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UniProtKB - P98160 (PGBM_HUMAN)

Entry version 236 (23 Feb 2022)
Sequence version 4 (11 Jan 2011)
Previous versions | rss
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Protein

Basement membrane-specific heparan sulfate proteoglycan core protein

Gene

HSPG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.

Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.

The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.

Miscellaneous

The LG3 peptide has been found in the urine of patients with end-stage renal disease and in the amniotic fluid of pregnant women with premature rupture of fetal membranes.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi4258Calcium1
Metal bindingi4275Calcium; via carbonyl oxygen1
Metal bindingi4325Calcium; via carbonyl oxygen1
Metal bindingi4327Calcium1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAngiogenesis
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P98160

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1474228, Degradation of the extracellular matrix
R-HSA-1971475, A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928, HS-GAG biosynthesis
R-HSA-2024096, HS-GAG degradation
R-HSA-216083, Integrin cell surface interactions
R-HSA-3000157, Laminin interactions
R-HSA-3000171, Non-integrin membrane-ECM interactions
R-HSA-3000178, ECM proteoglycans
R-HSA-3560783, Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801, Defective B3GAT3 causes JDSSDHD
R-HSA-3656237, Defective EXT2 causes exostoses 2
R-HSA-3656253, Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-4420332, Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-975634, Retinoid metabolism and transport
R-HSA-977225, Amyloid fiber formation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P98160

SIGNOR Signaling Network Open Resource

More...SIGNORi		P98160

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Basement membrane-specific heparan sulfate proteoglycan core protein
Short name:
HSPG
Alternative name(s):
Perlecan
Short name:
PLC
Cleaved into the following 2 chains:
Endorepellin
LG3 peptide
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HSPG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5273, HSPG2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		142461, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P98160

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000142798

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Schwartz-Jampel syndrome (SJS1)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionRare autosomal recessive disorder characterized by permanent myotonia (prolonged failure of muscle relaxation) and skeletal dysplasia, resulting in reduced stature, kyphoscoliosis, bowing of the diaphyses and irregular epiphyses.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0141221532C → Y in SJS1. 1 PublicationCorresponds to variant dbSNP:rs137853248EnsemblClinVar.1
Dyssegmental dysplasia Silverman-Handmaker type (DDSH)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionThe dyssegmental dysplasias are rare, autosomal recessive skeletal dysplasias with anisospondyly and micromelia. There are two recognized types: the severe, lethal DDSH and the milder Rolland-Desbuquois form. Individuals with DDSH also have a flat face, micrognathia, cleft palate and reduced joint mobility, and frequently have an encephalocoele. The endochondral growth plate is short, the calcospherites (which are spherical calcium-phosphorus crystals produced by hypertrophic chondrocytes) are unfused, and there is mucoid degeneration of the resting cartilage.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi4197D → I: Abolishes BMP1-mediated cleavage of endorepellin. 1 Publication1
Mutagenesisi4258D → A: Retains proper folding. Reduced calcium ion binding. 1 Publication1
Mutagenesisi4327N → A: Retains proper folding. Reduced calcium ion binding. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		3339

MalaCards human disease database

More...MalaCardsi		HSPG2
MIMi224410, phenotype
255800, phenotype

Open Targets

More...OpenTargetsi		ENSG00000142798

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1606, 1p36 deletion syndrome
1865, Dyssegmental dysplasia, Silverman-Handmaker type
800, Schwartz-Jampel syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29537

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P98160, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00039, Palifermin

