Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P98194 (AT2C1_HUMAN)

Protein

Calcium-transporting ATPase type 2C member 1

Gene

ATP2C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi303Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi304Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi306Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi308Calcium 2By similarity1
Active sitei3504-aspartylphosphate intermediateBy similarity1
Metal bindingi644MagnesiumBy similarity1
Metal bindingi648MagnesiumBy similarity1
Metal bindingi738Calcium 2By similarity1
Metal bindingi742Calcium 2By similarity1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.8 2681
ReactomeiR-HSA-936837 Ion transport by P-type ATPases
SIGNORiP98194

Protein family/group databases

TCDBi3.A.3.2.5 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase type 2C member 1 (EC:3.6.3.8)
Short name:
ATPase 2C1
Alternative name(s):
ATP-dependent Ca(2+) pump PMR1
Gene namesi
Name:ATP2C1
Synonyms:KIAA1347, PMR1L
ORF Names:HUSSY-28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000017260.19
HGNCiHGNC:13211 ATP2C1
MIMi604384 gene
neXtProtiNX_P98194

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 70CytoplasmicBy similarityAdd BLAST70
Transmembranei71 – 91Helical; Name=1By similarityAdd BLAST21
Topological domaini92 – 104LumenalBy similarityAdd BLAST13
Transmembranei105 – 123Helical; Name=2By similarityAdd BLAST19
Topological domaini124 – 262CytoplasmicBy similarityAdd BLAST139
Transmembranei263 – 282Helical; Name=3By similarityAdd BLAST20
Topological domaini283 – 294LumenalBy similarityAdd BLAST12
Transmembranei295 – 312Helical; Name=4By similarityAdd BLAST18
Topological domaini313 – 699CytoplasmicBy similarityAdd BLAST387
Transmembranei700 – 719Helical; Name=5By similarityAdd BLAST20
Topological domaini720 – 729LumenalBy similarity10
Transmembranei730 – 750Helical; Name=6By similarityAdd BLAST21
Topological domaini751 – 770CytoplasmicBy similarityAdd BLAST20
Transmembranei771 – 793Helical; Name=7By similarityAdd BLAST23
Topological domaini794 – 808LumenalBy similarityAdd BLAST15
Transmembranei809 – 828Helical; Name=8By similarityAdd BLAST20
Topological domaini829 – 841CytoplasmicBy similarityAdd BLAST13
Transmembranei842 – 860Helical; Name=9By similarityAdd BLAST19
Topological domaini861 – 875LumenalBy similarityAdd BLAST15
Transmembranei876 – 896Helical; Name=10By similarityAdd BLAST21
Topological domaini897 – 919CytoplasmicBy similarityAdd BLAST23

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Hailey-Hailey disease (HHD)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD.
See also OMIM:169600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010130201P → L in HHD. 1 Publication1
Natural variantiVAR_079698220G → E in HHD. 1 Publication1
Natural variantiVAR_008803304A → T in HHD. 1 PublicationCorresponds to variant dbSNP:rs137853012EnsemblClinVar.1
Natural variantiVAR_022672309G → C in HHD. 1 Publication1
Natural variantiVAR_079699309G → V in HHD. 1 PublicationCorresponds to variant dbSNP:rs1393570830Ensembl.1
Natural variantiVAR_008804318L → P in HHD. 1 Publication1
Natural variantiVAR_022673341L → P in HHD. 1 Publication1
Natural variantiVAR_010131344C → Y in HHD. 1 Publication1
Natural variantiVAR_022674411C → R in HHD. 1 Publication1
Natural variantiVAR_019523490C → F in HHD. 1 PublicationCorresponds to variant dbSNP:rs137853014EnsemblClinVar.1
Natural variantiVAR_010132570T → I in HHD. 1 Publication1
Natural variantiVAR_022675580I → V in HHD. 1 Publication1
Natural variantiVAR_019524584L → P in HHD. 1 PublicationCorresponds to variant dbSNP:rs137853015EnsemblClinVar.1
Natural variantiVAR_079700609 – 919Missing in HHD. 1 PublicationAdd BLAST311
Natural variantiVAR_008805641M → R in HHD. 1 Publication1
Natural variantiVAR_008806645G → R in HHD. 1 Publication1
Natural variantiVAR_008807709T → M in HHD. 1 PublicationCorresponds to variant dbSNP:rs778865612Ensembl.1
Natural variantiVAR_079701730 – 731Missing in HHD. 1 Publication2
Natural variantiVAR_079702731A → D in HHD. 1 Publication1
Natural variantiVAR_022676742D → Y in HHD. 1 Publication1
Natural variantiVAR_008808744P → R in HHD. 1 Publication1
Natural variantiVAR_022677789G → R in HHD. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi27032
MalaCardsiATP2C1
MIMi169600 phenotype
OpenTargetsiENSG00000017260
Orphaneti2841 Familial benign chronic pemphigus
PharmGKBiPA25111

