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Protein

Very low-density lipoprotein receptor

Gene

VLDLR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processCholesterol metabolism, Endocytosis, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-8866376 Reelin signalling pathway
R-HSA-8866427 VLDLR internalisation and degradation
R-HSA-8964046 VLDL clearance

SIGNOR Signaling Network Open Resource

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SIGNORi
P98155

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Very low-density lipoprotein receptor
Short name:
VLDL receptor
Short name:
VLDL-R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VLDLR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000147852.15

Human Gene Nomenclature Database

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HGNCi
HGNC:12698 VLDLR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
192977 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P98155

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 797ExtracellularSequence analysisAdd BLAST770
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei798 – 819HelicalSequence analysisAdd BLAST22
Topological domaini820 – 873CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Coated pit, Membrane, VLDL

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 1 (CAMRQ1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation, cerebellar hypoplasia and mild cerebral gyral simplification. Additional features include short stature, strabismus, pes planus and, rarely, seizures.
See also OMIM:224050

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi825K → R: Insensitive to MYLIP-triggered degradation; when associated with R-828 and R-839. 1 Publication1
Mutagenesisi828K → R: Insensitive to MYLIP-triggered degradation; when associated with R-825 and R-839. 1 Publication1
Mutagenesisi839K → R: Insensitive to MYLIP-triggered degradation. Insensitive to MYLIP-triggered degradation; when associated with R-825 and R-828. 1 Publication1

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7436

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
VLDLR

MalaCards human disease database

More...
MalaCardsi
VLDLR
MIMi224050 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000147852

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1766 Dysequilibrium syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37317

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB03017 Lauric Acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VLDLR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1730111

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001734328 – 873Very low-density lipoprotein receptorAdd BLAST846

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi33 ↔ 45By similarity
Disulfide bondi40 ↔ 58By similarity
Disulfide bondi52 ↔ 67By similarity
Disulfide bondi72 ↔ 84By similarity
Disulfide bondi79 ↔ 97By similarity
Disulfide bondi91 ↔ 108By similarity
Disulfide bondi113 ↔ 127
Disulfide bondi120 ↔ 140
Disulfide bondi134 ↔ 149
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi154 ↔ 166By similarity
Disulfide bondi161 ↔ 179By similarity
Disulfide bondi173 ↔ 188By similarity
Disulfide bondi193 ↔ 205By similarity
Disulfide bondi200 ↔ 218By similarity
Disulfide bondi212 ↔ 229By similarity
Disulfide bondi239 ↔ 251By similarity
Disulfide bondi246 ↔ 264By similarity
Disulfide bondi258 ↔ 273By similarity
Disulfide bondi278 ↔ 290By similarity
Disulfide bondi285 ↔ 303By similarity
Disulfide bondi297 ↔ 312By similarity
Disulfide bondi318 ↔ 331By similarity
Disulfide bondi326 ↔ 344By similarity
Disulfide bondi338 ↔ 355By similarity
Disulfide bondi360 ↔ 371By similarity
Disulfide bondi367 ↔ 380By similarity
Disulfide bondi382 ↔ 394By similarity
Disulfide bondi400 ↔ 410By similarity
Disulfide bondi406 ↔ 419By similarity
Disulfide bondi421 ↔ 434By similarity
Disulfide bondi706 ↔ 719By similarity
Disulfide bondi715 ↔ 734By similarity
Disulfide bondi736 ↔ 749By similarity
Glycosylationi765N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi781N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki839Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated at Lys-839 by MYLIP leading to degradation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P98155

MaxQB - The MaxQuant DataBase

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MaxQBi
P98155

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P98155

PeptideAtlas

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PeptideAtlasi
P98155

PRoteomics IDEntifications database

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PRIDEi
P98155

ProteomicsDB human proteome resource

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ProteomicsDBi
57794
57795 [P98155-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P98155

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P98155

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147852 Expressed in 211 organ(s), highest expression level in female gonad