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HSPG2

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373536

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002669622 – 4391Basement membrane-specific heparan sulfate proteoglycan core proteinAdd BLAST4370
ChainiPRO_00003916213687 – 4391EndorepellinAdd BLAST705
ChainiPRO_00003916224197 – 4391LG3 peptideAdd BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi42O-linked (GalNAc...) threonine1 Publication1
Glycosylationi65O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi71O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi76O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi199 ↔ 212By similarity
Disulfide bondi206 ↔ 225By similarity
Disulfide bondi219 ↔ 234By similarity
Disulfide bondi285 ↔ 297By similarity
Disulfide bondi292 ↔ 310By similarity
Disulfide bondi304 ↔ 319By similarity
Disulfide bondi325 ↔ 337By similarity
Disulfide bondi332 ↔ 350By similarity
Disulfide bondi344 ↔ 359By similarity
Disulfide bondi368 ↔ 381By similarity
Disulfide bondi375 ↔ 394By similarity
Disulfide bondi388 ↔ 403By similarity
Glycosylationi554N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi764 ↔ 773By similarity
Disulfide bondi766 ↔ 780By similarity
Disulfide bondi783 ↔ 792By similarity
Disulfide bondi795 ↔ 811By similarity
Disulfide bondi814 ↔ 829By similarity
Disulfide bondi816 ↔ 839By similarity
Disulfide bondi842 ↔ 851By similarity
Disulfide bondi854 ↔ 869By similarity
Disulfide bondi879 ↔ 892By similarity
Disulfide bondi894 ↔ 903By similarity
Disulfide bondi906 ↔ 921By similarity
Disulfide bondi1159 ↔ 1168By similarity
Disulfide bondi1161 ↔ 1175By similarity
Disulfide bondi1178 ↔ 1187By similarity
Disulfide bondi1190 ↔ 1206By similarity
Disulfide bondi1209 ↔ 1224By similarity
Disulfide bondi1211 ↔ 1234By similarity
Disulfide bondi1237 ↔ 1246By similarity
Disulfide bondi1249 ↔ 1263By similarity
Disulfide bondi1275 ↔ 1287By similarity
Disulfide bondi1277 ↔ 1293By similarity
Disulfide bondi1295 ↔ 1304By similarity
Disulfide bondi1307 ↔ 1322By similarity
Disulfide bondi1563 ↔ 1572By similarity
Disulfide bondi1565 ↔ 1579By similarity
Disulfide bondi1582 ↔ 1591By similarity
Disulfide bondi1594 ↔ 1610By similarity
Disulfide bondi1613 ↔ 1628By similarity
Disulfide bondi1615 ↔ 1638By similarity
Disulfide bondi1641 ↔ 1650By similarity
Disulfide bondi1653 ↔ 1668By similarity
Glycosylationi1755N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi2121N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2995O-linked (Xyl...) (chondroitin sulfate) serineSequence analysis1
Glycosylationi3072N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi3105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3279N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3780N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi3819 ↔ 3845By similarity
Glycosylationi3836N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi3848 ↔ 3859By similarity
Disulfide bondi3853 ↔ 3869By similarity
Disulfide bondi3871 ↔ 3880By similarity
Disulfide bondi3888 ↔ 3899By similarity
Disulfide bondi3893 ↔ 3910By similarity
Disulfide bondi3912 ↔ 3921By similarity
Glycosylationi3933O-linked (Xyl...) (chondroitin sulfate) serineSequence analysis1
Glycosylationi4068N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi4076 ↔ 4102By similarity
Disulfide bondi4108 ↔ 4119By similarity
Disulfide bondi4113 ↔ 4129By similarity
Disulfide bondi4131 ↔ 4140By similarity
Disulfide bondi4147 ↔ 4159By similarity
Disulfide bondi4153 ↔ 4164By similarity
Disulfide bondi4166 ↔ 4175By similarity
Glycosylationi4179O-linked (Xyl...) (chondroitin sulfate) serineSequence analysis1
Disulfide bondi4355 ↔ 43891 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytic processing produces the C-terminal angiogenic peptide, endorepellin. This peptide can be further processed to produce the LG3 peptide.2 Publications
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. Perlecan contains three heparan sulfate chains. The LG3 peptide contains at least three and up to five potential O-glycosylation sites but no N-glycosylation.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei4196 – 4197Cleavage; by BMP12

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P98160

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P98160

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P98160

MaxQB - The MaxQuant DataBase

More...MaxQBi		P98160

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P98160

PeptideAtlas

More...PeptideAtlasi		P98160

PRoteomics IDEntifications database

More...PRIDEi		P98160

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57796

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P98160

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P98160

GlyConnect protein glycosylation platform

More...GlyConnecti		653, 43 N-Linked glycans (5 sites), 4 O-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P98160, 55 sites, 43 N-linked glycans (5 sites), 10 O-linked glycans (37 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P98160

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P98160

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in the basement membranes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000142798, Expressed in fundus of stomach and 232 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P98160, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P98160, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000142798, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Purified perlecan has a strong tendency to aggregate in dimers or stellate structures. It interacts with other basement membrane components such as laminin, prolargin and collagen type IV.

Interacts with COL13A1, FGFBP1 and VWA1.

Interacts (via C-terminus) with ECM1 (via C-terminus).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109571, 68 interactors

Protein interaction database and analysis system

More...IntActi		P98160, 36 interactors

Molecular INTeraction database

More...MINTi		P98160

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000363827

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P98160, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