Chemistry databases

DrugBankiDB01373 Calcium
DB01189 Desflurane
DB00228 Enflurane
DB01159 Halothane
DB00753 Isoflurane
DB01028 Methoxyflurane
DB01236 Sevoflurane

Polymorphism and mutation databases

BioMutaiATP2C1
DMDMi68068024

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462231 – 919Calcium-transporting ATPase type 2C member 1Add BLAST919

Proteomic databases

EPDiP98194
MaxQBiP98194
PaxDbiP98194
PeptideAtlasiP98194
PRIDEiP98194
ProteomicsDBi57820
57821 [P98194-2]
57822 [P98194-3]
57823 [P98194-4]
57824 [P98194-5]
57825 [P98194-6]

PTM databases

iPTMnetiP98194
PhosphoSitePlusiP98194
SwissPalmiP98194

Expressioni

Tissue specificityi

Found in most tissues except colon, thymus, spleen and leukocytes. Most abundant in keratinocytes and kidney.

Gene expression databases

BgeeiENSG00000017260 Expressed in 229 organ(s), highest expression level in corpus callosum
CleanExiHS_ATP2C1
ExpressionAtlasiP98194 baseline and differential
GenevisibleiP98194 HS

Organism-specific databases

HPAiCAB010207
HPA035116
HPA069684

Interactioni

Protein-protein interaction databases

BioGridi117963, 22 interactors
IntActiP98194, 20 interactors
MINTiP98194
STRINGi9606.ENSP00000376914

Structurei

3D structure databases

ProteinModelPortaliP98194
SMRiP98194
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0202 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00890000139334
HOGENOMiHOG000265621
HOVERGENiHBG106478
InParanoidiP98194
KOiK01537
OMAiVGMSDPP
OrthoDBiEOG091G0NXU
PhylomeDBiP98194
TreeFamiTF354251

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030336 ATP2C1
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006413 P-type_ATPase_IIA_PMR1
IPR001757 P_typ_ATPase
PANTHERiPTHR42861:SF2 PTHR42861:SF2, 1 hit
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01522 ATPase-IIA2_Ca, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequences (9+)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Isoform 1 and isoform 2 are expressed in the same tissues.

