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Entry version 167 (16 Oct 2019)
Sequence version 2 (10 May 2004)
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Protein

Putative vitellogenin receptor

Gene

yl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in uptake of vitellogenin by endocytosis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1837Critical for endocytosisSequence analysis1
Sitei1878Critical for endocytosisSequence analysis1
Sitei1892Critical for endocytosisSequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • oogenesis Source: FlyBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative vitellogenin receptor
Alternative name(s):
Protein yolkless
Short name:
YL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yl
ORF Names:CG1372
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004649 yl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini? – 1800ExtracellularSequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1801 – 1821HelicalSequence analysisAdd BLAST21
Topological domaini1822 – 1984CytoplasmicSequence analysisAdd BLAST163

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – ?Sequence analysis
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000007781? – 1984Putative vitellogenin receptor

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi90 ↔ 102By similarity
Disulfide bondi97 ↔ 115By similarity
Disulfide bondi109 ↔ 124By similarity
Disulfide bondi129 ↔ 144By similarity
Disulfide bondi137 ↔ 157By similarity
Disulfide bondi151 ↔ 166By similarity
Disulfide bondi184 ↔ 197By similarity
Disulfide bondi191 ↔ 210By similarity
Disulfide bondi204 ↔ 220By similarity
Disulfide bondi227 ↔ 239By similarity
Disulfide bondi234 ↔ 253By similarity
Disulfide bondi247 ↔ 262By similarity
Disulfide bondi266 ↔ 281By similarity
Disulfide bondi275 ↔ 294By similarity
Disulfide bondi288 ↔ 304By similarity
Disulfide bondi310 ↔ 321By similarity
Disulfide bondi315 ↔ 331By similarity
Disulfide bondi333 ↔ 346By similarity
Disulfide bondi352 ↔ 363By similarity
Disulfide bondi359 ↔ 372By similarity
Glycosylationi365N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi374 ↔ 387By similarity
Glycosylationi384N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi429N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi664 ↔ 673By similarity
Glycosylationi666N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi669 ↔ 685By similarity
Disulfide bondi687 ↔ 700By similarity
Glycosylationi749N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi782N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi988 ↔ 999By similarity
Disulfide bondi995 ↔ 1009By similarity
Disulfide bondi1011 ↔ 1025By similarity
Glycosylationi1022N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1031 ↔ 1040By similarity
Disulfide bondi1035 ↔ 1053By similarity
Disulfide bondi1047 ↔ 1062By similarity
Disulfide bondi1074 ↔ 1087By similarity
Disulfide bondi1081 ↔ 1100By similarity
Disulfide bondi1094 ↔ 1109By similarity
Disulfide bondi1118 ↔ 1130By similarity
Disulfide bondi1125 ↔ 1143By similarity
Disulfide bondi1137 ↔ 1152By similarity
Disulfide bondi1158 ↔ 1170By similarity
Disulfide bondi1165 ↔ 1183By similarity
Disulfide bondi1177 ↔ 1193By similarity
Disulfide bondi1198 ↔ 1210By similarity
Disulfide bondi1205 ↔ 1223By similarity
Disulfide bondi1217 ↔ 1232By similarity
Glycosylationi1240N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1243 ↔ 1257By similarity
Disulfide bondi1250 ↔ 1270By similarity
Disulfide bondi1264 ↔ 1279By similarity
Glycosylationi1265N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1283 ↔ 1296By similarity
Disulfide bondi1290 ↔ 1309By similarity
Disulfide bondi1303 ↔ 1318By similarity
Glycosylationi1326N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1340 ↔ 1352By similarity
Disulfide bondi1347 ↔ 1365By similarity
Disulfide bondi1359 ↔ 1375By similarity
Disulfide bondi1379 ↔ 1392By similarity
Disulfide bondi1388 ↔ 1401By similarity
Disulfide bondi1403 ↔ 1416By similarity
Disulfide bondi1422 ↔ 1432By similarity
Disulfide bondi1428 ↔ 1441By similarity
Disulfide bondi1443 ↔ 1456By similarity
Glycosylationi1475N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1490N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1738 ↔ 1747By similarity
Disulfide bondi1743 ↔ 1756By similarity
Disulfide bondi1758 ↔ 1769By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1926Phosphoserine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P98163

PRoteomics IDEntifications database

More...
PRIDEi
P98163

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P98163

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ovary.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004649 Expressed in 7 organ(s), highest expression level in embryo

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P98163 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
58737, 8 interactors

