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Entry version 168 (12 Aug 2020)
Sequence version 2 (10 May 2004)
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Protein

Serine protease nudel

Gene

ndl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. Three proteases; ndl, gd and snk process easter to create active easter. Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo. Nudel, pipe and windbeutel together trigger the protease cascade within the extraembryonic perivitelline compartment which induces dorsoventral polarity of the Drosophila embryo.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1185Charge relay systemBy similarity1
Active sitei1233Charge relay systemBy similarity1
Active sitei1332Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • serine-type endopeptidase activity Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.013

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine protease nudel (EC:3.4.21.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ndl
ORF Names:CG10129
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0002926, ndl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 43Sequence analysisAdd BLAST43
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002813644 – 2616Serine protease nudelAdd BLAST2573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei215Phosphoserine1 Publication1
Modified residuei220Phosphoserine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi379N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi492N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei574Phosphoserine1 Publication1
Modified residuei581Phosphoserine1 Publication1
Glycosylationi598N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi794O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi827N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi829O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi861N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi891 ↔ 905By similarity
Disulfide bondi899 ↔ 918By similarity
Disulfide bondi912 ↔ 927By similarity
Disulfide bondi957 ↔ 982By similarity
Disulfide bondi964 ↔ 995By similarity
Glycosylationi975N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi989 ↔ 1004By similarity
Glycosylationi1064N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1134Phosphoserine1 Publication1
Modified residuei1136Phosphoserine1 Publication1
Disulfide bondi1170 ↔ 1186By similarity
Disulfide bondi1276 ↔ 1338Sequence analysis
Disulfide bondi1305 ↔ 1317By similarity
Disulfide bondi1328 ↔ 1359By similarity
Disulfide bondi1396 ↔ 1408By similarity
Disulfide bondi1401 ↔ 1421By similarity
Disulfide bondi1415 ↔ 1430By similarity
Glycosylationi1445N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1728 ↔ 1745By similarity
Disulfide bondi1734 ↔ 1764By similarity
Disulfide bondi1758 ↔ 1773By similarity
Disulfide bondi1776 ↔ 1789By similarity
Disulfide bondi1783 ↔ 1802By similarity
Disulfide bondi1796 ↔ 1811By similarity
Glycosylationi1878N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1956N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2023N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2055 ↔ 2071By similarity
Glycosylationi2144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2173N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2177 ↔ 2230By similarity
Glycosylationi2197N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2269N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2310 ↔ 2320By similarity
Disulfide bondi2315 ↔ 2333By similarity
Disulfide bondi2327 ↔ 2344By similarity
Disulfide bondi2351 ↔ 2364By similarity
Disulfide bondi2358 ↔ 2377By similarity
Disulfide bondi2371 ↔ 2387By similarity
Glycosylationi2420N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2421 ↔ 2435By similarity
Disulfide bondi2428 ↔ 2448By similarity
Disulfide bondi2442 ↔ 2457By similarity
Glycosylationi2556N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2601N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Requires cleavage for activation (presumably).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P98159

PRoteomics IDEntifications database

More...
PRIDEi
P98159

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P98159

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Follicle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0002926, Expressed in egg chamber and 13 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P98159, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
64189, 1 interactor

Protein interaction database and analysis system

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IntActi
P98159, 3 interactors

STRING: functional protein association networks

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STRINGi
7227.FBpp0076693

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P98159

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati261 – 269WIID 19
Repeati320 – 328WIID 29
Repeati399 – 407WIID 39
Repeati446 – 454WIID 49
Repeati477 – 485WIID 59
Repeati528 – 536WIID 69
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini889 – 929LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST41
Domaini929 – 956LDL-receptor class A 2; truncatedPROSITE-ProRule annotationAdd BLAST28
Domaini955 – 1006LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST52
Domaini1145 – 1383Peptidase S1 1PROSITE-ProRule annotationAdd BLAST239
Domaini1394 – 1432LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST39
Domaini1713 – 1743LDL-receptor class A 5; truncatedPROSITE-ProRule annotationAdd BLAST31
Domaini1745 – 1775LDL-receptor class A 6; truncatedPROSITE-ProRule annotationAdd BLAST31
Domaini1774 – 1813LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST40
Domaini2027 – 2301Peptidase S1 2PROSITE-ProRule annotationAdd BLAST275
Domaini2308 – 2346LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST39
Domaini2349 – 2389LDL-receptor class A 9PROSITE-ProRule annotationAdd BLAST41
Domaini2387 – 2419LDL-receptor class A 10; truncatedPROSITE-ProRule annotationAdd BLAST33
Domaini2419 – 2459LDL-receptor class A 11PROSITE-ProRule annotationAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1031 – 1033Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1489 – 1702Ser/Thr-richAdd BLAST214