This entry has 9 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P98194-1) [UniParc]FASTAAdd to basket
Also known as: ATP2C1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVARFQKIP NGENETMIPV LTSKKASELP VSEVASILQA DLQNGLNKCE 
        60         70         80         90        100
VSHRRAFHGW NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISVLMHQF 
       110        120        130        140        150
DDAVSITVAI LIVVTVAFVQ EYRSEKSLEE LSKLVPPECH CVREGKLEHT 
       160        170        180        190        200
LARDLVPGDT VCLSVGDRVP ADLRLFEAVD LSIDESSLTG ETTPCSKVTA 
       210        220        230        240        250
PQPAATNGDL ASRSNIAFMG TLVRCGKAKG VVIGTGENSE FGEVFKMMQA 
       260        270        280        290        300
EEAPKTPLQK SMDLLGKQLS FYSFGIIGII MLVGWLLGKD ILEMFTISVS 
       310        320        330        340        350
LAVAAIPEGL PIVVTVTLAL GVMRMVKKRA IVKKLPIVET LGCCNVICSD 
       360        370        380        390        400
KTGTLTKNEM TVTHIFTSDG LHAEVTGVGY NQFGEVIVDG DVVHGFYNPA 
       410        420        430        440        450
VSRIVEAGCV CNDAVIRNNT LMGKPTEGAL IALAMKMGLD GLQQDYIRKA 
       460        470        480        490        500
EYPFSSEQKW MAVKCVHRTQ QDRPEICFMK GAYEQVIKYC TTYQSKGQTL 
       510        520        530        540        550
TLTQQQRDVY QQEKARMGSA GLRVLALASG PELGQLTFLG LVGIIDPPRT 
       560        570        580        590        600
GVKEAVTTLI ASGVSIKMIT GDSQETAVAI ASRLGLYSKT SQSVSGEEID 
       610        620        630        640        650
AMDVQQLSQI VPKVAVFYRA SPRHKMKIIK SLQKNGSVVA MTGDGVNDAV 
       660        670        680        690        700
ALKAADIGVA MGQTGTDVCK EAADMILVDD DFQTIMSAIE EGKGIYNNIK 
       710        720        730        740        750
NFVRFQLSTS IAALTLISLA TLMNFPNPLN AMQILWINII MDGPPAQSLG 
       760        770        780        790        800
VEPVDKDVIR KPPRNWKDSI LTKNLILKIL VSSIIIVCGT LFVFWRELRD 
       810        820        830        840        850
NVITPRDTTM TFTCFVFFDM FNALSSRSQT KSVFEIGLCS NRMFCYAVLG 
       860        870        880        890        900
SIMGQLLVIY FPPLQKVFQT ESLSILDLLF LLGLTSSVCI VAEIIKKVER 
       910 
SREKIQKHVS STSSSFLEV
Length:919
Mass (Da):100,577
Last modified:June 21, 2005 - v3
Checksum:i4C1495D58FDA7EA1
GO
Isoform 2 (identifier: P98194-2) [UniParc]FASTAAdd to basket
Also known as: ATP2C1B, ATP2C1C

The sequence of this isoform differs from the canonical sequence as follows:
     877-919: DLLFLLGLTSSVCIVAEIIKKVERSREKIQKHVSSTSSSFLEV → GLALGEEWTAAG

Show »
Length:888
Mass (Da):96,960
Checksum:i27E2B0E13378BB98
GO
Isoform 3 (identifier: P98194-3) [UniParc]FASTAAdd to basket
Also known as: ATP2C1B

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     910-919: SSTSSSFLEV → WLWERSGQQLVEIHPHLETGLPLTEDVSCV

Show »
Length:923
Mass (Da):101,163
Checksum:iA7962E652B936D76
GO
Isoform 4 (identifier: P98194-4) [UniParc]FASTAAdd to basket
Also known as: ATP2C1A

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Show »
Length:903
Mass (Da):98,733
Checksum:iD15118E067B15ED4
GO
Isoform 5 (identifier: P98194-5) [UniParc]FASTAAdd to basket
Also known as: ATP2C1B

The sequence of this isoform differs from the canonical sequence as follows:
     910-919: SSTSSSFLEV → WLWERSGQQLVEIHPHLETGLPLTEDVSCV

Show »
Length:939
Mass (Da):103,007
Checksum:iE6B6914D20DFD0B7
GO
Isoform 6 (identifier: P98194-6) [UniParc]FASTAAdd to basket
Also known as: ATP2C1D

The sequence of this isoform differs from the canonical sequence as follows:
     919-919: V → VSSTSSSFLEVWLWERSGQQLVEIHPHLETGLPLTEDVSCV

