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Protein

Very low-density lipoprotein receptor

Gene

Vldlr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.

Miscellaneous

LRP8 and VLVLR together are required for correct embryonic development in the brain. Targeted disruption of both genes results in a phenotype virtually indistinguishable from that seen in "reeler" and "scrambler" mice. Subtle effects of VLDLR deletion are found mainly in the cerebellum, whereas lack of LRP8 predominantly affects the positioning of the neurons in the neocortex.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processCholesterol metabolism, Endocytosis, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

ReactomeiR-MMU-8866376 Reelin signalling pathway
R-MMU-8866427 VLDLR internalisation and degradation
R-MMU-8964046 VLDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Very low-density lipoprotein receptor
Short name:
VLDL receptor
Short name:
VLDL-R
Gene namesi
Name:Vldlr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:98935 Vldlr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 797ExtracellularSequence analysisAdd BLAST770
Transmembranei798 – 819HelicalSequence analysisAdd BLAST22
Topological domaini820 – 873CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Coated pit, Membrane, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001734428 – 873Very low-density lipoprotein receptorAdd BLAST846

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 45By similarity
Disulfide bondi40 ↔ 58By similarity
Disulfide bondi52 ↔ 67By similarity
Disulfide bondi72 ↔ 84By similarity
Disulfide bondi79 ↔ 97By similarity
Disulfide bondi91 ↔ 108By similarity
Disulfide bondi113 ↔ 127By similarity
Disulfide bondi120 ↔ 140By similarity
Disulfide bondi134 ↔ 149By similarity
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi154 ↔ 166By similarity
Disulfide bondi161 ↔ 179By similarity
Disulfide bondi173 ↔ 188By similarity
Disulfide bondi193 ↔ 205By similarity
Disulfide bondi200 ↔ 218By similarity
Disulfide bondi212 ↔ 229By similarity
Disulfide bondi239 ↔ 251By similarity
Disulfide bondi246 ↔ 264By similarity
Disulfide bondi258 ↔ 273By similarity
Disulfide bondi278 ↔ 290By similarity
Disulfide bondi285 ↔ 303By similarity
Disulfide bondi297 ↔ 312By similarity
Disulfide bondi318 ↔ 331By similarity
Disulfide bondi326 ↔ 344By similarity
Disulfide bondi338 ↔ 355By similarity
Disulfide bondi360 ↔ 371By similarity
Disulfide bondi367 ↔ 380By similarity
Disulfide bondi382 ↔ 394By similarity
Disulfide bondi400 ↔ 410By similarity
Disulfide bondi406 ↔ 419By similarity
Disulfide bondi421 ↔ 434By similarity
Disulfide bondi706 ↔ 719By similarity
Disulfide bondi715 ↔ 734By similarity
Disulfide bondi736 ↔ 749By similarity
Glycosylationi765N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi781N-linked (GlcNAc...) asparagineSequence analysis1
Cross-linki839Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitinated at Lys-839 by MYLIP leading to degradation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP98156
PaxDbiP98156
PeptideAtlasiP98156
PRIDEiP98156

PTM databases

iPTMnetiP98156
PhosphoSitePlusiP98156

Expressioni

Tissue specificityi

Abundant in heart and muscle; less in kidney, brain, ovary, testis, lung and adipose tissue.

Gene expression databases

BgeeiENSMUSG00000024924 Expressed in 323 organ(s), highest expression level in decidua
CleanExiMM_VLDLR
ExpressionAtlasiP98156 baseline and differential
GenevisibleiP98156 MM

Interactioni

Subunit structurei

Binds to the extracellular matrix protein Reelin. Interacts with DAB1. Interacts with VLDLR. Interacts with SNX17. Interacts with PCSK9 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204529, 3 interactors
DIPiDIP-33283N
IntActiP98156, 3 interactors
MINTiP98156
STRINGi10090.ENSMUSP00000127329

