UniProtKB - P98095 (FBLN2_HUMAN)
Fibulin-2
FBLN2
Functioni
GO - Molecular functioni
- calcium ion binding Source: ProtInc
- extracellular matrix binding Source: GO_Central
- extracellular matrix constituent conferring elasticity Source: BHF-UCL
- extracellular matrix structural constituent Source: ProtInc
GO - Biological processi
- extracellular matrix organization Source: InterPro
- positive regulation of cell-substrate adhesion Source: GO_Central
Keywordsi
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | P98095 |
Reactomei | R-HSA-2129379, Molecules associated with elastic fibres |
Names & Taxonomyi
Protein namesi | Recommended name: Fibulin-2Short name: FIBL-2 |
Gene namesi | Name:FBLN2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3601, FBLN2 |
MIMi | 135821, gene |
neXtProti | NX_P98095 |
VEuPathDBi | HostDB:ENSG00000163520.13 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- collagen-containing extracellular matrix Source: UniProtKB
- extracellular matrix Source: ProtInc
- extracellular region Source: BHF-UCL
- extracellular vesicle Source: UniProtKB
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 2199 |
OpenTargetsi | ENSG00000163520 |
PharmGKBi | PA28014 |
Miscellaneous databases
Pharosi | P98095, Tbio |
Genetic variation databases
BioMutai | FBLN2 |
DMDMi | 224471827 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000007568 | 28 – 1184 | Fibulin-2Add BLAST | 1157 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 180 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 277 | PhosphoserineCombined sources | 1 | |
Disulfide bondi | 445 ↔ 472 | By similarity | ||
Disulfide bondi | 446 ↔ 479 | By similarity | ||
Disulfide bondi | 459 ↔ 480 | By similarity | ||
Disulfide bondi | 489 ↔ 518 | By similarity | ||
Disulfide bondi | 502 ↔ 519 | By similarity | ||
Glycosylationi | 507 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 521 ↔ 545 | By similarity | ||
Disulfide bondi | 522 ↔ 552 | By similarity | ||
Disulfide bondi | 535 ↔ 553 | By similarity | ||
Disulfide bondi | 608 ↔ 620 | By similarity | ||
Disulfide bondi | 616 ↔ 629 | By similarity | ||
Disulfide bondi | 631 ↔ 644 | By similarity | ||
Disulfide bondi | 683 ↔ 693 | By similarity | ||
Disulfide bondi | 689 ↔ 702 | By similarity | ||
Disulfide bondi | 704 ↔ 717 | By similarity | ||
Disulfide bondi | 723 ↔ 736 | By similarity | ||
Disulfide bondi | 730 ↔ 745 | By similarity | ||
Disulfide bondi | 751 ↔ 762 | By similarity | ||
Disulfide bondi | 768 ↔ 781 | By similarity | ||
Disulfide bondi | 775 ↔ 790 | By similarity | ||
Disulfide bondi | 796 ↔ 808 | By similarity | ||
Disulfide bondi | 814 ↔ 827 | By similarity | ||
Disulfide bondi | 821 ↔ 836 | By similarity | ||
Disulfide bondi | 843 ↔ 856 | By similarity | ||
Disulfide bondi | 862 ↔ 875 | By similarity | ||
Disulfide bondi | 869 ↔ 884 | By similarity | ||
Disulfide bondi | 886 ↔ 899 | By similarity | ||
Disulfide bondi | 905 ↔ 917 | By similarity | ||
Disulfide bondi | 913 ↔ 926 | By similarity | ||
Disulfide bondi | 928 ↔ 941 | By similarity | ||
Disulfide bondi | 947 ↔ 956 | By similarity | ||
Disulfide bondi | 952 ↔ 965 | By similarity | ||
Disulfide bondi | 967 ↔ 980 | By similarity | ||
Disulfide bondi | 986 ↔ 998 | By similarity | ||
Disulfide bondi | 994 ↔ 1007 | By similarity | ||
Disulfide bondi | 1009 ↔ 1023 | By similarity | ||
Disulfide bondi | 1029 ↔ 1042 | By similarity | ||
Glycosylationi | 1035 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 1036 ↔ 1051 | By similarity | ||
Disulfide bondi | 1056 ↔ 1068 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P98095 |
jPOSTi | P98095 |
MassIVEi | P98095 |
MaxQBi | P98095 |
PaxDbi | P98095 |
PeptideAtlasi | P98095 |
PRIDEi | P98095 |
ProteomicsDBi | 57790 [P98095-1] 57791 [P98095-2] |
PTM databases
GlyConnecti | 751, 8 N-Linked glycans (2 sites) |
GlyGeni | P98095, 19 sites, 5 O-linked glycans (16 sites) |
iPTMneti | P98095 |
PhosphoSitePlusi | P98095 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000163520, Expressed in right atrium auricular region and 206 other tissues |
ExpressionAtlasi | P98095, baseline and differential |
Genevisiblei | P98095, HS |
Organism-specific databases
HPAi | ENSG00000163520, Tissue enhanced (heart) |
Interactioni
Subunit structurei
Homotrimer; disulfide-linked.