Show »
Length:959
Mass (Da):105,057
Checksum:iC25B54ABDE014607
GO
Isoform 7 (identifier: P98194-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MK → MDSLLPPSRFSYFKKYPLHAIRRYLSTLRNQRAEEQ
     910-919: SSTSSSFLEV → WLWERSGQQLVEIHPHLETGLPLTEDVSCV

Note: No experimental confirmation available.
Show »
Length:973
Mass (Da):107,143
Checksum:i0AC81DFDBA5DAB98
GO
Isoform 8 (identifier: P98194-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MK → MDSLLPPSRFSYFKKYPLHAIRRYLSTLRNQRAEEQ
     39-77: Missing.
     919-919: V → VWLWERSGQQLVEIHPHLETGLPLTEDVSCV

Note: No experimental confirmation available.
Show »
Length:944
Mass (Da):103,524
Checksum:i16F4A201591E4EA8
GO
Isoform 9 (identifier: P98194-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     919-919: V → VWLWERSGQQLVEIHPHLETGLPLTEDVSCV

Note: No experimental confirmation available.
Show »
Length:949
Mass (Da):104,032
Checksum:iDA7EBA526743BEDF
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4E2Q0B4E2Q0_HUMAN
Calcium-transporting ATPase
ATP2C1 hCG_14809
953Annotation score:
H0Y9V7H0Y9V7_HUMAN
Calcium-transporting ATPase type 2C...
ATP2C1
903Annotation score:
D6R9U9D6R9U9_HUMAN
Calcium-transporting ATPase type 2C...
ATP2C1
131Annotation score:
H0Y9S7H0Y9S7_HUMAN
Calcium-transporting ATPase type 2C...
ATP2C1
314Annotation score:
D6REJ1D6REJ1_HUMAN
Calcium-transporting ATPase type 2C...
ATP2C1
102Annotation score:
D6RHV9D6RHV9_HUMAN
Calcium-transporting ATPase type 2C...
ATP2C1
120Annotation score:
H0Y8X9H0Y8X9_HUMAN
Calcium-transporting ATPase type 2C...
ATP2C1
215Annotation score:
D6RGE9D6RGE9_HUMAN
Calcium-transporting ATPase type 2C...
ATP2C1
82Annotation score:
H0YAH2H0YAH2_HUMAN
Calcium-transporting ATPase type 2C...
ATP2C1
50Annotation score:

