UniProtKB - P98105 (LYAM2_RAT)
Protein
E-selectin
Gene
Sele
Organism
Rattus norvegicus (Rat)
Status
Functioni
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 101 | CalciumBy similarity | 1 | |
Metal bindingi | 103 | CalciumBy similarity | 1 | |
Metal bindingi | 109 | CalciumBy similarity | 1 | |
Metal bindingi | 126 | CalciumBy similarity | 1 | |
Metal bindingi | 127 | CalciumBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- oligosaccharide binding Source: RGD
- phospholipase binding Source: RGD
- sialic acid binding Source: RGD
- transmembrane signaling receptor activity Source: RGD
GO - Biological processi
- actin filament-based process Source: RGD
- activation of phospholipase C activity Source: RGD
- cell adhesion Source: RGD
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: RGD
- inflammatory response Source: RGD
- leukocyte cell-cell adhesion Source: RGD
- leukocyte migration Source: RGD
- leukocyte tethering or rolling Source: RGD
- positive regulation of leukocyte migration Source: RGD
- positive regulation of leukocyte tethering or rolling Source: UniProtKB
- positive regulation of receptor internalization Source: RGD
- response to cytokine Source: RGD
- response to interleukin-1 Source: RGD
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Lectin, Metal-binding |
Enzyme and pathway databases
Reactomei | R-RNO-202733, Cell surface interactions at the vascular wall |
Names & Taxonomyi
Protein namesi | Recommended name: E-selectinAlternative name(s): CD62 antigen-like family member E Endothelial leukocyte adhesion molecule 1 Short name: ELAM-1 Leukocyte-endothelial cell adhesion molecule 2 Short name: LECAM2 CD_antigen: CD62E |
Gene namesi | Name:Sele Synonyms:Elam-1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3654, Sele |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Cytoskeleton
- cortical cytoskeleton Source: RGD
Extracellular region or secreted
- extracellular space Source: RGD
Plasma Membrane
- caveola Source: RGD
- clathrin-coated pit Source: RGD
- integral component of plasma membrane Source: RGD
Other locations
- membrane raft Source: RGD
- perinuclear region of cytoplasm Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 494 | ExtracellularSequence analysisAdd BLAST | 473 | |
Transmembranei | 495 – 516 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 517 – 549 | CytoplasmicSequence analysisAdd BLAST | 33 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000017496 | 22 – 549 | E-selectinAdd BLAST | 528 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 40 ↔ 138 | By similarity | ||
Glycosylationi | 60 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 111 ↔ 130 | By similarity | ||
Disulfide bondi | 143 ↔ 154 | By similarity | ||
Glycosylationi | 145 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 148 ↔ 163 | By similarity | ||
Disulfide bondi | 165 ↔ 174 | By similarity | ||
Disulfide bondi | 180 ↔ 225 | By similarity | ||
Glycosylationi | 192 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 193 ↔ 206 | By similarity | ||
Glycosylationi | 203 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 210 ↔ 238 | By similarity | ||
Disulfide bondi | 243 ↔ 287 | By similarity | ||
Disulfide bondi | 256 ↔ 269 | By similarity | ||
Glycosylationi | 266 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 273 ↔ 300 | By similarity | ||
Disulfide bondi | 305 ↔ 350 | By similarity | ||
Glycosylationi | 313 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 320 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 333 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 336 ↔ 363 | By similarity | ||
Disulfide bondi | 368 ↔ 413 | By similarity | ||
Disulfide bondi | 399 ↔ 426 | By similarity | ||
Disulfide bondi | 431 ↔ 472 | By similarity | ||
Glycosylationi | 441 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 458 ↔ 485 | By similarity | ||
Glycosylationi | 465 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P98105 |
PRIDEi | P98105 |
PTM databases
GlyGeni | P98105, 11 sites |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000002723, Expressed in heart and 15 other tissues |
ExpressionAtlasi | P98105, baseline and differential |
Genevisiblei | P98105, RN |
Interactioni
Subunit structurei
Interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope. SELPLG sulfation appears not to be required for this interaction.