14391
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P98160

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini80 – 191SEAPROSITE-ProRule annotationAdd BLAST112
Domaini198 – 235LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST38
Domaini284 – 320LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST37
Domaini324 – 360LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST37
Domaini367 – 404LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST38
Domaini405 – 504Ig-like C2-type 1Add BLAST100
Domaini521 – 530Laminin EGF-like 1; first partPROSITE-ProRule annotation10
Domaini538 – 730Laminin IV type A 1PROSITE-ProRule annotationAdd BLAST193
Domaini731 – 763Laminin EGF-like 1; second partPROSITE-ProRule annotationAdd BLAST33
Domaini764 – 813Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST50
Domaini814 – 871Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST58
Domaini879 – 923Laminin EGF-like 4; truncatedPROSITE-ProRule annotationAdd BLAST45
Domaini924 – 933Laminin EGF-like 5; first partPROSITE-ProRule annotation10
Domaini941 – 1125Laminin IV type A 2PROSITE-ProRule annotationAdd BLAST185
Domaini1126 – 1158Laminin EGF-like 5; second partPROSITE-ProRule annotationAdd BLAST33
Domaini1159 – 1208Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST50
Domaini1209 – 1265Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST57
Domaini1275 – 1324Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST50
Domaini1325 – 1334Laminin EGF-like 9; first partPROSITE-ProRule annotation10
Domaini1344 – 1529Laminin IV type A 3PROSITE-ProRule annotationAdd BLAST186
Domaini1530 – 1562Laminin EGF-like 9; second partPROSITE-ProRule annotationAdd BLAST33
Domaini1563 – 1612Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST50
Domaini1613 – 1670Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST58
Domaini1677 – 1771Ig-like C2-type 2Add BLAST95
Domaini1772 – 1865Ig-like C2-type 3Add BLAST94
Domaini1866 – 1955Ig-like C2-type 4Add BLAST90
Domaini1956 – 2051Ig-like C2-type 5Add BLAST96
Domaini2052 – 2151Ig-like C2-type 6Add BLAST100
Domaini2152 – 2244Ig-like C2-type 7Add BLAST93
Domaini2245 – 2340Ig-like C2-type 8Add BLAST96
Domaini2341 – 2436Ig-like C2-type 9Add BLAST96
Domaini2437 – 2533Ig-like C2-type 10Add BLAST97
Domaini2534 – 2629Ig-like C2-type 11Add BLAST96
Domaini2630 – 2726Ig-like C2-type 12Add BLAST97
Domaini2727 – 2826Ig-like C2-type 13Add BLAST100
Domaini2827 – 2924Ig-like C2-type 14Add BLAST98
Domaini2925 – 3021Ig-like C2-type 15Add BLAST97
Domaini3022 – 3112Ig-like C2-type 16Add BLAST91
Domaini3113 – 3211Ig-like C2-type 17Add BLAST99
Domaini3212 – 3298Ig-like C2-type 18Add BLAST87
Domaini3299 – 3399Ig-like C2-type 19Add BLAST101
Domaini3400 – 3488Ig-like C2-type 20Add BLAST89
Domaini3489 – 3574Ig-like C2-type 21Add BLAST86
Domaini3575 – 3662Ig-like C2-type 22Add BLAST88
Domaini3663 – 3843Laminin G-like 1PROSITE-ProRule annotationAdd BLAST181
Domaini3844 – 3881EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini3884 – 3922EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Domaini3928 – 4103Laminin G-like 2PROSITE-ProRule annotationAdd BLAST176
Domaini4104 – 4141EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini4143 – 4176EGF-like 4PROSITE-ProRule annotationAdd BLAST34
Domaini4201 – 4389Laminin G-like 3PROSITE-ProRule annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2994 – 3014DisorderedSequence analysisAdd BLAST21
Regioni4149 – 4151Mediates motor neuron attachmentSequence analysis3
Regioni4299 – 4301Mediates motor neuron attachmentSequence analysis3
Regioni4364 – 4391DisorderedSequence analysisAdd BLAST28

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3509, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156670

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000078_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P98160

Identification of Orthologs from Complete Genome Data

More...OMAi		CDERGSM

Database of Orthologous Groups

More...OrthoDBi		414294at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P98160

