UniProtKB - P98194 (AT2C1_HUMAN)
Protein
Calcium-transporting ATPase type 2C member 1
Gene
ATP2C1
Organism
Homo sapiens (Human)
Status
Functioni
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
Catalytic activityi
- EC:7.2.2.10
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 303 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 304 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 306 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 308 | Calcium 2By similarity | 1 | |
Active sitei | 350 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 644 | MagnesiumBy similarity | 1 | |
Metal bindingi | 648 | MagnesiumBy similarity | 1 | |
Metal bindingi | 738 | Calcium 2By similarity | 1 | |
Metal bindingi | 742 | Calcium 2By similarity | 1 |
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: UniProtKB
- calcium ion binding Source: UniProtKB
- calcium transmembrane transporter activity, phosphorylative mechanism Source: UniProtKB
- manganese ion binding Source: UniProtKB
- manganese transmembrane transporter activity, phosphorylative mechanism Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- proton-exporting ATPase activity, phosphorylative mechanism Source: GO_Central
GO - Biological processi
- actin cytoskeleton reorganization Source: UniProtKB
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
- calcium ion transmembrane transport Source: GO_Central
- calcium ion transport Source: UniProtKB
- cellular calcium ion homeostasis Source: UniProtKB
- cellular manganese ion homeostasis Source: UniProtKB
- epidermis development Source: UniProtKB
- Golgi calcium ion homeostasis Source: UniProtKB
- Golgi calcium ion transport Source: UniProtKB
- ion transmembrane transport Source: Reactome
- manganese ion transport Source: UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Keywordsi
Molecular function | Translocase |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.6.3.8, 2681 |
PathwayCommonsi | P98194 |
Reactomei | R-HSA-936837, Ion transport by P-type ATPases |
SIGNORi | P98194 |
Protein family/group databases
TCDBi | 3.A.3.2.5, the p-type atpase (p-atpase) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-transporting ATPase type 2C member 1 (EC:7.2.2.10)Short name: ATPase 2C1 Alternative name(s): ATP-dependent Ca(2+) pump PMR1 |
Gene namesi | Name:ATP2C1 Synonyms:KIAA1347, PMR1L ORF Names:HUSSY-28 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13211, ATP2C1 |
MIMi | 604384, gene |
neXtProti | NX_P98194 |
VEuPathDBi | HostDB:ENSG00000017260.19 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: UniProtKB
- trans-Golgi network Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 70 | CytoplasmicBy similarityAdd BLAST | 70 | |
Transmembranei | 71 – 91 | Helical; Name=1By similarityAdd BLAST | 21 | |
Topological domaini | 92 – 104 | LumenalBy similarityAdd BLAST | 13 | |
Transmembranei | 105 – 123 | Helical; Name=2By similarityAdd BLAST | 19 | |
Topological domaini | 124 – 262 | CytoplasmicBy similarityAdd BLAST | 139 | |
Transmembranei | 263 – 282 | Helical; Name=3By similarityAdd BLAST | 20 | |
Topological domaini | 283 – 294 | LumenalBy similarityAdd BLAST | 12 | |
Transmembranei | 295 – 312 | Helical; Name=4By similarityAdd BLAST | 18 | |
Topological domaini | 313 – 699 | CytoplasmicBy similarityAdd BLAST | 387 | |
Transmembranei | 700 – 719 | Helical; Name=5By similarityAdd BLAST | 20 | |
Topological domaini | 720 – 729 | LumenalBy similarity | 10 | |
Transmembranei | 730 – 750 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 751 – 770 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 771 – 793 | Helical; Name=7By similarityAdd BLAST | 23 | |
Topological domaini | 794 – 808 | LumenalBy similarityAdd BLAST | 15 | |
