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Protein

Integral membrane protein DGCR2/IDD

Gene

Dgcr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cognition Source: MGI
  • response to drug Source: MGI

Keywordsi

Molecular functionReceptor
Biological processCell adhesion
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein DGCR2/IDD
Alternative name(s):
Seizure-related membrane-bound adhesion protein
Gene namesi
Name:Dgcr2
Synonyms:Dgsc, Idd, Sez-12, Sez12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:892866 Dgcr2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 347ExtracellularSequence analysisAdd BLAST323
Transmembranei348 – 366HelicalSequence analysisAdd BLAST19
Topological domaini367 – 548CytoplasmicSequence analysisAdd BLAST182

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000002148525 – 548Integral membrane protein DGCR2/IDDAdd BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 44By similarity
Disulfide bondi37 ↔ 57By similarity
Disulfide bondi51 ↔ 66By similarity
Disulfide bondi143 ↔ 263By similarity
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi236 ↔ 255By similarity
Modified residuei379PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP98154
PaxDbiP98154
PRIDEiP98154

PTM databases

iPTMnetiP98154
PhosphoSitePlusiP98154

Expressioni

Tissue specificityi

Ubiquitous in various organs with low abundance.

Gene expression databases

CleanExiMM_DGCR2

Structurei

3D structure databases

ProteinModelPortaliP98154
SMRiP98154
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 68LDL-receptor class APROSITE-ProRule annotationAdd BLAST41
Domaini113 – 239C-type lectinPROSITE-ProRule annotationAdd BLAST127
Domaini268 – 331VWFCAdd BLAST64

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J28G Eukaryota
ENOG4111WJC LUCA
HOGENOMiHOG000112997
HOVERGENiHBG006117
InParanoidiP98154
PhylomeDBiP98154

Family and domain databases

CDDicd03599 CLECT_DGCR2_like, 1 hit
cd00112 LDLa, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR034010 DGCR2-like_CTLD
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 1 hit
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00192 LDLa, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57424 SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS01208 VWFC_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P98154-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPKADSGAF LLLFLLVLTV TEPLRPELRC NPGQFACHGG TIQCIPLPWQ
60 70 80 90 100
CDGWPTCEDK SDEADCPVTG EARPYGKETV DLRQGRARGG DPTHFHTVNV
110 120 130 140 150
AQPVRFSSFL GKCPSGWHHY EGTASCYRVY LSGENYWDAA QTCQRVNGSL
160 170 180 190 200
ATFSTDQELR FVLAQEWDQP ERSFGWKDQR KLWVGYQYVI TGRNHSLEGR
210 220 230 240 250
WEVAFKGSPE VFLPPDPIFA SAMSENDNVF CAQLQCFHFP TLRHHDLHSW
260 270 280 290 300
HAESCSEKSS FLCKRSQTCV DIKDNVVDEG FYFTPKGDDP CLSCTCHRGE
310 320 330 340 350
PEMCVAALCE RPQGCQQYRK DPKECCKFMC LDPDGSSLFD SMASGMRLVV
360 370 380 390 400
SCISSFLILS LLLFMVHRLA QRRRERIESL IGANLHHFNL GRRIPGFDYG
410 420 430 440 450
PDGFGTGLTP LHLSDDGEGG TFHFHDPPPP YTAYKYPDMD QPDDPPPPYE
460 470 480 490 500
ASINPDSVFY DPADDDAFEP VEASLPAPRD GGIEGALPRH LDQPLPPAET
510 520 530 540
SLADLEDSTD SSSALLVPPD PAQSGSTPAT EAPPGGGRLP RASLNTVV
Length:548
Mass (Da):60,697
Last modified:October 1, 1996 - v1
Checksum:i77AF5CA839F6B817
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P5A9Q6P5A9_MOUSE
DiGeorge syndrome critical region g...
Dgcr2 mCG_131834
549Annotation score:
E9QNU3E9QNU3_MOUSE
Integral membrane protein DGCR2/IDD
Dgcr2
548Annotation score:
A0A0R4J1M6A0A0R4J1M6_MOUSE
DiGeorge syndrome critical region g...
Dgcr2 mCG_131834
546Annotation score:
Q8C2R4Q8C2R4_MOUSE
DiGeorge syndrome critical region g...
Dgcr2 mCG_131834
478Annotation score:
A0A338P7A8A0A338P7A8_MOUSE
DiGeorge syndrome critical region g...
Dgcr2 mCG_131834
326Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67P → PE in BAA11460 (PubMed:8630060).Curated1
Sequence conflicti108 – 111SFLG → R in BAA11460 (PubMed:8630060).Curated4
Sequence conflicti370A → R in BAA11460 (PubMed:8630060).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95480 mRNA Translation: CAA64749.1
D78641 mRNA Translation: BAA11460.1
PIRiJC4798
RefSeqiNP_001103220.1, NM_001109750.1
UniGeneiMm.254515

Genome annotation databases

GeneIDi13356
KEGGimmu:13356

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

IDD

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95480 mRNA Translation: CAA64749.1
D78641 mRNA Translation: BAA11460.1
PIRiJC4798
RefSeqiNP_001103220.1, NM_001109750.1
UniGeneiMm.254515

3D structure databases

ProteinModelPortaliP98154
SMRiP98154
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP98154
PhosphoSitePlusiP98154

Proteomic databases

MaxQBiP98154
PaxDbiP98154
PRIDEiP98154

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13356
KEGGimmu:13356

Organism-specific databases

CTDi9993
MGIiMGI:892866 Dgcr2

Phylogenomic databases

eggNOGiENOG410J28G Eukaryota
ENOG4111WJC LUCA
HOGENOMiHOG000112997
HOVERGENiHBG006117
InParanoidiP98154
PhylomeDBiP98154

Miscellaneous databases

ChiTaRSiDgcr2 mouse
PROiPR:P98154
SOURCEiSearch...

Gene expression databases

CleanExiMM_DGCR2

Family and domain databases

CDDicd03599 CLECT_DGCR2_like, 1 hit
cd00112 LDLa, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR034010 DGCR2-like_CTLD
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 1 hit
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00192 LDLa, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57424 SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS01208 VWFC_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIDD_MOUSE
AccessioniPrimary (citable) accession number: P98154
Secondary accession number(s): Q61844
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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