TreeFam database of animal gene trees

More...TreeFami		TF326548

Family and domain databases

Conserved Domains Database

More...CDDi		cd00055, EGF_Lam, 8 hits
cd00110, LamG, 3 hits
cd00112, LDLa, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 22 hits
4.10.400.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR001791, Laminin_G
IPR000034, Laminin_IV
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR002049, LE_dom
IPR000082, SEA_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00008, EGF, 2 hits
PF07679, I-set, 9 hits
PF13895, Ig_2, 1 hit
PF00052, Laminin_B, 3 hits
PF00053, Laminin_EGF, 9 hits
PF00054, Laminin_G_1, 3 hits
PF00057, Ldl_recept_a, 4 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181, EGF, 11 hits
SM00179, EGF_CA, 5 hits
SM00180, EGF_Lam, 9 hits
SM00409, IG, 22 hits
SM00408, IGc2, 22 hits
SM00406, IGv, 8 hits
SM00281, LamB, 3 hits
SM00282, LamG, 3 hits
SM00192, LDLa, 4 hits
SM00200, SEA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 22 hits
SSF49899, SSF49899, 3 hits
SSF57424, SSF57424, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 9 hits
PS01186, EGF_2, 6 hits
PS50026, EGF_3, 4 hits
PS01248, EGF_LAM_1, 11 hits
PS50027, EGF_LAM_2, 8 hits
PS50835, IG_LIKE, 22 hits
PS50025, LAM_G_DOMAIN, 3 hits
PS51115, LAMININ_IVA, 3 hits
PS01209, LDLRA_1, 4 hits
PS50068, LDLRA_2, 4 hits
PS50024, SEA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P98160-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGWRAAGALL LALLLHGRLL AVTHGLRAYD GLSLPEDIET VTASQMRWTH 
        60         70         80         90        100
SYLSDDEDML ADSISGDDLG SGDLGSGDFQ MVYFRALVNF TRSIEYSPQL 
       110        120        130        140        150
EDAGSREFRE VSEAVVDTLE SEYLKIPGDQ VVSVVFIKEL DGWVFVELDV 
       160        170        180        190        200
GSEGNADGAQ IQEMLLRVIS SGSVASYVTS PQGFQFRRLG TVPQFPRACT 
       210        220        230        240        250
EAEFACHSYN ECVALEYRCD RRPDCRDMSD ELNCEEPVLG ISPTFSLLVE 
       260        270        280        290        300
TTSLPPRPET TIMRQPPVTH APQPLLPGSV RPLPCGPQEA ACRNGHCIPR 
       310        320        330        340        350
DYLCDGQEDC EDGSDELDCG PPPPCEPNEF PCGNGHCALK LWRCDGDFDC 
       360        370        380        390        400
EDRTDEANCP TKRPEEVCGP TQFRCVSTNM CIPASFHCDE ESDCPDRSDE 
       410        420        430        440        450
FGCMPPQVVT PPRESIQASR GQTVTFTCVA IGVPTPIINW RLNWGHIPSH 
       460        470        480        490        500
PRVTVTSEGG RGTLIIRDVK ESDQGAYTCE AMNARGMVFG IPDGVLELVP 
       510        520        530        540        550
QRGPCPDGHF YLEHSAACLP CFCFGITSVC QSTRRFRDQI RLRFDQPDDF 
       560        570        580        590        600
KGVNVTMPAQ PGTPPLSSTQ LQIDPSLHEF QLVDLSRRFL VHDSFWALPE 
       610        620        630        640        650
QFLGNKVDSY GGSLRYNVRY ELARGMLEPV QRPDVVLMGA GYRLLSRGHT 
       660        670        680        690        700
PTQPGALNQR QVQFSEEHWV HESGRPVQRA ELLQVLQSLE AVLIQTVYNT 
       710        720        730        740        750
KMASVGLSDI AMDTTVTHAT SHGRAHSVEE CRCPIGYSGL SCESCDAHFT 
       760        770        780        790        800
RVPGGPYLGT CSGCNCNGHA SSCDPVYGHC LNCQHNTEGP QCNKCKAGFF 
       810        820        830        840        850
GDAMKATATS CRPCPCPYID ASRRFSDTCF LDTDGQATCD ACAPGYTGRR 
       860        870        880        890        900
CESCAPGYEG NPIQPGGKCR PVNQEIVRCD ERGSMGTSGE ACRCKNNVVG 
       910        920        930        940        950
RLCNECADGS FHLSTRNPDG CLKCFCMGVS RHCTSSSWSR AQLHGASEEP 
       960        970        980        990       1000
GHFSLTNAAS THTTNEGIFS PTPGELGFSS FHRLLSGPYF WSLPSRFLGD 
      1010       1020       1030       1040       1050
KVTSYGGELR FTVTQRSQPG STPLHGQPLV VLQGNNIILE HHVAQEPSPG 
      1060       1070       1080       1090       1100
QPSTFIVPFR EQAWQRPDGQ PATREHLLMA LAGIDTLLIR ASYAQQPAES 
      1110       1120       1130       1140       1150
RVSGISMDVA VPEETGQDPA LEVEQCSCPP GYRGPSCQDC DTGYTRTPSG 
      1160       1170       1180       1190       1200
LYLGTCERCS CHGHSEACEP ETGACQGCQH HTEGPRCEQC QPGYYGDAQR 