Transmembranei | 809 – 828 | Helical; Name=8By similarityAdd BLAST | 20 | |
Topological domaini | 829 – 841 | CytoplasmicBy similarityAdd BLAST | 13 | |
Transmembranei | 842 – 860 | Helical; Name=9By similarityAdd BLAST | 19 | |
Topological domaini | 861 – 875 | LumenalBy similarityAdd BLAST | 15 | |
Transmembranei | 876 – 896 | Helical; Name=10By similarityAdd BLAST | 21 | |
Topological domaini | 897 – 919 | CytoplasmicBy similarityAdd BLAST | 23 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Involvement in diseasei
Hailey-Hailey disease (HHD)5 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAutosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010130 | 201 | P → L in HHD. 1 Publication | 1 | |
Natural variantiVAR_079698 | 220 | G → E in HHD. 1 Publication | 1 | |
Natural variantiVAR_008803 | 304 | A → T in HHD. 1 PublicationCorresponds to variant dbSNP:rs137853012EnsemblClinVar. | 1 | |
Natural variantiVAR_022672 | 309 | G → C in HHD. 1 Publication | 1 | |
Natural variantiVAR_079699 | 309 | G → V in HHD. 1 PublicationCorresponds to variant dbSNP:rs1393570830Ensembl. | 1 | |
Natural variantiVAR_008804 | 318 | L → P in HHD. 1 Publication | 1 | |
Natural variantiVAR_022673 | 341 | L → P in HHD. 1 Publication | 1 | |
Natural variantiVAR_010131 | 344 | C → Y in HHD. 1 Publication | 1 | |
Natural variantiVAR_022674 | 411 | C → R in HHD. 1 Publication | 1 | |
Natural variantiVAR_019523 | 490 | C → F in HHD. 1 PublicationCorresponds to variant dbSNP:rs137853014EnsemblClinVar. | 1 | |
Natural variantiVAR_010132 | 570 | T → I in HHD. 1 Publication | 1 | |
Natural variantiVAR_022675 | 580 | I → V in HHD. 1 PublicationCorresponds to variant dbSNP:rs1282232888Ensembl. | 1 | |
Natural variantiVAR_019524 | 584 | L → P in HHD. 1 PublicationCorresponds to variant dbSNP:rs137853015EnsemblClinVar. | 1 | |
Natural variantiVAR_079700 | 609 – 919 | Missing in HHD. 1 PublicationAdd BLAST | 311 | |
Natural variantiVAR_008805 | 641 | M → R in HHD. 1 Publication | 1 | |
Natural variantiVAR_008806 | 645 | G → R in HHD. 1 Publication | 1 | |
Natural variantiVAR_008807 | 709 | T → M in HHD. 1 PublicationCorresponds to variant dbSNP:rs778865612Ensembl. | 1 | |
Natural variantiVAR_079701 | 730 – 731 | Missing in HHD. 1 Publication | 2 | |
Natural variantiVAR_079702 | 731 | A → D in HHD. 1 Publication | 1 | |
Natural variantiVAR_022676 | 742 | D → Y in HHD. 1 Publication | 1 | |
Natural variantiVAR_008808 | 744 | P → R in HHD. 1 Publication | 1 | |
Natural variantiVAR_022677 | 789 | G → R in HHD. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 27032 |
MalaCardsi | ATP2C1 |
MIMi | 169600, phenotype |
OpenTargetsi | ENSG00000017260 |
Orphaneti | 2841, Familial benign chronic pemphigus |
PharmGKBi | PA25111 |
Miscellaneous databases
Pharosi | P98194, Tbio |
Chemistry databases
DrugBanki | DB01373, Calcium DB01189, Desflurane DB00228, Enflurane DB00753, Isoflurane DB01028, Methoxyflurane DB01236, Sevoflurane |
Genetic variation databases
BioMutai | ATP2C1 |
DMDMi | 68068024 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046223 | 1 – 919 | Calcium-transporting ATPase type 2C member 1Add BLAST | 919 |
Proteomic databases
EPDi | P98194 |
jPOSTi | P98194 |
MassIVEi | P98194 |
MaxQBi | P98194 |
PaxDbi | P98194 |
PeptideAtlasi | P98194 |
PRIDEi | P98194 |
ProteomicsDBi | 33752 34290 57820 [P98194-1] 57821 [P98194-2] 57822 [P98194-3] 57823 [P98194-4] 57824 [P98194-5] 57825 [P98194-6] |
PTM databases
iPTMneti | P98194 |
MetOSitei | P98194 |
PhosphoSitePlusi | P98194 |
SwissPalmi | P98194 |
Expressioni
Tissue specificityi
Found in most tissues except colon, thymus, spleen and leukocytes. Most abundant in keratinocytes and kidney.