CleanEx database of gene expression profiles

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CleanExi
HS_VLDLR

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P98155 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P98155 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB032462
HPA051312

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to the extracellular matrix protein Reelin. Interacts with VLDLR. Interacts with SNX17 (By similarity). Interacts with DAB1. Receptor for the minor-group human rhinoviruses (HRVs); binds protein VP1 through the second and third LDL-receptor class A domains. Interacts with PCSK9.By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113277, 12 interactors

Database of interacting proteins

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DIPi
DIP-40925N

Protein interaction database and analysis system

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IntActi
P98155, 5 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000371532

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1873
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P98155

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P98155

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P98155

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 69LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST39
Domaini70 – 110LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST41
Domaini111 – 151LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST41
Domaini152 – 190LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST39
Domaini191 – 231LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST41
Domaini237 – 275LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST39
Domaini276 – 314LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST39
Domaini316 – 355LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST40
Domaini356 – 395EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini396 – 435EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati439 – 480LDL-receptor class B 1Add BLAST42
Repeati481 – 524LDL-receptor class B 2Add BLAST44
Repeati525 – 567LDL-receptor class B 3Add BLAST43
Repeati568 – 611LDL-receptor class B 4Add BLAST44
Repeati612 – 654LDL-receptor class B 5Add BLAST43
Repeati655 – 697LDL-receptor class B 6Add BLAST43
Domaini702 – 750EGF-like 3PROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni751 – 790Clustered O-linked oligosaccharidesAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi832 – 837Endocytosis signalSequence analysis6

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPT5 Eukaryota
ENOG410YQ6J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155460

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000115656

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006250

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P98155

KEGG Orthology (KO)

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KOi
K20053

Identification of Orthologs from Complete Genome Data

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OMAi
PCLPHEY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01MX

Database for complete collections of gene phylogenies

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PhylomeDBi
P98155

TreeFam database of animal gene trees

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TreeFami
TF351700

Family and domain databases

Conserved Domains Database

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CDDi
cd00112 LDLa, 8 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.120.10.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
IPR032931 VLDLR

The PANTHER Classification System

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PANTHERi
PTHR43966:SF6 PTHR43966:SF6, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07645 EGF_CA, 1 hit
PF00057 Ldl_recept_a, 8 hits
PF00058 Ldl_recept_b, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 6 hits
SM00179 EGF_CA, 2 hits
SM00192 LDLa, 8 hits
SM00135 LY, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57424 SSF57424, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS01209 LDLRA_1, 8 hits
PS50068 LDLRA_2, 8 hits
PS51120 LDLRB, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Long (identifier: P98155-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTSALWALW LLLALCWAPR ESGATGTGRK AKCEPSQFQC TNGRCITLLW
60 70 80 90 100
KCDGDEDCVD GSDEKNCVKK TCAESDFVCN NGQCVPSRWK CDGDPDCEDG
110 120 130 140 150
SDESPEQCHM RTCRIHEISC GAHSTQCIPV SWRCDGENDC DSGEDEENCG
160 170 180 190 200
NITCSPDEFT CSSGRCISRN FVCNGQDDCS DGSDELDCAP PTCGAHEFQC
210 220 230 240 250
STSSCIPISW VCDDDADCSD QSDESLEQCG RQPVIHTKCP ASEIQCGSGE
260 270 280 290 300
CIHKKWRCDG DPDCKDGSDE VNCPSRTCRP DQFECEDGSC IHGSRQCNGI
310 320 330 340 350
RDCVDGSDEV NCKNVNQCLG PGKFKCRSGE CIDISKVCNQ EQDCRDWSDE
360 370 380 390 400
PLKECHINEC LVNNGGCSHI CKDLVIGYEC DCAAGFELID RKTCGDIDEC
410 420 430 440 450
QNPGICSQIC INLKGGYKCE CSRGYQMDLA TGVCKAVGKE PSLIFTNRRD
460 470 480 490 500
IRKIGLERKE YIQLVEQLRN TVALDADIAA QKLFWADLSQ KAIFSASIDD
510 520 530 540 550
KVGRHVKMID NVYNPAAIAV DWVYKTIYWT DAASKTISVA TLDGTKRKFL
560 570 580 590 600
FNSDLREPAS IAVDPLSGFV YWSDWGEPAK IEKAGMNGFD RRPLVTADIQ
610 620 630 640 650
WPNGITLDLI KSRLYWLDSK LHMLSSVDLN GQDRRIVLKS LEFLAHPLAL
660 670 680 690 700
TIFEDRVYWI DGENEAVYGA NKFTGSELAT LVNNLNDAQD IIVYHELVQP
710 720 730 740 750
SGKNWCEEDM ENGGCEYLCL PAPQINDHSP KYTCSCPSGY NVEENGRDCQ
760 770 780 790 800
STATTVTYSE TKDTNTTEIS ATSGLVPGGI NVTTAVSEVS VPPKGTSAAW
810 820 830 840 850
AILPLLLLVM AAVGGYLMWR NWQHKNMKSM NFDNPVYLKT TEEDLSIDIG
860 870
RHSASVGHTY PAISVVSTDD DLA
Length:873
Mass (Da):96,098
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8BAC29438A78C2B8
GO
Isoform Short (identifier: P98155-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     751-779: STATTVTYSETKDTNTTEISATSGLVPGG → R

