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Protein

Basement membrane-specific heparan sulfate proteoglycan core protein

Gene

HSPG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.
Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.
The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.

Miscellaneous

The LG3 peptide has been found in the urine of patients with end-stage renal disease and in the amniotic fluid of pregnant women with premature rupture of fetal membranes.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi4258Calcium1
Metal bindingi4275Calcium; via carbonyl oxygen1
Metal bindingi4325Calcium; via carbonyl oxygen1
Metal bindingi4327Calcium1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAngiogenesis
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928 HS-GAG biosynthesis
R-HSA-2024096 HS-GAG degradation
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3656237 Defective EXT2 causes exostoses 2
R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-975634 Retinoid metabolism and transport
R-HSA-977225 Amyloid fiber formation

SIGNOR Signaling Network Open Resource

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SIGNORi
P98160

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Basement membrane-specific heparan sulfate proteoglycan core protein
Short name:
HSPG
Alternative name(s):
Perlecan
Short name:
PLC
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HSPG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000142798.17

Human Gene Nomenclature Database

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HGNCi
HGNC:5273 HSPG2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
142461 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P98160

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Schwartz-Jampel syndrome (SJS1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare autosomal recessive disorder characterized by permanent myotonia (prolonged failure of muscle relaxation) and skeletal dysplasia, resulting in reduced stature, kyphoscoliosis, bowing of the diaphyses and irregular epiphyses.
See also OMIM:255800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0141221532C → Y in SJS1. 1 PublicationCorresponds to variant dbSNP:rs137853248EnsemblClinVar.1
Dyssegmental dysplasia Silverman-Handmaker type (DDSH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionThe dyssegmental dysplasias are rare, autosomal recessive skeletal dysplasias with anisospondyly and micromelia. There are two recognized types: the severe, lethal DDSH and the milder Rolland-Desbuquois form. Individuals with DDSH also have a flat face, micrognathia, cleft palate and reduced joint mobility, and frequently have an encephalocoele. The endochondral growth plate is short, the calcospherites (which are spherical calcium-phosphorus crystals produced by hypertrophic chondrocytes) are unfused, and there is mucoid degeneration of the resting cartilage.
See also OMIM:224410

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi4197D → I: Abolishes BMP1-mediated cleavage of endorepellin. 1 Publication1
Mutagenesisi4258D → A: Retains proper folding. Reduced calcium ion binding. 1 Publication1
Mutagenesisi4327N → A: Retains proper folding. Reduced calcium ion binding. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3339

MalaCards human disease database

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MalaCardsi
HSPG2
MIMi224410 phenotype
255800 phenotype

Open Targets

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OpenTargetsi
ENSG00000142798

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1865 Dyssegmental dysplasia, Silverman-Handmaker type
800 Schwartz-Jampel syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29537

Chemistry databases

Drug and drug target database

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DrugBanki
DB00039 Palifermin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
HSPG2

Domain mapping of disease mutations (DMDM)