Gene expression databases
Bgeei | ENSG00000017260, Expressed in corpus callosum and 240 other tissues |
ExpressionAtlasi | P98194, baseline and differential |
Genevisiblei | P98194, HS |
Organism-specific databases
HPAi | ENSG00000017260, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 117963, 51 interactors |
IntActi | P98194, 25 interactors |
MINTi | P98194 |
STRINGi | 9606.ENSP00000421326 |
Miscellaneous databases
RNActi | P98194, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0202, Eukaryota |
GeneTreei | ENSGT00940000156421 |
HOGENOMi | CLU_002360_3_3_1 |
InParanoidi | P98194 |
OMAi | VGMSDPP |
OrthoDBi | 100699at2759 |
PhylomeDBi | P98194 |
TreeFami | TF354251 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR030336, ATP2C1 IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006413, P-type_ATPase_IIA_PMR1 IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
PANTHERi | PTHR42861:SF2, PTHR42861:SF2, 1 hit |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01522, ATPase-IIA2_Ca, 1 hit TIGR01494, ATPase_P-type, 3 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
s (9+)i Sequence
Sequence statusi: Complete.
This entry describes 9 produced by isoformsialternative splicing. AlignAdd to basketNote: Isoform 1 and isoform 2 are expressed in the same tissues.
This entry has 9 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P98194-1) [UniParc]FASTAAdd to basket
Also known as: ATP2C1A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKVARFQKIP NGENETMIPV LTSKKASELP VSEVASILQA DLQNGLNKCE
60 70 80 90 100
VSHRRAFHGW NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISVLMHQF
110 120 130 140 150
DDAVSITVAI LIVVTVAFVQ EYRSEKSLEE LSKLVPPECH CVREGKLEHT
160 170 180 190 200
LARDLVPGDT VCLSVGDRVP ADLRLFEAVD LSIDESSLTG ETTPCSKVTA
210 220 230 240 250
PQPAATNGDL ASRSNIAFMG TLVRCGKAKG VVIGTGENSE FGEVFKMMQA
260 270 280 290 300
EEAPKTPLQK SMDLLGKQLS FYSFGIIGII MLVGWLLGKD ILEMFTISVS
310 320 330 340 350
LAVAAIPEGL PIVVTVTLAL GVMRMVKKRA IVKKLPIVET LGCCNVICSD
360 370 380 390 400
KTGTLTKNEM TVTHIFTSDG LHAEVTGVGY NQFGEVIVDG DVVHGFYNPA
410 420 430 440 450
VSRIVEAGCV CNDAVIRNNT LMGKPTEGAL IALAMKMGLD GLQQDYIRKA
460 470 480 490 500
EYPFSSEQKW MAVKCVHRTQ QDRPEICFMK GAYEQVIKYC TTYQSKGQTL
510 520 530 540 550
TLTQQQRDVY QQEKARMGSA GLRVLALASG PELGQLTFLG LVGIIDPPRT
560 570 580 590 600
GVKEAVTTLI ASGVSIKMIT GDSQETAVAI ASRLGLYSKT SQSVSGEEID
610 620 630 640 650
AMDVQQLSQI VPKVAVFYRA SPRHKMKIIK SLQKNGSVVA MTGDGVNDAV
660 670 680 690 700
ALKAADIGVA MGQTGTDVCK EAADMILVDD DFQTIMSAIE EGKGIYNNIK
710 720 730 740 750
NFVRFQLSTS IAALTLISLA TLMNFPNPLN AMQILWINII MDGPPAQSLG
760 770 780 790 800
VEPVDKDVIR KPPRNWKDSI LTKNLILKIL VSSIIIVCGT LFVFWRELRD
810 820 830 840 850
NVITPRDTTM TFTCFVFFDM FNALSSRSQT KSVFEIGLCS NRMFCYAVLG
860 870 880 890 900
SIMGQLLVIY FPPLQKVFQT ESLSILDLLF LLGLTSSVCI VAEIIKKVER
910
SREKIQKHVS STSSSFLEV
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4E2Q0 | B4E2Q0_HUMAN | Calcium-transporting ATPase | ATP2C1 hCG_14809 | 953 | Annotation score: | ||
H0Y9V7 | H0Y9V7_HUMAN | Calcium-transporting ATPase type 2C... | ATP2C1 | 903 | Annotation score: | ||
H0Y9S7 | H0Y9S7_HUMAN | Calcium-transporting ATPase type 2C... | ATP2C1 | 314 | Annotation score: | ||
D6R9U9 | D6R9U9_HUMAN | Calcium-transporting ATPase type 2C... | ATP2C1 | 131 | Annotation score: | ||
D6REJ1 | D6REJ1_HUMAN | Calcium-transporting ATPase type 2C... | ATP2C1 | 102 | Annotation score: | ||
D6RHV9 | D6RHV9_HUMAN | Calcium-transporting ATPase type 2C... | ATP2C1 | 120 | Annotation score: | ||
