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Entry version 185 (07 Oct 2020)
Sequence version 2 (01 Jun 2001)
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Protein

Dorsal-related immunity factor Dif

Gene

Dif

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates an immune response in larvae (PubMed:8242747). DIF binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of the immunity gene CECA1 (PubMed:8242747). Involved in the melanization immune response to bacterial challenge, possibly by acting in a Toll signaling pathway that downregulates Spn27A in response to infection (PubMed:12456640). Part of a signaling pathway involving NF-kappa-B (rel) and Toll-related receptors, that functions in the apoptosis of unfit cells during cell competition (PubMed:25477468). May be part of a NF-kappa-B and Tollo signaling cascade that regulates development of the peripheral nervous system (PubMed:18000549).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1169091, Activation of NF-kappaB in B cells
R-DME-1810476, RIP-mediated NFkB activation via ZBP1
R-DME-202424, Downstream TCR signaling
R-DME-209400, Transcriptional activtion by phosphorylated DL/DIF dimer
R-DME-209406, Degradation of NF-kappa-B inhibitor, CACT
R-DME-209560, NF-kB is activated and signals survival
R-DME-214842, DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'
R-DME-214844, DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'
R-DME-214869, Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'
R-DME-2871837, FCERI mediated NF-kB activation
R-DME-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-DME-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-DME-4755510, SUMOylation of immune response proteins
R-DME-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764, CLEC7A (Dectin-1) signaling
R-DME-5621575, CD209 (DC-SIGN) signaling
R-DME-5676590, NIK-->noncanonical NF-kB signaling
R-DME-6798695, Neutrophil degranulation
R-DME-9020702, Interleukin-1 signaling
R-DME-933542, TRAF6 mediated NF-kB activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dorsal-related immunity factor Dif
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DifImported
ORF Names:CG6794Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0011274, Dif

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi181G → D in Dif1; immune response defective. Reduced survival following infection with fungi, and reduced levels of Drs following immune challenge with fungi or bacteria. No down-regulation of the serpin Spn27A in response to bacterial infection. Ectopic bristles form on the dorsocentral, scutellar and lateral regions of the notum. 3 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002051631 – 667Dorsal-related immunity factor DifAdd BLAST667

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei343Phosphoserine; by PKASequence analysis1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P98149

PRoteomics IDEntifications database

More...
PRIDEi
P98149

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0011274, Expressed in digestive system element and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P98149, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P98149, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
61041, 10 interactors

Database of interacting proteins

More...
DIPi
DIP-34965N

Protein interaction database and analysis system

More...
IntActi
P98149, 6 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0290792

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P98149

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 372RHDPROSITE-ProRule annotationAdd BLAST295

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi364 – 368Nuclear localization signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi548 – 560Asn-richAdd BLAST13
Compositional biasi582 – 622Gln-richAdd BLAST41

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQS6, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171058

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_452907_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P98149

KEGG Orthology (KO)

More...
KOi
K09254

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P98149

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.340, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011363, Dif
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR000451, NFkB/Dor
IPR008967, p53-like_TF_DNA-bd
IPR030492, RHD_CS
IPR032397, RHD_dimer
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24169, PTHR24169, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16179, RHD_dimer, 1 hit
PF00554, RHD_DNA_bind, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001716, Dorsal, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00057, NFKBTNSCPFCT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429, IPT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01204, REL_1, 1 hit
PS50254, REL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P98149-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFEEAFGDIQ EIINASMELN GGATGGGSVA GAVGGGGAAH HILSQSTSLP
60 70 80 90 100
VMPSHIPLHL QNQNMNQNLP EPSARSGPHL RIVEEPTSNI IRFRYKCEGR
110 120 130 140 150
TAGSIPGMNS SSETGKTFPT IEVCNYDGPV IIVVSCVTSD EPFRQHPHWL
160 170 180 190 200
VSKEEADACK SGIYQKKLPP EERRLVLQKV GIQCAKKLEM RDSLVERERR
210 220 230 240 250
NIDPFNAKFD HKDQIDKINR YELRLCYQAF ITVGNSKVPL DPIVSSPIYG
260 270 280 290 300
KSSELTITRL CSCAATANGG DEIIMLCEKI AKDDIEVRFY ETDKDGRETW
310 320 330 340 350
FANAEFQPTD VFKQMAIAFK TPRYRNTEIT QSVNVELKLV RPSDGATSAP
360 370 380 390 400
LPFEYYPNPE LLTKHNRRVA QKTVESLKRS LMSTNLHPSK QVKTSSQYTI
410 420 430 440 450
FSKPQIATTT PQTQVSPGMP LMFPGGSPNF VQDIKMENGF MDVDSQSSQC
460 470 480 490 500
PSVERNFASP RSNCSTVDSI PPMQMGQNQT HLYLPDATNF TFNGNFASPS
510 520 530 540 550
SNCSTVDSIP PFQIGQRNNH MYLPENSNFP VNGCSPTHFS GGSMTPINNN
560 570 580 590 600
NNVLINNNNN DFLSQKMSAI SIPPQGNFGI KQVYQQTQQF LPQLQPESIP
610 620 630 640 650
YLAQSHPEQS QYQQQQQPQE QQPPADEPTQ SFSDLISSSI GMAPIDTSEL
660
IQDIEAELNS LGIQPFK
Length:667
Mass (Da):73,935
Last modified:June 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB548B2AE35AC86C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JHK1E1JHK1_DROME
Dorsal-related immunity factor, iso...
Dif 6794, DIF, dif, Dif2, Dmel\CG6794
667Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JHK2E1JHK2_DROME
Dorsal-related immunity factor, iso...
Dif 6794, DIF, dif, Dif2, Dmel\CG6794
987Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM48404 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti403K → T in AAA28465 (PubMed:8242747).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L29015 mRNA Translation: AAA28465.1
AE014134 Genomic DNA Translation: AAF53608.1
AE014134 Genomic DNA Translation: AAN10989.1
AY118375 mRNA Translation: AAM48404.1 Frameshift.
BT025231 mRNA Translation: ABF17922.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A49435