Interacts with LAMA2 (By similarity).
Interacts with FBN1 (via N-terminal domain).
Forms a ternary complex with ELN and FBN1 (PubMed:17255108).
By similarity1 PublicationBinary interactionsi
Hide detailsP98095
Protein-protein interaction databases
BioGRIDi | 108493, 45 interactors |
CORUMi | P98095 |
IntActi | P98095, 13 interactors |
STRINGi | 9606.ENSP00000384169 |
Miscellaneous databases
RNActi | P98095, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 445 – 480 | Anaphylatoxin-like 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 488 – 519 | Anaphylatoxin-like 2PROSITE-ProRule annotationAdd BLAST | 32 | |
Domaini | 521 – 553 | Anaphylatoxin-like 3PROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 604 – 645 | EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 679 – 718 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 719 – 763 | EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 45 | |
Domaini | 764 – 809 | EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 810 – 857 | EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 858 – 900 | EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 901 – 942 | EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 943 – 981 | EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 982 – 1024 | EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 1025 – 1069 | EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 45 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 28 – 444 | NAdd BLAST | 417 | |
Regioni | 28 – 177 | Subdomain NA (Cys-rich)Add BLAST | 150 | |
Regioni | 178 – 444 | Subdomain NB (Cys-free)Add BLAST | 267 | |
Regioni | 1070 – 1184 | Domain IIIAdd BLAST | 115 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG1217, Eukaryota |
GeneTreei | ENSGT00940000156047 |
HOGENOMi | CLU_268948_0_0_1 |
InParanoidi | P98095 |
OMAi | CHCPNAG |
PhylomeDBi | P98095 |
TreeFami | TF317514 |
Family and domain databases
CDDi | cd00017, ANATO, 2 hits |
InterProi | View protein in InterPro IPR000020, Anaphylatoxin/fibulin IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR037286, Fibulin-2 IPR009030, Growth_fac_rcpt_cys_sf |
PANTHERi | PTHR24039:SF32, PTHR24039:SF32, 2 hits |
Pfami | View protein in Pfam PF01821, ANATO, 1 hit PF12662, cEGF, 2 hits PF07645, EGF_CA, 5 hits |
SMARTi | View protein in SMART SM00104, ANATO, 3 hits SM00181, EGF, 11 hits SM00179, EGF_CA, 9 hits |
SUPFAMi | SSF57184, SSF57184, 4 hits |
PROSITEi | View protein in PROSITE PS01177, ANAPHYLATOXIN_1, 3 hits PS01178, ANAPHYLATOXIN_2, 3 hits PS00010, ASX_HYDROXYL, 5 hits PS01186, EGF_2, 5 hits PS50026, EGF_3, 4 hits PS01187, EGF_CA, 9 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVLLWEPAGA WLALGLALAL GPSVAAAAPR QDCTGVECPP LENCIEEALE
60 70 80 90 100
PGACCATCVQ QGCACEGYQY YDCLQGGFVR GRVPAGQSYF VDFGSTECSC
110 120 130 140 150
PPGGGKISCQ FMLCPELPPN CIEAVVVADS CPQCGQVGCV HAGHKYAAGH
160 170 180 190 200
TVHLPPCRAC HCPDAGGELI CYQLPGCHGN FSDAEEGDPE RHYEDPYSYD
210 220 230 240 250
QEVAEVEAAT ALGGEVQAGA VQAGAGGPPA ALGGGSQPLS TIQAPPWPAV
260 270 280 290 300
LPRPTAAAAL GPPAPVQAKA RRVTEDSEEE EEEEEEREEM AVTEQLAAGG
310 320 330 340 350
HRGLDGLPTT APAGPSLPIQ EERAEAGARA EAGARPEENL ILDAQATSRS
360 370 380 390 400
TGPEGVTHAP SLGKAALVPT QAVPGSPRDP VKPSPHNILS TSLPDAAWIP
410 420 430 440 450
PTREVPRKPQ VLPHSHVEED TDPNSVHSIP RSSPEGSTKD LIETCCAAGQ
460 470 480 490 500