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DMDMi
317373536

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002669622 – 4391Basement membrane-specific heparan sulfate proteoglycan core proteinAdd BLAST4370
ChainiPRO_00003916213687 – 4391EndorepellinAdd BLAST705
ChainiPRO_00003916224197 – 4391LG3 peptideAdd BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi42O-linked (GalNAc...) threonine1 Publication1
Glycosylationi65O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi71O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi76O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi199 ↔ 212By similarity
Disulfide bondi206 ↔ 225By similarity
Disulfide bondi219 ↔ 234By similarity
Disulfide bondi285 ↔ 297By similarity
Disulfide bondi292 ↔ 310By similarity
Disulfide bondi304 ↔ 319By similarity
Disulfide bondi325 ↔ 337By similarity
Disulfide bondi332 ↔ 350By similarity
Disulfide bondi344 ↔ 359By similarity
Disulfide bondi368 ↔ 381By similarity
Disulfide bondi375 ↔ 394By similarity
Disulfide bondi388 ↔ 403By similarity
Glycosylationi554N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi764 ↔ 773By similarity
Disulfide bondi766 ↔ 780By similarity
Disulfide bondi783 ↔ 792By similarity
Disulfide bondi795 ↔ 811By similarity
Disulfide bondi814 ↔ 829By similarity
Disulfide bondi816 ↔ 839By similarity
Disulfide bondi842 ↔ 851By similarity
Disulfide bondi854 ↔ 869By similarity
Disulfide bondi879 ↔ 892By similarity
Disulfide bondi894 ↔ 903By similarity
Disulfide bondi906 ↔ 921By similarity
Disulfide bondi1159 ↔ 1168By similarity
Disulfide bondi1161 ↔ 1175By similarity
Disulfide bondi1178 ↔ 1187By similarity
Disulfide bondi1190 ↔ 1206By similarity
Disulfide bondi1209 ↔ 1224By similarity
Disulfide bondi1211 ↔ 1234By similarity
Disulfide bondi1237 ↔ 1246By similarity
Disulfide bondi1249 ↔ 1263By similarity
Disulfide bondi1275 ↔ 1287By similarity
Disulfide bondi1277 ↔ 1293By similarity
Disulfide bondi1295 ↔ 1304By similarity
Disulfide bondi1307 ↔ 1322By similarity
Disulfide bondi1563 ↔ 1572By similarity
Disulfide bondi1565 ↔ 1579By similarity
Disulfide bondi1582 ↔ 1591By similarity
Disulfide bondi1594 ↔ 1610By similarity
Disulfide bondi1613 ↔ 1628By similarity
Disulfide bondi1615 ↔ 1638By similarity
Disulfide bondi1641 ↔ 1650By similarity
Disulfide bondi1653 ↔ 1668By similarity
Glycosylationi1755N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi2121N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2995O-linked (Xyl...) (chondroitin sulfate) serineSequence analysis1
Glycosylationi3072N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi3105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3279N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3780N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi3819 ↔ 3845By similarity
Glycosylationi3836N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi3848 ↔ 3859By similarity
Disulfide bondi3853 ↔ 3869By similarity
Disulfide bondi3871 ↔ 3880By similarity
Disulfide bondi3888 ↔ 3899By similarity
Disulfide bondi3893 ↔ 3910By similarity
Disulfide bondi3912 ↔ 3921By similarity
Glycosylationi3933O-linked (Xyl...) (chondroitin sulfate) serineSequence analysis1
Glycosylationi4068N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi4076 ↔ 4102By similarity
Disulfide bondi4108 ↔ 4119By similarity
Disulfide bondi4113 ↔ 4129By similarity
Disulfide bondi4131 ↔ 4140By similarity
Disulfide bondi4147 ↔ 4159By similarity
Disulfide bondi4153 ↔ 4164By similarity
Disulfide bondi4166 ↔ 4175By similarity
Glycosylationi4179O-linked (Xyl...) (chondroitin sulfate) serineSequence analysis1
Disulfide bondi4355 ↔ 43891 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytic processing produces the C-terminal angiogenic peptide, endorepellin. This peptide can be further processed to produce the LG3 peptide.2 Publications
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. Perlecan contains three heparan sulfate chains. The LG3 peptide contains at least three and up to five potential O-glycosylation sites but no N-glycosylation.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei4196 – 4197Cleavage; by BMP12

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P98160

MaxQB - The MaxQuant DataBase

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MaxQBi
P98160

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P98160

PeptideAtlas

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PeptideAtlasi
P98160

PRoteomics IDEntifications database

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PRIDEi
P98160

ProteomicsDB human proteome resource

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ProteomicsDBi
57796

2D gel databases

DOSAC-COBS 2D-PAGE database

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DOSAC-COBS-2DPAGEi
P98160

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P98160

GlyConnect protein glycosylation platform

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GlyConnecti
653

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P98160

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P98160

UniCarbKB; an annotated and curated database of glycan structures

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UniCarbKBi
P98160

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in the basement membranes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000142798 Expressed in 217 organ(s), highest expression level in fundus of stomach

CleanEx database of gene expression profiles

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CleanExi
HS_HSPG2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P98160 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P98160 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB009820
CAB020718
HPA018892

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Purified perlecan has a strong tendency to aggregate in dimers or stellate structures. It interacts with other basement membrane components such as laminin, prolargin and collagen type IV. Interacts with COL13A1, FGFBP1 and VWA1. Interacts (via C-terminus) with ECM1 (via C-terminus).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109571, 37 interactors

Protein interaction database and analysis system

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IntActi
P98160, 30 interactors

Molecular INTeraction database

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MINTi
P98160

STRING: functional protein association networks

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STRINGi
9606.ENSP00000363827

