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Protein

RNA-binding protein 3

Gene

RBM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • positive regulation of translation Source: UniProtKB
  • regulation of translation Source: UniProtKB
  • RNA processing Source: ProtInc

Keywordsi

Molecular functionRNA-binding
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 3
Alternative name(s):
RNA-binding motif protein 3
RNPL
Gene namesi
Name:RBM3
Synonyms:RNPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102317.17
HGNCiHGNC:9900 RBM3
MIMi300027 gene
neXtProtiNX_P98179

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5935
OpenTargetsiENSG00000102317
PharmGKBiPA34265

Polymorphism and mutation databases

BioMutaiRBM3
DMDMi1710620

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817521 – 157RNA-binding protein 3Add BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47Omega-N-methylarginineCombined sources1
Modified residuei105Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei105Dimethylated arginine; in A2780 ovarian carcinoma cell line1 Publication1
Modified residuei105Omega-N-methylarginine; alternateCombined sources1
Modified residuei121Omega-N-methylarginineCombined sources1
Modified residuei131Omega-N-methylarginineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei155PhosphotyrosineCombined sources1

Post-translational modificationi

Arg-105 is dimethylated, probably to asymmetric dimethylarginine.
Phosphorylated.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiP98179
MaxQBiP98179
PaxDbiP98179
PeptideAtlasiP98179
PRIDEiP98179
ProteomicsDBi57816
TopDownProteomicsiP98179

PTM databases

iPTMnetiP98179
PhosphoSitePlusiP98179

Expressioni

Inductioni

Up-regulated by hypoxia.1 Publication

Gene expression databases

BgeeiENSG00000102317 Expressed in 236 organ(s), highest expression level in endometrium epithelium
CleanExiHS_RBM3
ExpressionAtlasiP98179 baseline and differential
GenevisibleiP98179 HS

Organism-specific databases

HPAiCAB062559
HPA003624

Interactioni

Subunit structurei

Interacts with RPL4. Associates with the 60S ribosomal subunits in an RNA-independent manner. Associates with ribosomes (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi111870, 102 interactors
IntActiP98179, 26 interactors
MINTiP98179
STRINGi9606.ENSP00000365946

Structurei

3D structure databases

ProteinModelPortaliP98179
SMRiP98179
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 84RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi88 – 149Gly-richAdd BLAST62

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00710000106295
HOGENOMiHOG000276232
HOVERGENiHBG107480
InParanoidiP98179
KOiK13186
OMAiWHTTDDA
OrthoDBiEOG091G13K0
PhylomeDBiP98179
TreeFamiTF354331

Family and domain databases

CDDicd12449 RRM_CIRBP_RBM3, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034278 RBM3/CIRBP_RRM
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P98179-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSEEGKLFV GGLNFNTDEQ ALEDHFSSFG PISEVVVVKD RETQRSRGFG
60 70 80 90 100
FITFTNPEHA SVAMRAMNGE SLDGRQIRVD HAGKSARGTR GGGFGAHGRG
110 120 130 140 150
RSYSRGGGDQ GYGSGRYYDS RPGGYGYGYG RSRDYNGRNQ GGYDRYSGGN

YRDNYDN
Length:157
Mass (Da):17,170
Last modified:October 1, 1996 - v1
Checksum:i91C12E2A3E32CFA4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9H5V0Q9H5V0_HUMAN
RNA binding motif (RNP1, RRM) prote...
RBM3 hCG_19813
155Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28686 mRNA Translation: AAB17212.1
AF196969 Genomic DNA No translation available.
BC006825 mRNA Translation: AAH06825.1
CCDSiCCDS14301.1
PIRiG01859
RefSeqiNP_006734.1, NM_006743.4
UniGeneiHs.301404

Genome annotation databases

EnsembliENST00000376755; ENSP00000365946; ENSG00000102317
ENST00000376759; ENSP00000365950; ENSG00000102317
GeneIDi5935
KEGGihsa:5935
UCSCiuc004dkf.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28686 mRNA Translation: AAB17212.1
AF196969 Genomic DNA No translation available.
BC006825 mRNA Translation: AAH06825.1
CCDSiCCDS14301.1
PIRiG01859
RefSeqiNP_006734.1, NM_006743.4
UniGeneiHs.301404

3D structure databases

ProteinModelPortaliP98179
SMRiP98179
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111870, 102 interactors
IntActiP98179, 26 interactors
MINTiP98179
STRINGi9606.ENSP00000365946

PTM databases

iPTMnetiP98179
PhosphoSitePlusiP98179

Polymorphism and mutation databases

BioMutaiRBM3
DMDMi1710620

Proteomic databases

EPDiP98179
MaxQBiP98179
PaxDbiP98179
PeptideAtlasiP98179
PRIDEiP98179
ProteomicsDBi57816
TopDownProteomicsiP98179

Protocols and materials databases

DNASUi5935
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376755; ENSP00000365946; ENSG00000102317
ENST00000376759; ENSP00000365950; ENSG00000102317
GeneIDi5935
KEGGihsa:5935
UCSCiuc004dkf.3 human

Organism-specific databases

CTDi5935
DisGeNETi5935
EuPathDBiHostDB:ENSG00000102317.17
GeneCardsiRBM3
HGNCiHGNC:9900 RBM3
HPAiCAB062559
HPA003624
MIMi300027 gene
neXtProtiNX_P98179
OpenTargetsiENSG00000102317
PharmGKBiPA34265
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00710000106295
HOGENOMiHOG000276232
HOVERGENiHBG107480
InParanoidiP98179
KOiK13186
OMAiWHTTDDA
OrthoDBiEOG091G13K0
PhylomeDBiP98179
TreeFamiTF354331

Miscellaneous databases

ChiTaRSiRBM3 human
GeneWikiiRBM3
GenomeRNAii5935
PROiPR:P98179
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102317 Expressed in 236 organ(s), highest expression level in endometrium epithelium
CleanExiHS_RBM3
ExpressionAtlasiP98179 baseline and differential
GenevisibleiP98179 HS

Family and domain databases

CDDicd12449 RRM_CIRBP_RBM3, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034278 RBM3/CIRBP_RRM
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBM3_HUMAN
AccessioniPrimary (citable) accession number: P98179
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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