      1210       1220       1230       1240       1250
GTPQDCQLCP CYGDPAAGQA AHTCFLDTDG HPTCDACSPG HSGRHCERCA 
      1260       1270       1280       1290       1300
PGYYGNPSQG QPCQRDSQVP GPIGCNCDPQ GSVSSQCDAA GQCQCKAQVE 
      1310       1320       1330       1340       1350
GLTCSHCRPH HFHLSASNPD GCLPCFCMGI TQQCASSAYT RHLISTHFAP 
      1360       1370       1380       1390       1400
GDFQGFALVN PQRNSRLTGE FTVEPVPEGA QLSFGNFAQL GHESFYWQLP 
      1410       1420       1430       1440       1450
ETYQGDKVAA YGGKLRYTLS YTAGPQGSPL SDPDVQITGN NIMLVASQPA 
      1460       1470       1480       1490       1500
LQGPERRSYE IMFREEFWRR PDGQPATREH LLMALADLDE LLIRATFSSV 
      1510       1520       1530       1540       1550
PLAASISAVS LEVAQPGPSN RPRALEVEEC RCPPGYIGLS CQDCAPGYTR 
      1560       1570       1580       1590       1600
TGSGLYLGHC ELCECNGHSD LCHPETGACS QCQHNAAGEF CELCAPGYYG 
      1610       1620       1630       1640       1650
DATAGTPEDC QPCACPLTNP ENMFSRTCES LGAGGYRCTA CEPGYTGQYC 
      1660       1670       1680       1690       1700
EQCGPGYVGN PSVQGGQCLP ETNQAPLVVE VHPARSIVPQ GGSHSLRCQV 
      1710       1720       1730       1740       1750
SGSPPHYFYW SREDGRPVPS GTQQRHQGSE LHFPSVQPSD AGVYICTCRN 
      1760       1770       1780       1790       1800
LHQSNTSRAE LLVTEAPSKP ITVTVEEQRS QSVRPGADVT FICTAKSKSP 
      1810       1820       1830       1840       1850
AYTLVWTRLH NGKLPTRAMD FNGILTIRNV QLSDAGTYVC TGSNMFAMDQ 
      1860       1870       1880       1890       1900
GTATLHVQAS GTLSAPVVSI HPPQLTVQPG QLAEFRCSAT GSPTPTLEWT 
      1910       1920       1930       1940       1950
GGPGGQLPAK AQIHGGILRL PAVEPTDQAQ YLCRAHSSAG QQVARAVLHV 
      1960       1970       1980       1990       2000
HGGGGPRVQV SPERTQVHAG RTVRLYCRAA GVPSATITWR KEGGSLPPQA 
      2010       2020       2030       2040       2050
RSERTDIATL LIPAITTADA GFYLCVATSP AGTAQARIQV VVLSASDASP 
      2060       2070       2080       2090       2100
PPVKIESSSP SVTEGQTLDL NCVVAGSAHA QVTWYRRGGS LPPHTQVHGS 
      2110       2120       2130       2140       2150
RLRLPQVSPA DSGEYVCRVE NGSGPKEASI TVSVLHGTHS GPSYTPVPGS 
      2160       2170       2180       2190       2200
TRPIRIEPSS SHVAEGQTLD LNCVVPGQAH AQVTWHKRGG SLPARHQTHG 
      2210       2220       2230       2240       2250
SLLRLHQVTP ADSGEYVCHV VGTSGPLEAS VLVTIEASVI PGPIPPVRIE 
      2260       2270       2280       2290       2300
SSSSTVAEGQ TLDLSCVVAG QAHAQVTWYK RGGSLPARHQ VRGSRLYIFQ 
      2310       2320       2330       2340       2350
ASPADAGQYV CRASNGMEAS ITVTVTGTQG ANLAYPAGST QPIRIEPSSS 
      2360       2370       2380       2390       2400
QVAEGQTLDL NCVVPGQSHA QVTWHKRGGS LPVRHQTHGS LLRLYQASPA 
      2410       2420       2430       2440       2450
DSGEYVCRVL GSSVPLEASV LVTIEPAGSV PALGVTPTVR IESSSSQVAE 
      2460       2470       2480       2490       2500
GQTLDLNCLV AGQAHAQVTW HKRGGSLPAR HQVHGSRLRL LQVTPADSGE 
      2510       2520       2530       2540       2550
YVCRVVGSSG TQEASVLVTI QQRLSGSHSQ GVAYPVRIES SSASLANGHT 
      2560       2570       2580       2590       2600
LDLNCLVASQ APHTITWYKR GGSLPSRHQI VGSRLRIPQV TPADSGEYVC 
      2610       2620       2630       2640       2650
HVSNGAGSRE TSLIVTIQGS GSSHVPSVSP PIRIESSSPT VVEGQTLDLN 
      2660       2670       2680       2690       2700
CVVARQPQAI ITWYKRGGSL PSRHQTHGSH LRLHQMSVAD SGEYVCRANN 
      2710       2720       2730       2740       2750
NIDALEASIV ISVSPSAGSP SAPGSSMPIR IESSSSHVAE GETLDLNCVV 
      2760       2770       2780       2790       2800
PGQAHAQVTW HKRGGSLPSH HQTRGSRLRL HHVSPADSGE YVCRVMGSSG 
      2810       2820       2830       2840       2850
PLEASVLVTI EASGSSAVHV PAPGGAPPIR IEPSSSRVAE GQTLDLKCVV 
      2860       2870       2880       2890       2900
PGQAHAQVTW HKRGGNLPAR HQVHGPLLRL NQVSPADSGE YSCQVTGSSG 
      2910       2920       2930       2940       2950
TLEASVLVTI EPSSPGPIPA PGLAQPIYIE ASSSHVTEGQ TLDLNCVVPG 
      2960       2970       2980       2990       3000
QAHAQVTWYK RGGSLPARHQ THGSQLRLHL VSPADSGEYV CRAASGPGPE 
      3010       3020       3030       3040       3050