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

14391
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P98160

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P98160

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini80 – 191SEAPROSITE-ProRule annotationAdd BLAST112
Domaini198 – 235LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST38
Domaini284 – 320LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST37
Domaini324 – 360LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST37
Domaini367 – 404LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST38
Domaini405 – 504Ig-like C2-type 1Add BLAST100
Domaini521 – 530Laminin EGF-like 1; first partPROSITE-ProRule annotation10
Domaini538 – 730Laminin IV type A 1PROSITE-ProRule annotationAdd BLAST193
Domaini731 – 763Laminin EGF-like 1; second partPROSITE-ProRule annotationAdd BLAST33
Domaini764 – 813Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST50
Domaini814 – 871Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST58
Domaini879 – 923Laminin EGF-like 4; truncatedPROSITE-ProRule annotationAdd BLAST45
Domaini924 – 933Laminin EGF-like 5; first partPROSITE-ProRule annotation10
Domaini941 – 1125Laminin IV type A 2PROSITE-ProRule annotationAdd BLAST185
Domaini1126 – 1158Laminin EGF-like 5; second partPROSITE-ProRule annotationAdd BLAST33
Domaini1159 – 1208Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST50
Domaini1209 – 1265Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST57
Domaini1275 – 1324Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST50
Domaini1325 – 1334Laminin EGF-like 9; first partPROSITE-ProRule annotation10
Domaini1344 – 1529Laminin IV type A 3PROSITE-ProRule annotationAdd BLAST186
Domaini1530 – 1562Laminin EGF-like 9; second partPROSITE-ProRule annotationAdd BLAST33
Domaini1563 – 1612Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST50
Domaini1613 – 1670Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST58
Domaini1677 – 1771Ig-like C2-type 2Add BLAST95
Domaini1772 – 1865Ig-like C2-type 3Add BLAST94
Domaini1866 – 1955Ig-like C2-type 4Add BLAST90
Domaini1956 – 2051Ig-like C2-type 5Add BLAST96
Domaini2052 – 2151Ig-like C2-type 6Add BLAST100
Domaini2152 – 2244Ig-like C2-type 7Add BLAST93
Domaini2245 – 2340Ig-like C2-type 8Add BLAST96
Domaini2341 – 2436Ig-like C2-type 9Add BLAST96
Domaini2437 – 2533Ig-like C2-type 10Add BLAST97
Domaini2534 – 2629Ig-like C2-type 11Add BLAST96
Domaini2630 – 2726Ig-like C2-type 12Add BLAST97
Domaini2727 – 2826Ig-like C2-type 13Add BLAST100
Domaini2827 – 2924Ig-like C2-type 14Add BLAST98
Domaini2925 – 3021Ig-like C2-type 15Add BLAST97
Domaini3022 – 3112Ig-like C2-type 16Add BLAST91
Domaini3113 – 3211Ig-like C2-type 17Add BLAST99
Domaini3212 – 3298Ig-like C2-type 18Add BLAST87
Domaini3299 – 3399Ig-like C2-type 19Add BLAST101
Domaini3400 – 3488Ig-like C2-type 20Add BLAST89
Domaini3489 – 3574Ig-like C2-type 21Add BLAST86
Domaini3575 – 3662Ig-like C2-type 22Add BLAST88
Domaini3663 – 3843Laminin G-like 1PROSITE-ProRule annotationAdd BLAST181
Domaini3844 – 3881EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini3884 – 3922EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Domaini3928 – 4103Laminin G-like 2PROSITE-ProRule annotationAdd BLAST176
Domaini4104 – 4141EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini4143 – 4176EGF-like 4PROSITE-ProRule annotationAdd BLAST34
Domaini4201 – 4389Laminin G-like 3PROSITE-ProRule annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4149 – 4151Mediates motor neuron attachmentSequence analysis3
Regioni4299 – 4301Mediates motor neuron attachmentSequence analysis3

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3509 Eukaryota
ENOG410XTD2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156670

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049276

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG008174

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P98160

KEGG Orthology (KO)

