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Protein

Protein FAM3A

Gene

FAM3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a defensin against invading fungal microorganisms.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM3A
Alternative name(s):
Cytokine-like protein 2-19
Gene namesi
Name:FAM3A
Synonyms:2-19, 2.19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000071889.16
HGNCiHGNC:13749 FAM3A
MIMi300492 gene
neXtProtiNX_P98173

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000071889
PharmGKBiPA38366

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000000874834 – 230Protein FAM3AAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 87By similarity
Disulfide bondi65 ↔ 222By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP98173
MaxQBiP98173
PaxDbiP98173
PeptideAtlasiP98173
PRIDEiP98173
ProteomicsDBi57807
57808 [P98173-2]

PTM databases

iPTMnetiP98173

Expressioni

Tissue specificityi

In similar amounts in testis, pancreas, adrenal, placenta, brain, fetal brain, liver, kidney, skeletal muscle and heart.

Gene expression databases

BgeeiENSG00000071889 Expressed in 209 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_FAM3A
ExpressionAtlasiP98173 baseline and differential
GenevisibleiP98173 HS

Organism-specific databases

HPAiCAB025016
HPA056991

Interactioni

Protein-protein interaction databases

BioGridi121898, 13 interactors
IntActiP98173, 3 interactors
MINTiP98173
STRINGi9606.ENSP00000352955

Structurei

3D structure databases

ProteinModelPortaliP98173
SMRiP98173
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKQR Eukaryota
ENOG410ZQT7 LUCA
GeneTreeiENSGT00530000063020
HOGENOMiHOG000285992
HOVERGENiHBG051544
InParanoidiP98173
PhylomeDBiP98173
TreeFamiTF353414

Family and domain databases

InterProiView protein in InterPro
IPR039220 FAM3
IPR039221 FAM3A
PANTHERiPTHR14592 PTHR14592, 1 hit
PTHR14592:SF11 PTHR14592:SF11, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P98173-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLAGPLRIV VLVVSVGVTW IVVSILLGGP GSGFPRIQQL FTSPESSVTA
60 70 80 90 100
APRARKYKCG LPQPCPEEHL AFRVVSGAAN VIGPKICLED KMLMSSVKDN
110 120 130 140 150
VGRGLNIALV NGVSGELIEA RAFDMWAGDV NDLLKFIRPL HEGTLVFVAS
160 170 180 190 200
YDDPATKMNE ETRKLFSELG SRNAKELAFR DSWVFVGAKG VQNKSPFEQH
210 220 230
VKNSKHSNKY EGWPEALEME GCIPRRSTAS
Length:230
Mass (Da):25,152
Last modified:November 28, 2006 - v2
Checksum:iFE23EE191F98CAAD
GO
Isoform 2 (identifier: P98173-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-128: Missing.

Note: No experimental confirmation available.
Show »
Length:213
Mass (Da):23,361
Checksum:iF586DA014DEBFF50
GO
Isoform 3 (identifier: P98173-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-43: Missing.

Note: Gene prediction based on EST data.
Show »
Length:192
Mass (Da):21,164
Checksum:iB7E349DBE65E0A36
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BU27Q9BU27_HUMAN
FAM3A protein
FAM3A
70Annotation score:
Q5HY75Q5HY75_HUMAN
Protein FAM3A
FAM3A
237Annotation score:
A6QRH7A6QRH7_HUMAN
Protein FAM3A
FAM3A
163Annotation score:
F8WEM7F8WEM7_HUMAN
Protein FAM3A
FAM3A
51Annotation score:
F8WEW8F8WEW8_HUMAN
Protein FAM3A
FAM3A
53Annotation score:
F8WD39F8WD39_HUMAN
Protein FAM3A
FAM3A
77Annotation score:
F8WCK6F8WCK6_HUMAN
Protein FAM3A
FAM3A
70Annotation score:
D3DWX8D3DWX8_HUMAN
Family with sequence similarity 3, ...
FAM3A hCG_41348
244Annotation score:
A6QRH8A6QRH8_HUMAN
Protein FAM3A
FAM3A
21Annotation score:
F8WB47F8WB47_HUMAN
Protein FAM3A
FAM3A
39Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05753121I → M. Corresponds to variant dbSNP:rs35985994Ensembl.1
Natural variantiVAR_011923213W → C3 PublicationsCorresponds to variant dbSNP:rs1050788Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0467336 – 43Missing in isoform 3. CuratedAdd BLAST38
Alternative sequenceiVSP_042778112 – 128Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55448 Genomic DNA Translation: CAA39090.1
X87193 mRNA Translation: CAA60645.1
L44140 Genomic DNA Translation: AAA92652.1
AK294116 mRNA Translation: BAG57449.1
AK314682 mRNA Translation: BAG37234.1
BX664739 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72689.1
CH471172 Genomic DNA Translation: EAW72692.1
CH471172 Genomic DNA Translation: EAW72693.1
CH471172 Genomic DNA Translation: EAW72694.1
CH471172 Genomic DNA Translation: EAW72695.1
BC008912 mRNA Translation: AAH08912.1
CCDSiCCDS35453.1 [P98173-1]
CCDS55542.1 [P98173-3]
CCDS55543.1 [P98173-2]
PIRiI37095
RefSeqiNP_001164603.1, NM_001171132.2 [P98173-1]
NP_001164604.1, NM_001171133.2 [P98173-3]
NP_001164605.1, NM_001171134.2 [P98173-2]
NP_001269240.1, NM_001282311.1
NP_001269241.1, NM_001282312.1 [P98173-1]
NP_068578.2, NM_021806.3 [P98173-1]
XP_005277936.1, XM_005277879.4 [P98173-2]
UniGeneiHs.289108