QEASFTVTVP PSEGSSYRLR SPVISIDPPS STVQQGQDAS FKCLIHDGAA 
      3060       3070       3080       3090       3100
PISLEWKTRN QELEDNVHIS PNGSIITIVG TRPSNHGTYR CVASNAYGVA 
      3110       3120       3130       3140       3150
QSVVNLSVHG PPTVSVLPEG PVWVKVGKAV TLECVSAGEP RSSARWTRIS 
      3160       3170       3180       3190       3200
STPAKLEQRT YGLMDSHAVL QISSAKPSDA GTYVCLAQNA LGTAQKQVEV 
      3210       3220       3230       3240       3250
IVDTGAMAPG APQVQAEEAE LTVEAGHTAT LRCSATGSPA PTIHWSKLRS 
      3260       3270       3280       3290       3300
PLPWQHRLEG DTLIIPRVAQ QDSGQYICNA TSPAGHAEAT IILHVESPPY 
      3310       3320       3330       3340       3350
ATTVPEHASV QAGETVQLQC LAHGTPPLTF QWSRVGSSLP GRATARNELL 
      3360       3370       3380       3390       3400
HFERAAPEDS GRYRCRVTNK VGSAEAFAQL LVQGPPGSLP ATSIPAGSTP 
      3410       3420       3430       3440       3450
TVQVTPQLET KSIGASVEFH CAVPSDRGTQ LRWFKEGGQL PPGHSVQDGV 
      3460       3470       3480       3490       3500
LRIQNLDQSC QGTYICQAHG PWGKAQASAQ LVIQALPSVL INIRTSVQTV 
      3510       3520       3530       3540       3550
VVGHAVEFEC LALGDPKPQV TWSKVGGHLR PGIVQSGGVV RIAHVELADA 
      3560       3570       3580       3590       3600
GQYRCTATNA AGTTQSHVLL LVQALPQISM PQEVRVPAGS AAVFPCIASG 
      3610       3620       3630       3640       3650
YPTPDISWSK LDGSLPPDSR LENNMLMLPS VRPQDAGTYV CTATNRQGKV 
      3660       3670       3680       3690       3700
KAFAHLQVPE RVVPYFTQTP YSFLPLPTIK DAYRKFEIKI TFRPDSADGM 
      3710       3720       3730       3740       3750
LLYNGQKRVP GSPTNLANRQ PDFISFGLVG GRPEFRFDAG SGMATIRHPT 
      3760       3770       3780       3790       3800
PLALGHFHTV TLLRSLTQGS LIVGDLAPVN GTSQGKFQGL DLNEELYLGG 
      3810       3820       3830       3840       3850
YPDYGAIPKA GLSSGFIGCV RELRIQGEEI VFHDLNLTAH GISHCPTCRD 
      3860       3870       3880       3890       3900
RPCQNGGQCH DSESSSYVCV CPAGFTGSRC EHSQALHCHP EACGPDATCV 
      3910       3920       3930       3940       3950
NRPDGRGYTC RCHLGRSGLR CEEGVTVTTP SLSGAGSYLA LPALTNTHHE 
      3960       3970       3980       3990       4000
LRLDVEFKPL APDGVLLFSG GKSGPVEDFV SLAMVGGHLE FRYELGSGLA 
      4010       4020       4030       4040       4050
VLRSAEPLAL GRWHRVSAER LNKDGSLRVN GGRPVLRSSP GKSQGLNLHT 
      4060       4070       4080       4090       4100
LLYLGGVEPS VPLSPATNMS AHFRGCVGEV SVNGKRLDLT YSFLGSQGIG 
      4110       4120       4130       4140       4150
QCYDSSPCER QPCQHGATCM PAGEYEFQCL CRDGFKGDLC EHEENPCQLR 
      4160       4170       4180       4190       4200
EPCLHGGTCQ GTRCLCLPGF SGPRCQQGSG HGIAESDWHL EGSGGNDAPG 
      4210       4220       4230       4240       4250
QYGAYFHDDG FLAFPGHVFS RSLPEVPETI ELEVRTSTAS GLLLWQGVEV 
      4260       4270       4280       4290       4300
GEAGQGKDFI SLGLQDGHLV FRYQLGSGEA RLVSEDPIND GEWHRVTALR 
      4310       4320       4330       4340       4350
EGRRGSIQVD GEELVSGRSP GPNVAVNAKG SVYIGGAPDV ATLTGGRFSS 
      4360       4370       4380       4390 
GITGCVKNLV LHSARPGAPP PQPLDLQHRA QAGANTRPCP S
Length:4,391
Mass (Da):468,830
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC587660E24C83324
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RQT3A0A0U1RQT3_HUMAN
Basement membrane-specific heparan ...
HSPG2
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IT11A0A3B3IT11_HUMAN
Basement membrane-specific heparan ...
HSPG2
288Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5A9H0Y5A9_HUMAN
Basement membrane-specific heparan ...
HSPG2
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YH07A0A2R8YH07_HUMAN
Basement membrane-specific heparan ...
HSPG2
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYA5H7BYA5_HUMAN
Basement membrane-specific heparan ...
HSPG2
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6A → P in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti6A → P in AAA52700 (PubMed:1569102).Curated1
Sequence conflicti58D → Y in AAA52700 (PubMed:1569102).Curated1
Sequence conflicti435 – 437TPI → APFL in CAA44373 (PubMed:1730768).Curated3
