Serine protease nudel

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• serine-type endopeptidase activity Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Transfer of Dorsoventral and Terminal Information from the Ovary to the Embryo by a Common Group of Eggshell Proteins in Drosophila."
    Mineo A., Furriols M., Casanova J.
    Genetics 205:1529-1536(2017) [PubMed] [Europe PMC] [Abstract]
  • "Role of Nudel protease activation in triggering dorsoventral polarization of the Drosophila embryo."
    LeMosy E.K., Kemler D., Hashimoto C.
    Development 125:4045-4053(1998) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• dorsal/ventral axis specification Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The polarity of the dorsoventral axis in the Drosophila embryo is defined by an extracellular signal."
    Stein D., Roth S., Vogelsang E., Nusslein-Volhard C.
    Cell 65:725-735(1991) [PubMed] [Europe PMC] [Abstract]
  • "Transfer of Dorsoventral and Terminal Information from the Ovary to the Embryo by a Common Group of Eggshell Proteins in Drosophila."
    Mineo A., Furriols M., Casanova J.
    Genetics 205:1529-1536(2017) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "An unusual mosaic protein with a protease domain, encoded by the nudel gene, is involved in defining embryonic dorsoventral polarity in Drosophila."
    Hong C.C., Hashimoto C.
    Cell 82:785-794(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  • "The maternal nudel protein of Drosophila has two distinct roles important for embryogenesis."
    Hong C.C., Hashimoto C.
    Genetics 143:1653-1661(1996) [PubMed] [Europe PMC] [Abstract]
  • "Role of Nudel protease activation in triggering dorsoventral polarization of the Drosophila embryo."
    LeMosy E.K., Kemler D., Hashimoto C.
    Development 125:4045-4053(1998) [PubMed] [Europe PMC] [Abstract]
• egg activation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Regulation of maternal transcript destabilization during egg activation in Drosophila."
    Tadros W., Houston S.A., Bashirullah A., Cooperstock R.L., Semotok J.L., Reed B.H., Lipshitz H.D.
    Genetics 164:989-1001(2003) [PubMed] [Europe PMC] [Abstract]
• eggshell chorion assembly Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The maternal nudel protein of Drosophila has two distinct roles important for embryogenesis."
    Hong C.C., Hashimoto C.
    Genetics 143:1653-1661(1996) [PubMed] [Europe PMC] [Abstract]
• maternal specification of dorsal/ventral axis, oocyte, soma encoded Source: InterPro
• positive regulation of Toll signaling pathway Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Activation of a protease cascade involved in patterning the Drosophila embryo."
    LeMosy E.K., Tan Y.Q., Hashimoto C.
    Proc Natl Acad Sci U S A 98:5055-5060(2001) [PubMed] [Europe PMC] [Abstract]
• protein autoprocessing Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Role of Nudel protease activation in triggering dorsoventral polarization of the Drosophila embryo."
    LeMosy E.K., Kemler D., Hashimoto C.
    Development 125:4045-4053(1998) [PubMed] [Europe PMC] [Abstract]
• protein processing Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Transfer of Dorsoventral and Terminal Information from the Ovary to the Embryo by a Common Group of Eggshell Proteins in Drosophila."
    Mineo A., Furriols M., Casanova J.
    Genetics 205:1529-1536(2017) [PubMed] [Europe PMC] [Abstract]
• proteolysis Source: FlyBaseInferred from sequence modelⁱ
  • "Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships."
    Ross J., Jiang H., Kanost M.R., Wang Y.
    Gene 304:117-131(2003) [PubMed] [Europe PMC] [Abstract]
• zymogen activation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Activation of a protease cascade involved in patterning the Drosophila embryo."
    LeMosy E.K., Tan Y.Q., Hashimoto C.
    Proc Natl Acad Sci U S A 98:5055-5060(2001) [PubMed] [Europe PMC] [Abstract]
  • "Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos."
    Steen P.W., Tian S., Tully S.E., Cravatt B.F., LeMosy E.K.
    FEBS Lett 584:3557-3560(2010) [PubMed] [Europe PMC] [Abstract]
  • "Role of Nudel protease activation in triggering dorsoventral polarization of the Drosophila embryo."
    LeMosy E.K., Kemler D., Hashimoto C.