Structurei

3D structure databases

ProteinModelPortaliP98156
SMRiP98156
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 69LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST39
Domaini70 – 110LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST41
Domaini111 – 151LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST41
Domaini152 – 190LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST39
Domaini191 – 231LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST41
Domaini237 – 275LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST39
Domaini276 – 314LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST39
Domaini316 – 355LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST40
Domaini356 – 391EGF-like 1PROSITE-ProRule annotationAdd BLAST36
Domaini396 – 431EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Repeati439 – 480LDL-receptor class B 1Add BLAST42
Repeati481 – 524LDL-receptor class B 2Add BLAST44
Repeati525 – 567LDL-receptor class B 3Add BLAST43
Repeati568 – 611LDL-receptor class B 4Add BLAST44
Repeati612 – 654LDL-receptor class B 5Add BLAST43
Repeati655 – 697LDL-receptor class B 6Add BLAST43
Domaini702 – 750EGF-like 3PROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni751 – 790Clustered O-linked oligosaccharidesAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi832 – 837Endocytosis signalSequence analysis6

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPT5 Eukaryota
ENOG410YQ6J LUCA
GeneTreeiENSGT00760000118968
HOGENOMiHOG000115656
HOVERGENiHBG006250
InParanoidiP98156
KOiK20053
OrthoDBiEOG091G01MX
PhylomeDBiP98156
TreeFamiTF351700

Family and domain databases

CDDicd00112 LDLa, 8 hits
Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
IPR032931 VLDLR
PANTHERiPTHR43966:SF6 PTHR43966:SF6, 1 hit
PfamiView protein in Pfam
PF07645 EGF_CA, 1 hit
PF00057 Ldl_recept_a, 8 hits
PF00058 Ldl_recept_b, 5 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00181 EGF, 6 hits
SM00179 EGF_CA, 2 hits
SM00192 LDLa, 8 hits
SM00135 LY, 5 hits
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57424 SSF57424, 8 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS01209 LDLRA_1, 8 hits
PS50068 LDLRA_2, 8 hits
PS51120 LDLRB, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P98156-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTSARWALW LLLALCWAPR DSGATASGKK AKCDSSQFQC TNGRCITLLW
60 70 80 90 100
KCDGDEDCAD GSDEKNCVKK TCAESDFVCK NGQCVPNRWQ CDGDPDCEDG
110 120 130 140 150
SDESPEQCHM RTCRINEISC GARSTQCIPV SWRCDGENDC DNGEDEENCG
160 170 180 190 200
NITCSADEFT CSSGRCVSRN FVCNGQDDCD DGSDELDCAP PTCGAHEFQC
210 220 230 240 250
STSSCIPLSW VCDDDADCSD QSDESLEQCG RQPVIHTKCP TSEIQCGSGE
260 270 280 290 300
CIHKKWRCDG DPDCKDGSDE VNCPSRTCRP DQFECEDGSC IHGSRQCNGI
310 320 330 340 350
RDCVDGSDEV NCKNVNQCLG PGKFKCRSGE CIDMSKVCDQ EQDCRDWSDE
360 370 380 390 400
PLKECHINEC LVNNGGCSHI CKDLVIGYEC DCAAGFELID RKTCGDIDEC
410 420 430 440 450
QNPGICSQIC INLKGGYKCE CSRGYQMDLA TGVCKAVGKE PSLIFTNRRD
460 470 480 490 500
IRKIGLERKE YIQLVEQLRN TVALDADIAA QKLFWADLSQ KAIFSASIDD
510 520 530 540 550
KVGRHFKMID NVYNPAAIAV DWVYKTIYWT DAASKTISVA TLDGAKRKFL
560 570 580 590 600
FNSDLREPAS IAVDPLSGFV YWSDWGEPAK IEKAGMNGFD RRPLVTEDIQ
610 620 630 640 650
WPNGITLDLV KSRLYWLDSK LHMLSSVDLN GQDRRIVLKS LEFLAHPLAL
660 670 680 690 700
TIFEDRVYWI DGENEAVYGA NKFTGSELAT LVNNLNDAQD IIVYHELVQP
710 720 730 740 750
SGKNWCEDDM ENGGCEYLCL PAPQINDHSP KYTCSCPNGY NLEENGRECQ
760 770 780 790 800
STSTPVTYSE TKDINTTDIL RTSGLVPGGI NVTTAVSEVS VPPKGTSAAW
810 820 830 840 850
AILPLLLLVM AAVGGYLMWR NWQHKNMKSM NFDNPVYLKT TEEDLSIDIG
860 870
RHSASVGHTY PAISVVSTDD DLA
Length:873
Mass (Da):96,373
Last modified:October 1, 1996 - v1
Checksum:i08F09F93825195CB
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WGI9F8WGI9_MOUSE
Very low-density lipoprotein recept...
Vldlr
804Annotation score:
Q91YY0Q91YY0_MOUSE
Very low-density lipoprotein recept...
Vldlr
845Annotation score:
F8WIN7F8WIN7_MOUSE
Very low-density lipoprotein recept...
Vldlr
498Annotation score:
E9Q643E9Q643_MOUSE
Very low-density lipoprotein recept...
Vldlr
89Annotation score:
F6RKS4F6RKS4_MOUSE
Very low-density lipoprotein recept...
Vldlr
258Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161C → G in AAC37668 (PubMed:7925422).Curated1
Sequence conflicti262P → L in AAB32228 (PubMed:7919660).Curated1
Sequence conflicti297C → S in AAA59384 (PubMed:8013374).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33417 mRNA Translation: AAC37668.1
U06670 mRNA Translation: AAA59384.1
S73732 Genomic DNA Translation: AAB32228.2
CCDSiCCDS29721.1
PIRiI48952
RefSeqiNP_001154892.1, NM_001161420.1
NP_038731.2, NM_013703.2
XP_006526980.1, XM_006526917.1
XP_006526981.1, XM_006526918.2
UniGeneiMm.4141

