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Entry version 174 (16 Oct 2019)
Sequence version 3 (24 Jan 2006)
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Protein

Probable phospholipid-transporting ATPase IH

Gene

ATP11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.Curated1 Publication

Miscellaneous

Overexpression of ATP11A confers resistance to lonafarnib.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). EC:7.6.2.1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4144-aspartylphosphate intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi825MagnesiumBy similarity1
Metal bindingi829MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processLipid transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation
R-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.3.8.17 the p-type atpase (p-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase IH (EC:7.6.2.1)
Alternative name(s):
ATPase IS
ATPase class VI type 11A
P4-ATPase flippase complex alpha subunit ATP11A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP11A
Synonyms:ATPIH, ATPIS, KIAA1021
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13552 ATP11A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605868 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P98196

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 88ExtracellularSequence analysis6
Transmembranei89 – 110HelicalSequence analysisAdd BLAST22
Topological domaini111 – 296CytoplasmicSequence analysisAdd BLAST186
Transmembranei297 – 318HelicalSequence analysisAdd BLAST22
Topological domaini319 – 349ExtracellularSequence analysisAdd BLAST31
Transmembranei350 – 372HelicalSequence analysisAdd BLAST23
Topological domaini373 – 881CytoplasmicSequence analysisAdd BLAST509
Transmembranei882 – 902HelicalSequence analysisAdd BLAST21
Topological domaini903 – 914ExtracellularSequence analysisAdd BLAST12
Transmembranei915 – 934HelicalSequence analysisAdd BLAST20
Topological domaini935 – 964CytoplasmicSequence analysisAdd BLAST30
Transmembranei965 – 986HelicalSequence analysisAdd BLAST22
Topological domaini987 – 1000ExtracellularSequence analysisAdd BLAST14
Transmembranei1001 – 1023HelicalSequence analysisAdd BLAST23
Topological domaini1024 – 1029CytoplasmicSequence analysis6
Transmembranei1030 – 1050HelicalSequence analysisAdd BLAST21
Topological domaini1051 – 1068ExtracellularSequence analysisAdd BLAST18
Transmembranei1069 – 1093HelicalSequence analysisAdd BLAST25
Topological domaini1094 – 1134CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23250

MalaCards human disease database

More...
MalaCardsi
ATP11A

Open Targets

More...
OpenTargetsi
ENSG00000068650

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2032 Idiopathic pulmonary fibrosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25101

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P98196

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATP11A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85700404

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000463691 – 1134Probable phospholipid-transporting ATPase IHAdd BLAST1134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei738PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P98196

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P98196

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P98196

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P98196

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P98196

PeptideAtlas

More...
PeptideAtlasi
P98196

PRoteomics IDEntifications database

More...
PRIDEi
P98196

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57826

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P98196

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P98196

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P98196

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000068650 Expressed in 207 organ(s), highest expression level in visceral pleura

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P98196 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P98196 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035583
HPA035584

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable).

Interacts with beta subunit TMEM30A.

Curated1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116854, 8 interactors

Protein interaction database and analysis system

More...
IntActi
P98196, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000420387

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P98196

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0206 Eukaryota
COG0474 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157849

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000202528

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P98196

KEGG Orthology (KO)

More...
KOi
K01530

Database of Orthologous Groups

More...
OrthoDBi
587717at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P98196

TreeFam database of animal gene trees

More...
TreeFami
TF326897

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030361 ATP11A
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c

