UniProtKB - P98139 (FA7_RABIT)
Coagulation factor VII
F7
Functioni
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity).
By similarityCatalytic activityi
- Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa. EC:3.4.21.21
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 232 | Charge relay systemBy similarity | 1 | |
Active sitei | 281 | Charge relay systemBy similarity | 1 | |
Binding sitei | 377 | SubstrateBy similarity | 1 | |
Active sitei | 383 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- serine-type endopeptidase activity Source: UniProtKB-EC
GO - Biological processi
- blood coagulation Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Blood coagulation, Hemostasis |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Coagulation factor VII (EC:3.4.21.21)Alternative name(s): Serum prothrombin conversion accelerator Cleaved into the following 2 chains: |
Gene namesi | Name:F7 |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
PropeptideiPRO_0000027735 | 22 – 39 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000027736 | 40 – 191 | Factor VII light chainAdd BLAST | 152 | |
ChainiPRO_0000027737 | 192 – 444 | Factor VII heavy chainAdd BLAST | 253 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 45 | 4-carboxyglutamatePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 46 | 4-carboxyglutamatePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 53 | 4-carboxyglutamatePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 55 | 4-carboxyglutamatePROSITE-ProRule annotationBy similarity | 1 | |
Disulfide bondi | 56 ↔ 61 | By similarity | ||
Modified residuei | 58 | 4-carboxyglutamatePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 59 | 4-carboxyglutamatePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 64 | 4-carboxyglutamatePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 65 | 4-carboxyglutamatePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 68 | 4-carboxyglutamatePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 74 | 4-carboxyglutamatePROSITE-ProRule annotationBy similarity | 1 | |
Disulfide bondi | 89 ↔ 100 | By similarity | ||
Glycosylationi | 91 | O-linked (Glc...) serine; alternateBy similarity | 1 | |
Glycosylationi | 91 | O-linked (Xyl...) serine; alternateBy similarity | 1 | |
Disulfide bondi | 94 ↔ 109 | By similarity | ||
Glycosylationi | 99 | O-linked (Fuc) serineBy similarity | 1 | |
Modified residuei | 102 | (3R)-3-hydroxyaspartateBy similarity | 1 | |
Disulfide bondi | 111 ↔ 120 | By similarity | ||
Disulfide bondi | 130 ↔ 141 | By similarity | ||
Disulfide bondi | 137 ↔ 151 | By similarity | ||
Disulfide bondi | 153 ↔ 166 | By similarity | ||
Disulfide bondi | 174 ↔ 301 | By similarity | ||
Disulfide bondi | 198 ↔ 203 | By similarity | ||
Glycosylationi | 211 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 217 ↔ 233 | By similarity | ||
Glycosylationi | 242 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 306 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 349 ↔ 368 | By similarity | ||
Disulfide bondi | 379 ↔ 407 | By similarity |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 191 – 192 | Cleavage; by factor Xa, factor XIIa, factor IXa, or thrombinBy similarity | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Hydroxylation, ZymogenExpressioni
Tissue specificityi
Interactioni
Subunit structurei
Heterodimer of a light chain and a heavy chain linked by a disulfide bond.
By similarityProtein-protein interaction databases
STRINGi | 9986.ENSOCUP00000024648 |
Chemistry databases
BindingDBi | P98139 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 84 | GlaPROSITE-ProRule annotationAdd BLAST | 45 | |
Domaini | 85 – 121 | EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 126 – 167 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 192 – 431 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 240 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QRGI, Eukaryota |
InParanoidi | P98139 |
OrthoDBi | 1314811at2759 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 4.10.740.10, 1 hit |
InterProi | View protein in InterPro IPR017857, Coagulation_fac-like_Gla_dom IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR033190, F7 IPR035972, GLA-like_dom_SF IPR000294, GLA_domain IPR012224, Pept_S1A_FX IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
PANTHERi | PTHR24278:SF26, PTHR24278:SF26, 1 hit |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00594, Gla, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001143, Factor_X, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN PR00001, GLABLOOD |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00179, EGF_CA, 1 hit SM00069, GLA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57630, SSF57630, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit PS00011, GLA_1, 1 hit PS50998, GLA_2, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAPQARGLGL CSLLALQASL AAVFITQEEA HSVLRRQRRA NSFLEELRPG
60 70 80 90 100
SLERECKEEL CSFEEAREVF QSTERTKQFW ITYNDGDQCA SNPCQNGGSC
110 120 130 140 150
EDQIQSYICF CLADFEGRNC EKNKNDQLIC MYENGGCEQY CSDHVGSQRS
160 170 180 190 200
CRCHEGYTLL PNGVSCTPTV DYPCGKVPAL EKRGASNPQG RIVGGKVCPK
210 220 230 240 250
GECPWQAALM NGSTLLCGGS LLDTHWVVSA AHCFDKLSSL RNLTIVLGEH
260 270 280 290 300
DLSEHEGDEQ VRHVAQLIMP DKYVPGKTDH DIALLRLLQP AALTNNVVPL
310 320 330 340 350
CLPERNFSES TLATIRFSRV SGWGQLLYRG ALARELMAID VPRLMTQDCV
360 370 380 390 400
EQSEHKPGSP EVTGNMFCAG YLDGSKDACK GDSGGPHATS YHGTWYLTGV
410 420 430 440
VSWGEGCAAV GHVGVYTRVS RYTEWLSRLM RSKLHHGIQR HPFP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77477 mRNA Translation: AAB37326.1 |
PIRi | I46932 |
RefSeqi | NP_001076148.1, NM_001082679.1 |
Genome annotation databases
GeneIDi | 100009399 |
KEGGi | ocu:100009399 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77477 mRNA Translation: AAB37326.1 |
PIRi | I46932 |
RefSeqi | NP_001076148.1, NM_001082679.1 |
3D structure databases
AlphaFoldDBi | P98139 |
SMRi | P98139 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000024648 |
Chemistry databases
BindingDBi | P98139 |
ChEMBLi | CHEMBL3351187 |
Genome annotation databases
GeneIDi | 100009399 |
KEGGi | ocu:100009399 |
Organism-specific databases
CTDi | 2155 |
Phylogenomic databases
eggNOGi | ENOG502QRGI, Eukaryota |
InParanoidi | P98139 |
OrthoDBi | 1314811at2759 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 4.10.740.10, 1 hit |
InterProi | View protein in InterPro IPR017857, Coagulation_fac-like_Gla_dom IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR033190, F7 IPR035972, GLA-like_dom_SF IPR000294, GLA_domain IPR012224, Pept_S1A_FX IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
PANTHERi | PTHR24278:SF26, PTHR24278:SF26, 1 hit |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00594, Gla, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001143, Factor_X, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN PR00001, GLABLOOD |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00179, EGF_CA, 1 hit SM00069, GLA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57630, SSF57630, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit PS00011, GLA_1, 1 hit PS50998, GLA_2, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FA7_RABIT | |
Accessioni | P98139Primary (citable) accession number: P98139 Secondary accession number(s): P79224 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | July 15, 1998 | |
Last modified: | May 25, 2022 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families