Sequence cautioni

The sequence BAA92585 differs from that shown. Reason: Frameshift at position 8.Curated
The sequence BAC11142 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62E → K in AAF26295 (PubMed:10615129).Curated1
Sequence conflicti62E → K in AAF26296 (PubMed:10615129).Curated1
Sequence conflicti112I → F in AAF35375 (PubMed:10767338).Curated1
Sequence conflicti150T → I in BAC11142 (PubMed:14702039).Curated1
Sequence conflicti346V → A in BAH12365 (PubMed:14702039).Curated1
Sequence conflicti373A → T in AAF26295 (PubMed:10615129).Curated1
Sequence conflicti373A → T in AAF26296 (PubMed:10615129).Curated1
Sequence conflicti516R → H in CAA09425 (PubMed:11124703).Curated1
Sequence conflicti713A → T in BAC11142 (PubMed:14702039).Curated1
Sequence conflicti868F → L in BAG61775 (PubMed:14702039).Curated1
Sequence conflicti901S → G in BAC11142 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010130201P → L in HHD. 1 Publication1
Natural variantiVAR_079698220G → E in HHD. 1 Publication1
Natural variantiVAR_008803304A → T in HHD. 1 PublicationCorresponds to variant dbSNP:rs137853012EnsemblClinVar.1
Natural variantiVAR_022672309G → C in HHD. 1 Publication1
Natural variantiVAR_079699309G → V in HHD. 1 PublicationCorresponds to variant dbSNP:rs1393570830Ensembl.1
Natural variantiVAR_008804318L → P in HHD. 1 Publication1
Natural variantiVAR_022673341L → P in HHD. 1 Publication1
Natural variantiVAR_010131344C → Y in HHD. 1 Publication1
Natural variantiVAR_022674411C → R in HHD. 1 Publication1
Natural variantiVAR_048373450A → T. Corresponds to variant dbSNP:rs41434650EnsemblClinVar.1
Natural variantiVAR_019523490C → F in HHD. 1 PublicationCorresponds to variant dbSNP:rs137853014EnsemblClinVar.1
Natural variantiVAR_010132570T → I in HHD. 1 Publication1
Natural variantiVAR_022675580I → V in HHD. 1 Publication1
Natural variantiVAR_019524584L → P in HHD. 1 PublicationCorresponds to variant dbSNP:rs137853015EnsemblClinVar.1
Natural variantiVAR_079700609 – 919Missing in HHD. 1 PublicationAdd BLAST311
Natural variantiVAR_008805641M → R in HHD. 1 Publication1
Natural variantiVAR_008806645G → R in HHD. 1 Publication1
Natural variantiVAR_008807709T → M in HHD. 1 PublicationCorresponds to variant dbSNP:rs778865612Ensembl.1
Natural variantiVAR_079701730 – 731Missing in HHD. 1 Publication2
Natural variantiVAR_079702731A → D in HHD. 1 Publication1
Natural variantiVAR_022676742D → Y in HHD. 1 Publication1
Natural variantiVAR_008808744P → R in HHD. 1 Publication1
Natural variantiVAR_022677789G → R in HHD. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0004081 – 16Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0458921 – 2MK → MDSLLPPSRFSYFKKYPLHA IRRYLSTLRNQRAEEQ in isoform 7 and isoform 8. 1 Publication2
Alternative sequenceiVSP_05503639 – 77Missing in isoform 8. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_000409877 – 919DLLFL…SFLEV → GLALGEEWTAAG in isoform 2. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_000410910 – 919SSTSSSFLEV → WLWERSGQQLVEIHPHLETG LPLTEDVSCV in isoform 3, isoform 5 and isoform 7. 3 Publications10
Alternative sequenceiVSP_014102919V → VSSTSSSFLEVWLWERSGQQ LVEIHPHLETGLPLTEDVSC V in isoform 6. 2 Publications1
Alternative sequenceiVSP_055037919V → VWLWERSGQQLVEIHPHLET GLPLTEDVSCV in isoform 9 and isoform 8. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181120 mRNA Translation: AAF26295.1
AF181121 mRNA Translation: AAF26296.1
AF189723 mRNA Translation: AAF27813.2
AF225981 mRNA Translation: AAF35375.1
AY268374 mRNA Translation: AAP30008.1
AY268375 mRNA Translation: AAP30009.1
AB037768 mRNA Translation: BAA92585.1 Frameshift.
AK001684 mRNA Translation: BAA91835.1
AK074692 mRNA Translation: BAC11142.1 Different initiation.
AK296470 mRNA Translation: BAH12365.1
AK299945 mRNA Translation: BAG61775.1
AK314342 mRNA Translation: BAG36984.1
AC055733 Genomic DNA No translation available.
AC097105 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79218.1
CH471052 Genomic DNA Translation: EAW79219.1
BC028139 mRNA Translation: AAH28139.1
AJ010953 mRNA Translation: CAA09425.1
CCDSiCCDS33856.1 [P98194-9]
CCDS46912.1 [P98194-5]
CCDS46913.1 [P98194-2]
CCDS46914.1 [P98194-1]
CCDS56278.1 [P98194-7]
CCDS56279.1 [P98194-8]
CCDS56280.1 [P98194-3]
CCDS56281.1 [P98194-4]
RefSeqiNP_001001485.1, NM_001001485.2 [P98194-2]
NP_001001486.1, NM_001001486.1 [P98194-9]
NP_001001487.1, NM_001001487.1 [P98194-5]
NP_001186108.1, NM_001199179.1 [P98194-1]
NP_001186109.1, NM_001199180.1 [P98194-7]
NP_001186110.1, NM_001199181.1
NP_001186111.1, NM_001199182.1 [P98194-8]
NP_001186112.1, NM_001199183.1 [P98194-3]
NP_001186113.1, NM_001199184.1 [P98194-4]
NP_001186114.1, NM_001199185.1 [P98194-2]
NP_055197.2, NM_014382.3 [P98194-1]
XP_005247412.1, XM_005247355.2 [P98194-9]
XP_005247413.1, XM_005247356.2 [P98194-9]
XP_016861653.1, XM_017006164.1 [P98194-5]
UniGeneiHs.584884

