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UniProtKB - P98169 (ZXDB_HUMAN)
Protein
Zinc finger X-linked protein ZXDB
Gene
ZXDB
Organism
Homo sapiens (Human)
Status
Functioni
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 271 – 295 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 304 – 328 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 334 – 358 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 364 – 386 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 393 – 417 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 424 – 448 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 454 – 478 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 484 – 508 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 514 – 538 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 547 – 572 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 26 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- transcription coregulator activity Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P98169 |
SignaLinki | P98169 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger X-linked protein ZXDB |
Gene namesi | Name:ZXDB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13199, ZXDB |
MIMi | 300236, gene |
neXtProti | NX_P98169 |
VEuPathDBi | HostDB:ENSG00000198455 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000198455 |
PharmGKBi | PA37764 |
Miscellaneous databases
Pharosi | P98169, Tdark |
Genetic variation databases
BioMutai | ZXDB |
DMDMi | 12644370 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047777 | 1 – 803 | Zinc finger X-linked protein ZXDBAdd BLAST | 803 |
Proteomic databases
EPDi | P98169 |
jPOSTi | P98169 |
MassIVEi | P98169 |
MaxQBi | P98169 |
PaxDbi | P98169 |
PeptideAtlasi | P98169 |
PRIDEi | P98169 |
ProteomicsDBi | 57802 |
PTM databases
iPTMneti | P98169 |
PhosphoSitePlusi | P98169 |
Expressioni
Tissue specificityi
May be expressed in brain, heart, kidney, liver, lung, muscle and placenta.1 Publication
Gene expression databases
Bgeei | ENSG00000198455, Expressed in cerebral cortex and 203 other tissues |
Genevisiblei | P98169, HS |
Organism-specific databases
HPAi | ENSG00000198455, Low tissue specificity |
Interactioni
Subunit structurei
Self-associates.
Interacts with ZXDC and CIITA (By similarity).
By similarityBinary interactionsi
P98169
With | #Exp. | IntAct |
---|---|---|
EIF4A3 [P38919] | 3 | EBI-17493569,EBI-299104 |
USP20 [A0A024R8A9] | 3 | EBI-17493569,EBI-14096082 |
ZGPAT - isoform 2 [Q8N5A5-2] | 3 | EBI-17493569,EBI-10183064 |
Protein-protein interaction databases
BioGRIDi | 127694, 18 interactors |
IntActi | P98169, 3 interactors |
STRINGi | 9606.ENSP00000364023 |
Miscellaneous databases
RNActi | P98169, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 91 | DisorderedSequence analysisAdd BLAST | 91 | |
Regioni | 120 – 140 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 218 – 260 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 271 – 577 | Required for interaction with ZXDCBy similarityAdd BLAST | 307 | |
Regioni | 576 – 703 | Required for transcriptional activationBy similarityAdd BLAST | 128 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 232 – 246 | Pro residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the ZXD family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 271 – 295 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 304 – 328 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 334 – 358 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 364 – 386 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 393 – 417 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 424 – 448 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 454 – 478 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 484 – 508 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 514 – 538 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 547 – 572 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164739 |
HOGENOMi | CLU_007312_0_0_1 |
InParanoidi | P98169 |
OMAi | DWNVHPD |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P98169 |
TreeFami | TF330996 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
i Sequence
Sequence statusi: Complete.
P98169-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLLRGP
60 70 80 90 100
QDGGPGRRRE EASTASRGPG PSLLAPRTDQ PSGGGGGGGD DFFLVLLDPV
110 120 130 140 150