Genome annotation databases

EnsembliENSMUST00000167487; ENSMUSP00000127329; ENSMUSG00000024924
GeneIDi22359
KEGGimmu:22359
UCSCiuc008hbt.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33417 mRNA Translation: AAC37668.1
U06670 mRNA Translation: AAA59384.1
S73732 Genomic DNA Translation: AAB32228.2
CCDSiCCDS29721.1
PIRiI48952
RefSeqiNP_001154892.1, NM_001161420.1
NP_038731.2, NM_013703.2
XP_006526980.1, XM_006526917.1
XP_006526981.1, XM_006526918.2
UniGeneiMm.4141

3D structure databases

ProteinModelPortaliP98156
SMRiP98156
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204529, 3 interactors
DIPiDIP-33283N
IntActiP98156, 3 interactors
MINTiP98156
STRINGi10090.ENSMUSP00000127329

PTM databases

iPTMnetiP98156
PhosphoSitePlusiP98156

Proteomic databases

MaxQBiP98156
PaxDbiP98156
PeptideAtlasiP98156
PRIDEiP98156

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167487; ENSMUSP00000127329; ENSMUSG00000024924
GeneIDi22359
KEGGimmu:22359
UCSCiuc008hbt.2 mouse

Organism-specific databases

CTDi7436
MGIiMGI:98935 Vldlr

Phylogenomic databases

eggNOGiENOG410IPT5 Eukaryota
ENOG410YQ6J LUCA
GeneTreeiENSGT00760000118968
HOGENOMiHOG000115656
HOVERGENiHBG006250
InParanoidiP98156
KOiK20053
OrthoDBiEOG091G01MX
PhylomeDBiP98156
TreeFamiTF351700

Enzyme and pathway databases

ReactomeiR-MMU-8866376 Reelin signalling pathway
R-MMU-8866427 VLDLR internalisation and degradation
R-MMU-8964046 VLDL clearance

Miscellaneous databases

PROiPR:P98156
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024924 Expressed in 323 organ(s), highest expression level in decidua
CleanExiMM_VLDLR
ExpressionAtlasiP98156 baseline and differential
GenevisibleiP98156 MM

Family and domain databases

CDDicd00112 LDLa, 8 hits
Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
IPR032931 VLDLR
PANTHERiPTHR43966:SF6 PTHR43966:SF6, 1 hit
PfamiView protein in Pfam
PF07645 EGF_CA, 1 hit
PF00057 Ldl_recept_a, 8 hits
PF00058 Ldl_recept_b, 5 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00181 EGF, 6 hits
SM00179 EGF_CA, 2 hits
SM00192 LDLa, 8 hits
SM00135 LY, 5 hits
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57424 SSF57424, 8 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS01209 LDLRA_1, 8 hits
PS50068 LDLRA_2, 8 hits
PS51120 LDLRB, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiVLDLR_MOUSE
AccessioniPrimary (citable) accession number: P98156
Secondary accession number(s): Q64022
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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