D6RGE9 | D6RGE9_HUMAN | Calcium-transporting ATPase type 2C... | ATP2C1 | 82 | Annotation score: | ||
H0Y8X9 | H0Y8X9_HUMAN | Calcium-transporting ATPase type 2C... | ATP2C1 | 215 | Annotation score: | ||
H0YAH2 | H0YAH2_HUMAN | Calcium-transporting ATPase type 2C... | ATP2C1 | 50 | Annotation score: |
Sequence cautioni
The sequence BAA92585 differs from that shown. Reason: Frameshift.Curated
The sequence BAC11142 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 62 | E → K in AAF26295 (PubMed:10615129).Curated | 1 | |
Sequence conflicti | 62 | E → K in AAF26296 (PubMed:10615129).Curated | 1 | |
Sequence conflicti | 112 | I → F in AAF35375 (PubMed:10767338).Curated | 1 | |
Sequence conflicti | 150 | T → I in BAC11142 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 346 | V → A in BAH12365 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 373 | A → T in AAF26295 (PubMed:10615129).Curated | 1 | |
Sequence conflicti | 373 | A → T in AAF26296 (PubMed:10615129).Curated | 1 | |
Sequence conflicti | 516 | R → H in CAA09425 (PubMed:11124703).Curated | 1 | |
Sequence conflicti | 713 | A → T in BAC11142 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 868 | F → L in BAG61775 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 901 | S → G in BAC11142 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010130 | 201 | P → L in HHD. 1 Publication | 1 | |
Natural variantiVAR_079698 | 220 | G → E in HHD. 1 Publication | 1 | |
Natural variantiVAR_008803 | 304 | A → T in HHD. 1 PublicationCorresponds to variant dbSNP:rs137853012EnsemblClinVar. | 1 | |
Natural variantiVAR_022672 | 309 | G → C in HHD. 1 Publication | 1 | |
Natural variantiVAR_079699 | 309 | G → V in HHD. 1 PublicationCorresponds to variant dbSNP:rs1393570830Ensembl. | 1 | |
Natural variantiVAR_008804 | 318 | L → P in HHD. 1 Publication | 1 | |
Natural variantiVAR_022673 | 341 | L → P in HHD. 1 Publication | 1 | |
Natural variantiVAR_010131 | 344 | C → Y in HHD. 1 Publication | 1 | |
Natural variantiVAR_022674 | 411 | C → R in HHD. 1 Publication | 1 | |
Natural variantiVAR_048373 | 450 | A → T. Corresponds to variant dbSNP:rs41434650EnsemblClinVar. | 1 | |
Natural variantiVAR_019523 | 490 | C → F in HHD. 1 PublicationCorresponds to variant dbSNP:rs137853014EnsemblClinVar. | 1 | |
Natural variantiVAR_010132 | 570 | T → I in HHD. 1 Publication | 1 | |
Natural variantiVAR_022675 | 580 | I → V in HHD. 1 PublicationCorresponds to variant dbSNP:rs1282232888Ensembl. | 1 | |
Natural variantiVAR_019524 | 584 | L → P in HHD. 1 PublicationCorresponds to variant dbSNP:rs137853015EnsemblClinVar. | 1 | |
Natural variantiVAR_079700 | 609 – 919 | Missing in HHD. 1 PublicationAdd BLAST | 311 | |
Natural variantiVAR_008805 | 641 | M → R in HHD. 1 Publication | 1 | |
Natural variantiVAR_008806 | 645 | G → R in HHD. 1 Publication | 1 | |
Natural variantiVAR_008807 | 709 | T → M in HHD. 1 PublicationCorresponds to variant dbSNP:rs778865612Ensembl. | 1 | |
Natural variantiVAR_079701 | 730 – 731 | Missing in HHD. 1 Publication | 2 | |
Natural variantiVAR_079702 | 731 | A → D in HHD. 1 Publication | 1 | |
Natural variantiVAR_022676 | 742 | D → Y in HHD. 1 Publication | 1 | |
Natural variantiVAR_008808 | 744 | P → R in HHD. 1 Publication | 1 | |
Natural variantiVAR_022677 | 789 | G → R in HHD. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000408 | 1 – 16 | Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_045892 | 1 – 2 | MK → MDSLLPPSRFSYFKKYPLHA IRRYLSTLRNQRAEEQ in isoform 7 and isoform 8. 1 Publication | 2 | |