Protein interaction database and analysis system

More...
IntActi
P98163, 4 interactors

Molecular INTeraction database

More...
MINTi
P98163

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0073715

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini89 – 125LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST37
Domaini128 – 167LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST40
Domaini183 – 221LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST39
Domaini226 – 263LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST38
Domaini265 – 305LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST41
Domaini306 – 347EGF-like 1PROSITE-ProRule annotationAdd BLAST42
Domaini348 – 388EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati441 – 485LDL-receptor class B 1Add BLAST45
Repeati486 – 528LDL-receptor class B 2Add BLAST43
Repeati529 – 572LDL-receptor class B 3Add BLAST44
Repeati573 – 614LDL-receptor class B 4Add BLAST42
Repeati615 – 649LDL-receptor class B 5Add BLAST35
Domaini660 – 701EGF-like 3PROSITE-ProRule annotationAdd BLAST42
Repeati750 – 792LDL-receptor class B 6Add BLAST43
Repeati793 – 836LDL-receptor class B 7Add BLAST44
Repeati884 – 925LDL-receptor class B 8Add BLAST42
Repeati934 – 976LDL-receptor class B 9Add BLAST43
Domaini984 – 1026EGF-like 4PROSITE-ProRule annotationAdd BLAST43
Domaini1024 – 1063LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST40
Domaini1073 – 1110LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST38
Domaini1117 – 1153LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST37
Domaini1157 – 1194LDL-receptor class A 9PROSITE-ProRule annotationAdd BLAST38
Domaini1197 – 1233LDL-receptor class A 10PROSITE-ProRule annotationAdd BLAST37
Domaini1242 – 1280LDL-receptor class A 11PROSITE-ProRule annotationAdd BLAST39
Domaini1282 – 1319LDL-receptor class A 12PROSITE-ProRule annotationAdd BLAST38
Domaini1339 – 1376LDL-receptor class A 13PROSITE-ProRule annotationAdd BLAST38
Domaini1375 – 1417EGF-like 5PROSITE-ProRule annotationAdd BLAST43
Domaini1418 – 1457EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Repeati1588 – 1637LDL-receptor class B 10Add BLAST50
Repeati1638 – 1687LDL-receptor class B 11Add BLAST50
Domaini1734 – 1770EGF-like 7PROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPSU Eukaryota
ENOG410YUAB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000165170