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3627, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_228608_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P98159

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGWGAIR

Database of Orthologous Groups

More...
OrthoDBi
1314811at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P98159

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 7 hits
cd00190, Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 3 hits
4.10.400.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR034381, Nudel
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR015420, Peptidase_S1A_nudel
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER

The PANTHER Classification System

More...
PANTHERi
PTHR24258:SF133, PTHR24258:SF133, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09342, DUF1986, 1 hit
PF00057, Ldl_recept_a, 4 hits
PF00089, Trypsin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00192, LDLa, 9 hits
SM00020, Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 2 hits
SSF57424, SSF57424, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01209, LDLRA_1, 6 hits
PS50068, LDLRA_2, 8 hits
PS50240, TRYPSIN_DOM, 2 hits
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P98159-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNYNMDEMEA TRLLRHPRRW WSIGFGKRIV AISILVIIVL LFSLVYHGLV
60 70 80 90 100
VEKIDQVQQI AALNARHQVL FNQPFEEDQS ALIVSPQTLH FKLLDEDMNK
110 120 130 140 150
DMEDSKNRRR KHMRQMLVKF RLNKKHRMRR DLHGLDLLDP VRMEANMQHL
160 170 180 190 200
YTKLRSKRAR EALSQLEHEF VRCKKHTPQD CMSAFLRMYK MAKEVTEKME
210 220 230 240 250
KMKAIMREQQ PKLESSSMES HEQKGTFSPA DLIQVTTAEA TTVAVHATEK
260 270 280 290 300
PARTKIKPSR ISWIIDGHDH DESPVYTDGA PKKETTKAPW NTTQLVEITT
310 320 330 340 350
TKIDATATER TTVESTTEKI SWILDHFDKP QEILRTTEGP GQRIIRNVTT
360 370 380 390 400
TSASSEPIVD TENTNSDHVP TTENGLVFNI TTDGPVETTK STAQRKLSFD
410 420 430 440 450
WILDGEENVE PEVKSTNTTT TTAATTTTGA TSETIIVTTE LPKITFDWII
460 470 480 490 500
DGREVVEPQE TTTEVTGTTE RLRKMPFDWI IDGEEVVEPQ ENVTTTTIAT
510 520 530 540 550
TVAVSTTEIN ERIHNSTAYP TKPKPVKFDW IIDGGESSGE VSTSSTSQPK
560 570 580 590 600
LTTREAISNP ESPRSSHPLD NPTSIENMLE SFEQHEEQKP ILRVLNANES
610 620 630 640 650
SSETVTDGYE RQLWLKKFED QARPNQNELI DTFGTALDAK ALDKMGPKIN
660 670 680 690 700
PLNGHTWNAA DAQILSLCER VALRMRNKVA TMSDGETKEK GETFTASPSV
710 720 730 740 750
QFTSRAPGGF PVSGETMKAS AQFMFNPNFG MPSIPVCFYM TPANFRMPMW
760 770 780 790 800
SNTPTFMGMQ GAHFGGSSNP GAGIFFVPQQ FGPSGNFFGG SGGSGAGGQG
810 820 830 840 850
ANIFSKNASP QKPTNGQQQV YCSYMQNQSG QGAGQSQTSS QQQQGGQSAF
860 870 880 890 900
SNANFKMRHA NQTNTANQQG QIIYASYAGL PQQPIQERSR CPEPDQFSCF
910 920 930 940 950
GQQECIPAAR WCDNVVDCSD GSDESACTCA DRVDEERLCD GYEDCPMGED
960 970 980 990 1000
ELGCFGCESL AYSCYENPQD FAKRNRSTIS MCYSRLERCD GFMNCLNGRD
1010 1020 1030 1040 1050
EEQCSMLVTD VADHMSHGAS ASEGYLYHNY RGDWHPVCNN GEKWAALACQ
1060 1070 1080 1090 1100
MDENSRMDHS ASLNVSFQTL TLPGPFIEPS LHAGVHFAQA CHGRNSHDSL
1110 1120 1130 1140 1150
VDHVAYVKCP PMQCGLPSKS SMLEHSKRVR RAVSDSKEIV GDGRIVGGSY
1160 1170 1180 1190 1200
TSALQWPFVV AIYRNGKFHC GGTIYSDRWI ISAAHCVINY GKYFYEVRAG
1210 1220 1230 1240 1250
LLRRSSYSPA TQIQPVSHVV VHQAYERRSM RNDLSLLRLL NPLQFNRWVK
1260 1270 1280 1290 1300
PICLPDKGRT TVGDDWIWGP VEHTLCTVVG WGAIREKGPS SDPMRQVIVP
1310 1320 1330 1340 1350
IRKKCTDPED QASEDICAGD PDGGRDACQG DSGGPLFCRS VSNPDEFYLA