Sequence conflicti450H → Q in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti502R → RA in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti793N → K in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti890 – 891EA → RT in AAB21121 (PubMed:1685141).Curated2
Sequence conflicti909G → R in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti909G → R in AAB21121 (PubMed:1685141).Curated1
Sequence conflicti1102V → L in AAB21121 (PubMed:1685141).Curated1
Sequence conflicti1133R → L in AAB21121 (PubMed:1685141).Curated1
Sequence conflicti1222H → L in AAB21121 (PubMed:1685141).Curated1
Sequence conflicti1406D → G in AAA52699 (PubMed:1679749).Curated1
Sequence conflicti1410A → G in AAA52699 (PubMed:1679749).Curated1
Sequence conflicti1466 – 1470EFWRR → LNLRQ in AAA52699 (PubMed:1679749).Curated5
Sequence conflicti1703 – 1704SP → RG in CAA44373 (PubMed:1730768).Curated2
Sequence conflicti1753Q → R in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti2038I → M in AAA52700 (PubMed:1569102).Curated1
Sequence conflicti2050P → Q in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti2052P → G in AAA52700 (PubMed:1569102).Curated1
Sequence conflicti2093P → H in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti2627S → R in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti2770H → Y in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti3241P → R in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti3427R → Q in AAA52700 (PubMed:1569102).Curated1
Sequence conflicti4004S → T in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti4135F → I in CAA44373 (PubMed:1730768).Curated1
Sequence conflicti4332V → I in CAA44373 (PubMed:1730768).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04797968D → E. Corresponds to variant dbSNP:rs1869780EnsemblClinVar.1
Natural variantiVAR_057051303L → H. Corresponds to variant dbSNP:rs17460381Ensembl.1
Natural variantiVAR_047980638M → V3 PublicationsCorresponds to variant dbSNP:rs1874792EnsemblClinVar.1
Natural variantiVAR_047981765N → S3 PublicationsCorresponds to variant dbSNP:rs989994EnsemblClinVar.1
Natural variantiVAR_0479821186R → Q. Corresponds to variant dbSNP:rs2229481EnsemblClinVar.1
Natural variantiVAR_0570521323L → V. Corresponds to variant dbSNP:rs10917058EnsemblClinVar.1
Natural variantiVAR_0479831503A → V3 PublicationsCorresponds to variant dbSNP:rs897471EnsemblClinVar.1
Natural variantiVAR_0141221532C → Y in SJS1. 1 PublicationCorresponds to variant dbSNP:rs137853248EnsemblClinVar.1
Natural variantiVAR_0479841758R → Q. Corresponds to variant dbSNP:rs2229483Ensembl.1
Natural variantiVAR_0479851919R → C. Corresponds to variant dbSNP:rs2229474EnsemblClinVar.1
Natural variantiVAR_0479861967V → I. Corresponds to variant dbSNP:rs2229475EnsemblClinVar.1
Natural variantiVAR_0479872980L → H1 PublicationCorresponds to variant dbSNP:rs2229489EnsemblClinVar.1
Natural variantiVAR_0479882981V → I. Corresponds to variant dbSNP:rs2229490EnsemblClinVar.1
Natural variantiVAR_0479892995S → G1 PublicationCorresponds to variant dbSNP:rs2229491EnsemblClinVar.1
Natural variantiVAR_0479903168A → T1 PublicationCorresponds to variant dbSNP:rs2228349EnsemblClinVar.1
Natural variantiVAR_0479913256H → Y. Corresponds to variant dbSNP:rs2291827EnsemblClinVar.1
Natural variantiVAR_0479923530R → W. Corresponds to variant dbSNP:rs2270699EnsemblClinVar.1
Natural variantiVAR_0479933632R → Q1 PublicationCorresponds to variant dbSNP:rs2229493EnsemblClinVar.1
Natural variantiVAR_0479943640V → I. Corresponds to variant dbSNP:rs17459097EnsemblClinVar.1
Natural variantiVAR_0479954331S → N. Corresponds to variant dbSNP:rs3736360EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M85289 mRNA Translation: AAA52700.1
X62515 mRNA Translation: CAA44373.1
AL590556 Genomic DNA No translation available.
AL590103 Genomic DNA No translation available.
L22078 Genomic DNA No translation available.
AL445795 Genomic DNA Translation: CAC18534.1
S76436 mRNA Translation: AAB21121.2
M64283 mRNA Translation: AAA52699.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30625.1