The PANTHER Classification System

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PANTHERi
PTHR24092 PTHR24092, 1 hit
PTHR24092:SF33 PTHR24092:SF33, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P98196-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDCSLVRTLV HRYCAGEENW VDSRTIYVGH REPPPGAEAY IPQRYPDNRI
60 70 80 90 100
VSSKYTFWNF IPKNLFEQFR RVANFYFLII FLVQLIIDTP TSPVTSGLPL
110 120 130 140 150
FFVITVTAIK QGYEDWLRHK ADNAMNQCPV HFIQHGKLVR KQSRKLRVGD
160 170 180 190 200
IVMVKEDETF PCDLIFLSSN RGDGTCHVTT ASLDGESSHK THYAVQDTKG
210 220 230 240 250
FHTEEDIGGL HATIECEQPQ PDLYKFVGRI NVYSDLNDPV VRPLGSENLL
260 270 280 290 300
LRGATLKNTE KIFGVAIYTG METKMALNYQ SKSQKRSAVE KSMNAFLIVY
310 320 330 340 350
LCILISKALI NTVLKYMWQS EPFRDEPWYN QKTESERQRN LFLKAFTDFL
360 370 380 390 400
AFMVLFNYII PVSMYVTVEM QKFLGSYFIT WDEDMFDEET GEGPLVNTSD
410 420 430 440 450
LNEELGQVEY IFTDKTGTLT ENNMEFKECC IEGHVYVPHV ICNGQVLPES
460 470 480 490 500
SGIDMIDSSP SVNGREREEL FFRALCLCHT VQVKDDDSVD GPRKSPDGGK
510 520 530 540 550
SCVYISSSPD EVALVEGVQR LGFTYLRLKD NYMEILNREN HIERFELLEI
560 570 580 590 600
LSFDSVRRRM SVIVKSATGE IYLFCKGADS SIFPRVIEGK VDQIRARVER
610 620 630 640 650
NAVEGLRTLC VAYKRLIQEE YEGICKLLQA AKVALQDREK KLAEAYEQIE
660 670 680 690 700
KDLTLLGATA VEDRLQEKAA DTIEALQKAG IKVWVLTGDK METAAATCYA
710 720 730 740 750
CKLFRRNTQL LELTTKRIEE QSLHDVLFEL SKTVLRHSGS LTRDNLSGLS
760 770 780 790 800
ADMQDYGLII DGAALSLIMK PREDGSSGNY RELFLEICRS CSAVLCCRMA
810 820 830 840 850
PLQKAQIVKL IKFSKEHPIT LAIGDGANDV SMILEAHVGI GVIGKEGRQA
860 870 880 890 900
ARNSDYAIPK FKHLKKMLLV HGHFYYIRIS ELVQYFFYKN VCFIFPQFLY
910 920 930 940 950
QFFCGFSQQT LYDTAYLTLY NISFTSLPIL LYSLMEQHVG IDVLKRDPTL
960 970 980 990 1000
YRDVAKNALL RWRVFIYWTL LGLFDALVFF FGAYFVFENT TVTSNGQIFG
1010 1020 1030 1040 1050
NWTFGTLVFT VMVFTVTLKL ALDTHYWTWI NHFVIWGSLL FYVVFSLLWG
1060 1070 1080 1090 1100
GVIWPFLNYQ RMYYVFIQML SSGPAWLAIV LLVTISLLPD VLKKVLCRQL
1110 1120 1130
WPTATERVQT KSQCLSVEQS TIFMLSQTSS SLSF
Length:1,134
Mass (Da):129,756
Last modified:January 24, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA486BDFC85D6D3B2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y547H0Y547_HUMAN
Phospholipid-transporting ATPase
ATP11A
935Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PEJ6E9PEJ6_HUMAN
Phospholipid-transporting ATPase
ATP11A
1,191Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8F0H0Y8F0_HUMAN
Probable phospholipid-transporting ...
ATP11A
352Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3G9A2A3G9_HUMAN
Probable phospholipid-transporting ...
ATP11A
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y624H0Y624_HUMAN
Probable phospholipid-transporting ...
ATP11A
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVE8A0A087WVE8_HUMAN
Probable phospholipid-transporting ...
ATP11A
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059139317M → V1 PublicationCorresponds to variant dbSNP:rs368865Ensembl.1
Natural variantiVAR_0483791091V → I. Corresponds to variant dbSNP:rs11616795Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL356740 Genomic DNA No translation available.
AL139384 Genomic DNA No translation available.
AL356752 Genomic DNA No translation available.
AB028944 mRNA Translation: BAA82973.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32011.1

NCBI Reference Sequences

More...
RefSeqi
NP_056020.2, NM_015205.2
NP_115565.3, NM_032189.3
XP_005268362.1, XM_005268305.4
XP_005268363.1, XM_005268306.4
XP_016875981.1, XM_017020492.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375645; ENSP00000364796; ENSG00000068650
ENST00000487903; ENSP00000420387; ENSG00000068650

Database of genes from NCBI RefSeq genomes

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GeneIDi
23250

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23250

UCSC genome browser

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UCSCi
uc001vsi.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356740 Genomic DNA No translation available.
AL139384 Genomic DNA No translation available.
AL356752 Genomic DNA No translation available.
AB028944 mRNA Translation: BAA82973.2
CCDSiCCDS32011.1
RefSeqiNP_056020.2, NM_015205.2
NP_115565.3, NM_032189.3
XP_005268362.1, XM_005268305.4
XP_005268363.1, XM_005268306.4
XP_016875981.1, XM_017020492.1

3D structure databases

SMRiP98196
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116854, 8 interactors
IntActiP98196, 2 interactors
STRINGi9606.ENSP00000420387

Protein family/group databases

TCDBi3.A.3.8.17 the p-type atpase (p-atpase) superfamily

PTM databases

iPTMnetiP98196
PhosphoSitePlusiP98196
SwissPalmiP98196

Polymorphism and mutation databases

BioMutaiATP11A
DMDMi85700404

Proteomic databases

EPDiP98196
jPOSTiP98196
MassIVEiP98196
MaxQBiP98196
PaxDbiP98196
PeptideAtlasiP98196
PRIDEiP98196
ProteomicsDBi57826

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23250

Genome annotation databases

EnsembliENST00000375645; ENSP00000364796; ENSG00000068650
ENST00000487903; ENSP00000420387; ENSG00000068650
GeneIDi23250
KEGGihsa:23250
UCSCiuc001vsi.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23250
DisGeNETi23250

GeneCards: human genes, protein and diseases

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GeneCardsi
ATP11A
HGNCiHGNC:13552 ATP11A
HPAiHPA035583
HPA035584
MalaCardsiATP11A
MIMi605868 gene
neXtProtiNX_P98196
OpenTargetsiENSG00000068650
Orphaneti2032 Idiopathic pulmonary fibrosis
PharmGKBiPA25101

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0206 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00940000157849
HOGENOMiHOG000202528
InParanoidiP98196
KOiK01530
OrthoDBi587717at2759
PhylomeDBiP98196
TreeFamiTF326897

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ATP11A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23250
PharosiP98196

Protein Ontology

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PROi
PR:P98196

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000068650 Expressed in 207 organ(s), highest expression level in visceral pleura
ExpressionAtlasiP98196 baseline and differential
GenevisibleiP98196 HS

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030361 ATP11A
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF33 PTHR24092:SF33, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT11A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P98196
Secondary accession number(s): Q5VXT2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 24, 2006
Last modified: October 16, 2019
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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