More...
KOi
K06255

Identification of Orthologs from Complete Genome Data

More...
OMAi
QAQYLCR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G048M

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P98160

TreeFam database of animal gene trees

More...
TreeFami
TF326548

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112 LDLa, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 22 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR000082 SEA_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 2 hits
PF07679 I-set, 9 hits
PF13895 Ig_2, 1 hit
PF00052 Laminin_B, 3 hits
PF00053 Laminin_EGF, 9 hits
PF00054 Laminin_G_1, 3 hits
PF00057 Ldl_recept_a, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 11 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 9 hits
SM00409 IG, 22 hits
SM00408 IGc2, 22 hits
SM00406 IGv, 8 hits
SM00281 LamB, 3 hits
SM00282 LamG, 3 hits
SM00192 LDLa, 4 hits
SM00200 SEA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 22 hits
SSF49899 SSF49899, 3 hits
SSF57424 SSF57424, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 6 hits
PS50026 EGF_3, 4 hits
PS01248 EGF_LAM_1, 11 hits
PS50027 EGF_LAM_2, 8 hits
PS50835 IG_LIKE, 22 hits
PS50025 LAM_G_DOMAIN, 3 hits
PS51115 LAMININ_IVA, 3 hits
PS01209 LDLRA_1, 4 hits
PS50068 LDLRA_2, 4 hits
PS50024 SEA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P98160-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGWRAAGALL LALLLHGRLL AVTHGLRAYD GLSLPEDIET VTASQMRWTH
60 70 80 90 100
SYLSDDEDML ADSISGDDLG SGDLGSGDFQ MVYFRALVNF TRSIEYSPQL
110 120 130 140 150
EDAGSREFRE VSEAVVDTLE SEYLKIPGDQ VVSVVFIKEL DGWVFVELDV
160 170 180 190 200
GSEGNADGAQ IQEMLLRVIS SGSVASYVTS PQGFQFRRLG TVPQFPRACT
210 220 230 240 250
EAEFACHSYN ECVALEYRCD RRPDCRDMSD ELNCEEPVLG ISPTFSLLVE
260 270 280 290 300
TTSLPPRPET TIMRQPPVTH APQPLLPGSV RPLPCGPQEA ACRNGHCIPR
310 320 330 340 350
DYLCDGQEDC EDGSDELDCG PPPPCEPNEF PCGNGHCALK LWRCDGDFDC
360 370 380 390 400
EDRTDEANCP TKRPEEVCGP TQFRCVSTNM CIPASFHCDE ESDCPDRSDE
410 420 430 440 450
FGCMPPQVVT PPRESIQASR GQTVTFTCVA IGVPTPIINW RLNWGHIPSH
460 470 480 490 500
PRVTVTSEGG RGTLIIRDVK ESDQGAYTCE AMNARGMVFG IPDGVLELVP
510 520 530 540 550
QRGPCPDGHF YLEHSAACLP CFCFGITSVC QSTRRFRDQI RLRFDQPDDF
560 570 580 590 600
KGVNVTMPAQ PGTPPLSSTQ LQIDPSLHEF QLVDLSRRFL VHDSFWALPE
610 620 630 640 650
QFLGNKVDSY GGSLRYNVRY ELARGMLEPV QRPDVVLMGA GYRLLSRGHT
660 670 680 690 700
PTQPGALNQR QVQFSEEHWV HESGRPVQRA ELLQVLQSLE AVLIQTVYNT
710 720 730 740 750
KMASVGLSDI AMDTTVTHAT SHGRAHSVEE CRCPIGYSGL SCESCDAHFT
760 770 780 790 800
RVPGGPYLGT CSGCNCNGHA SSCDPVYGHC LNCQHNTEGP QCNKCKAGFF
810 820 830 840 850
GDAMKATATS CRPCPCPYID ASRRFSDTCF LDTDGQATCD ACAPGYTGRR
860 870 880 890 900
CESCAPGYEG NPIQPGGKCR PVNQEIVRCD ERGSMGTSGE ACRCKNNVVG
910 920 930 940 950
RLCNECADGS FHLSTRNPDG CLKCFCMGVS RHCTSSSWSR AQLHGASEEP
960 970 980 990 1000
GHFSLTNAAS THTTNEGIFS PTPGELGFSS FHRLLSGPYF WSLPSRFLGD
1010 1020 1030 1040 1050
KVTSYGGELR FTVTQRSQPG STPLHGQPLV VLQGNNIILE HHVAQEPSPG
1060 1070 1080 1090 1100
QPSTFIVPFR EQAWQRPDGQ PATREHLLMA LAGIDTLLIR ASYAQQPAES
1110 1120 1130 1140 1150
RVSGISMDVA VPEETGQDPA LEVEQCSCPP GYRGPSCQDC DTGYTRTPSG
1160 1170 1180 1190 1200
LYLGTCERCS CHGHSEACEP ETGACQGCQH HTEGPRCEQC QPGYYGDAQR
1210 1220 1230 1240 1250
GTPQDCQLCP CYGDPAAGQA AHTCFLDTDG HPTCDACSPG HSGRHCERCA
1260 1270 1280 1290 1300