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P98163

Identification of Orthologs from Complete Genome Data

More...
OMAi
DEHDKCG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P98163

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112 LDLa, 13 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 3 hits
4.10.400.10, 13 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 1 hit
PF00057 Ldl_recept_a, 12 hits
PF00058 Ldl_recept_b, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 7 hits
SM00179 EGF_CA, 4 hits
SM00192 LDLa, 13 hits
SM00135 LY, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57424 SSF57424, 13 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 2 hits
PS01209 LDLRA_1, 12 hits
PS50068 LDLRA_2, 13 hits
PS51120 LDLRB, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform B (identifier: P98163-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCQAEHQVHP SEQRIRVESP KMTASRRGFN LTSQTRAHPS SGGSTSSRYG
60 70 80 90 100
NCQRTHLIIN GRHVAISLLL LVGLCGGTAA GTPGSADTRC DAGQFQCRDG
110 120 130 140 150
GCILQAKMCD GRGDCKDSSD ELDCDYRLCR PPHWFPCAQP HGACLAAELM
160 170 180 190 200
CNGIDNCPGG EDELNCPVRP GFRFGDTAHR MRSCSKYEFM CQQDRTCIPI
210 220 230 240 250
DFMCDGRPDC TDKSDEVAGC KQAEITCPGE GHLCANGRCL RRKQWVCDGV
260 270 280 290 300
DDCGDGSDER GCLNLCEPQK GKFLCRNRET CLTLSEVCDG HSDCSDGSDE
310 320 330 340 350
TDLCHSKPDC DAKKCALGAK CHMMPASGAE CFCPKGFRLA KFEDKCEDVD
360 370 380 390 400
ECKEQDDLCS QGCENTSGGY RCVCDAGYLL DKDNRTCRAV VYGSKEQQPL
410 420 430 440 450
LLYTTQMTIM GMHLREDNVR NHVYQVAGNL SKVIGVAYDG SHIYWTNIQN
460 470 480 490 500
EAESIVKANG DGSNAEILLT SGLDAPEDLA VDWLTQNIYF SDNIMRHIAV
510 520 530 540 550
CSNDGLNCAV LVTQDVHQPR SLAVWPQKGL MFWTDWGEKP MIGRASMDGS
560 570 580 590 600
RSRPIVSDNI EWPNGIALDM HQQRIYWVDA KLGSVQTVRP DGTGRRTVLD
610 620 630 640 650
GMLKHPYGLA IFEDQLYWSD WATKSVHACH KFSGKDHRIL AKDRTIYAVH
660 670 680 690 700
IYHPAKQPNS PHGCENATCS HLCLLAEPEI GGHSCACPDG MRLAPDHRRC
710 720 730 740 750
MLMEKRQRLF IGLGQVLLEI EHTAFGRHQV SKSYTLPCLI NEMVYNRING
760 770 780 790 800
SLIIADNDQR LILEFQPESH ESNVLVRSNL GNVSALAFDH LSRNLYWADT
810 820 830 840 850
ERAVIEVLSL QTRHRALIRF FPGQEVPIGL TVMPAEGYLY VVLKAKRHSH
860 870 880 890 900
IDKIPLSGKG EQVHVFEDDL GDDDIKLVTD YETQTIFWSD SDLGRISYSN
910 920 930 940 950
YRVPHSQIFR GKLRRPYSLA MVHHDLFWNE LGTPRIYWTH KSNMGPRKVI
960 970 980 990 1000
DIMEKDDPAA IMPYVPVATP NGIPLAASSP VGQESHPCQQ QNGGCSHICV
1010 1020 1030 1040 1050
GEGPYHSICL CPAGFVYRDA GNRTCVEALD CEFRCHSGEC LTMNHRCNGR
1060 1070 1080 1090 1100
RDCVDNSDEM NCDEEHRRKP KVLCSPNQFA CHSGEQCVDK ERRCDNRKDC
1110 1120 1130 1140 1150
HDHSDEQHCE KFDKSKKCHV HQHGCDNGKC VDSSLVCDGT NDCGDNSDEL
1160 1170 1180 1190 1200
LCEATSRCEP GMFQCGSGSC IAGSWECDGR IDCSDGSDEH DKCVHRSCPP
1210 1220 1230 1240 1250
DMQRCLLGQC LDRSLVCDGH NDCGDKSDEL NCGTDSSTMN ISCAEDQYQC
1260 1270 1280 1290 1300
TSNLKICLPS TVRCNGTTEC PRGEDEADCG DVCSIYEFKC RSGRECIRRE
1310 1320 1330 1340 1350
FRCDGQKDCG DGSDELSCEL EKGHHNQSQI QPWSTSSRSC RPHLFDCQDG
1360 1370 1380 1390 1400
ECVDLSRVCN NFPDCTNGHD EGPKCATACR SASGRQVCQH KCRATPAGAV
1410 1420 1430 1440 1450
CSCFDGYRLD ADQKSCLDID ECQEQQPCAQ LCENTLGGYQ CQCHADFMLR
1460 1470 1480 1490 1500
QDRVSCKSLQ SGATLLFSSF NEVRNLSEQP VMLNVAWSAN DSRITGFDLA
1510 1520 1530 1540 1550
MHRQMGYFSA EDEGIVYQID LQTKVIVRAL GLPAPTKLSV DWVTGNVYVL
1560 1570 1580 1590 1600
SGAQEIQACS FVGRMCGRIV HVKSPRHVKH LAVDGYHARI FYIVIRTEGY
1610 1620 1630 1640 1650
GQTSSEIHMA RLDGSRRDML LQRSESFMTA LTTDPHQQLL YFVDQHMRTL
1660 1670 1680 1690 1700
ERISYRLKTG PMRRPEIMLQ KSNALMHPSG LSVYENNAFI VNLGSVEAVQ
1710 1720 1730 1740 1750
CALYGSRICH KISINVLNAQ DIVVAGRSRQ PQKASHPCAH AHCHGLCLQA
1760 1770 1780 1790 1800
DYGYECMCGN RLVAEGERCP HGSGNEVAVL GAVNSLELEH EHEQNGHFHW
1810 1820 1830 1840 1850
LMALFVLAAG SLIAGLGYMY YQYRQRGHTD LNINMHFQNP LATLGGTKAF
1860 1870 1880 1890 1900
LEHERAEAGV GFTTETGTVS SRGSNDTFTT TSATSSFAAQ QFSVPNALQR
1910 1920 1930 1940 1950
LLRPRQSASG DPMAQELLLE SPSRESKLHA LDGGGAGGDG DGGRGVGRQV
1960 1970 1980
PDILVADMDD DAAKSAGQFG GNYAGNDANA RFVS
Note: No experimental confirmation available.
Length:1,984
Mass (Da):219,521
Last modified:May 10, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B6F9CF4EFC4914C
GO
Isoform A (identifier: P98163-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1925-1984: ESKLHALDGGGAGGDGDGGRGVGRQVPDILVADMDDDAAKSAGQFGGNYAGNDANARFVS → VSSDGGQMAVEDM