Show »
Length:845
Mass (Da):93,383
Checksum:i588311D7C6B2C1FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VVF8Q5VVF8_HUMAN
Very low-density lipoprotein recept...
VLDLR
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9L → V in AAA53684 (PubMed:8128315).Curated1
Sequence conflicti13L → V in AAA61344 (PubMed:8020981).Curated1
Sequence conflicti424G → A in AAA53684 (PubMed:8128315).Curated1
Sequence conflicti678L → H in AAA53684 (PubMed:8128315).Curated1
Sequence conflicti766T → S in AAA61344 (PubMed:8020981).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01186559V → I2 PublicationsCorresponds to variant dbSNP:rs6149EnsemblClinVar.1
Natural variantiVAR_025063262P → H1 PublicationCorresponds to variant dbSNP:rs34761707Ensembl.1
Natural variantiVAR_011866379E → K1 PublicationCorresponds to variant dbSNP:rs6146Ensembl.1
Natural variantiVAR_025064464L → I1 PublicationCorresponds to variant dbSNP:rs34753566Ensembl.1
Natural variantiVAR_025065561I → V1 PublicationCorresponds to variant dbSNP:rs35724190Ensembl.1
Natural variantiVAR_025066613R → H1 PublicationCorresponds to variant dbSNP:rs35948251EnsemblClinVar.1
Natural variantiVAR_025067791V → I1 PublicationCorresponds to variant dbSNP:rs35334949EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004304751 – 779STATT…LVPGG → R in isoform Short. CuratedAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L20470 mRNA Translation: AAA53684.1
S73849 mRNA Translation: AAB31735.1
D16532 Genomic DNA Translation: BAA03969.1
D16493 mRNA Translation: BAA03945.1
D16494 mRNA Translation: BAA03946.1
L22431 mRNA Translation: AAA61344.1
DQ067198 Genomic DNA Translation: AAY46157.1
AL450467 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58805.1
CH471071 Genomic DNA Translation: EAW58806.1
BC136562 mRNA Translation: AAI36563.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34979.1 [P98155-2]
CCDS6446.1 [P98155-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A49729

NCBI Reference Sequences

More...
RefSeqi
NP_001018066.1, NM_001018056.2 [P98155-2]
NP_003374.3, NM_003383.4 [P98155-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.370422

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000382099; ENSP00000371531; ENSG00000147852 [P98155-2]
ENST00000382100; ENSP00000371532; ENSG00000147852 [P98155-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7436