PGYYGNPSQG QPCQRDSQVP GPIGCNCDPQ GSVSSQCDAA GQCQCKAQVE
1310 1320 1330 1340 1350
GLTCSHCRPH HFHLSASNPD GCLPCFCMGI TQQCASSAYT RHLISTHFAP
1360 1370 1380 1390 1400
GDFQGFALVN PQRNSRLTGE FTVEPVPEGA QLSFGNFAQL GHESFYWQLP
1410 1420 1430 1440 1450
ETYQGDKVAA YGGKLRYTLS YTAGPQGSPL SDPDVQITGN NIMLVASQPA
1460 1470 1480 1490 1500
LQGPERRSYE IMFREEFWRR PDGQPATREH LLMALADLDE LLIRATFSSV
1510 1520 1530 1540 1550
PLAASISAVS LEVAQPGPSN RPRALEVEEC RCPPGYIGLS CQDCAPGYTR
1560 1570 1580 1590 1600
TGSGLYLGHC ELCECNGHSD LCHPETGACS QCQHNAAGEF CELCAPGYYG
1610 1620 1630 1640 1650
DATAGTPEDC QPCACPLTNP ENMFSRTCES LGAGGYRCTA CEPGYTGQYC
1660 1670 1680 1690 1700
EQCGPGYVGN PSVQGGQCLP ETNQAPLVVE VHPARSIVPQ GGSHSLRCQV
1710 1720 1730 1740 1750
SGSPPHYFYW SREDGRPVPS GTQQRHQGSE LHFPSVQPSD AGVYICTCRN
1760 1770 1780 1790 1800
LHQSNTSRAE LLVTEAPSKP ITVTVEEQRS QSVRPGADVT FICTAKSKSP
1810 1820 1830 1840 1850
AYTLVWTRLH NGKLPTRAMD FNGILTIRNV QLSDAGTYVC TGSNMFAMDQ
1860 1870 1880 1890 1900
GTATLHVQAS GTLSAPVVSI HPPQLTVQPG QLAEFRCSAT GSPTPTLEWT
1910 1920 1930 1940 1950
GGPGGQLPAK AQIHGGILRL PAVEPTDQAQ YLCRAHSSAG QQVARAVLHV
1960 1970 1980 1990 2000
HGGGGPRVQV SPERTQVHAG RTVRLYCRAA GVPSATITWR KEGGSLPPQA
2010 2020 2030 2040 2050
RSERTDIATL LIPAITTADA GFYLCVATSP AGTAQARIQV VVLSASDASP
2060 2070 2080 2090 2100
PPVKIESSSP SVTEGQTLDL NCVVAGSAHA QVTWYRRGGS LPPHTQVHGS
2110 2120 2130 2140 2150
RLRLPQVSPA DSGEYVCRVE NGSGPKEASI TVSVLHGTHS GPSYTPVPGS
2160 2170 2180 2190 2200
TRPIRIEPSS SHVAEGQTLD LNCVVPGQAH AQVTWHKRGG SLPARHQTHG
2210 2220 2230 2240 2250
SLLRLHQVTP ADSGEYVCHV VGTSGPLEAS VLVTIEASVI PGPIPPVRIE
2260 2270 2280 2290 2300
SSSSTVAEGQ TLDLSCVVAG QAHAQVTWYK RGGSLPARHQ VRGSRLYIFQ
2310 2320 2330 2340 2350
ASPADAGQYV CRASNGMEAS ITVTVTGTQG ANLAYPAGST QPIRIEPSSS
2360 2370 2380 2390 2400
QVAEGQTLDL NCVVPGQSHA QVTWHKRGGS LPVRHQTHGS LLRLYQASPA
2410 2420 2430 2440 2450
DSGEYVCRVL GSSVPLEASV LVTIEPAGSV PALGVTPTVR IESSSSQVAE
2460 2470 2480 2490 2500
GQTLDLNCLV AGQAHAQVTW HKRGGSLPAR HQVHGSRLRL LQVTPADSGE
2510 2520 2530 2540 2550
YVCRVVGSSG TQEASVLVTI QQRLSGSHSQ GVAYPVRIES SSASLANGHT
2560 2570 2580 2590 2600
LDLNCLVASQ APHTITWYKR GGSLPSRHQI VGSRLRIPQV TPADSGEYVC
2610 2620 2630 2640 2650
HVSNGAGSRE TSLIVTIQGS GSSHVPSVSP PIRIESSSPT VVEGQTLDLN
2660 2670 2680 2690 2700
CVVARQPQAI ITWYKRGGSL PSRHQTHGSH LRLHQMSVAD SGEYVCRANN
2710 2720 2730 2740 2750
NIDALEASIV ISVSPSAGSP SAPGSSMPIR IESSSSHVAE GETLDLNCVV
2760 2770 2780 2790 2800
PGQAHAQVTW HKRGGSLPSH HQTRGSRLRL HHVSPADSGE YVCRVMGSSG
2810 2820 2830 2840 2850
PLEASVLVTI EASGSSAVHV PAPGGAPPIR IEPSSSRVAE GQTLDLKCVV
2860 2870 2880 2890 2900
PGQAHAQVTW HKRGGNLPAR HQVHGPLLRL NQVSPADSGE YSCQVTGSSG
2910 2920 2930 2940 2950
TLEASVLVTI EPSSPGPIPA PGLAQPIYIE ASSSHVTEGQ TLDLNCVVPG
2960 2970 2980 2990 3000
QAHAQVTWYK RGGSLPARHQ THGSQLRLHL VSPADSGEYV CRAASGPGPE
3010 3020 3030 3040 3050
QEASFTVTVP PSEGSSYRLR SPVISIDPPS STVQQGQDAS FKCLIHDGAA
3060 3070 3080 3090 3100
PISLEWKTRN QELEDNVHIS PNGSIITIVG TRPSNHGTYR CVASNAYGVA
3110 3120 3130 3140 3150
QSVVNLSVHG PPTVSVLPEG PVWVKVGKAV TLECVSAGEP RSSARWTRIS
3160 3170 3180 3190 3200
STPAKLEQRT YGLMDSHAVL QISSAKPSDA GTYVCLAQNA LGTAQKQVEV
3210 3220 3230 3240 3250
IVDTGAMAPG APQVQAEEAE LTVEAGHTAT LRCSATGSPA PTIHWSKLRS
3260 3270 3280 3290 3300
PLPWQHRLEG DTLIIPRVAQ QDSGQYICNA TSPAGHAEAT IILHVESPPY
3310 3320 3330 3340 3350