Genome annotation databases

EnsembliENST00000359889; ENSP00000352955; ENSG00000071889 [P98173-1]
ENST00000369643; ENSP00000358657; ENSG00000071889 [P98173-1]
ENST00000393572; ENSP00000377202; ENSG00000071889 [P98173-3]
ENST00000419205; ENSP00000393086; ENSG00000071889 [P98173-2]
ENST00000447601; ENSP00000416146; ENSG00000071889 [P98173-1]
GeneIDi60343
KEGGihsa:60343
UCSCiuc004fls.4 human [P98173-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55448 Genomic DNA Translation: CAA39090.1
X87193 mRNA Translation: CAA60645.1
L44140 Genomic DNA Translation: AAA92652.1
AK294116 mRNA Translation: BAG57449.1
AK314682 mRNA Translation: BAG37234.1
BX664739 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72689.1
CH471172 Genomic DNA Translation: EAW72692.1
CH471172 Genomic DNA Translation: EAW72693.1
CH471172 Genomic DNA Translation: EAW72694.1
CH471172 Genomic DNA Translation: EAW72695.1
BC008912 mRNA Translation: AAH08912.1
CCDSiCCDS35453.1 [P98173-1]
CCDS55542.1 [P98173-3]
CCDS55543.1 [P98173-2]
PIRiI37095
RefSeqiNP_001164603.1, NM_001171132.2 [P98173-1]
NP_001164604.1, NM_001171133.2 [P98173-3]
NP_001164605.1, NM_001171134.2 [P98173-2]
NP_001269240.1, NM_001282311.1
NP_001269241.1, NM_001282312.1 [P98173-1]
NP_068578.2, NM_021806.3 [P98173-1]
XP_005277936.1, XM_005277879.4 [P98173-2]
UniGeneiHs.289108

3D structure databases

ProteinModelPortaliP98173
SMRiP98173
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121898, 13 interactors
IntActiP98173, 3 interactors
MINTiP98173
STRINGi9606.ENSP00000352955

PTM databases

iPTMnetiP98173

Proteomic databases

EPDiP98173
MaxQBiP98173
PaxDbiP98173
PeptideAtlasiP98173
PRIDEiP98173
ProteomicsDBi57807
57808 [P98173-2]

Protocols and materials databases

DNASUi60343
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359889; ENSP00000352955; ENSG00000071889 [P98173-1]
ENST00000369643; ENSP00000358657; ENSG00000071889 [P98173-1]
ENST00000393572; ENSP00000377202; ENSG00000071889 [P98173-3]
ENST00000419205; ENSP00000393086; ENSG00000071889 [P98173-2]
ENST00000447601; ENSP00000416146; ENSG00000071889 [P98173-1]
GeneIDi60343
KEGGihsa:60343
UCSCiuc004fls.4 human [P98173-1]

Organism-specific databases

CTDi60343
EuPathDBiHostDB:ENSG00000071889.16
GeneCardsiFAM3A
H-InvDBiHIX0017160
HGNCiHGNC:13749 FAM3A
HPAiCAB025016
HPA056991
MIMi300492 gene
neXtProtiNX_P98173
OpenTargetsiENSG00000071889
PharmGKBiPA38366
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKQR Eukaryota
ENOG410ZQT7 LUCA
GeneTreeiENSGT00530000063020
HOGENOMiHOG000285992
HOVERGENiHBG051544
InParanoidiP98173
PhylomeDBiP98173
TreeFamiTF353414

Miscellaneous databases

ChiTaRSiFAM3A human
GenomeRNAii60343
PROiPR:P98173
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000071889 Expressed in 209 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_FAM3A
ExpressionAtlasiP98173 baseline and differential
GenevisibleiP98173 HS

Family and domain databases

InterProiView protein in InterPro
IPR039220 FAM3
IPR039221 FAM3A
PANTHERiPTHR14592 PTHR14592, 1 hit
PTHR14592:SF11 PTHR14592:SF11, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFAM3A_HUMAN
AccessioniPrimary (citable) accession number: P98173
Secondary accession number(s): A6QRH6
, B2RBI7, B4DFI8, D3DWX4, Q5HY76, Q96H51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 28, 2006
Last modified: September 12, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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