QWAIDNDECL EIPESGTEDN VCRTAQRHCC VSYLQEKSCM AGVLGAKEGE
510 520 530 540 550
TCGAEDNDSC GISLYKQCCD CCGLGLRVRA EGQSCESNPN LGYPCNHVML
560 570 580 590 600
SCCEGEEPLI VPEVRRPPEP AAAPRRVSEA EMAGREALSL GTEAELPNSL
610 620 630 640 650
PGDDQDECLL LPGELCQHLC INTVGSYHCA CFPGFSLQDD GRTCRPEGHP
660 670 680 690 700
PQPEAPQEPA LKSEFSQVAS NTIPLPLPQP NTCKDNGPCK QVCSTVGGSA
710 720 730 740 750
ICSCFPGYAI MADGVSCEDI NECVTDLHTC SRGEHCVNTL GSFHCYKALT
760 770 780 790 800
CEPGYALKDG ECEDVDECAM GTHTCQPGFL CQNTKGSFYC QARQRCMDGF
810 820 830 840 850
LQDPEGNCVD INECTSLSEP CRPGFSCINT VGSYTCQRNP LICARGYHAS
860 870 880 890 900
DDGTKCVDVN ECETGVHRCG EGQVCHNLPG SYRCDCKAGF QRDAFGRGCI
910 920 930 940 950
DVNECWASPG RLCQHTCENT LGSYRCSCAS GFLLAADGKR CEDVNECEAQ
960 970 980 990 1000
RCSQECANIY GSYQCYCRQG YQLAEDGHTC TDIDECAQGA GILCTFRCLN
1010 1020 1030 1040 1050
VPGSYQCACP EQGYTMTANG RSCKDVDECA LGTHNCSEAE TCHNIQGSFR
1060 1070 1080 1090 1100
CLRFECPPNY VQVSKTKCER TTCHDFLECQ NSPARITHYQ LNFQTGLLVP
1110 1120 1130 1140 1150
AHIFRIGPAP AFTGDTIALN IIKGNEEGYF GTRRLNAYTG VVYLQRAVLE
1160 1170 1180
PRDFALDVEM KLWRQGSVTT FLAKMHIFFT TFAL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JQS6 | C9JQS6_HUMAN | Fibulin-2 | FBLN2 | 158 | Annotation score: | ||
H7BXL0 | H7BXL0_HUMAN | Fibulin-2 | FBLN2 | 109 | Annotation score: | ||
H7C1A3 | H7C1A3_HUMAN | Fibulin-2 | FBLN2 | 101 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 145 | K → E in CAA57876 (PubMed:7806230).Curated | 1 | |
Sequence conflicti | 145 | K → E in AAN05436 (Ref. 2) Curated | 1 | |
Sequence conflicti | 664 | E → G in BAH14261 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061159 | 45 | I → V. Corresponds to variant dbSNP:rs60850813Ensembl. | 1 | |
Natural variantiVAR_061160 | 144 | H → R. Corresponds to variant dbSNP:rs28587534Ensembl. | 1 | |
Natural variantiVAR_059266 | 361 | S → G. Corresponds to variant dbSNP:rs3732666Ensembl. | 1 | |
Natural variantiVAR_059267 | 387 | N → T. Corresponds to variant dbSNP:rs3796318Ensembl. | 1 | |
Natural variantiVAR_059268 | 854 | T → A1 PublicationCorresponds to variant dbSNP:rs9843344Ensembl. | 1 | |
Natural variantiVAR_055722 | 1114 | G → R. Corresponds to variant dbSNP:rs1061375Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041404 | 718 | E → EDQDECLMGAHDCSRRQFCV NTLGSFYCVNHTVLCADGYI LNAHRKCV in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82494 mRNA Translation: CAA57876.1 AY130458, AY130456, AY130457 Genomic DNA Translation: AAN05435.1 AY130459 mRNA Translation: AAN05436.1 AK304827 mRNA Translation: BAH14261.1 AC090509 Genomic DNA No translation available. |
CCDSi | CCDS46761.1 [P98095-2] CCDS46762.1 [P98095-1] |
PIRi | A55184 |
RefSeqi | NP_001004019.1, NM_001004019.1 [P98095-2] NP_001158507.1, NM_001165035.1 [P98095-2] NP_001989.2, NM_001998.2 [P98095-1] |
Genome annotation databases
Ensembli | ENST00000295760; ENSP00000295760; ENSG00000163520 [P98095-1] ENST00000404922; ENSP00000384169; ENSG00000163520 [P98095-2] ENST00000492059; ENSP00000420042; ENSG00000163520 [P98095-2] |
GeneIDi | 2199 |
KEGGi | hsa:2199 |
UCSCi | uc011ava.3, human [P98095-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82494 mRNA Translation: CAA57876.1 AY130458, AY130456, AY130457 Genomic DNA Translation: AAN05435.1 AY130459 mRNA Translation: AAN05436.1 AK304827 mRNA Translation: BAH14261.1 AC090509 Genomic DNA No translation available. |