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Length:1,937
Mass (Da):214,968
Checksum:iBB5A09AF1096FEBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti457K → E in AAO39481 (Ref. 4) Curated1
Sequence conflicti470T → S in AAO39481 (Ref. 4) Curated1
Sequence conflicti727R → A in AAB60217 (PubMed:7878005).Curated1
Sequence conflicti1068R → H in AAB60217 (PubMed:7878005).Curated1
Sequence conflicti1077N → S in AAB60217 (PubMed:7878005).Curated1
Sequence conflicti1156S → L in AAB60217 (PubMed:7878005).Curated1
Sequence conflicti1203Q → H in AAB60217 (PubMed:7878005).Curated1
Sequence conflicti1207L → S in AAB60217 (PubMed:7878005).Curated1
Sequence conflicti1261T → A in AAB60217 (PubMed:7878005).Curated1
Sequence conflicti1519I → V in AAB60217 (PubMed:7878005).Curated1
Sequence conflicti1696V → M in AAB60217 (PubMed:7878005).Curated1
Sequence conflicti1884T → S in AAB60217 (PubMed:7878005).Curated1
Sequence conflicti1944R → C in AAB60217 (PubMed:7878005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0103001925 – 1984ESKLH…ARFVS → VSSDGGQMAVEDM in isoform A. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U13637 mRNA Translation: AAB60217.1
AE014298 Genomic DNA Translation: AAF48349.2
AE014298 Genomic DNA Translation: AAS65339.1
BT003478 mRNA Translation: AAO39481.1

Protein sequence database of the Protein Information Resource

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PIRi
T13171

NCBI Reference Sequences

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RefSeqi
NP_511151.2, NM_078596.3 [P98163-2]
NP_996433.1, NM_206710.2 [P98163-1]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0073897; FBpp0073714; FBgn0004649 [P98163-2]
FBtr0073898; FBpp0073715; FBgn0004649 [P98163-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
32367

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG1372

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13637 mRNA Translation: AAB60217.1
AE014298 Genomic DNA Translation: AAF48349.2
AE014298 Genomic DNA Translation: AAS65339.1
BT003478 mRNA Translation: AAO39481.1
PIRiT13171
RefSeqiNP_511151.2, NM_078596.3 [P98163-2]
NP_996433.1, NM_206710.2 [P98163-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi58737, 8 interactors
IntActiP98163, 4 interactors
MINTiP98163
STRINGi7227.FBpp0073715

PTM databases

iPTMnetiP98163

Proteomic databases

PaxDbiP98163
PRIDEiP98163

Genome annotation databases

EnsemblMetazoaiFBtr0073897; FBpp0073714; FBgn0004649 [P98163-2]
FBtr0073898; FBpp0073715; FBgn0004649 [P98163-1]
GeneIDi32367
KEGGidme:Dmel_CG1372

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32367
FlyBaseiFBgn0004649 yl

Phylogenomic databases

eggNOGiENOG410IPSU Eukaryota
ENOG410YUAB LUCA
GeneTreeiENSGT00940000165170
InParanoidiP98163
OMAiDEHDKCG
PhylomeDBiP98163

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
32367

Protein Ontology

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PROi
PR:P98163

Gene expression databases

BgeeiFBgn0004649 Expressed in 7 organ(s), highest expression level in embryo
GenevisibleiP98163 DM

Family and domain databases

CDDicd00112 LDLa, 13 hits
Gene3Di2.120.10.30, 3 hits
4.10.400.10, 13 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 1 hit
PF00057 Ldl_recept_a, 12 hits
PF00058 Ldl_recept_b, 3 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00181 EGF, 7 hits
SM00179 EGF_CA, 4 hits
SM00192 LDLa, 13 hits
SM00135 LY, 10 hits
SUPFAMiSSF57424 SSF57424, 13 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 2 hits
PS01209 LDLRA_1, 12 hits
PS50068 LDLRA_2, 13 hits
PS51120 LDLRB, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYL_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P98163
Secondary accession number(s): Q86P52, Q9VY56
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 10, 2004
Last modified: October 16, 2019
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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