NCBI Reference Sequences

More...
RefSeqi
NP_001162999.1, NM_001169528.1
NP_523589.2, NM_078865.4
NP_724050.1, NM_165216.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0081008; FBpp0080561; FBgn0011274
FBtr0081009; FBpp0080562; FBgn0011274
FBtr0301578; FBpp0290793; FBgn0011274

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35045

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6794

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29015 mRNA Translation: AAA28465.1
AE014134 Genomic DNA Translation: AAF53608.1
AE014134 Genomic DNA Translation: AAN10989.1
AY118375 mRNA Translation: AAM48404.1 Frameshift.
BT025231 mRNA Translation: ABF17922.1
PIRiA49435
RefSeqiNP_001162999.1, NM_001169528.1
NP_523589.2, NM_078865.4
NP_724050.1, NM_165216.3

3D structure databases

SMRiP98149
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi61041, 10 interactors
DIPiDIP-34965N
IntActiP98149, 6 interactors
STRINGi7227.FBpp0290792

Proteomic databases

PaxDbiP98149
PRIDEiP98149

Genome annotation databases

EnsemblMetazoaiFBtr0081008; FBpp0080561; FBgn0011274
FBtr0081009; FBpp0080562; FBgn0011274
FBtr0301578; FBpp0290793; FBgn0011274
GeneIDi35045
KEGGidme:Dmel_CG6794

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
35045
FlyBaseiFBgn0011274, Dif

Phylogenomic databases

eggNOGiENOG502QQS6, Eukaryota
GeneTreeiENSGT00940000171058
HOGENOMiCLU_452907_0_0_1
InParanoidiP98149
KOiK09254
PhylomeDBiP98149

Enzyme and pathway databases

ReactomeiR-DME-1169091, Activation of NF-kappaB in B cells
R-DME-1810476, RIP-mediated NFkB activation via ZBP1
R-DME-202424, Downstream TCR signaling
R-DME-209400, Transcriptional activtion by phosphorylated DL/DIF dimer
R-DME-209406, Degradation of NF-kappa-B inhibitor, CACT
R-DME-209560, NF-kB is activated and signals survival
R-DME-214842, DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'
R-DME-214844, DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'
R-DME-214869, Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'
R-DME-2871837, FCERI mediated NF-kB activation
R-DME-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-DME-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-DME-4755510, SUMOylation of immune response proteins
R-DME-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764, CLEC7A (Dectin-1) signaling
R-DME-5621575, CD209 (DC-SIGN) signaling
R-DME-5676590, NIK-->noncanonical NF-kB signaling
R-DME-6798695, Neutrophil degranulation
R-DME-9020702, Interleukin-1 signaling
R-DME-933542, TRAF6 mediated NF-kB activation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
35045, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
35045

Protein Ontology

More...
PROi
PR:P98149

Gene expression databases

BgeeiFBgn0011274, Expressed in digestive system element and 21 other tissues
ExpressionAtlasiP98149, baseline and differential
GenevisibleiP98149, DM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR011363, Dif
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR000451, NFkB/Dor
IPR008967, p53-like_TF_DNA-bd
IPR030492, RHD_CS
IPR032397, RHD_dimer
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf
PANTHERiPTHR24169, PTHR24169, 2 hits
PfamiView protein in Pfam
PF16179, RHD_dimer, 1 hit
PF00554, RHD_DNA_bind, 1 hit
PIRSFiPIRSF001716, Dorsal, 1 hit
PRINTSiPR00057, NFKBTNSCPFCT
SMARTiView protein in SMART
SM00429, IPT, 1 hit
SUPFAMiSSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS01204, REL_1, 1 hit
PS50254, REL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIF_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P98149
Secondary accession number(s): Q1LYZ5, Q8MT54, Q9VJE2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 1, 2001
Last modified: October 7, 2020
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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