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7436

UCSC genome browser

More...
UCSCi
uc003zhk.2 human [P98155-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20470 mRNA Translation: AAA53684.1
S73849 mRNA Translation: AAB31735.1
D16532 Genomic DNA Translation: BAA03969.1
D16493 mRNA Translation: BAA03945.1
D16494 mRNA Translation: BAA03946.1
L22431 mRNA Translation: AAA61344.1
DQ067198 Genomic DNA Translation: AAY46157.1
AL450467 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58805.1
CH471071 Genomic DNA Translation: EAW58806.1
BC136562 mRNA Translation: AAI36563.1
CCDSiCCDS34979.1 [P98155-2]
CCDS6446.1 [P98155-1]
PIRiA49729
RefSeqiNP_001018066.1, NM_001018056.2 [P98155-2]
NP_003374.3, NM_003383.4 [P98155-1]
UniGeneiHs.370422

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V9UX-ray3.605111-151[»]
3DPRX-ray3.50E113-151[»]
6BYVNMR-A70-190[»]
ProteinModelPortaliP98155
SMRiP98155
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113277, 12 interactors
DIPiDIP-40925N
IntActiP98155, 5 interactors
STRINGi9606.ENSP00000371532

Chemistry databases

DrugBankiDB03017 Lauric Acid

PTM databases

iPTMnetiP98155
PhosphoSitePlusiP98155

Polymorphism and mutation databases

BioMutaiVLDLR
DMDMi1730111

Proteomic databases

EPDiP98155
MaxQBiP98155
PaxDbiP98155
PeptideAtlasiP98155
PRIDEiP98155
ProteomicsDBi57794
57795 [P98155-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382099; ENSP00000371531; ENSG00000147852 [P98155-2]
ENST00000382100; ENSP00000371532; ENSG00000147852 [P98155-1]
GeneIDi7436
KEGGihsa:7436
UCSCiuc003zhk.2 human [P98155-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7436
DisGeNETi7436
EuPathDBiHostDB:ENSG00000147852.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
VLDLR
GeneReviewsiVLDLR
HGNCiHGNC:12698 VLDLR
HPAiCAB032462
HPA051312
MalaCardsiVLDLR
MIMi192977 gene
224050 phenotype
neXtProtiNX_P98155
OpenTargetsiENSG00000147852
Orphaneti1766 Dysequilibrium syndrome
PharmGKBiPA37317

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPT5 Eukaryota
ENOG410YQ6J LUCA
GeneTreeiENSGT00940000155460
HOGENOMiHOG000115656
HOVERGENiHBG006250
InParanoidiP98155
KOiK20053
OMAiPCLPHEY
OrthoDBiEOG091G01MX
PhylomeDBiP98155
TreeFamiTF351700

Enzyme and pathway databases

ReactomeiR-HSA-8866376 Reelin signalling pathway
R-HSA-8866427 VLDLR internalisation and degradation
R-HSA-8964046 VLDL clearance
SIGNORiP98155

Miscellaneous databases

EvolutionaryTraceiP98155

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
VLDL_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7436

Protein Ontology

More...
PROi
PR:P98155

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147852 Expressed in 211 organ(s), highest expression level in female gonad
CleanExiHS_VLDLR
ExpressionAtlasiP98155 baseline and differential
GenevisibleiP98155 HS

Family and domain databases

CDDicd00112 LDLa, 8 hits
Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
IPR032931 VLDLR
PANTHERiPTHR43966:SF6 PTHR43966:SF6, 1 hit
PfamiView protein in Pfam
PF07645 EGF_CA, 1 hit
PF00057 Ldl_recept_a, 8 hits
PF00058 Ldl_recept_b, 5 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00181 EGF, 6 hits
SM00179 EGF_CA, 2 hits
SM00192 LDLa, 8 hits
SM00135 LY, 5 hits
SUPFAMiSSF57424 SSF57424, 8 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS01209 LDLRA_1, 8 hits
PS50068 LDLRA_2, 8 hits
PS51120 LDLRB, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVLDLR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P98155
Secondary accession number(s): B2RMZ7, D3DRH6, Q5VVF6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 5, 2018
This is version 193 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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