Genome annotation databases

EnsembliENST00000328560; ENSP00000329664; ENSG00000017260 [P98194-2]
ENST00000359644; ENSP00000352665; ENSG00000017260 [P98194-9]
ENST00000422190; ENSP00000402677; ENSG00000017260 [P98194-5]
ENST00000428331; ENSP00000395809; ENSG00000017260 [P98194-1]
ENST00000504381; ENSP00000425320; ENSG00000017260 [P98194-8]
ENST00000504948; ENSP00000423330; ENSG00000017260 [P98194-4]
ENST00000507488; ENSP00000421326; ENSG00000017260 [P98194-7]
ENST00000508532; ENSP00000424783; ENSG00000017260 [P98194-1]
ENST00000510168; ENSP00000427461; ENSG00000017260 [P98194-1]
ENST00000513801; ENSP00000422872; ENSG00000017260 [P98194-3]
ENST00000533801; ENSP00000432956; ENSG00000017260 [P98194-2]
GeneIDi27032
KEGGihsa:27032
UCSCiuc003enk.4 human [P98194-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181120 mRNA Translation: AAF26295.1
AF181121 mRNA Translation: AAF26296.1
AF189723 mRNA Translation: AAF27813.2
AF225981 mRNA Translation: AAF35375.1
AY268374 mRNA Translation: AAP30008.1
AY268375 mRNA Translation: AAP30009.1
AB037768 mRNA Translation: BAA92585.1 Frameshift.
AK001684 mRNA Translation: BAA91835.1
AK074692 mRNA Translation: BAC11142.1 Different initiation.
AK296470 mRNA Translation: BAH12365.1
AK299945 mRNA Translation: BAG61775.1
AK314342 mRNA Translation: BAG36984.1
AC055733 Genomic DNA No translation available.
AC097105 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79218.1
CH471052 Genomic DNA Translation: EAW79219.1
BC028139 mRNA Translation: AAH28139.1
AJ010953 mRNA Translation: CAA09425.1
CCDSiCCDS33856.1 [P98194-9]
CCDS46912.1 [P98194-5]
CCDS46913.1 [P98194-2]
CCDS46914.1 [P98194-1]
CCDS56278.1 [P98194-7]
CCDS56279.1 [P98194-8]
CCDS56280.1 [P98194-3]
CCDS56281.1 [P98194-4]
RefSeqiNP_001001485.1, NM_001001485.2 [P98194-2]
NP_001001486.1, NM_001001486.1 [P98194-9]
NP_001001487.1, NM_001001487.1 [P98194-5]
NP_001186108.1, NM_001199179.1 [P98194-1]
NP_001186109.1, NM_001199180.1 [P98194-7]
NP_001186110.1, NM_001199181.1
NP_001186111.1, NM_001199182.1 [P98194-8]
NP_001186112.1, NM_001199183.1 [P98194-3]
NP_001186113.1, NM_001199184.1 [P98194-4]
NP_001186114.1, NM_001199185.1 [P98194-2]
NP_055197.2, NM_014382.3 [P98194-1]
XP_005247412.1, XM_005247355.2 [P98194-9]
XP_005247413.1, XM_005247356.2 [P98194-9]
XP_016861653.1, XM_017006164.1 [P98194-5]
UniGeneiHs.584884