By similarityGO - Molecular functioni
- phospholipase binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000068171 |
Chemistry databases
BindingDBi | P98105 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 139 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 140 – 175 | EGF-likePROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 178 – 240 | Sushi 1PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 241 – 302 | Sushi 2PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 303 – 365 | Sushi 3PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 366 – 428 | Sushi 4PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 429 – 487 | Sushi 5PROSITE-ProRule annotationAdd BLAST | 59 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 101 – 109 | Carbohydrate bindingBy similarity | 9 | |
Regioni | 113 – 118 | Carbohydrate bindingBy similarity | 6 | |
Regioni | 126 – 128 | Carbohydrate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the selectin/LECAM family.Curated
Keywords - Domaini
EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000160168 |
HOGENOMi | CLU_020848_1_0_1 |
InParanoidi | P98105 |
OrthoDBi | 445079at2759 |
Family and domain databases
CDDi | cd00033, CCP, 5 hits cd03592, CLECT_selectins_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR016187, CTDL_fold IPR000742, EGF-like_dom IPR033991, Selectin_CTLD IPR002396, Selectin_superfamily IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00059, Lectin_C, 1 hit PF00084, Sushi, 5 hits |
PRINTSi | PR00343, SELECTIN |
SMARTi | View protein in SMART SM00032, CCP, 5 hits SM00034, CLECT, 1 hit SM00181, EGF, 2 hits |
SUPFAMi | SSF56436, SSF56436, 1 hit SSF57535, SSF57535, 5 hits |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS50923, SUSHI, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P98105-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNASCFLSAL TFVLLIGKSI AWYYNASSEL MTYDEASAYC QRDYTHLVAI
60 70 80 90 100
QNKEEINYLN STLRYSPSYY WIGIRKVNNV WIWVGTQKPL TEEAKNWAPG
110 120 130 140 150
EPNNKQRNED CVEIYIQRPK DSGMWNDERC DKKKLALCYT ASCTNTSCSG
160 170 180 190 200
HGECVETINS YTCKCHPGFL GPKCDQVVTC QEQEYPDHGS LNCTHPFGLF
210 220 230 240 250
SYNSSCSFSC ERGYVPSSME TTVRCTSSGE WSAPAPACHV VECKALTQPA
260 270 280 290 300
HGVRKCSSNP GSYPWNTTCT FDCEEGYRRV GAQNLQCTSS GVWDNEKPSC
310 320 330 340 350
KAVTCDAIPR PQNGSVSCSN STAGALAFKS SCNFTCEHSF TLQGPAQVEC
360 370 380 390 400
SAQGQWTPQI PVCKASQCEA LSAPQRGHMK CLPSASAPFQ SGSSCKFSCD
410 420 430 440 450
EGFELKGSRR LQCGPRGEWD SEKPTCAGVQ CSSLDLPGKM NMSCSGPAVF
460 470 480 490 500
GTVCEFTCPE GWTLNGSSIL TCGATGRWSA MLPTCEAPAN PPRPLVVALS
510 520 530 540
VAATSLLTLS SLIYVLKRFF WKKAKKFVPA SSCQSLQSFE NYQGPSYII
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0H2UHU5 | A0A0H2UHU5_RAT | E-selectin | Sele rCG_46147 | 556 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L25527 mRNA Translation: AAA41113.1 |
RefSeqi | NP_620234.1, NM_138879.1 |
Genome annotation databases
Ensembli | ENSRNOT00000076757; ENSRNOP00000068171; ENSRNOG00000002723 |
GeneIDi | 25544 |
KEGGi | rno:25544 |
UCSCi | RGD:3654, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L25527 mRNA Translation: AAA41113.1 |
RefSeqi | NP_620234.1, NM_138879.1 |
3D structure databases
SMRi | P98105 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000068171 |
Chemistry databases
BindingDBi | P98105 |
ChEMBLi | CHEMBL2554 |
PTM databases
GlyGeni | P98105, 11 sites |
Proteomic databases
PaxDbi | P98105 |
PRIDEi | P98105 |
Genome annotation databases
Ensembli | ENSRNOT00000076757; ENSRNOP00000068171; ENSRNOG00000002723 |
GeneIDi | 25544 |
KEGGi | rno:25544 |
UCSCi | RGD:3654, rat |
Organism-specific databases
CTDi | 6401 |
RGDi | 3654, Sele |
Phylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000160168 |
HOGENOMi | CLU_020848_1_0_1 |
InParanoidi | P98105 |
OrthoDBi | 445079at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-202733, Cell surface interactions at the vascular wall |
Miscellaneous databases
PROi | PR:P98105 |
Gene expression databases
Bgeei | ENSRNOG00000002723, Expressed in heart and 15 other tissues |
ExpressionAtlasi | P98105, baseline and differential |
Genevisiblei | P98105, RN |
Family and domain databases
CDDi | cd00033, CCP, 5 hits cd03592, CLECT_selectins_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR016187, CTDL_fold IPR000742, EGF-like_dom IPR033991, Selectin_CTLD IPR002396, Selectin_superfamily IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00059, Lectin_C, 1 hit PF00084, Sushi, 5 hits |
PRINTSi | PR00343, SELECTIN |
SMARTi | View protein in SMART SM00032, CCP, 5 hits SM00034, CLECT, 1 hit SM00181, EGF, 2 hits |
SUPFAMi | SSF56436, SSF56436, 1 hit SSF57535, SSF57535, 5 hits |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS50923, SUSHI, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LYAM2_RAT | |
Accessioni | P98105Primary (citable) accession number: P98105 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families