    Development 125:4045-4053(1998) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MNYNMDEMEA TRLLRHPRRW WSIGFGKRIV AISILVIIVL LFSLVYHGLV 
        60         70         80         90        100
VEKIDQVQQI AALNARHQVL FNQPFEEDQS ALIVSPQTLH FKLLDEDMNK 
       110        120        130        140        150
DMEDSKNRRR KHMRQMLVKF RLNKKHRMRR DLHGLDLLDP VRMEANMQHL 
       160        170        180        190        200
YTKLRSKRAR EALSQLEHEF VRCKKHTPQD CMSAFLRMYK MAKEVTEKME 
       210        220        230        240        250
KMKAIMREQQ PKLESSSMES HEQKGTFSPA DLIQVTTAEA TTVAVHATEK 
       260        270        280        290        300
PARTKIKPSR ISWIIDGHDH DESPVYTDGA PKKETTKAPW NTTQLVEITT 
       310        320        330        340        350
TKIDATATER TTVESTTEKI SWILDHFDKP QEILRTTEGP GQRIIRNVTT 
       360        370        380        390        400
TSASSEPIVD TENTNSDHVP TTENGLVFNI TTDGPVETTK STAQRKLSFD 
       410        420        430        440        450
WILDGEENVE PEVKSTNTTT TTAATTTTGA TSETIIVTTE LPKITFDWII 
       460        470        480        490        500
DGREVVEPQE TTTEVTGTTE RLRKMPFDWI IDGEEVVEPQ ENVTTTTIAT 
       510        520        530        540        550
TVAVSTTEIN ERIHNSTAYP TKPKPVKFDW IIDGGESSGE VSTSSTSQPK 
       560        570        580        590        600
LTTREAISNP ESPRSSHPLD NPTSIENMLE SFEQHEEQKP ILRVLNANES 
       610        620        630        640        650
SSETVTDGYE RQLWLKKFED QARPNQNELI DTFGTALDAK ALDKMGPKIN 
       660        670        680        690        700
PLNGHTWNAA DAQILSLCER VALRMRNKVA TMSDGETKEK GETFTASPSV 
       710        720        730        740        750
QFTSRAPGGF PVSGETMKAS AQFMFNPNFG MPSIPVCFYM TPANFRMPMW 
       760        770        780        790        800
SNTPTFMGMQ GAHFGGSSNP GAGIFFVPQQ FGPSGNFFGG SGGSGAGGQG 
       810        820        830        840        850
ANIFSKNASP QKPTNGQQQV YCSYMQNQSG QGAGQSQTSS QQQQGGQSAF 
       860        870        880        890        900
SNANFKMRHA NQTNTANQQG QIIYASYAGL PQQPIQERSR CPEPDQFSCF 
       910        920        930        940        950
GQQECIPAAR WCDNVVDCSD GSDESACTCA DRVDEERLCD GYEDCPMGED 
       960        970        980        990       1000
ELGCFGCESL AYSCYENPQD FAKRNRSTIS MCYSRLERCD GFMNCLNGRD 
      1010       1020       1030       1040       1050
EEQCSMLVTD VADHMSHGAS ASEGYLYHNY RGDWHPVCNN GEKWAALACQ 
      1060       1070       1080       1090       1100
MDENSRMDHS ASLNVSFQTL TLPGPFIEPS LHAGVHFAQA CHGRNSHDSL 
      1110       1120       1130       1140       1150
VDHVAYVKCP PMQCGLPSKS SMLEHSKRVR RAVSDSKEIV GDGRIVGGSY 
      1160       1170       1180       1190       1200
TSALQWPFVV AIYRNGKFHC GGTIYSDRWI ISAAHCVINY GKYFYEVRAG 
      1210       1220       1230       1240       1250
LLRRSSYSPA TQIQPVSHVV VHQAYERRSM RNDLSLLRLL NPLQFNRWVK 
      1260       1270       1280       1290       1300
PICLPDKGRT TVGDDWIWGP VEHTLCTVVG WGAIREKGPS SDPMRQVIVP 
      1310       1320       1330       1340       1350
IRKKCTDPED QASEDICAGD PDGGRDACQG DSGGPLFCRS VSNPDEFYLA 