CCDSi | CCDS46761.1 [P98095-2] CCDS46762.1 [P98095-1] |
PIRi | A55184 |
RefSeqi | NP_001004019.1, NM_001004019.1 [P98095-2] NP_001158507.1, NM_001165035.1 [P98095-2] NP_001989.2, NM_001998.2 [P98095-1] |
3D structure databases
SMRi | P98095 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108493, 45 interactors |
CORUMi | P98095 |
IntActi | P98095, 13 interactors |
STRINGi | 9606.ENSP00000384169 |
PTM databases
GlyConnecti | 751, 8 N-Linked glycans (2 sites) |
GlyGeni | P98095, 19 sites, 5 O-linked glycans (16 sites) |
iPTMneti | P98095 |
PhosphoSitePlusi | P98095 |
Genetic variation databases
BioMutai | FBLN2 |
DMDMi | 224471827 |
Proteomic databases
EPDi | P98095 |
jPOSTi | P98095 |
MassIVEi | P98095 |
MaxQBi | P98095 |
PaxDbi | P98095 |
PeptideAtlasi | P98095 |
PRIDEi | P98095 |
ProteomicsDBi | 57790 [P98095-1] 57791 [P98095-2] |
Protocols and materials databases
Antibodypediai | 1165, 256 antibodies |
Genome annotation databases
Ensembli | ENST00000295760; ENSP00000295760; ENSG00000163520 [P98095-1] ENST00000404922; ENSP00000384169; ENSG00000163520 [P98095-2] ENST00000492059; ENSP00000420042; ENSG00000163520 [P98095-2] |
GeneIDi | 2199 |
KEGGi | hsa:2199 |
UCSCi | uc011ava.3, human [P98095-1] |
Organism-specific databases
CTDi | 2199 |
DisGeNETi | 2199 |
GeneCardsi | FBLN2 |
HGNCi | HGNC:3601, FBLN2 |
HPAi | ENSG00000163520, Tissue enhanced (heart) |
MIMi | 135821, gene |
neXtProti | NX_P98095 |
OpenTargetsi | ENSG00000163520 |
PharmGKBi | PA28014 |
VEuPathDBi | HostDB:ENSG00000163520.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1217, Eukaryota |
GeneTreei | ENSGT00940000156047 |
HOGENOMi | CLU_268948_0_0_1 |
InParanoidi | P98095 |
OMAi | CHCPNAG |
PhylomeDBi | P98095 |
TreeFami | TF317514 |
Enzyme and pathway databases
PathwayCommonsi | P98095 |
Reactomei | R-HSA-2129379, Molecules associated with elastic fibres |
Miscellaneous databases
BioGRID-ORCSi | 2199, 1 hit in 874 CRISPR screens |
ChiTaRSi | FBLN2, human |
GeneWikii | FBLN2 |
GenomeRNAii | 2199 |
Pharosi | P98095, Tbio |
PROi | PR:P98095 |
RNActi | P98095, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163520, Expressed in right atrium auricular region and 206 other tissues |
ExpressionAtlasi | P98095, baseline and differential |
Genevisiblei | P98095, HS |
Family and domain databases
CDDi | cd00017, ANATO, 2 hits |
InterProi | View protein in InterPro IPR000020, Anaphylatoxin/fibulin IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR037286, Fibulin-2 IPR009030, Growth_fac_rcpt_cys_sf |
PANTHERi | PTHR24039:SF32, PTHR24039:SF32, 2 hits |
Pfami | View protein in Pfam PF01821, ANATO, 1 hit PF12662, cEGF, 2 hits PF07645, EGF_CA, 5 hits |
SMARTi | View protein in SMART SM00104, ANATO, 3 hits SM00181, EGF, 11 hits SM00179, EGF_CA, 9 hits |
SUPFAMi | SSF57184, SSF57184, 4 hits |
PROSITEi | View protein in PROSITE PS01177, ANAPHYLATOXIN_1, 3 hits PS01178, ANAPHYLATOXIN_2, 3 hits PS00010, ASX_HYDROXYL, 5 hits PS01186, EGF_2, 5 hits PS50026, EGF_3, 4 hits PS01187, EGF_CA, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FBLN2_HUMAN | |
Accessioni | P98095Primary (citable) accession number: P98095 Secondary accession number(s): B7Z9C5, Q8IUI0, Q8IUI1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | March 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 191 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families