ATTVPEHASV QAGETVQLQC LAHGTPPLTF QWSRVGSSLP GRATARNELL
3360 3370 3380 3390 3400
HFERAAPEDS GRYRCRVTNK VGSAEAFAQL LVQGPPGSLP ATSIPAGSTP
3410 3420 3430 3440 3450
TVQVTPQLET KSIGASVEFH CAVPSDRGTQ LRWFKEGGQL PPGHSVQDGV
3460 3470 3480 3490 3500
LRIQNLDQSC QGTYICQAHG PWGKAQASAQ LVIQALPSVL INIRTSVQTV
3510 3520 3530 3540 3550
VVGHAVEFEC LALGDPKPQV TWSKVGGHLR PGIVQSGGVV RIAHVELADA
3560 3570 3580 3590 3600
GQYRCTATNA AGTTQSHVLL LVQALPQISM PQEVRVPAGS AAVFPCIASG
3610 3620 3630 3640 3650
YPTPDISWSK LDGSLPPDSR LENNMLMLPS VRPQDAGTYV CTATNRQGKV
3660 3670 3680 3690 3700
KAFAHLQVPE RVVPYFTQTP YSFLPLPTIK DAYRKFEIKI TFRPDSADGM
3710 3720 3730 3740 3750
LLYNGQKRVP GSPTNLANRQ PDFISFGLVG GRPEFRFDAG SGMATIRHPT
3760 3770 3780 3790 3800
PLALGHFHTV TLLRSLTQGS LIVGDLAPVN GTSQGKFQGL DLNEELYLGG
3810 3820 3830 3840 3850
YPDYGAIPKA GLSSGFIGCV RELRIQGEEI VFHDLNLTAH GISHCPTCRD
3860 3870 3880 3890 3900
RPCQNGGQCH DSESSSYVCV CPAGFTGSRC EHSQALHCHP EACGPDATCV
3910 3920 3930 3940 3950
NRPDGRGYTC RCHLGRSGLR CEEGVTVTTP SLSGAGSYLA LPALTNTHHE
3960 3970 3980 3990 4000
LRLDVEFKPL APDGVLLFSG GKSGPVEDFV SLAMVGGHLE FRYELGSGLA
4010 4020 4030 4040 4050
VLRSAEPLAL GRWHRVSAER LNKDGSLRVN GGRPVLRSSP GKSQGLNLHT
4060 4070 4080 4090 4100
LLYLGGVEPS VPLSPATNMS AHFRGCVGEV SVNGKRLDLT YSFLGSQGIG
4110 4120 4130 4140 4150
QCYDSSPCER QPCQHGATCM PAGEYEFQCL CRDGFKGDLC EHEENPCQLR
4160 4170 4180 4190 4200
EPCLHGGTCQ GTRCLCLPGF SGPRCQQGSG HGIAESDWHL EGSGGNDAPG
4210 4220 4230 4240 4250
QYGAYFHDDG FLAFPGHVFS RSLPEVPETI ELEVRTSTAS GLLLWQGVEV
4260 4270 4280 4290 4300
GEAGQGKDFI SLGLQDGHLV FRYQLGSGEA RLVSEDPIND GEWHRVTALR
4310 4320 4330 4340 4350
EGRRGSIQVD GEELVSGRSP GPNVAVNAKG SVYIGGAPDV ATLTGGRFSS
4360 4370 4380 4390
GITGCVKNLV LHSARPGAPP PQPLDLQHRA QAGANTRPCP S
Length:4,391
Mass (Da):468,830
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC587660E24C83324
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RQT3A0A0U1RQT3_HUMAN
Basement membrane-specific heparan ...
HSPG2
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5A9H0Y5A9_HUMAN
Basement membrane-specific heparan ...
HSPG2
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYA5H7BYA5_HUMAN
Basement membrane-specific heparan ...
HSPG2
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YH07A0A2R8YH07_HUMAN
Basement membrane-specific heparan ...
HSPG2
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6A → P in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti6A → P in AAA52700 (PubMed:1569102).Curated1
Sequence conflicti58D → Y in AAA52700 (PubMed:1569102).Curated1
Sequence conflicti435 – 437TPI → APFL in CAA44373 (PubMed:1730768).Curated3
Sequence conflicti450H → Q in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti502R → RA in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti793N → K in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti890 – 891EA → RT in AAB21121 (PubMed:1685141).Curated2
Sequence conflicti909G → R in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti909G → R in AAB21121 (PubMed:1685141).Curated1
Sequence conflicti1102V → L in AAB21121 (PubMed:1685141).Curated1
Sequence conflicti1133R → L in AAB21121 (PubMed:1685141).Curated1
Sequence conflicti1222H → L in AAB21121 (PubMed:1685141).Curated1
Sequence conflicti1406D → G in AAA52699 (PubMed:1679749).Curated1
Sequence conflicti1410A → G in AAA52699 (PubMed:1679749).Curated1