1360 1370 1380 1390 1400
GVVSHGNGCA RPQEFGVYTR VTLYLDWLEM ATTPRLLPKL QPLQLCPGFI
1410 1420 1430 1440 1450
CVWGGKRCIA KRQRCDRNVD CLGGEDEVGC TYNFLPDMVG GVRQNISTTT
1460 1470 1480 1490 1500
ESDYHPVKES EEKSKMREVI PIDDEDLKAE QDEEDLLKST TSLGQTETTQ
1510 1520 1530 1540 1550
GPMDLSFAEQ ITSTTSDDLS ITDETTSTDF TVSDSATSPS TLLPTTTNPS
1560 1570 1580 1590 1600
TWLPSTNIET STFSFTTTES EASTKQETLP TTVAQTTTIP TSTEDLKKLT
1610 1620 1630 1640 1650
DLVTEFIEST TFETTMEVET TTLSLTSTDA PKLVTTEGVK ETTTTEDTTT
1660 1670 1680 1690 1700
ISSIVTLTTT PLATISTTIL TTEKHVAVTT LAPTTTTESA KTTTTHSSST
1710 1720 1730 1740 1750
HSEKDQIQIP NKFVCKKMSQ IVDIMMRCDR KVDCEDGTDE LDCTCKDYLK
1760 1770 1780 1790 1800
GSLKGLICDG KADCEDLTDE QNCVECQSNE FRCPLSKTCL PLSSRCDNKV
1810 1820 1830 1840 1850
DCKFKEDEKD CFALTNGHDV HFDVHQQPKF SSTGIFSRNG HGVWRVVCAH
1860 1870 1880 1890 1900
ETGYHEHQAK TADAVCALLG FNGAHYFNSS EFVTQHEMQP ITPELKGGRN
1910 1920 1930 1940 1950
RMSAQIHSMV GDNVQFTENE VIIPELGHPS ASRPEKDRLL PRKCVGIYVE
1960 1970 1980 1990 2000
CNPYSNKTTP LKTFSAGQVV KEKPIEQVPV LSPTIETHNT PNVHFKPQIP
2010 2020 2030 2040 2050
AMVVNKKDEI LDRLDKLIKS KKNKTILVNE QLHEAIEELH WPWLADVYMN
2060 2070 2080 2090 2100
GDLWCIGVLI DKHWVMVHES CLSGIDLETH YVSVLLGGGK TKRSAHRSNH
2110 2120 2130 2140 2150
EQIRRVDCFE GVPKSNVLLL HLERPVRFTH HVLPTFLPDS SHQNQSHARQ
2160 2170 2180 2190 2200
CISVLHDDAT GRIKTVAITR IHNATNCDSC YKLQEKQPPA NLMRLLNVSA
2210 2220 2230 2240 2250
EDMASISEEV ELINGVAPTE LPAITKFTTC NQFGLKNVSD AHHNPSDQGV
2260 2270 2280 2290 2300
LVCRDSHTGW FPTALFNYNN SDCQSFKQPF GIRTLELVYK SLQDIIDKPS
2310 2320 2330 2340 2350
CKMLLPAPDC STHRCPLGTC LPQAAMCNGR SDCHDGSDEE ETKCRQQKQQ
2360 2370 2380 2390 2400
CAPGEMKCRT SFKCVPKSKF CDHVPDCEDM TDEPTICSCF TYLQATDPSK
2410 2420 2430 2440 2450
ICDGKRNCWD KSDESSVLCN CTADHFQCSS SPEDCIPRDF VCDKEKDCPN
2460 2470 2480 2490 2500
GEDERYCFGI EHPLHLQKKD FWTNSQHTQP EIAPQYGQVI EQTYGIWHTK
2510 2520 2530 2540 2550
CFPKSKPPQV DEVREICKKL GYNPYRQPSY RLIDDEENKP VHTYELADRQ
2560 2570 2580 2590 2600
GRSFSNESLM GKYRDSTKAL IISKFSPLQL NERLTLFLKS SRPIAELVRW
2610
NATDSSMCYR LEIRCA
Length:2,616
Mass (Da):292,492
Last modified:May 10, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i052F92CBAE9EB163
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti83I → T in AAA83086 (PubMed:7671306).Curated1
Sequence conflicti120F → L in AAA83086 (PubMed:7671306).Curated1
Sequence conflicti363N → T in AAA83086 (PubMed:7671306).Curated1
Sequence conflicti831Q → R in AAA83086 (PubMed:7671306).Curated1
Sequence conflicti864N → S in AAA83086 (PubMed:7671306).Curated1
Sequence conflicti1150Y → H in AAA83086 (PubMed:7671306).Curated1
Sequence conflicti1344P → A in AAA83086 (PubMed:7671306).Curated1
Sequence conflicti1410A → S in AAA83086 (PubMed:7671306).Curated1
Sequence conflicti1607I → M in AAA83086 (PubMed:7671306).Curated1
Sequence conflicti1632K → I in AAA83086 (PubMed:7671306).Curated1
Sequence conflicti1670L → P in AAA83086 (PubMed:7671306).Curated1
Sequence conflicti1794S → K in AAA83086 (PubMed:7671306).Curated1
Sequence conflicti1863D → N in AAA83086 (PubMed:7671306).Curated1
Sequence conflicti1886 – 1888HEM → QEK in AAA83086 (PubMed:7671306).Curated3
Sequence conflicti1903S → A in AAA83086 (PubMed:7671306).Curated1
Sequence conflicti2147H → N in AAA83086 (PubMed:7671306).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U29153 mRNA Translation: AAA83086.1
AE014296 Genomic DNA Translation: AAF50656.1