3D structure databases

ProteinModelPortaliP98194
SMRiP98194
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117963, 22 interactors
IntActiP98194, 20 interactors
MINTiP98194
STRINGi9606.ENSP00000376914

Chemistry databases

DrugBankiDB01373 Calcium
DB01189 Desflurane
DB00228 Enflurane
DB01159 Halothane
DB00753 Isoflurane
DB01028 Methoxyflurane
DB01236 Sevoflurane

Protein family/group databases

TCDBi3.A.3.2.5 the p-type atpase (p-atpase) superfamily

PTM databases

iPTMnetiP98194
PhosphoSitePlusiP98194
SwissPalmiP98194

Polymorphism and mutation databases

BioMutaiATP2C1
DMDMi68068024

Proteomic databases

EPDiP98194
MaxQBiP98194
PaxDbiP98194
PeptideAtlasiP98194
PRIDEiP98194
ProteomicsDBi57820
57821 [P98194-2]
57822 [P98194-3]
57823 [P98194-4]
57824 [P98194-5]
57825 [P98194-6]

Protocols and materials databases

DNASUi27032
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328560; ENSP00000329664; ENSG00000017260 [P98194-2]
ENST00000359644; ENSP00000352665; ENSG00000017260 [P98194-9]
ENST00000422190; ENSP00000402677; ENSG00000017260 [P98194-5]
ENST00000428331; ENSP00000395809; ENSG00000017260 [P98194-1]
ENST00000504381; ENSP00000425320; ENSG00000017260 [P98194-8]
ENST00000504948; ENSP00000423330; ENSG00000017260 [P98194-4]
ENST00000507488; ENSP00000421326; ENSG00000017260 [P98194-7]
ENST00000508532; ENSP00000424783; ENSG00000017260 [P98194-1]
ENST00000510168; ENSP00000427461; ENSG00000017260 [P98194-1]
ENST00000513801; ENSP00000422872; ENSG00000017260 [P98194-3]
ENST00000533801; ENSP00000432956; ENSG00000017260 [P98194-2]
GeneIDi27032
KEGGihsa:27032
UCSCiuc003enk.4 human [P98194-1]

Organism-specific databases

CTDi27032
DisGeNETi27032
EuPathDBiHostDB:ENSG00000017260.19
GeneCardsiATP2C1
HGNCiHGNC:13211 ATP2C1
HPAiCAB010207
HPA035116
HPA069684
MalaCardsiATP2C1
MIMi169600 phenotype
604384 gene
neXtProtiNX_P98194
OpenTargetsiENSG00000017260
Orphaneti2841 Familial benign chronic pemphigus
PharmGKBiPA25111
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0202 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00890000139334
HOGENOMiHOG000265621
HOVERGENiHBG106478
InParanoidiP98194
KOiK01537
OMAiVGMSDPP
OrthoDBiEOG091G0NXU
PhylomeDBiP98194
TreeFamiTF354251

Enzyme and pathway databases

BRENDAi3.6.3.8 2681
ReactomeiR-HSA-936837 Ion transport by P-type ATPases
SIGNORiP98194

Miscellaneous databases

ChiTaRSiATP2C1 human
GeneWikiiATP2C1
GenomeRNAii27032
PROiPR:P98194
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000017260 Expressed in 229 organ(s), highest expression level in corpus callosum
CleanExiHS_ATP2C1
ExpressionAtlasiP98194 baseline and differential
GenevisibleiP98194 HS

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030336 ATP2C1
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006413 P-type_ATPase_IIA_PMR1
IPR001757 P_typ_ATPase
PANTHERiPTHR42861:SF2 PTHR42861:SF2, 1 hit
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01522 ATPase-IIA2_Ca, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAT2C1_HUMAN
AccessioniPrimary (citable) accession number: P98194
Secondary accession number(s): B2RAT7
, B4DSW3, B7Z3X9, G3XAH8, G8JLN9, O76005, Q86V72, Q86V73, Q8N6V1, Q8NCJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 21, 2005
Last modified: November 7, 2018
This is version 195 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again