Sequence conflicti1466 – 1470EFWRR → LNLRQ in AAA52699 (PubMed:1679749).Curated5
Sequence conflicti1703 – 1704SP → RG in CAA44373 (PubMed:1730768).Curated2
Sequence conflicti1753Q → R in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti2038I → M in AAA52700 (PubMed:1569102).Curated1
Sequence conflicti2050P → Q in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti2052P → G in AAA52700 (PubMed:1569102).Curated1
Sequence conflicti2093P → H in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti2627S → R in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti2770H → Y in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti3241P → R in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti3427R → Q in AAA52700 (PubMed:1569102).Curated1
Sequence conflicti4004S → T in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti4135F → I in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti4332V → I in CAA44373 (PubMed:1730768).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04797968D → E. Corresponds to variant dbSNP:rs1869780EnsemblClinVar.1
Natural variantiVAR_057051303L → H. Corresponds to variant dbSNP:rs17460381Ensembl.1
Natural variantiVAR_047980638M → V3 PublicationsCorresponds to variant dbSNP:rs1874792EnsemblClinVar.1
Natural variantiVAR_047981765N → S3 PublicationsCorresponds to variant dbSNP:rs989994EnsemblClinVar.1
Natural variantiVAR_0479821186R → Q. Corresponds to variant dbSNP:rs2229481EnsemblClinVar.1
Natural variantiVAR_0570521323L → V. Corresponds to variant dbSNP:rs10917058Ensembl.1
Natural variantiVAR_0479831503A → V3 PublicationsCorresponds to variant dbSNP:rs897471EnsemblClinVar.1
Natural variantiVAR_0141221532C → Y in SJS1. 1 PublicationCorresponds to variant dbSNP:rs137853248EnsemblClinVar.1
Natural variantiVAR_0479841758R → Q. Corresponds to variant dbSNP:rs2229483Ensembl.1
Natural variantiVAR_0479851919R → C. Corresponds to variant dbSNP:rs2229474EnsemblClinVar.1
Natural variantiVAR_0479861967V → I. Corresponds to variant dbSNP:rs2229475EnsemblClinVar.1
Natural variantiVAR_0479872980L → H1 PublicationCorresponds to variant dbSNP:rs2229489EnsemblClinVar.1
Natural variantiVAR_0479882981V → I. Corresponds to variant dbSNP:rs2229490EnsemblClinVar.1
Natural variantiVAR_0479892995S → G1 PublicationCorresponds to variant dbSNP:rs2229491EnsemblClinVar.1
Natural variantiVAR_0479903168A → T1 PublicationCorresponds to variant dbSNP:rs2228349EnsemblClinVar.1
Natural variantiVAR_0479913256H → Y. Corresponds to variant dbSNP:rs2291827EnsemblClinVar.1
Natural variantiVAR_0479923530R → W. Corresponds to variant dbSNP:rs2270699Ensembl.1
Natural variantiVAR_0479933632R → Q1 PublicationCorresponds to variant dbSNP:rs2229493EnsemblClinVar.1
Natural variantiVAR_0479943640V → I. Corresponds to variant dbSNP:rs17459097EnsemblClinVar.1
Natural variantiVAR_0479954331S → N. Corresponds to variant dbSNP:rs3736360EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M85289 mRNA Translation: AAA52700.1
X62515 mRNA Translation: CAA44373.1
AL590556 Genomic DNA No translation available.
AL590103 Genomic DNA No translation available.
L22078 Genomic DNA No translation available.
AL445795 Genomic DNA Translation: CAC18534.1
S76436 mRNA Translation: AAB21121.2
M64283 mRNA Translation: AAA52699.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS30625.1

