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Protein

Probable phospholipid-transporting ATPase IH

Gene

ATP11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.Curated1 Publication

Miscellaneous

Overexpression of ATP11A confers resistance to lonafarnib.

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4144-aspartylphosphate intermediateBy similarity1
Metal bindingi825MagnesiumBy similarity1
Metal bindingi829MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • neutrophil degranulation Source: Reactome
  • phospholipid translocation Source: UniProtKB

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi3.A.3.8.17 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase IH (EC:3.6.3.1)
Alternative name(s):
ATPase IS
ATPase class VI type 11A
P4-ATPase flippase complex alpha subunit ATP11A
Gene namesi
Name:ATP11A
Synonyms:ATPIH, ATPIS, KIAA1021
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000068650.18
HGNCiHGNC:13552 ATP11A
MIMi605868 gene
neXtProtiNX_P98196

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 88ExtracellularSequence analysis6
Transmembranei89 – 110HelicalSequence analysisAdd BLAST22
Topological domaini111 – 296CytoplasmicSequence analysisAdd BLAST186
Transmembranei297 – 318HelicalSequence analysisAdd BLAST22
Topological domaini319 – 349ExtracellularSequence analysisAdd BLAST31
Transmembranei350 – 372HelicalSequence analysisAdd BLAST23
Topological domaini373 – 881CytoplasmicSequence analysisAdd BLAST509
Transmembranei882 – 902HelicalSequence analysisAdd BLAST21
Topological domaini903 – 914ExtracellularSequence analysisAdd BLAST12
Transmembranei915 – 934HelicalSequence analysisAdd BLAST20
Topological domaini935 – 964CytoplasmicSequence analysisAdd BLAST30
Transmembranei965 – 986HelicalSequence analysisAdd BLAST22
Topological domaini987 – 1000ExtracellularSequence analysisAdd BLAST14
Transmembranei1001 – 1023HelicalSequence analysisAdd BLAST23
Topological domaini1024 – 1029CytoplasmicSequence analysis6
Transmembranei1030 – 1050HelicalSequence analysisAdd BLAST21
Topological domaini1051 – 1068ExtracellularSequence analysisAdd BLAST18
Transmembranei1069 – 1093HelicalSequence analysisAdd BLAST25
Topological domaini1094 – 1134CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23250
MalaCardsiATP11A
OpenTargetsiENSG00000068650
Orphaneti2032 Idiopathic pulmonary fibrosis
PharmGKBiPA25101

Polymorphism and mutation databases

BioMutaiATP11A
DMDMi85700404

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463691 – 1134Probable phospholipid-transporting ATPase IHAdd BLAST1134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei738PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP98196
MaxQBiP98196
PaxDbiP98196
PeptideAtlasiP98196
PRIDEiP98196
ProteomicsDBi57826

PTM databases

iPTMnetiP98196
PhosphoSitePlusiP98196
SwissPalmiP98196

Expressioni

Gene expression databases

BgeeiENSG00000068650
CleanExiHS_ATP11A
ExpressionAtlasiP98196 baseline and differential
GenevisibleiP98196 HS

Organism-specific databases

HPAiHPA035583
HPA035584

Interactioni

Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with beta subunit TMEM30A.Curated1 Publication

Protein-protein interaction databases

BioGridi116854, 5 interactors
STRINGi9606.ENSP00000283558

Structurei

3D structure databases

ProteinModelPortaliP98196
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0206 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00910000144008
HOGENOMiHOG000202528
HOVERGENiHBG050601
InParanoidiP98196
KOiK01530
PhylomeDBiP98196
TreeFamiTF326897

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030361 ATP11A
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF33 PTHR24092:SF33, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 2 hits
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