Protein sequence database of the Protein Information Resource

More...PIRi		A38096

NCBI Reference Sequences

More...RefSeqi		NP_001278789.1, NM_001291860.1
NP_005520.4, NM_005529.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000374695; ENSP00000363827; ENSG00000142798

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3339

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3339

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000374695.8; ENSP00000363827.3; NM_005529.7; NP_005520.4

UCSC genome browser

More...UCSCi		uc001bfj.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Wikipedia

Perlecan entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85289 mRNA Translation: AAA52700.1
X62515 mRNA Translation: CAA44373.1
AL590556 Genomic DNA No translation available.
AL590103 Genomic DNA No translation available.
L22078 Genomic DNA No translation available.
AL445795 Genomic DNA Translation: CAC18534.1
S76436 mRNA Translation: AAB21121.2
M64283 mRNA Translation: AAA52699.1
CCDSiCCDS30625.1
PIRiA38096
RefSeqiNP_001278789.1, NM_001291860.1
NP_005520.4, NM_005529.6

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SH4X-ray1.50A4197-4391[»]
3SH5X-ray2.80A4197-4391[»]
SMRiP98160
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109571, 68 interactors
IntActiP98160, 36 interactors
MINTiP98160
STRINGi9606.ENSP00000363827

Chemistry databases

DrugBankiDB00039, Palifermin

PTM databases

CarbonylDBiP98160
GlyConnecti653, 43 N-Linked glycans (5 sites), 4 O-Linked glycans (3 sites)
GlyGeniP98160, 55 sites, 43 N-linked glycans (5 sites), 10 O-linked glycans (37 sites)
iPTMnetiP98160
PhosphoSitePlusiP98160

Genetic variation databases

BioMutaiHSPG2
DMDMi317373536

2D gel databases

DOSAC-COBS-2DPAGEiP98160

Proteomic databases

EPDiP98160
jPOSTiP98160
MassIVEiP98160
MaxQBiP98160
PaxDbiP98160
PeptideAtlasiP98160
PRIDEiP98160
ProteomicsDBi57796

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		980, 483 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		3339

Genome annotation databases

EnsembliENST00000374695; ENSP00000363827; ENSG00000142798
GeneIDi3339
KEGGihsa:3339
MANE-SelectiENST00000374695.8; ENSP00000363827.3; NM_005529.7; NP_005520.4
UCSCiuc001bfj.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3339
DisGeNETi3339

GeneCards: human genes, protein and diseases

More...GeneCardsi		HSPG2
HGNCiHGNC:5273, HSPG2
HPAiENSG00000142798, Low tissue specificity
MalaCardsiHSPG2
MIMi142461, gene
224410, phenotype
255800, phenotype
neXtProtiNX_P98160
OpenTargetsiENSG00000142798
Orphaneti1606, 1p36 deletion syndrome
1865, Dyssegmental dysplasia, Silverman-Handmaker type
800, Schwartz-Jampel syndrome
PharmGKBiPA29537
VEuPathDBiHostDB:ENSG00000142798

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3509, Eukaryota
GeneTreeiENSGT00940000156670
HOGENOMiCLU_000078_1_0_1
InParanoidiP98160
OMAiCDERGSM
OrthoDBi414294at2759
PhylomeDBiP98160
TreeFamiTF326548

Enzyme and pathway databases

PathwayCommonsiP98160
ReactomeiR-HSA-1474228, Degradation of the extracellular matrix
R-HSA-1971475, A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928, HS-GAG biosynthesis
R-HSA-2024096, HS-GAG degradation
R-HSA-216083, Integrin cell surface interactions
R-HSA-3000157, Laminin interactions
R-HSA-3000171, Non-integrin membrane-ECM interactions
R-HSA-3000178, ECM proteoglycans
R-HSA-3560783, Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801, Defective B3GAT3 causes JDSSDHD
R-HSA-3656237, Defective EXT2 causes exostoses 2
R-HSA-3656253, Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-4420332, Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-975634, Retinoid metabolism and transport
R-HSA-977225, Amyloid fiber formation
SignaLinkiP98160
SIGNORiP98160

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3339, 3 hits in 1040 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HSPG2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Perlecan

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3339
PharosiP98160, Tbio

Protein Ontology

More...PROi		PR:P98160
RNActiP98160, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000142798, Expressed in fundus of stomach and 232 other tissues
ExpressionAtlasiP98160, baseline and differential
GenevisibleiP98160, HS

Family and domain databases

CDDicd00055, EGF_Lam, 8 hits
cd00110, LamG, 3 hits
cd00112, LDLa, 4 hits
Gene3Di2.60.40.10, 22 hits
4.10.400.10, 4 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR001791, Laminin_G
IPR000034, Laminin_IV
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR002049, LE_dom
IPR000082, SEA_dom
PfamiView protein in Pfam
PF00008, EGF, 2 hits
PF07679, I-set, 9 hits
PF13895, Ig_2, 1 hit
PF00052, Laminin_B, 3 hits
PF00053, Laminin_EGF, 9 hits
PF00054, Laminin_G_1, 3 hits
PF00057, Ldl_recept_a, 4 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00181, EGF, 11 hits
SM00179, EGF_CA, 5 hits
SM00180, EGF_Lam, 9 hits
SM00409, IG, 22 hits
SM00408, IGc2, 22 hits
SM00406, IGv, 8 hits
SM00281, LamB, 3 hits
SM00282, LamG, 3 hits
SM00192, LDLa, 4 hits
SM00200, SEA, 1 hit
SUPFAMiSSF48726, SSF48726, 22 hits
SSF49899, SSF49899, 3 hits
SSF57424, SSF57424, 4 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 9 hits
PS01186, EGF_2, 6 hits
PS50026, EGF_3, 4 hits
PS01248, EGF_LAM_1, 11 hits
PS50027, EGF_LAM_2, 8 hits
PS50835, IG_LIKE, 22 hits
PS50025, LAM_G_DOMAIN, 3 hits
PS51115, LAMININ_IVA, 3 hits
PS01209, LDLRA_1, 4 hits
PS50068, LDLRA_2, 4 hits
PS50024, SEA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGBM_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P98160
Secondary accession number(s): Q16287, Q5SZI3, Q9H3V5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2011
Last modified: February 23, 2022
This is version 236 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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