PF16209, PhoLip_ATPase_N, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDF00027, p-type_atpase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01652, ATPase-Plipid, 1 hit
TIGR01494, ATPase_P-type, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P98197-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDCSLLRTLV RRYCAGEENW VDSRTIYVGH KEPPPGAEAY IPQRYPDNRI
60 70 80 90 100
VSSKYTFWNF IPKNLFEQFR RIANFYFLII FLVQLIIDTP TSPVTSGLPL
110 120 130 140 150
FFVITVTAIK QGYEDWLRHK ADNAMNQCPV HFIQHGKLVR KQSRKLRVGD
160 170 180 190 200
IVMVKEDETF PCDLIFLSSN RADGTCHVTT ASLDGESSHK THYAVQDTKG
210 220 230 240 250
FHTEADVDSL HATIECEQPQ PDLYKFVGRI NVYNDLNDPV VRPLGSENLL
260 270 280 290 300
LRGATLKNTE KIFGVAIYTG METKMALNYQ SKSQKRSAVE KSMNTFLIVY
310 320 330 340 350
LCILVSKALI NTVLKYVWQS EPFRDEPWYN EKTESERQRN LFLRAFTDFL
360 370 380 390 400
AFMVLFNYII PVSMYVTVEM QKFLGSYFIT WDEDMFDEEM GEGPLVNTSD
410 420 430 440 450
LNEELGQVEY IFTDKTGTLT ENNMAFKECC IEGHVYVPHV ICNGQVLPDS
460 470 480 490 500
SGIDMIDSSP GVCGREREEL FFRAICLCHT VQVKDDHCGD DVDGPQKSPD
510 520 530 540 550
AKSCVYISSS PDEVALVEGV QRLGFTYLRL KDNYMEILNR ENDIERFELL
560 570 580 590 600
EVLTFDSVRR RMSVIVKSTT GEIYLFCKGA DSSIFPRVIE GKVDQVRSRV
610 620 630 640 650
ERNAVEGLRT LCVAYKRLEP EQYEDACRLL QSAKVALQDR EKKLAEAYEQ
660 670 680 690 700
IEKDLVLLGA TAVEDRLQEK AADTIEALQK AGIKVWVLTG DKMETASATC
710 720 730 740 750
YACKLFRRST QLLELTTKKL EEQSLHDVLF DLSKTVLRCS GSMTRDSFSG
760 770 780 790 800
LSTDMHDYGL IIDGAALSLI MKPREDGSSS GNYRELFLEI CRNCSAVLCC
810 820 830 840 850
RMAPLQKAQI VKLIKFSKEH PITLAIGDGA NDVSMILEAH VGIGVIGKEG
860 870 880 890 900
RQAARNSDYA IPKFKHLKKM LLVHGHFYYI RISELVQYFF YKNVCFIFPQ
910 920 930 940 950
FLYQFFCGFS QQTLYDTAYL TLYNISFTSL PILLYSLMEQ HVGIDVLKRD
960 970 980 990 1000
PTLYRDIAKN ALLRWRVFIY WTFLGVFDAL VFFFGAYFIF ENTTVTINGQ
1010 1020 1030 1040 1050
MFGNWTFGTL VFTVMVLTVT LKLALDTHYW TWINHFVIWG SLLFYIAFSL
1060 1070 1080 1090 1100
LWGGVIWPFL SYQRMYYVFI SMLSSGPAWL GIILLVTVGL LPDVLKKVLC
1110 1120 1130 1140 1150
RQLWPTATER TQNIQHQDSI SEFTPLASLP SWGAQGSRLL AAQCSSPSGR
1160 1170 1180
VVCSRWESEE CPVLPLHPGL PHKARYGCCR SSLEMPT
Length:1,187
Mass (Da):135,502
Last modified:May 30, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i999A8BE19E9296C1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Z4J2F6Z4J2_MOUSE
Phospholipid-transporting ATPase
Atp11a
590Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q3G7E9Q3G7_MOUSE
Phospholipid-transporting ATPase
Atp11a
1,142Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6R5M4F6R5M4_MOUSE
P-type phospholipid transporter
Atp11a
163Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RII8D6RII8_MOUSE
Phospholipid-transporting ATPase IH
Atp11a
291Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Z063F6Z063_MOUSE
Phospholipid-transporting ATPase IH
Atp11a
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QJS5F6QJS5_MOUSE
Phospholipid-transporting ATPase IH
Atp11a
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF156551 mRNA Translation: AAF09449.1
BC138715 mRNA Translation: AAI38716.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40223.1

NCBI Reference Sequences

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RefSeqi
NP_056619.1, NM_015804.3
XP_011240370.1, XM_011242068.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000091237; ENSMUSP00000088779; ENSMUSG00000031441

Database of genes from NCBI RefSeq genomes

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GeneIDi
50770

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:50770

UCSC genome browser

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UCSCi
uc009kwg.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156551 mRNA Translation: AAF09449.1
BC138715 mRNA Translation: AAI38716.1
CCDSiCCDS40223.1
RefSeqiNP_056619.1, NM_015804.3
XP_011240370.1, XM_011242068.1

3D structure databases

SMRiP98197
ModBaseiSearch...

Protein-protein interaction databases

MINTiP98197
STRINGi10090.ENSMUSP00000088779

PTM databases

iPTMnetiP98197
PhosphoSitePlusiP98197
SwissPalmiP98197

Proteomic databases

jPOSTiP98197
MaxQBiP98197
PaxDbiP98197
PRIDEiP98197
ProteomicsDBi281928

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
48747, 59 antibodies

The DNASU plasmid repository

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DNASUi
50770

Genome annotation databases

EnsembliENSMUST00000091237; ENSMUSP00000088779; ENSMUSG00000031441
GeneIDi50770
KEGGimmu:50770
UCSCiuc009kwg.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23250
MGIiMGI:1354735, Atp11a
VEuPathDBiHostDB:ENSMUSG00000031441

Phylogenomic databases

eggNOGiKOG0206, Eukaryota
GeneTreeiENSGT00940000157849
HOGENOMiCLU_000846_3_2_1
InParanoidiP98197
OMAiTMWWESH
OrthoDBi587717at2759
PhylomeDBiP98197
TreeFamiTF326897

Enzyme and pathway databases

BRENDAi7.6.2.1, 3474
ReactomeiR-MMU-6798695, Neutrophil degranulation
R-MMU-936837, Ion transport by P-type ATPases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
50770, 2 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Atp11a, mouse

Protein Ontology

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PROi
PR:P98197
RNActiP98197, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000031441, Expressed in kidney and 331 other tissues
ExpressionAtlasiP98197, baseline and differential
GenevisibleiP98197, MM

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030361, ATP11A
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006539, P-type_ATPase_IV
IPR032631, P-type_ATPase_N
IPR001757, P_typ_ATPase
IPR032630, P_typ_ATPase_c
IPR044492, P_typ_ATPase_HD_dom
PANTHERiPTHR24092, PTHR24092, 1 hit
PTHR24092:SF33, PTHR24092:SF33, 1 hit
PfamiView protein in Pfam
PF16212, PhoLip_ATPase_C, 1 hit
PF16209, PhoLip_ATPase_N, 1 hit
SFLDiSFLDF00027, p-type_atpase, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit
TIGRFAMsiTIGR01652, ATPase-Plipid, 1 hit
TIGR01494, ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT11A_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P98197
Secondary accession number(s): B2RS49
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: September 29, 2021
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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