P98196-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCSLVRTLV HRYCAGEENW VDSRTIYVGH REPPPGAEAY IPQRYPDNRI
60 70 80 90 100
VSSKYTFWNF IPKNLFEQFR RVANFYFLII FLVQLIIDTP TSPVTSGLPL
110 120 130 140 150
FFVITVTAIK QGYEDWLRHK ADNAMNQCPV HFIQHGKLVR KQSRKLRVGD
160 170 180 190 200
IVMVKEDETF PCDLIFLSSN RGDGTCHVTT ASLDGESSHK THYAVQDTKG
210 220 230 240 250
FHTEEDIGGL HATIECEQPQ PDLYKFVGRI NVYSDLNDPV VRPLGSENLL
260 270 280 290 300
LRGATLKNTE KIFGVAIYTG METKMALNYQ SKSQKRSAVE KSMNAFLIVY
310 320 330 340 350
LCILISKALI NTVLKYMWQS EPFRDEPWYN QKTESERQRN LFLKAFTDFL
360 370 380 390 400
AFMVLFNYII PVSMYVTVEM QKFLGSYFIT WDEDMFDEET GEGPLVNTSD
410 420 430 440 450
LNEELGQVEY IFTDKTGTLT ENNMEFKECC IEGHVYVPHV ICNGQVLPES
460 470 480 490 500
SGIDMIDSSP SVNGREREEL FFRALCLCHT VQVKDDDSVD GPRKSPDGGK
510 520 530 540 550
SCVYISSSPD EVALVEGVQR LGFTYLRLKD NYMEILNREN HIERFELLEI
560 570 580 590 600
LSFDSVRRRM SVIVKSATGE IYLFCKGADS SIFPRVIEGK VDQIRARVER
610 620 630 640 650
NAVEGLRTLC VAYKRLIQEE YEGICKLLQA AKVALQDREK KLAEAYEQIE
660 670 680 690 700
KDLTLLGATA VEDRLQEKAA DTIEALQKAG IKVWVLTGDK METAAATCYA
710 720 730 740 750
CKLFRRNTQL LELTTKRIEE QSLHDVLFEL SKTVLRHSGS LTRDNLSGLS
760 770 780 790 800
ADMQDYGLII DGAALSLIMK PREDGSSGNY RELFLEICRS CSAVLCCRMA
810 820 830 840 850
PLQKAQIVKL IKFSKEHPIT LAIGDGANDV SMILEAHVGI GVIGKEGRQA
860 870 880 890 900
ARNSDYAIPK FKHLKKMLLV HGHFYYIRIS ELVQYFFYKN VCFIFPQFLY
910 920 930 940 950
QFFCGFSQQT LYDTAYLTLY NISFTSLPIL LYSLMEQHVG IDVLKRDPTL
960 970 980 990 1000
YRDVAKNALL RWRVFIYWTL LGLFDALVFF FGAYFVFENT TVTSNGQIFG
1010 1020 1030 1040 1050
NWTFGTLVFT VMVFTVTLKL ALDTHYWTWI NHFVIWGSLL FYVVFSLLWG
1060 1070 1080 1090 1100
GVIWPFLNYQ RMYYVFIQML SSGPAWLAIV LLVTISLLPD VLKKVLCRQL
1110 1120 1130
WPTATERVQT KSQCLSVEQS TIFMLSQTSS SLSF
Length:1,134
Mass (Da):129,756
Last modified:January 24, 2006 - v3
Checksum:iA486BDFC85D6D3B2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059139317M → V1 PublicationCorresponds to variant dbSNP:rs368865Ensembl.1
Natural variantiVAR_0483791091V → I. Corresponds to variant dbSNP:rs11616795Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356740 Genomic DNA No translation available.
AL139384 Genomic DNA No translation available.
AL356752 Genomic DNA No translation available.
AB028944 mRNA Translation: BAA82973.2
CCDSiCCDS32011.1
RefSeqiNP_056020.2, NM_015205.2
NP_115565.3, NM_032189.3
XP_005268362.1, XM_005268305.4
XP_005268363.1, XM_005268306.4
XP_016875981.1, XM_017020492.1
UniGeneiHs.29189

Genome annotation databases

EnsembliENST00000375645; ENSP00000364796; ENSG00000068650
ENST00000487903; ENSP00000420387; ENSG00000068650
GeneIDi23250
KEGGihsa:23250
UCSCiuc001vsi.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAT11A_HUMAN
AccessioniPrimary (citable) accession number: P98196
Secondary accession number(s): Q5VXT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 24, 2006
Last modified: July 18, 2018
This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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