GGDVETAGSG QAAGPVLREE AEEGPGLQGG ESGANPAGPT ALGPRCLSAV
160 170 180 190 200
PTPAPISAPG PAAAFAGTVT IHNQDLLLRF ENGVLTLATP PPHAWEPGAA
210 220 230 240 250
PAQQPGCLIA PQAGFPHAAH PGDCPELPPD LLLAEPAEPA PAPAPEEEAE
260 270 280 290 300
GPAAALGPRG PLGSGPGVVL YLCPEAQCGQ TFAKKHQLKV HLLTHSSSQG
310 320 330 340 350
QRPFKCPLGG CGWTFTTSYK LKRHLQSHDK LRPFGCPAEG CGKSFTTVYN
360 370 380 390 400
LKAHMKGHEQ ENSFKCEVCE ESFPTQAKLS AHQRSHFEPE RPYQCAFSGC
410 420 430 440 450
KKTFITVSAL FSHNRAHFRE QELFSCSFPG CSKQYDKACR LKIHLRSHTG
460 470 480 490 500
ERPFLCDFDG CGWNFTSMSK LLRHKRKHDD DRRFMCPVEG CGKSFTRAEH
510 520 530 540 550
LKGHSITHLG TKPFVCPVAG CCARFSARSS LYIHSKKHLQ DVDTWKSRCP
560 570 580 590 600
ISSCNKLFTS KHSMKTHMVK RHKVGQDLLA QLEAANSLTP SSELTSQRQN
610 620 630 640 650
DLSDAEIVSL FSDVPDSTSA ALLDTALVNS GILTIDVASV SSTLAGHLPA
660 670 680 690 700
NNNNSVGQAV DPPSLMATSD PPQSLDTSLF FGTAATGFQQ SSLNMDEVSS
710 720 730 740 750
VSVGPLGSLD SLAMKNSSPE PQALTPSSKL TVDTDALTPS STLCENSVSE
760 770 780 790 800
LLTPTKAEWN VHPDSDFFGQ EGETQFGFPN AAGNHGSQKE TDLITVTGSS
FLV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033003 | 736 | A → T. Corresponds to variant dbSNP:rs1057338Ensembl. | 1 | |
Natural variantiVAR_033004 | 760 | N → S. Corresponds to variant dbSNP:rs1057340Ensembl. | 1 | |
Natural variantiVAR_033005 | 764 | D → N. Corresponds to variant dbSNP:rs1057341Ensembl. | 1 | |
Natural variantiVAR_033006 | 791 | T → R. Corresponds to variant dbSNP:rs1057343Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK289766 mRNA Translation: BAF82455.1 AL031115 Genomic DNA No translation available. Z99130 Genomic DNA Translation: CAB16205.1 CH471154 Genomic DNA Translation: EAW93246.1 L14788 mRNA Translation: AAC37522.1 |
CCDSi | CCDS35313.1 |
PIRi | I54340 |
RefSeqi | NP_009088.1, NM_007157.3 |
Genome annotation databases
Ensembli | ENST00000374888; ENSP00000364023; ENSG00000198455 |
GeneIDi | 158586 |
KEGGi | hsa:158586 |
MANE-Selecti | ENST00000374888.3; ENSP00000364023.1; NM_007157.4; NP_009088.1 |
UCSCi | uc004dvd.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK289766 mRNA Translation: BAF82455.1 AL031115 Genomic DNA No translation available. Z99130 Genomic DNA Translation: CAB16205.1 CH471154 Genomic DNA Translation: EAW93246.1 L14788 mRNA Translation: AAC37522.1 |
CCDSi | CCDS35313.1 |
PIRi | I54340 |
RefSeqi | NP_009088.1, NM_007157.3 |
3D structure databases
SMRi | P98169 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127694, 18 interactors |
IntActi | P98169, 3 interactors |
STRINGi | 9606.ENSP00000364023 |
PTM databases
iPTMneti | P98169 |
PhosphoSitePlusi | P98169 |
Genetic variation databases
BioMutai | ZXDB |
DMDMi | 12644370 |
Proteomic databases
EPDi | P98169 |
jPOSTi | P98169 |
MassIVEi | P98169 |
MaxQBi | P98169 |
PaxDbi | P98169 |
PeptideAtlasi | P98169 |
PRIDEi | P98169 |
ProteomicsDBi | 57802 |
Protocols and materials databases
Antibodypediai | 77180, 4 antibodies from 4 providers |
DNASUi | 158586 |
Genome annotation databases
Ensembli | ENST00000374888; ENSP00000364023; ENSG00000198455 |
GeneIDi | 158586 |
KEGGi | hsa:158586 |
MANE-Selecti | ENST00000374888.3; ENSP00000364023.1; NM_007157.4; NP_009088.1 |
UCSCi | uc004dvd.4, human |
Organism-specific databases
CTDi | 158586 |
GeneCardsi | ZXDB |
HGNCi | HGNC:13199, ZXDB |
HPAi | ENSG00000198455, Low tissue specificity |
MIMi | 300236, gene |
neXtProti | NX_P98169 |
OpenTargetsi | ENSG00000198455 |
PharmGKBi | PA37764 |
VEuPathDBi | HostDB:ENSG00000198455 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164739 |
HOGENOMi | CLU_007312_0_0_1 |
InParanoidi | P98169 |
OMAi | DWNVHPD |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P98169 |
TreeFami | TF330996 |
Enzyme and pathway databases
PathwayCommonsi | P98169 |
SignaLinki | P98169 |
Miscellaneous databases
BioGRID-ORCSi | 158586, 5 hits in 634 CRISPR screens |
ChiTaRSi | ZXDB, human |
GenomeRNAii | 158586 |
Pharosi | P98169, Tdark |
PROi | PR:P98169 |
RNActi | P98169, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198455, Expressed in cerebral cortex and 203 other tissues |
Genevisiblei | P98169, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZXDB_HUMAN | |
Accessioni | P98169Primary (citable) accession number: P98169 Secondary accession number(s): A8K151, Q9UBB3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | January 11, 2001 | |
Last modified: | February 23, 2022 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families