      1360       1370       1380       1390       1400
GVVSHGNGCA RPQEFGVYTR VTLYLDWLEM ATTPRLLPKL QPLQLCPGFI 
      1410       1420       1430       1440       1450
CVWGGKRCIA KRQRCDRNVD CLGGEDEVGC TYNFLPDMVG GVRQNISTTT 
      1460       1470       1480       1490       1500
ESDYHPVKES EEKSKMREVI PIDDEDLKAE QDEEDLLKST TSLGQTETTQ 
      1510       1520       1530       1540       1550
GPMDLSFAEQ ITSTTSDDLS ITDETTSTDF TVSDSATSPS TLLPTTTNPS 
      1560       1570       1580       1590       1600
TWLPSTNIET STFSFTTTES EASTKQETLP TTVAQTTTIP TSTEDLKKLT 
      1610       1620       1630       1640       1650
DLVTEFIEST TFETTMEVET TTLSLTSTDA PKLVTTEGVK ETTTTEDTTT 
      1660       1670       1680       1690       1700
ISSIVTLTTT PLATISTTIL TTEKHVAVTT LAPTTTTESA KTTTTHSSST 
      1710       1720       1730       1740       1750
HSEKDQIQIP NKFVCKKMSQ IVDIMMRCDR KVDCEDGTDE LDCTCKDYLK 
      1760       1770       1780       1790       1800
GSLKGLICDG KADCEDLTDE QNCVECQSNE FRCPLSKTCL PLSSRCDNKV 
      1810       1820       1830       1840       1850
DCKFKEDEKD CFALTNGHDV HFDVHQQPKF SSTGIFSRNG HGVWRVVCAH 
      1860       1870       1880       1890       1900
ETGYHEHQAK TADAVCALLG FNGAHYFNSS EFVTQHEMQP ITPELKGGRN 
      1910       1920       1930       1940       1950
RMSAQIHSMV GDNVQFTENE VIIPELGHPS ASRPEKDRLL PRKCVGIYVE 
      1960       1970       1980       1990       2000
CNPYSNKTTP LKTFSAGQVV KEKPIEQVPV LSPTIETHNT PNVHFKPQIP 
      2010       2020       2030       2040       2050
AMVVNKKDEI LDRLDKLIKS KKNKTILVNE QLHEAIEELH WPWLADVYMN 
      2060       2070       2080       2090       2100
GDLWCIGVLI DKHWVMVHES CLSGIDLETH YVSVLLGGGK TKRSAHRSNH 
      2110       2120       2130       2140       2150
EQIRRVDCFE GVPKSNVLLL HLERPVRFTH HVLPTFLPDS SHQNQSHARQ 
      2160       2170       2180       2190       2200
CISVLHDDAT GRIKTVAITR IHNATNCDSC YKLQEKQPPA NLMRLLNVSA 
      2210       2220       2230       2240       2250
EDMASISEEV ELINGVAPTE LPAITKFTTC NQFGLKNVSD AHHNPSDQGV 
      2260       2270       2280       2290       2300
LVCRDSHTGW FPTALFNYNN SDCQSFKQPF GIRTLELVYK SLQDIIDKPS 
      2310       2320       2330       2340       2350
CKMLLPAPDC STHRCPLGTC LPQAAMCNGR SDCHDGSDEE ETKCRQQKQQ 
      2360       2370       2380       2390       2400
CAPGEMKCRT SFKCVPKSKF CDHVPDCEDM TDEPTICSCF TYLQATDPSK 
      2410       2420       2430       2440       2450
ICDGKRNCWD KSDESSVLCN CTADHFQCSS SPEDCIPRDF VCDKEKDCPN 
      2460       2470       2480       2490       2500
GEDERYCFGI EHPLHLQKKD FWTNSQHTQP EIAPQYGQVI EQTYGIWHTK 
      2510       2520       2530       2540       2550
CFPKSKPPQV DEVREICKKL GYNPYRQPSY RLIDDEENKP VHTYELADRQ 
      2560       2570       2580       2590       2600
GRSFSNESLM GKYRDSTKAL IISKFSPLQL NERLTLFLKS SRPIAELVRW 
      2610 
NATDSSMCYR LEIRCA                                      

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase
2. SIMILARITY comments
   Index of protein domains and families
3. Peptidase families
   Classification of peptidase families and list of entries