Protein sequence database of the Protein Information Resource

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PIRi
A57096

NCBI Reference Sequences

More...
RefSeqi
NP_523947.2, NM_079223.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0076984; FBpp0076693; FBgn0002926

Database of genes from NCBI RefSeq genomes

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GeneIDi
38738

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG10129

UCSC genome browser

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UCSCi
CG10129-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29153 mRNA Translation: AAA83086.1
AE014296 Genomic DNA Translation: AAF50656.1
PIRiA57096
RefSeqiNP_523947.2, NM_079223.2

3D structure databases

SMRiP98159
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi64189, 1 interactor
IntActiP98159, 3 interactors
STRINGi7227.FBpp0076693

Protein family/group databases

MEROPSiS01.013

PTM databases

iPTMnetiP98159

Proteomic databases

PaxDbiP98159
PRIDEiP98159

Genome annotation databases

EnsemblMetazoaiFBtr0076984; FBpp0076693; FBgn0002926
GeneIDi38738
KEGGidme:Dmel_CG10129
UCSCiCG10129-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
38738
FlyBaseiFBgn0002926, ndl

Phylogenomic databases

eggNOGiKOG3627, Eukaryota
HOGENOMiCLU_228608_0_0_1
InParanoidiP98159
OMAiVGWGAIR
OrthoDBi1314811at2759
PhylomeDBiP98159

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
38738, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
38738

Protein Ontology

More...
PROi
PR:P98159

Gene expression databases

BgeeiFBgn0002926, Expressed in egg chamber and 13 other tissues
GenevisibleiP98159, DM

Family and domain databases

CDDicd00112, LDLa, 7 hits
cd00190, Tryp_SPc, 1 hit
Gene3Di2.40.10.10, 3 hits
4.10.400.10, 6 hits
InterProiView protein in InterPro
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR034381, Nudel
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR015420, Peptidase_S1A_nudel
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER
PANTHERiPTHR24258:SF133, PTHR24258:SF133, 1 hit
PfamiView protein in Pfam
PF09342, DUF1986, 1 hit
PF00057, Ldl_recept_a, 4 hits
PF00089, Trypsin, 1 hit
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00192, LDLa, 9 hits
SM00020, Tryp_SPc, 1 hit
SUPFAMiSSF50494, SSF50494, 2 hits
SSF57424, SSF57424, 7 hits
PROSITEiView protein in PROSITE
PS01209, LDLRA_1, 6 hits
PS50068, LDLRA_2, 8 hits
PS50240, TRYPSIN_DOM, 2 hits
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUDEL_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P98159
Secondary accession number(s): Q9VRX5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 10, 2004
Last modified: August 12, 2020
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
  3. Peptidase families
    Classification of peptidase families and list of entries
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