Protein sequence database of the Protein Information Resource

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PIRi
A38096

NCBI Reference Sequences

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RefSeqi
NP_001278789.1, NM_001291860.1
NP_005520.4, NM_005529.6

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.562227

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000374695; ENSP00000363827; ENSG00000142798

Database of genes from NCBI RefSeq genomes

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GeneIDi
3339

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3339

UCSC genome browser

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UCSCi
uc001bfj.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Wikipedia

Perlecan entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85289 mRNA Translation: AAA52700.1
X62515 mRNA Translation: CAA44373.1
AL590556 Genomic DNA No translation available.
AL590103 Genomic DNA No translation available.
L22078 Genomic DNA No translation available.
AL445795 Genomic DNA Translation: CAC18534.1
S76436 mRNA Translation: AAB21121.2
M64283 mRNA Translation: AAA52699.1
CCDSiCCDS30625.1
PIRiA38096
RefSeqiNP_001278789.1, NM_001291860.1
NP_005520.4, NM_005529.6
UniGeneiHs.562227

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SH4X-ray1.50A4197-4391[»]
3SH5X-ray2.80A4197-4391[»]
ProteinModelPortaliP98160
SMRiP98160
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109571, 37 interactors
IntActiP98160, 30 interactors
MINTiP98160
STRINGi9606.ENSP00000363827

Chemistry databases

DrugBankiDB00039 Palifermin

PTM databases

CarbonylDBiP98160
GlyConnecti653
iPTMnetiP98160
PhosphoSitePlusiP98160
UniCarbKBiP98160

Polymorphism and mutation databases

BioMutaiHSPG2
DMDMi317373536

2D gel databases

DOSAC-COBS-2DPAGEiP98160

Proteomic databases

EPDiP98160
MaxQBiP98160
PaxDbiP98160
PeptideAtlasiP98160
PRIDEiP98160
ProteomicsDBi57796

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374695; ENSP00000363827; ENSG00000142798
GeneIDi3339
KEGGihsa:3339
UCSCiuc001bfj.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3339
DisGeNETi3339
EuPathDBiHostDB:ENSG00000142798.17

GeneCards: human genes, protein and diseases

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GeneCardsi
HSPG2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0023554
HIX0023598
HGNCiHGNC:5273 HSPG2
HPAiCAB009820
CAB020718
HPA018892
MalaCardsiHSPG2
MIMi142461 gene
224410 phenotype
255800 phenotype
neXtProtiNX_P98160
OpenTargetsiENSG00000142798
Orphaneti1865 Dyssegmental dysplasia, Silverman-Handmaker type
800 Schwartz-Jampel syndrome
PharmGKBiPA29537

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3509 Eukaryota
ENOG410XTD2 LUCA
GeneTreeiENSGT00940000156670
HOGENOMiHOG000049276
HOVERGENiHBG008174
InParanoidiP98160
KOiK06255
OMAiQAQYLCR
OrthoDBiEOG091G048M
PhylomeDBiP98160
TreeFamiTF326548

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928 HS-GAG biosynthesis
R-HSA-2024096 HS-GAG degradation
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3656237 Defective EXT2 causes exostoses 2
R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-975634 Retinoid metabolism and transport
R-HSA-977225 Amyloid fiber formation
SIGNORiP98160

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HSPG2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Perlecan

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3339

Protein Ontology

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PROi
PR:P98160

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000142798 Expressed in 217 organ(s), highest expression level in fundus of stomach
CleanExiHS_HSPG2
ExpressionAtlasiP98160 baseline and differential
GenevisibleiP98160 HS

Family and domain databases

CDDicd00112 LDLa, 4 hits
Gene3Di2.60.40.10, 22 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR000082 SEA_dom
PfamiView protein in Pfam
PF00008 EGF, 2 hits
PF07679 I-set, 9 hits
PF13895 Ig_2, 1 hit
PF00052 Laminin_B, 3 hits
PF00053 Laminin_EGF, 9 hits
PF00054 Laminin_G_1, 3 hits
PF00057 Ldl_recept_a, 4 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00181 EGF, 11 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 9 hits
SM00409 IG, 22 hits
SM00408 IGc2, 22 hits
SM00406 IGv, 8 hits
SM00281 LamB, 3 hits
SM00282 LamG, 3 hits
SM00192 LDLa, 4 hits
SM00200 SEA, 1 hit
SUPFAMiSSF48726 SSF48726, 22 hits
SSF49899 SSF49899, 3 hits
SSF57424 SSF57424, 4 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 6 hits
PS50026 EGF_3, 4 hits
PS01248 EGF_LAM_1, 11 hits
PS50027 EGF_LAM_2, 8 hits
PS50835 IG_LIKE, 22 hits
PS50025 LAM_G_DOMAIN, 3 hits
PS51115 LAMININ_IVA, 3 hits
PS01209 LDLRA_1, 4 hits
PS50068 LDLRA_2, 4 hits
PS50024 SEA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGBM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P98160
Secondary accession number(s): Q16287, Q5SZI3, Q9H3V5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2011
Last modified: December 5, 2018
This is version 216 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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