Alternative sequenceiVSP_055036 | 39 – 77 | Missing in isoform 8. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_000409 | 877 – 919 | DLLFL…SFLEV → GLALGEEWTAAG in isoform 2. 2 PublicationsAdd BLAST | 43 | |
Alternative sequenceiVSP_000410 | 910 – 919 | SSTSSSFLEV → WLWERSGQQLVEIHPHLETG LPLTEDVSCV in isoform 3, isoform 5 and isoform 7. 3 Publications | 10 | |
Alternative sequenceiVSP_014102 | 919 | V → VSSTSSSFLEVWLWERSGQQ LVEIHPHLETGLPLTEDVSC V in isoform 6. 2 Publications | 1 | |
Alternative sequenceiVSP_055037 | 919 | V → VWLWERSGQQLVEIHPHLET GLPLTEDVSCV in isoform 9 and isoform 8. 1 Publication | 1 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | P98194 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117963, 51 interactors |
IntActi | P98194, 25 interactors |
MINTi | P98194 |
STRINGi | 9606.ENSP00000421326 |
Chemistry databases
DrugBanki | DB01373, Calcium DB01189, Desflurane DB00228, Enflurane DB00753, Isoflurane DB01028, Methoxyflurane DB01236, Sevoflurane |
Protein family/group databases
TCDBi | 3.A.3.2.5, the p-type atpase (p-atpase) superfamily |
PTM databases
iPTMneti | P98194 |
MetOSitei | P98194 |
PhosphoSitePlusi | P98194 |
SwissPalmi | P98194 |
Genetic variation databases
BioMutai | ATP2C1 |
DMDMi | 68068024 |
Proteomic databases
EPDi | P98194 |
jPOSTi | P98194 |
MassIVEi | P98194 |
MaxQBi | P98194 |
PaxDbi | P98194 |
PeptideAtlasi | P98194 |
PRIDEi | P98194 |
ProteomicsDBi | 33752 34290 57820 [P98194-1] 57821 [P98194-2] 57822 [P98194-3] 57823 [P98194-4] 57824 [P98194-5] 57825 [P98194-6] |
Protocols and materials databases
Antibodypediai | 4128, 333 antibodies |
DNASUi | 27032 |
Genome annotation databases
Organism-specific databases
CTDi | 27032 |
DisGeNETi | 27032 |
GeneCardsi | ATP2C1 |
HGNCi | HGNC:13211, ATP2C1 |
HPAi | ENSG00000017260, Low tissue specificity |
MalaCardsi | ATP2C1 |
MIMi | 169600, phenotype 604384, gene |
neXtProti | NX_P98194 |
OpenTargetsi | ENSG00000017260 |
Orphaneti | 2841, Familial benign chronic pemphigus |
PharmGKBi | PA25111 |
VEuPathDBi | HostDB:ENSG00000017260.19 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0202, Eukaryota |
GeneTreei | ENSGT00940000156421 |
HOGENOMi | CLU_002360_3_3_1 |
InParanoidi | P98194 |
OMAi | VGMSDPP |
OrthoDBi | 100699at2759 |
PhylomeDBi | P98194 |
TreeFami | TF354251 |
Enzyme and pathway databases
BRENDAi | 3.6.3.8, 2681 |
PathwayCommonsi | P98194 |
Reactomei | R-HSA-936837, Ion transport by P-type ATPases |
SIGNORi | P98194 |
Miscellaneous databases
BioGRID-ORCSi | 27032, 48 hits in 997 CRISPR screens |
ChiTaRSi | ATP2C1, human |
GeneWikii | ATP2C1 |
GenomeRNAii | 27032 |
Pharosi | P98194, Tbio |
PROi | PR:P98194 |
RNActi | P98194, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000017260, Expressed in corpus callosum and 240 other tissues |
ExpressionAtlasi | P98194, baseline and differential |
Genevisiblei | P98194, HS |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR030336, ATP2C1 IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006413, P-type_ATPase_IIA_PMR1 IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
PANTHERi | PTHR42861:SF2, PTHR42861:SF2, 1 hit |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01522, ATPase-IIA2_Ca, 1 hit TIGR01494, ATPase_P-type, 3 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AT2C1_HUMAN | |
Accessioni | P98194Primary (citable) accession number: P98194 Secondary accession number(s): B2RAT7 Q8NCJ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | June 21, 2005 | |
Last modified: | April 7, 2021 | |
This is version 214 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families